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Penile Lymphoepithelioma-Like Carcinoma

MedGen UID:
1705111
•Concept ID:
C5204296
•
Neoplastic Process
Synonym: Lymphoepithelioma-Like Carcinoma of the Penis

Definition

A variant of penile squamous cell carcinoma characterized by the presence of islands of malignant cells with uniform vesicular nuclei and prominent nucleoli, and a dense lymphocytic infiltrate. [from NCI]

Recent clinical studies

Etiology

Tumor lesions of penis and scrotum according to WHO classification 2022.
Michalová K, Beniač P, Kacerovská D
Cesk Patol 2022 Fall;67(4):192-197. PMID: 36513504
Penile Lymphoepithelioma-Like Carcinoma: A Rare Case With PD-L1 Expression.
Machado-Neves R, Teixeira B, Fonseca E, Valente P, Lindoro J, Vila F, Polónia A
Int J Surg Pathol 2021 Sep;29(6):690-692. Epub 2021 Jan 16 doi: 10.1177/1066896920988340. PMID: 33455515
Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989
Histologic and immunohistochemical assessment of penile carcinomas in a North American population.
Mentrikoski MJ, Stelow EB, Culp S, Frierson HF Jr, Cathro HP
Am J Surg Pathol 2014 Oct;38(10):1340-8. doi: 10.1097/PAS.0000000000000124. PMID: 25210933
Absence of Epstein-Barr virus, human papillomavirus, and simian virus 40 in patients of central european origin with lymphoepithelioma-like carcinoma of the skin.
Kazakov DV, Nemcova J, Mikyskova I, Michal M
Am J Dermatopathol 2007 Aug;29(4):365-9. doi: 10.1097/DAD.0b013e31806f7fa9. PMID: 17667169

Diagnosis

Penile Lymphoepithelioma-Like Carcinoma: A Rare Case With PD-L1 Expression.
Machado-Neves R, Teixeira B, Fonseca E, Valente P, Lindoro J, Vila F, Polónia A
Int J Surg Pathol 2021 Sep;29(6):690-692. Epub 2021 Jan 16 doi: 10.1177/1066896920988340. PMID: 33455515
Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989
Histologic and immunohistochemical assessment of penile carcinomas in a North American population.
Mentrikoski MJ, Stelow EB, Culp S, Frierson HF Jr, Cathro HP
Am J Surg Pathol 2014 Oct;38(10):1340-8. doi: 10.1097/PAS.0000000000000124. PMID: 25210933
Absence of Epstein-Barr virus, human papillomavirus, and simian virus 40 in patients of central european origin with lymphoepithelioma-like carcinoma of the skin.
Kazakov DV, Nemcova J, Mikyskova I, Michal M
Am J Dermatopathol 2007 Aug;29(4):365-9. doi: 10.1097/DAD.0b013e31806f7fa9. PMID: 17667169

Prognosis

Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989
Histologic and immunohistochemical assessment of penile carcinomas in a North American population.
Mentrikoski MJ, Stelow EB, Culp S, Frierson HF Jr, Cathro HP
Am J Surg Pathol 2014 Oct;38(10):1340-8. doi: 10.1097/PAS.0000000000000124. PMID: 25210933
Absence of Epstein-Barr virus, human papillomavirus, and simian virus 40 in patients of central european origin with lymphoepithelioma-like carcinoma of the skin.
Kazakov DV, Nemcova J, Mikyskova I, Michal M
Am J Dermatopathol 2007 Aug;29(4):365-9. doi: 10.1097/DAD.0b013e31806f7fa9. PMID: 17667169

Clinical prediction guides

Pathology of Invasive and Intraepithelial Penile Neoplasia.
Canete-Portillo S, Sanchez DF, Cubilla AL
Eur Urol Focus 2019 Sep;5(5):713-717. Epub 2019 Jul 6 doi: 10.1016/j.euf.2019.06.013. PMID: 31288989
Histologic and immunohistochemical assessment of penile carcinomas in a North American population.
Mentrikoski MJ, Stelow EB, Culp S, Frierson HF Jr, Cathro HP
Am J Surg Pathol 2014 Oct;38(10):1340-8. doi: 10.1097/PAS.0000000000000124. PMID: 25210933

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