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Endometrial Large Cell Neuroendocrine Carcinoma

MedGen UID:
927120
•Concept ID:
C4289588
•
Neoplastic Process

Definition

A high grade neuroendocrine carcinoma that arises from the endometrium. It is composed of large polygonal cells arranged in well-demarcated nests, trabeculae or cords with peripheral palisading. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811

Recent clinical studies

Diagnosis

Primary mixed large cell neuroendocrine and high grade serous carcinoma of the endometrium.
Hardy LE, Chaudry Z, Wan K, Ayres C
BMJ Case Rep 2020 Sep 2;13(9) doi: 10.1136/bcr-2020-234977. PMID: 32878852Free PMC Article

Prognosis

Collision Tumor of Endometrial Large Cell Neuroendocrine Carcinoma and Low-Grade Endometrial Stromal Sarcoma: A Case Report and Review of the Literature.
Rivera G, Niu S, Chen H, Fahim D, Peng Y
Int J Surg Pathol 2020 Aug;28(5):569-573. Epub 2020 Jan 28 doi: 10.1177/1066896920901764. PMID: 31992096

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