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Interstitial lung disease

MedGen UID:
60064
Concept ID:
C0206062
Disease or Syndrome
Synonyms: Diffuse Parenchymal Lung Disease; Diffuse Parenchymal Lung Diseases; Interstitial Lung Disease; Interstitial Lung Diseases; Lung Disease, Interstitial; Lung Diseases, Interstitial
SNOMED CT: Diffuse parenchymal lung disease (233703007); Interstitial lung disease (233703007); ILD - Interstitial lung disease (233703007)

Definition

A category of lung diseases characterized by varying degrees of inflammation and fibrosis of the interstitial lung tissue. Causes include occupational lung exposures and drugs. In a minority of cases there is no clear cause and such cases are termed idiopathic interstitial pneumonia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInterstitial lung disease
Follow this link to review classifications for Interstitial lung disease in Orphanet.

Professional guidelines

PubMed

Hallowell RW, Danoff SK
Chest 2023 Jun;163(6):1476-1491. Epub 2023 Feb 9 doi: 10.1016/j.chest.2023.01.031. PMID: 36764512
Waldman R, DeWane ME, Lu J
J Am Acad Dermatol 2020 Feb;82(2):283-296. Epub 2019 Jul 4 doi: 10.1016/j.jaad.2019.05.105. PMID: 31279813
Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ, Behr J, Cottin V, Danoff SK, Morell F, Flaherty KR, Wells A, Martinez FJ, Azuma A, Bice TJ, Bouros D, Brown KK, Collard HR, Duggal A, Galvin L, Inoue Y, Jenkins RG, Johkoh T, Kazerooni EA, Kitaichi M, Knight SL, Mansour G, Nicholson AG, Pipavath SNJ, Buendía-Roldán I, Selman M, Travis WD, Walsh S, Wilson KC; American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Latin American Thoracic Society
Am J Respir Crit Care Med 2018 Sep 1;198(5):e44-e68. doi: 10.1164/rccm.201807-1255ST. PMID: 30168753

Recent clinical studies

Etiology

Kim Y, Yang HI, Kim KS
Int J Mol Sci 2023 Sep 25;24(19) doi: 10.3390/ijms241914509. PMID: 37833957Free PMC Article
Serrano Gotarredona MP, Navarro Herrero S, Gómez Izquierdo L, Rodríguez Portal JA
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:277-289. doi: 10.1016/j.rxeng.2022.10.008. PMID: 36737166
Basuita M, Fidler LM
J Appl Lab Med 2022 Jan 5;7(1):240-258. doi: 10.1093/jalm/jfab108. PMID: 34996093
Fujisawa T
Medicina (Kaunas) 2021 Apr 3;57(4) doi: 10.3390/medicina57040347. PMID: 33916864Free PMC Article
Meyer KC
Expert Rev Respir Med 2017 May;11(5):343-359. Epub 2017 Apr 10 doi: 10.1080/17476348.2017.1312346. PMID: 28345383

Diagnosis

Serrano Gotarredona MP, Navarro Herrero S, Gómez Izquierdo L, Rodríguez Portal JA
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:277-289. doi: 10.1016/j.rxeng.2022.10.008. PMID: 36737166
Wijsenbeek M, Suzuki A, Maher TM
Lancet 2022 Sep 3;400(10354):769-786. Epub 2022 Aug 11 doi: 10.1016/S0140-6736(22)01052-2. PMID: 35964592
Basuita M, Fidler LM
J Appl Lab Med 2022 Jan 5;7(1):240-258. doi: 10.1093/jalm/jfab108. PMID: 34996093
Perelas A, Silver RM, Arrossi AV, Highland KB
Lancet Respir Med 2020 Mar;8(3):304-320. Epub 2020 Feb 27 doi: 10.1016/S2213-2600(19)30480-1. PMID: 32113575
Meyer KC
Expert Rev Respir Med 2017 May;11(5):343-359. Epub 2017 Apr 10 doi: 10.1080/17476348.2017.1312346. PMID: 28345383

Therapy

Pope JE, Denton CP, Johnson SR, Fernandez-Codina A, Hudson M, Nevskaya T
Nat Rev Rheumatol 2023 Apr;19(4):212-226. Epub 2023 Feb 27 doi: 10.1038/s41584-023-00909-5. PMID: 36849541Free PMC Article
Waxman A, Restrepo-Jaramillo R, Thenappan T, Ravichandran A, Engel P, Bajwa A, Allen R, Feldman J, Argula R, Smith P, Rollins K, Deng C, Peterson L, Bell H, Tapson V, Nathan SD
N Engl J Med 2021 Jan 28;384(4):325-334. Epub 2021 Jan 13 doi: 10.1056/NEJMoa2008470. PMID: 33440084
Luppi F, Sebastiani M, Silva M, Sverzellati N, Cavazza A, Salvarani C, Manfredi A
Clin Exp Rheumatol 2020 Jul-Aug;38 Suppl 126(4):291-300. Epub 2020 Oct 23 PMID: 33095142
Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, Sohn J, Denduluri N, Perrin C, Aogi K, Tokunaga E, Im SA, Lee KS, Hurvitz SA, Cortes J, Lee C, Chen S, Zhang L, Shahidi J, Yver A, Krop I; DESTINY-Breast01 Investigators
N Engl J Med 2020 Feb 13;382(7):610-621. Epub 2019 Dec 11 doi: 10.1056/NEJMoa1914510. PMID: 31825192Free PMC Article
Distler O, Highland KB, Gahlemann M, Azuma A, Fischer A, Mayes MD, Raghu G, Sauter W, Girard M, Alves M, Clerisme-Beaty E, Stowasser S, Tetzlaff K, Kuwana M, Maher TM; SENSCIS Trial Investigators
N Engl J Med 2019 Jun 27;380(26):2518-2528. Epub 2019 May 20 doi: 10.1056/NEJMoa1903076. PMID: 31112379

