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Prostate Large Cell Neuroendocrine Carcinoma

MedGen UID:
1686188
•Concept ID:
C5203852
•
Neoplastic Process

Definition

An exceptionally rare neuroendocrine carcinoma that arises from the prostate gland. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists.
Mohanty SK, Lobo A, Williamson SR, Shah RB, Trpkov K, Varma M, Sirohi D, Aron M, Kandukari SR, Balzer BL, Luthringer DL, Ro J, Osunkoya AO, Desai S, Menon S, Nigam LK, Sardana R, Roy P, Kaushal S, Midha D, Swain M, Ambekar A, Mitra S, Rao V, Soni S, Jain K, Diwaker P, Pattnaik N, Sharma S, Chakrabarti I, Sable M, Jain E, Jain D, Samra S, Vankalakunti M, Mohanty S, Parwani AV, Sancheti S, Kumari N, Jha S, Dixit M, Malik V, Arora S, Munjal G, Gopalan A, Magi-Galluzzi C, Dhillon J
Int J Surg Pathol 2023 Sep;31(6):993-1005. Epub 2022 Aug 9 doi: 10.1177/10668969221116629. PMID: 35946087
Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity.
Aggarwal RR, Quigley DA, Huang J, Zhang L, Beer TM, Rettig MB, Reiter RE, Gleave ME, Thomas GV, Foye A, Playdle D, Lloyd P, Chi KN, Evans CP, Lara PN, Feng FY, Alumkal JJ, Small EJ
Mol Cancer Res 2019 Jun;17(6):1235-1240. Epub 2019 Mar 27 doi: 10.1158/1541-7786.MCR-18-1101. PMID: 30918106Free PMC Article
The role of neuroendocrine cells in prostate cancer: a comprehensive review of current literature and subsequent rationale to broaden and integrate current treatment modalities.
Lugnani F, Simone G, Biava PM, Ablin RJ
Curr Med Chem 2014;21(9):1082-92. doi: 10.2174/0929867321666131201143752. PMID: 24304274

Recent clinical studies

Etiology

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Contemporary Incidence and Mortality Rates of Neuroendocrine Prostate Cancer.
Alanee S, Moore A, Nutt M, Holland B, Dynda D, El-Zawahry A, McVary KT
Anticancer Res 2015 Jul;35(7):4145-50. PMID: 26124369
Neuroendocrine prostate cancer: subtypes, biology, and clinical outcomes.
Aggarwal R, Zhang T, Small EJ, Armstrong AJ
J Natl Compr Canc Netw 2014 May;12(5):719-26. doi: 10.6004/jnccn.2014.0073. PMID: 24812138
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets.
Beltran H, Rickman DS, Park K, Chae SS, Sboner A, MacDonald TY, Wang Y, Sheikh KL, Terry S, Tagawa ST, Dhir R, Nelson JB, de la Taille A, Allory Y, Gerstein MB, Perner S, Pienta KJ, Chinnaiyan AM, Wang Y, Collins CC, Gleave ME, Demichelis F, Nanus DM, Rubin MA
Cancer Discov 2011 Nov;1(6):487-95. doi: 10.1158/2159-8290.CD-11-0130. PMID: 22389870Free PMC Article

Diagnosis

Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues.
Gerlach L, Beyer AL, Kaemmerer D, Sänger J, Evert K, Schulz S, Lupp A
Sci Rep 2023 Nov 3;13(1):18993. doi: 10.1038/s41598-023-46395-3. PMID: 37923782Free PMC Article
Morphologic, Molecular and Clinical Features of Aggressive Variant Prostate Cancer.
Montironi R, Cimadamore A, Lopez-Beltran A, Scarpelli M, Aurilio G, Santoni M, Massari F, Cheng L
Cells 2020 Apr 25;9(5) doi: 10.3390/cells9051073. PMID: 32344931Free PMC Article
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Neuroendocrine differentiation in prostate cancer: novel morphological insights and future therapeutic perspectives.
Santoni M, Conti A, Burattini L, Berardi R, Scarpelli M, Cheng L, Lopez-Beltran A, Cascinu S, Montironi R
Biochim Biophys Acta 2014 Dec;1846(2):630-7. Epub 2014 Nov 4 doi: 10.1016/j.bbcan.2014.10.008. PMID: 25450825
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets.
Beltran H, Rickman DS, Park K, Chae SS, Sboner A, MacDonald TY, Wang Y, Sheikh KL, Terry S, Tagawa ST, Dhir R, Nelson JB, de la Taille A, Allory Y, Gerstein MB, Perner S, Pienta KJ, Chinnaiyan AM, Wang Y, Collins CC, Gleave ME, Demichelis F, Nanus DM, Rubin MA
Cancer Discov 2011 Nov;1(6):487-95. doi: 10.1158/2159-8290.CD-11-0130. PMID: 22389870Free PMC Article

