U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anal Canal Large Cell Neuroendocrine Carcinoma

MedGen UID:
473535
Concept ID:
C2111706
Neoplastic Process
Synonyms: Anal Canal Large Cell NEC; Anal Large Cell NEC; Anal Large Cell Neuroendocrine Carcinoma

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal Canal Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Recent clinical studies

Etiology

Navale P, Gonzalez RS, Vyas M
Hum Pathol 2021 Mar;109:12-20. Epub 2020 Nov 24 doi: 10.1016/j.humpath.2020.11.008. PMID: 33245989
Metildi C, McLemore EC, Tran T, Chang D, Cosman B, Ramamoorthy SL, Saltzstein SL, Sadler GR
Am Surg 2013 Oct;79(10):1068-74. PMID: 24160801Free PMC Article
Shia J, Tang LH, Weiser MR, Brenner B, Adsay NV, Stelow EB, Saltz LB, Qin J, Landmann R, Leonard GD, Dhall D, Temple L, Guillem JG, Paty PB, Kelsen D, Wong WD, Klimstra DS
Am J Surg Pathol 2008 May;32(5):719-31. doi: 10.1097/PAS.0b013e318159371c. PMID: 18360283
Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, Thaler H, Guillem J, Paty P, Cohen AM, Wong WD
Dis Colon Rectum 2004 Feb;47(2):163-9. doi: 10.1007/s10350-003-0038-1. PMID: 15043285
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Diagnosis

Navale P, Gonzalez RS, Vyas M
Hum Pathol 2021 Mar;109:12-20. Epub 2020 Nov 24 doi: 10.1016/j.humpath.2020.11.008. PMID: 33245989
Metildi C, McLemore EC, Tran T, Chang D, Cosman B, Ramamoorthy SL, Saltzstein SL, Sadler GR
Am Surg 2013 Oct;79(10):1068-74. PMID: 24160801Free PMC Article
Shia J, Tang LH, Weiser MR, Brenner B, Adsay NV, Stelow EB, Saltz LB, Qin J, Landmann R, Leonard GD, Dhall D, Temple L, Guillem JG, Paty PB, Kelsen D, Wong WD, Klimstra DS
Am J Surg Pathol 2008 May;32(5):719-31. doi: 10.1097/PAS.0b013e318159371c. PMID: 18360283
Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, Thaler H, Guillem J, Paty P, Cohen AM, Wong WD
Dis Colon Rectum 2004 Feb;47(2):163-9. doi: 10.1007/s10350-003-0038-1. PMID: 15043285
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Therapy

Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Prognosis

Metildi C, McLemore EC, Tran T, Chang D, Cosman B, Ramamoorthy SL, Saltzstein SL, Sadler GR
Am Surg 2013 Oct;79(10):1068-74. PMID: 24160801Free PMC Article
Shia J, Tang LH, Weiser MR, Brenner B, Adsay NV, Stelow EB, Saltz LB, Qin J, Landmann R, Leonard GD, Dhall D, Temple L, Guillem JG, Paty PB, Kelsen D, Wong WD, Klimstra DS
Am J Surg Pathol 2008 May;32(5):719-31. doi: 10.1097/PAS.0b013e318159371c. PMID: 18360283
Bernick PE, Klimstra DS, Shia J, Minsky B, Saltz L, Shi W, Thaler H, Guillem J, Paty P, Cohen AM, Wong WD
Dis Colon Rectum 2004 Feb;47(2):163-9. doi: 10.1007/s10350-003-0038-1. PMID: 15043285
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Clinical prediction guides

Metildi C, McLemore EC, Tran T, Chang D, Cosman B, Ramamoorthy SL, Saltzstein SL, Sadler GR
Am Surg 2013 Oct;79(10):1068-74. PMID: 24160801Free PMC Article
Shia J, Tang LH, Weiser MR, Brenner B, Adsay NV, Stelow EB, Saltz LB, Qin J, Landmann R, Leonard GD, Dhall D, Temple L, Guillem JG, Paty PB, Kelsen D, Wong WD, Klimstra DS
Am J Surg Pathol 2008 May;32(5):719-31. doi: 10.1097/PAS.0b013e318159371c. PMID: 18360283

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...