U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Laryngeal Large Cell Neuroendocrine Carcinoma

MedGen UID:
1732308
•Concept ID:
C5420185
•
Neoplastic Process

Definition

A large cell neuroendocrine carcinoma that arises from the larynx. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

How phenotype guides management of the neuroendocrine carcinomas of the larynx.
López F, Hunt JL, Nixon IJ, Rinaldo A, Williams MD, Cardesa A, Ferlito A
J Laryngol Otol 2018 Jul;132(7):568-574. Epub 2018 Jun 18 doi: 10.1017/S0022215118000968. PMID: 29909787
Differential Diagnosis in Neuroendocrine Neoplasms of the Larynx.
Hunt JL, Ferlito A, Hellquist H, Rinaldo A, Skálová A, Slootweg PJ, Willems SM, Cardesa A
Adv Anat Pathol 2017 May;24(3):161-168. doi: 10.1097/PAP.0000000000000147. PMID: 28338500
Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: A meta-analysis of 436 reported cases.
van der Laan TP, Plaat BE, van der Laan BF, Halmos GB
Head Neck 2015 May;37(5):707-15. Epub 2014 Jun 18 doi: 10.1002/hed.23666. PMID: 24596175

Recent clinical studies

Therapy

Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
High-Grade Neuroendocrine Carcinoma of the Larynx: The Mayo Clinic Experience.
Deep NL, Ekbom DC, Hinni ML, Zarka MA, Patel SH
Ann Otol Rhinol Laryngol 2016 Jun;125(6):464-9. Epub 2015 Nov 26 doi: 10.1177/0003489415619179. PMID: 26611246
Unusual presentation of large-cell poorly differentiated neuroendocrine carcinoma of the epiglottis.
Patel KJ, Chandana SR, Wiese DA, Olsen B, Conley BA
J Clin Oncol 2010 Sep 20;28(27):e461-3. Epub 2010 Aug 2 doi: 10.1200/JCO.2010.28.6237. PMID: 20679623

Prognosis

Neuroendocrine Neoplasms of the Larynx: A Clinicopathologic Analysis of 27 Neuroendocrine Tumors and Neuroendocrine Carcinomas.
Bal M, Sharma A, Rane SU, Mittal N, Chaukar D, Prabhash K, Patil A
Head Neck Pathol 2022 Jun;16(2):375-387. Epub 2021 Aug 16 doi: 10.1007/s12105-021-01367-9. PMID: 34401980Free PMC Article
Small cell and large cell neuroendocrine carcinoma of the larynx: A comparative analysis.
Strojan P, Hernandez-Prera JC, Beitler JJ, Eisbruch A, Saba NF, Mendenhall WM, Nieto CS, Smee R, Rinaldo A, Ferlito A
Cancer Treat Rev 2019 Aug;78:42-51. Epub 2019 Aug 8 doi: 10.1016/j.ctrv.2019.08.002. PMID: 31437725
How phenotype guides management of the neuroendocrine carcinomas of the larynx.
López F, Hunt JL, Nixon IJ, Rinaldo A, Williams MD, Cardesa A, Ferlito A
J Laryngol Otol 2018 Jul;132(7):568-574. Epub 2018 Jun 18 doi: 10.1017/S0022215118000968. PMID: 29909787
Differential Diagnosis in Neuroendocrine Neoplasms of the Larynx.
Hunt JL, Ferlito A, Hellquist H, Rinaldo A, Skálová A, Slootweg PJ, Willems SM, Cardesa A
Adv Anat Pathol 2017 May;24(3):161-168. doi: 10.1097/PAP.0000000000000147. PMID: 28338500
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Clinical prediction guides

The histological spectrum and immunoprofile of head and neck NUT carcinoma: A multicentre series of 30 cases.
Viswanathan K, Hahn E, Dogan S, Weinreb I, Dickson BC, MacMillan C, Katabi N, Magliocca K, Ghossein R, Xu B
Histopathology 2024 Aug;85(2):317-326. Epub 2024 May 6 doi: 10.1111/his.15204. PMID: 38708903Free PMC Article
Neuroendocrine Neoplasms of the Larynx: A Clinicopathologic Analysis of 27 Neuroendocrine Tumors and Neuroendocrine Carcinomas.
Bal M, Sharma A, Rane SU, Mittal N, Chaukar D, Prabhash K, Patil A
Head Neck Pathol 2022 Jun;16(2):375-387. Epub 2021 Aug 16 doi: 10.1007/s12105-021-01367-9. PMID: 34401980Free PMC Article
Application of INSM1 in Diagnosis and Grading of Laryngeal Neuroendocrine Carcinoma.
Yuan C, Jiao F, Zhai C, Zhang J, Wang S, Zhu L
Laryngoscope 2021 Oct;131(10):E2662-E2668. Epub 2021 Apr 13 doi: 10.1002/lary.29554. PMID: 33847383
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Mucosal large cell neuroendocrine carcinoma of the head and neck regions in Japanese patients: a distinct clinicopathological entity.
Kusafuka K, Abe M, Iida Y, Onitsuka T, Fuke T, Asano R, Kamijo T, Nakajima T
J Clin Pathol 2012 Aug;65(8):704-9. Epub 2012 Jun 20 doi: 10.1136/jclinpath-2012-200801. PMID: 22718848Free PMC Article

Recent systematic reviews

Small cell and large cell neuroendocrine carcinoma of the larynx: A comparative analysis.
Strojan P, Hernandez-Prera JC, Beitler JJ, Eisbruch A, Saba NF, Mendenhall WM, Nieto CS, Smee R, Rinaldo A, Ferlito A
Cancer Treat Rev 2019 Aug;78:42-51. Epub 2019 Aug 8 doi: 10.1016/j.ctrv.2019.08.002. PMID: 31437725

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...