Therapy

Current and emerging therapies for neuroendocrine prostate cancer.
Alabi BR, Liu S, Stoyanova T
Pharmacol Ther 2022 Oct;238:108255. Epub 2022 Jul 26 doi: 10.1016/j.pharmthera.2022.108255. PMID: 35905791
Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.
Cheng Q, Butler W, Zhou Y, Zhang H, Tang L, Perkinson K, Chen X, Jiang XS, McCall SJ, Inman BA, Huang J
Eur Urol 2022 May;81(5):446-455. Epub 2022 Jan 17 doi: 10.1016/j.eururo.2021.12.039. PMID: 35058087Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Neuroendocrine differentiation in prostate cancer: novel morphological insights and future therapeutic perspectives.
Santoni M, Conti A, Burattini L, Berardi R, Scarpelli M, Cheng L, Lopez-Beltran A, Cascinu S, Montironi R
Biochim Biophys Acta 2014 Dec;1846(2):630-7. Epub 2014 Nov 4 doi: 10.1016/j.bbcan.2014.10.008. PMID: 25450825
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets.
Beltran H, Rickman DS, Park K, Chae SS, Sboner A, MacDonald TY, Wang Y, Sheikh KL, Terry S, Tagawa ST, Dhir R, Nelson JB, de la Taille A, Allory Y, Gerstein MB, Perner S, Pienta KJ, Chinnaiyan AM, Wang Y, Collins CC, Gleave ME, Demichelis F, Nanus DM, Rubin MA
Cancer Discov 2011 Nov;1(6):487-95. doi: 10.1158/2159-8290.CD-11-0130. PMID: 22389870Free PMC Article

Prognosis

Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.
Cheng Q, Butler W, Zhou Y, Zhang H, Tang L, Perkinson K, Chen X, Jiang XS, McCall SJ, Inman BA, Huang J
Eur Urol 2022 May;81(5):446-455. Epub 2022 Jan 17 doi: 10.1016/j.eururo.2021.12.039. PMID: 35058087Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Morphologic, Molecular and Clinical Features of Aggressive Variant Prostate Cancer.
Montironi R, Cimadamore A, Lopez-Beltran A, Scarpelli M, Aurilio G, Santoni M, Massari F, Cheng L
Cells 2020 Apr 25;9(5) doi: 10.3390/cells9051073. PMID: 32344931Free PMC Article
Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328
The Colorful Palette of Neuroendocrine Neoplasms in the Genitourinary Tract.
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671

Clinical prediction guides

Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues.
Gerlach L, Beyer AL, Kaemmerer D, Sänger J, Evert K, Schulz S, Lupp A
Sci Rep 2023 Nov 3;13(1):18993. doi: 10.1038/s41598-023-46395-3. PMID: 37923782Free PMC Article
Large-cell neuroendocrine tumor of the prostate: a case report and review of the literature.
Sleiman W, Karray O, Abi Abdallah M, Bleichner-Perez S, Kourda J, Cosma-Opris M, Assouad S, Riffaud JC, Bart S, Coloby P
J Med Case Rep 2021 May 7;15(1):254. doi: 10.1186/s13256-021-02830-5. PMID: 33957979Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Contemporary Incidence and Mortality Rates of Neuroendocrine Prostate Cancer.
Alanee S, Moore A, Nutt M, Holland B, Dynda D, El-Zawahry A, McVary KT
Anticancer Res 2015 Jul;35(7):4145-50. PMID: 26124369
Neuroendocrine prostate cancer: subtypes, biology, and clinical outcomes.
Aggarwal R, Zhang T, Small EJ, Armstrong AJ
J Natl Compr Canc Netw 2014 May;12(5):719-26. doi: 10.6004/jnccn.2014.0073. PMID: 24812138

Recent systematic reviews

Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328

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