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Head and Neck Large Cell Neuroendocrine Carcinoma

MedGen UID:
1698499
•Concept ID:
C5205701
•
Neoplastic Process

Definition

A large cell neuroendocrine carcinoma that arises from the head and neck. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHead and Neck Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Management of olfactory neuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma involving the skullbase.
Mehta GU, Raza SM, Su SY, Hanna EY, DeMonte F
J Neurooncol 2020 Dec;150(3):367-375. Epub 2020 May 18 doi: 10.1007/s11060-020-03537-1. PMID: 32424573
How phenotype guides management of the neuroendocrine carcinomas of the larynx.
López F, Hunt JL, Nixon IJ, Rinaldo A, Williams MD, Cardesa A, Ferlito A
J Laryngol Otol 2018 Jul;132(7):568-574. Epub 2018 Jun 18 doi: 10.1017/S0022215118000968. PMID: 29909787
Differential Diagnosis in Neuroendocrine Neoplasms of the Larynx.
Hunt JL, Ferlito A, Hellquist H, Rinaldo A, Skálová A, Slootweg PJ, Willems SM, Cardesa A
Adv Anat Pathol 2017 May;24(3):161-168. doi: 10.1097/PAP.0000000000000147. PMID: 28338500

Recent clinical studies

Etiology

Proceedings of the 2023 North American Society of Head and Neck Pathology Companion Meeting, New Orleans, LA, March 12, 2023: Navigating New Developments in High Grade Sinonasal Neuroendocrine and Neuroectodermal Neoplasms.
Rooper LM
Head Neck Pathol 2023 Jun;17(2):299-312. Epub 2023 May 15 doi: 10.1007/s12105-023-01548-8. PMID: 37184733Free PMC Article
Merkel cell carcinoma of the head and neck in the south-east of England.
Bowe CM, Bean T, Loke R, Gallagher N, Rooney J, Surwald C, Dhanda J, Moody A, Bisase B, Norris P, Barrett AW, Lachanas V, Doumas S
Br J Oral Maxillofac Surg 2021 Dec;59(10):1280-1286. Epub 2021 Jun 25 doi: 10.1016/j.bjoms.2021.06.009. PMID: 34465487
Clinicopathological and genomic features in patients with head and neck neuroendocrine carcinoma.
Ohmoto A, Sato Y, Asaka R, Fukuda N, Wang X, Urasaki T, Hayashi N, Sato Y, Nakano K, Yunokawa M, Ono M, Tomomatsu J, Toshiyasu T, Mitani H, Takeuchi K, Mori S, Takahashi S
Mod Pathol 2021 Nov;34(11):1979-1989. Epub 2021 Jul 10 doi: 10.1038/s41379-021-00869-9. PMID: 34247193Free PMC Article
Large Cell Neuroendocrine Carcinoma of the Head and Neck: A Clinicopathologic Series of 10 Cases With an Emphasis on HPV Status.
Thompson ED, Stelow EB, Mills SE, Westra WH, Bishop JA
Am J Surg Pathol 2016 Apr;40(4):471-8. doi: 10.1097/PAS.0000000000000580. PMID: 26735857Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms.
Mete O, Wenig BM
Head Neck Pathol 2022 Mar;16(1):123-142. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01435-8. PMID: 35312985Free PMC Article
SMARCA4/BRG1-Deficient Sinonasal Carcinoma.
Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D
Arch Pathol Lab Med 2022 Sep 1;146(9):1122-1130. doi: 10.5858/arpa.2021-0001-OA. PMID: 34871352
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
von Hippel-Lindau syndrome.
Chou A, Toon C, Pickett J, Gill AJ
Front Horm Res 2013;41:30-49. Epub 2013 Mar 19 doi: 10.1159/000345668. PMID: 23652669

Therapy

Spectrum of Nonkeratinocyte Skin Cancer Risk Among Solid Organ Transplant Recipients in the US.
Sargen MR, Cahoon EK, Yu KJ, Madeleine MM, Zeng Y, Rees JR, Lynch CF, Engels EA
JAMA Dermatol 2022 Apr 1;158(4):414-425. doi: 10.1001/jamadermatol.2022.0036. PMID: 35262623Free PMC Article
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
High-Grade Neuroendocrine Carcinoma of the Larynx: The Mayo Clinic Experience.
Deep NL, Ekbom DC, Hinni ML, Zarka MA, Patel SH
Ann Otol Rhinol Laryngol 2016 Jun;125(6):464-9. Epub 2015 Nov 26 doi: 10.1177/0003489415619179. PMID: 26611246
Hypopharyngeal large cell neuroendocrine carcinoma.
Lee WI, Ameratunga M, du Plessis J, Gan H
BMJ Case Rep 2015 Dec 29;2015 doi: 10.1136/bcr-2015-211908. PMID: 26715138Free PMC Article
The cervico-submental keystone island flap for locoregional head and neck reconstruction.
Behan FC, Rozen WM, Wilson J, Kapila S, Sizeland A, Findlay MW
J Plast Reconstr Aesthet Surg 2013 Jan;66(1):23-8. Epub 2012 Sep 11 doi: 10.1016/j.bjps.2012.08.027. PMID: 22974756