Prognosis

Shah Gupta R, Koteci A, Morgan A, George PM, Quint JK
BMJ Open Respir Res 2023 Jun;10(1) doi: 10.1136/bmjresp-2022-001291. PMID: 37308252Free PMC Article
Maher TM, Bendstrup E, Dron L, Langley J, Smith G, Khalid JM, Patel H, Kreuter M
Respir Res 2021 Jul 7;22(1):197. doi: 10.1186/s12931-021-01791-z. PMID: 34233665Free PMC Article
McGovern MM, Avetisyan R, Sanson BJ, Lidove O
Orphanet J Rare Dis 2017 Feb 23;12(1):41. doi: 10.1186/s13023-017-0572-x. PMID: 28228103Free PMC Article
Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, Elicker BM, Wolters PJ, Koth LL, King TE Jr, Collard HR
Chest 2014 Apr;145(4):723-728. doi: 10.1378/chest.13-1474. PMID: 24114524
Ley B, Collard HR, King TE Jr
Am J Respir Crit Care Med 2011 Feb 15;183(4):431-40. Epub 2010 Oct 8 doi: 10.1164/rccm.201006-0894CI. PMID: 20935110

Clinical prediction guides

Lin W, Xin Z, Zhang J, Liu N, Ren X, Liu M, Su Y, Liu Y, Yang L, Guo S, Yang Y, Li Y, Cao J, Ning X, Li J, Xue H, Niu N, Chen Y, Li F, Sun L, Zhang X, Zhang F, Zhang W
BMC Pulm Med 2022 Feb 27;22(1):73. doi: 10.1186/s12890-022-01868-5. PMID: 35220958Free PMC Article
Cottin V, Hirani NA, Hotchkin DL, Nambiar AM, Ogura T, Otaola M, Skowasch D, Park JS, Poonyagariyagorn HK, Wuyts W, Wells AU
Eur Respir Rev 2018 Dec 31;27(150) Epub 2018 Dec 21 doi: 10.1183/16000617.0076-2018. PMID: 30578335Free PMC Article
Flament T, Bigot A, Chaigne B, Henique H, Diot E, Marchand-Adam S
Eur Respir Rev 2016 Jun;25(140):110-23. doi: 10.1183/16000617.0011-2016. PMID: 27246587Free PMC Article
Antoniou KM, Margaritopoulos GA, Tomassetti S, Bonella F, Costabel U, Poletti V
Eur Respir Rev 2014 Mar 1;23(131):40-54. doi: 10.1183/09059180.00009113. PMID: 24591661Free PMC Article
Goh NS, Desai SR, Veeraraghavan S, Hansell DM, Copley SJ, Maher TM, Corte TJ, Sander CR, Ratoff J, Devaraj A, Bozovic G, Denton CP, Black CM, du Bois RM, Wells AU
Am J Respir Crit Care Med 2008 Jun 1;177(11):1248-54. Epub 2008 Mar 27 doi: 10.1164/rccm.200706-877OC. PMID: 18369202

Recent systematic reviews

Shah Gupta R, Koteci A, Morgan A, George PM, Quint JK
BMJ Open Respir Res 2023 Jun;10(1) doi: 10.1136/bmjresp-2022-001291. PMID: 37308252Free PMC Article
Joy GM, Arbiv OA, Wong CK, Lok SD, Adderley NA, Dobosz KM, Johannson KA, Ryerson CJ
Eur Respir Rev 2023 Mar 31;32(167) Epub 2023 Mar 8 doi: 10.1183/16000617.0210-2022. PMID: 36889782Free PMC Article
McPherson M, Economidou S, Liampas A, Zis P, Parperis K
Semin Arthritis Rheum 2022 Apr;53:151959. Epub 2022 Jan 31 doi: 10.1016/j.semarthrit.2022.151959. PMID: 35134633
Dowman L, Hill CJ, May A, Holland AE
Cochrane Database Syst Rev 2021 Feb 1;2(2):CD006322. doi: 10.1002/14651858.CD006322.pub4. PMID: 34559419Free PMC Article
Fazeli MS, Khaychuk V, Wittstock K, Han X, Crocket G, Lin M, Hill SL, Ferri L
Clin Exp Rheumatol 2021 Sep-Oct;39(5):1108-1118. Epub 2021 Feb 26 doi: 10.55563/clinexprheumatol/h9tc57. PMID: 33635222

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