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Lung combined large cell neuroendocrine carcinoma

MedGen UID:
232386
•Concept ID:
C1333122
•
Neoplastic Process
Synonyms: Combined Large Cell Lung Neuroendocrine Carcinoma; combined large cell lung neuroendocrine carcinoma; Combined Large Cell Neuroendocrine Carcinoma of Lung; combined large cell neuroendocrine carcinoma of lung; Combined Large Cell Neuroendocrine Carcinoma of the Lung; combined large cell neuroendocrine carcinoma of the lung; Combined Lung Large Cell Neuroendocrine Carcinoma; Lung Combined Large Cell Neuroendocrine Carcinoma; lung combined large cell neuroendocrine carcinoma; Pulmonary Combined Large Cell Neuroendocrine Carcinoma; pulmonary combined large cell neuroendocrine carcinoma
 
Monarch Initiative: MONDO:0004142

Definition

A subtype of large cell neuroendocrine lung carcinoma characterized by the presence of large neuroendocrine cells in combination with adenocarcinoma, squamous cell carcinoma, giant cell carcinoma and/ or spindle cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung combined large cell neuroendocrine carcinoma

Professional guidelines

PubMed

Combined large cell neuroendocrine carcinoma: clinical characteristics, prognosis and postoperative management.
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Current Treatment Options in Gastroenteropancreatic Neuroendocrine Carcinoma.
Thomas KEH, Voros BA, Boudreaux JP, Thiagarajan R, Woltering EA, Ramirez RA
Oncologist 2019 Aug;24(8):1076-1088. Epub 2019 Jan 11 doi: 10.1634/theoncologist.2018-0604. PMID: 30635447Free PMC Article
Treatment of lung large cell neuroendocrine carcinoma.
Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC
Tumour Biol 2016 Jun;37(6):7047-57. Epub 2016 Mar 4 doi: 10.1007/s13277-016-5003-4. PMID: 26943800

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Pulmonary Combined Large Cell Neuroendocrine Carcinoma.
Li M, Yang L, Lu H
Pathol Oncol Res 2022;28:1610747. Epub 2022 Nov 23 doi: 10.3389/pore.2022.1610747. PMID: 36507119Free PMC Article
Combined large cell neuroendocrine carcinoma: clinical characteristics, prognosis and postoperative management.
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Survival and prognosis of lung large cell neuroendocrine carcinoma.
Jiang H, Wu Q, Zhong Y
Bull Cancer 2021 Oct;108(10):981-987. Epub 2021 Aug 12 doi: 10.1016/j.bulcan.2021.04.010. PMID: 34392973
Recent advances and current controversies in lung neuroendocrine neoplasms(✰).
Metovic J, Bianchi F, Rossi G, Barella M, Sonzogni A, Harari S, Papotti M, Pelosi G
Semin Diagn Pathol 2021 Sep;38(5):90-97. Epub 2021 Mar 19 doi: 10.1053/j.semdp.2021.03.002. PMID: 33810912
Treatment of lung large cell neuroendocrine carcinoma.
Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC
Tumour Biol 2016 Jun;37(6):7047-57. Epub 2016 Mar 4 doi: 10.1007/s13277-016-5003-4. PMID: 26943800

Diagnosis

Pulmonary Combined Large Cell Neuroendocrine Carcinoma.
Li M, Yang L, Lu H
Pathol Oncol Res 2022;28:1610747. Epub 2022 Nov 23 doi: 10.3389/pore.2022.1610747. PMID: 36507119Free PMC Article
Expression patterns and prognostic relevance of subtype-specific transcription factors in surgically resected small-cell lung cancer: an international multicenter study.
Megyesfalvi Z, Barany N, Lantos A, Valko Z, Pipek O, Lang C, Schwendenwein A, Oberndorfer F, Paku S, Ferencz B, Dezso K, Fillinger J, Lohinai Z, Moldvay J, Galffy G, Szeitz B, Rezeli M, Rivard C, Hirsch FR, Brcic L, Popper H, Kern I, Kovacevic M, Skarda J, Mittak M, Marko-Varga G, Bogos K, Renyi-Vamos F, Hoda MA, Klikovits T, Hoetzenecker K, Schelch K, Laszlo V, Dome B
J Pathol 2022 Aug;257(5):674-686. Epub 2022 May 25 doi: 10.1002/path.5922. PMID: 35489038Free PMC Article
Recent advances and current controversies in lung neuroendocrine neoplasms(✰).
Metovic J, Bianchi F, Rossi G, Barella M, Sonzogni A, Harari S, Papotti M, Pelosi G
Semin Diagn Pathol 2021 Sep;38(5):90-97. Epub 2021 Mar 19 doi: 10.1053/j.semdp.2021.03.002. PMID: 33810912
High-grade neuroendocrine carcinoma.
Rossi G, Bisagni A, Cavazza A
Curr Opin Pulm Med 2014 Jul;20(4):332-9. doi: 10.1097/MCP.0000000000000061. PMID: 24811834
Large cell/neuroendocrine carcinoma.
Gollard R, Jhatakia S, Elliott M, Kosty M
Lung Cancer 2010 Jul;69(1):13-8. Epub 2010 Feb 4 doi: 10.1016/j.lungcan.2009.12.011. PMID: 20133008