Prognosis

Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Differential Diagnosis in Neuroendocrine Neoplasms of the Larynx.
Hunt JL, Ferlito A, Hellquist H, Rinaldo A, Skálová A, Slootweg PJ, Willems SM, Cardesa A
Adv Anat Pathol 2017 May;24(3):161-168. doi: 10.1097/PAP.0000000000000147. PMID: 28338500
Neuroendocrine neoplasms of the sinonasal region.
Bell D, Hanna EY, Weber RS, DeMonte F, Triantafyllou A, Lewis JS Jr, Cardesa A, Slootweg PJ, Stenman G, Gnepp DR, Devaney KO, Rodrigo JP, Rinaldo A, Wenig BM, Westra WH, Bishop JA, Hellquist H, Hunt JL, Kusafuka K, Perez-Ordoñez B, Williams MD, Takes RP, Ferlito A
Head Neck 2016 Apr;38 Suppl 1:E2259-66. Epub 2015 Jul 18 doi: 10.1002/hed.24152. PMID: 26041714
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Large cell neuroendocrine carcinoma of the head and neck.
Kusafuka K, Ferlito A, Lewis JS Jr, Woolgar JA, Rinaldo A, Slootweg PJ, Gnepp DR, Devaney KO, Travis WD, Barnes L
Oral Oncol 2012 Mar;48(3):211-5. Epub 2011 Oct 22 doi: 10.1016/j.oraloncology.2011.09.016. PMID: 22024350

Clinical prediction guides

YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities.
Stewart CA, Diao L, Xi Y, Wang R, Ramkumar K, Serrano AG, Tanimoto A, Rodriguez BL, Morris BB, Shen L, Zhang B, Yang Y, Hamad SH, Cardnell RJ, Duarte A Jr, Sahu M, Novegil VY, Weissman BE, Frumovitz M, Kalhor N, Solis Soto L, da Rocha P, Vokes N, Gibbons DL, Wang J, Heymach JV, Glisson B, Byers LA, Gay CM
Clin Cancer Res 2024 Oct 15;30(20):4743-4754. doi: 10.1158/1078-0432.CCR-24-0361. PMID: 39150543Free PMC Article
The histological spectrum and immunoprofile of head and neck NUT carcinoma: A multicentre series of 30 cases.
Viswanathan K, Hahn E, Dogan S, Weinreb I, Dickson BC, MacMillan C, Katabi N, Magliocca K, Ghossein R, Xu B
Histopathology 2024 Aug;85(2):317-326. Epub 2024 May 6 doi: 10.1111/his.15204. PMID: 38708903Free PMC Article
Neuroendocrine Neoplasms of the Larynx: A Clinicopathologic Analysis of 27 Neuroendocrine Tumors and Neuroendocrine Carcinomas.
Bal M, Sharma A, Rane SU, Mittal N, Chaukar D, Prabhash K, Patil A
Head Neck Pathol 2022 Jun;16(2):375-387. Epub 2021 Aug 16 doi: 10.1007/s12105-021-01367-9. PMID: 34401980Free PMC Article
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Recent systematic reviews

Utility of KI-67 as a prognostic biomarker in pulmonary neuroendocrine neoplasms: a systematic review and meta-analysis.
Naheed S, Holden C, Tanno L, Pattini L, Pearce NW, Green B, Jaynes E, Cave J, Ottensmeier CH, Pelosi G
BMJ Open 2022 Mar 3;12(3):e041961. doi: 10.1136/bmjopen-2020-041961. PMID: 35241462Free PMC Article
Small cell and large cell neuroendocrine carcinoma of the larynx: A comparative analysis.
Strojan P, Hernandez-Prera JC, Beitler JJ, Eisbruch A, Saba NF, Mendenhall WM, Nieto CS, Smee R, Rinaldo A, Ferlito A
Cancer Treat Rev 2019 Aug;78:42-51. Epub 2019 Aug 8 doi: 10.1016/j.ctrv.2019.08.002. PMID: 31437725

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