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Endometrial Large Cell Neuroendocrine Carcinoma

MedGen UID:
927120
•Concept ID:
C4289588
•
Neoplastic Process

Definition

A high grade neuroendocrine carcinoma that arises from the endometrium. It is composed of large polygonal cells arranged in well-demarcated nests, trabeculae or cords with peripheral palisading. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811

Recent clinical studies

Etiology

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Clinical characteristic and prognostic factors in high-grade endometrial neuroendocrine carcinoma.
Zhang Z, Wang J, Wu X, Liu Y, Xi X
J Obstet Gynaecol Res 2022 Aug;48(8):2180-2188. Epub 2022 Jul 1 doi: 10.1111/jog.15321. PMID: 35778826Free PMC Article
Pathological processes and pretreatment cytologic diagnosis of neuroendocrine carcinoma of the endometrium: addendum report of the Kansai Clinical Oncology Group/Intergroup study in Japan.
Matsumoto H, Nasu K, Shikama A, Shiozaki T, Futagami M, Kai K, Mori T, Yano M, Yamada T, Teramoto N
Med Mol Morphol 2021 Sep;54(3):237-244. Epub 2021 May 2 doi: 10.1007/s00795-021-00288-4. PMID: 33934220
Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy.
Akgor U, Kuru O, Sakinci M, Boyraz G, Sen S, Cakır I, Turan T, Gokcu M, Gultekin M, Sayhan S, Salman C, Ozgul N
J Gynecol Obstet Hum Reprod 2021 May;50(5):101897. Epub 2020 Aug 19 doi: 10.1016/j.jogoh.2020.101897. PMID: 32827837
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681

Diagnosis

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Clinical characteristic and prognostic factors in high-grade endometrial neuroendocrine carcinoma.
Zhang Z, Wang J, Wu X, Liu Y, Xi X
J Obstet Gynaecol Res 2022 Aug;48(8):2180-2188. Epub 2022 Jul 1 doi: 10.1111/jog.15321. PMID: 35778826Free PMC Article
Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy.
Akgor U, Kuru O, Sakinci M, Boyraz G, Sen S, Cakır I, Turan T, Gokcu M, Gultekin M, Sayhan S, Salman C, Ozgul N
J Gynecol Obstet Hum Reprod 2021 May;50(5):101897. Epub 2020 Aug 19 doi: 10.1016/j.jogoh.2020.101897. PMID: 32827837
Primary mixed large cell neuroendocrine and high grade serous carcinoma of the endometrium.
Hardy LE, Chaudry Z, Wan K, Ayres C
BMJ Case Rep 2020 Sep 2;13(9) doi: 10.1136/bcr-2020-234977. PMID: 32878852Free PMC Article
Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review.
Tu YA, Chen YL, Lin MC, Chen CA, Cheng WF
Taiwan J Obstet Gynecol 2018 Feb;57(1):144-149. doi: 10.1016/j.tjog.2017.12.025. PMID: 29458887

Therapy

Pathological processes and pretreatment cytologic diagnosis of neuroendocrine carcinoma of the endometrium: addendum report of the Kansai Clinical Oncology Group/Intergroup study in Japan.
Matsumoto H, Nasu K, Shikama A, Shiozaki T, Futagami M, Kai K, Mori T, Yano M, Yamada T, Teramoto N
Med Mol Morphol 2021 Sep;54(3):237-244. Epub 2021 May 2 doi: 10.1007/s00795-021-00288-4. PMID: 33934220
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Mixed large and small cell neuroendocrine carcinoma of the endometrium with serous carcinoma: A case report and literature review.
Hu R, Jiang J, Song G, Zhu C, Chen L, Wang C, Wang X
Medicine (Baltimore) 2019 Jul;98(29):e16433. doi: 10.1097/MD.0000000000016433. PMID: 31335697Free PMC Article
Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review.
Tu YA, Chen YL, Lin MC, Chen CA, Cheng WF
Taiwan J Obstet Gynecol 2018 Feb;57(1):144-149. doi: 10.1016/j.tjog.2017.12.025. PMID: 29458887
Large cell neuroendocrine carcinoma with sarcomatous changes of the endometrium: a case report with immunohistochemical studies and molecular genetic study of KIT and PDGFRA.
Terada T
Pathol Res Pract 2010 Jun 15;206(6):420-5. Epub 2010 Feb 26 doi: 10.1016/j.prp.2009.12.008. PMID: 20189318

Prognosis

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Clinical characteristic and prognostic factors in high-grade endometrial neuroendocrine carcinoma.
Zhang Z, Wang J, Wu X, Liu Y, Xi X
J Obstet Gynaecol Res 2022 Aug;48(8):2180-2188. Epub 2022 Jul 1 doi: 10.1111/jog.15321. PMID: 35778826Free PMC Article
Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy.
Akgor U, Kuru O, Sakinci M, Boyraz G, Sen S, Cakır I, Turan T, Gokcu M, Gultekin M, Sayhan S, Salman C, Ozgul N
J Gynecol Obstet Hum Reprod 2021 May;50(5):101897. Epub 2020 Aug 19 doi: 10.1016/j.jogoh.2020.101897. PMID: 32827837
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Large-cell Neuroendocrine Carcinoma of the Endometrium in Myomatous Uterus.
Shopov ST, Anavi BL, Krastev DK
Folia Med (Plovdiv) 2020 Jun 30;62(2):412-417. doi: 10.3897/folmed.62.e49815. PMID: 32666759

Clinical prediction guides

Mixed high-grade serous and large cell neuroendocrine carcinoma arising from rectal endometriosis 11 years after hysterectomy.
Yanagita T, Hikichi T, Waragai Y, Shimizu H, Takahashi Y, Abe N, Hashimoto C, Kumakawa H, Kobayakawa M, Ohira H
Clin J Gastroenterol 2023 Jun;16(3):366-371. Epub 2023 Feb 10 doi: 10.1007/s12328-023-01769-y. PMID: 36763235
Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy.
Akgor U, Kuru O, Sakinci M, Boyraz G, Sen S, Cakır I, Turan T, Gokcu M, Gultekin M, Sayhan S, Salman C, Ozgul N
J Gynecol Obstet Hum Reprod 2021 May;50(5):101897. Epub 2020 Aug 19 doi: 10.1016/j.jogoh.2020.101897. PMID: 32827837
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Small-cell neuroendocrine carcinoma in directly sampled endometrial cytology: A monocentric retrospective study of six cases.
Ebisu Y, Ishida M, Okano K, Sandoh K, Mizokami T, Kita M, Okada H, Tsuta K
Diagn Cytopathol 2019 Dec;47(12):1297-1301. Epub 2019 Aug 6 doi: 10.1002/dc.24298. PMID: 31386298
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790

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