Therapy

Pulmonary Combined Large Cell Neuroendocrine Carcinoma.
Li M, Yang L, Lu H
Pathol Oncol Res 2022;28:1610747. Epub 2022 Nov 23 doi: 10.3389/pore.2022.1610747. PMID: 36507119Free PMC Article
Combined large cell neuroendocrine carcinoma: clinical characteristics, prognosis and postoperative management.
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Survival and prognosis of lung large cell neuroendocrine carcinoma.
Jiang H, Wu Q, Zhong Y
Bull Cancer 2021 Oct;108(10):981-987. Epub 2021 Aug 12 doi: 10.1016/j.bulcan.2021.04.010. PMID: 34392973
Treatment of lung large cell neuroendocrine carcinoma.
Lo Russo G, Pusceddu S, Proto C, Macerelli M, Signorelli D, Vitali M, Ganzinelli M, Gallucci R, Zilembo N, Platania M, Buzzoni R, de Braud F, Garassino MC
Tumour Biol 2016 Jun;37(6):7047-57. Epub 2016 Mar 4 doi: 10.1007/s13277-016-5003-4. PMID: 26943800
Large cell/neuroendocrine carcinoma.
Gollard R, Jhatakia S, Elliott M, Kosty M
Lung Cancer 2010 Jul;69(1):13-8. Epub 2010 Feb 4 doi: 10.1016/j.lungcan.2009.12.011. PMID: 20133008

Prognosis

Pulmonary Combined Large Cell Neuroendocrine Carcinoma.
Li M, Yang L, Lu H
Pathol Oncol Res 2022;28:1610747. Epub 2022 Nov 23 doi: 10.3389/pore.2022.1610747. PMID: 36507119Free PMC Article
Expression patterns and prognostic relevance of subtype-specific transcription factors in surgically resected small-cell lung cancer: an international multicenter study.
Megyesfalvi Z, Barany N, Lantos A, Valko Z, Pipek O, Lang C, Schwendenwein A, Oberndorfer F, Paku S, Ferencz B, Dezso K, Fillinger J, Lohinai Z, Moldvay J, Galffy G, Szeitz B, Rezeli M, Rivard C, Hirsch FR, Brcic L, Popper H, Kern I, Kovacevic M, Skarda J, Mittak M, Marko-Varga G, Bogos K, Renyi-Vamos F, Hoda MA, Klikovits T, Hoetzenecker K, Schelch K, Laszlo V, Dome B
J Pathol 2022 Aug;257(5):674-686. Epub 2022 May 25 doi: 10.1002/path.5922. PMID: 35489038Free PMC Article
Classification and Pathology of Lung Cancer.
Zheng M
Surg Oncol Clin N Am 2016 Jul;25(3):447-68. doi: 10.1016/j.soc.2016.02.003. PMID: 27261908
High-grade neuroendocrine carcinoma.
Rossi G, Bisagni A, Cavazza A
Curr Opin Pulm Med 2014 Jul;20(4):332-9. doi: 10.1097/MCP.0000000000000061. PMID: 24811834
Large cell/neuroendocrine carcinoma.
Gollard R, Jhatakia S, Elliott M, Kosty M
Lung Cancer 2010 Jul;69(1):13-8. Epub 2010 Feb 4 doi: 10.1016/j.lungcan.2009.12.011. PMID: 20133008

Clinical prediction guides

Advances in combined neuroendocrine carcinoma of lung cancer.
Han Z, Yang F, Wang F, Zheng H, Chen X, Meng H, Li F
Pathol Oncol Res 2024;30:1611693. Epub 2024 May 14 doi: 10.3389/pore.2024.1611693. PMID: 38807858Free PMC Article
Spread Through Air Spaces in Stage I Pulmonary Large Cell Neuroendocrine Carcinoma.
Wan S, Shen Z, Hu S, Zhang L, Yu H, Chen Y, Wang J, Wang D, Zhang J, Zhang P
Ann Thorac Surg 2024 Aug;118(2):385-393. Epub 2024 Jan 17 doi: 10.1016/j.athoracsur.2024.01.002. PMID: 38242341
Exploring the molecular features and genetic prognostic factors of pulmonary high-grade neuroendocrine carcinomas.
Wang H, Yan L, Zhu Y, Sun W, Yang X, Liu X, Chi K, Huang X, Zhou L, Lin D
Hum Pathol 2023 Dec;142:81-89. Epub 2023 Sep 22 doi: 10.1016/j.humpath.2023.09.002. PMID: 37742943
Combined large cell neuroendocrine carcinoma: clinical characteristics, prognosis and postoperative management.
Yang Z, Wang Y, Chen Y, Qian F, Zhang Y, Hu M, Zhang W, Han B
Eur J Cardiothorac Surg 2022 Jul 11;62(2) doi: 10.1093/ejcts/ezac069. PMID: 35147672
Survival and prognosis of lung large cell neuroendocrine carcinoma.
Jiang H, Wu Q, Zhong Y
Bull Cancer 2021 Oct;108(10):981-987. Epub 2021 Aug 12 doi: 10.1016/j.bulcan.2021.04.010. PMID: 34392973

Recent systematic reviews

Neuroendocrine carcinoma of unknown primary: a systematic review of the literature and a comparative study with other neuroendocrine tumors.
Stoyianni A, Pentheroudakis G, Pavlidis N
Cancer Treat Rev 2011 Aug;37(5):358-65. Epub 2011 Apr 9 doi: 10.1016/j.ctrv.2011.03.002. PMID: 21481536

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
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    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

    Consumer resources

    Reviews

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