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Farmers lung

MedGen UID:
8785
•Concept ID:
C0015634
•
Disease or Syndrome
Synonyms: Farmer's lung; Farmer's lung disease
SNOMED CT: Moldy hay disease (18690003); Farmers lung (18690003); Farmers' lung (18690003); Farmers' lung disease (18690003); Moldy-hay disease (18690003)
 
Monarch Initiative: MONDO:0001971
Orphanet: ORPHA99906

Definition

Farmer's lung disease is the main form of occupational hypersensitivity pneumonitis (see this term), caused by chronic inhalation of microorganisms, often thermophilic actinomycetes and less commonly <i>saccharopolyspora rectivirgula</i>, living in mouldy hay, straw, or grain. It is characterized by variable degrees of dyspnea, cough, tiredness, headaches and occasional fever/night sweats, with acute, sub-acute or chronic clinical course [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFarmers lung
Follow this link to review classifications for Farmers lung in Orphanet.

Professional guidelines

PubMed

Recommendations From the International Consensus Conference on Anemia Management in Surgical Patients (ICCAMS).
Shander A, Corwin HL, Meier J, Auerbach M, Bisbe E, Blitz J, Erhard J, Faraoni D, Farmer SL, Frank SM, Girelli D, Hall T, Hardy JF, Hofmann A, Lee CK, Leung TW, Ozawa S, Sathar J, Spahn DR, Torres R, Warner MA, Muñoz M
Ann Surg 2023 Apr 1;277(4):581-590. Epub 2022 Sep 21 doi: 10.1097/SLA.0000000000005721. PMID: 36134567Free PMC Article
The Multi-Drug Resistant Tuberculosis Diagnosis and Treatment Cascade in Bangladesh.
Hossain ST, Isaakidis P, Sagili KD, Islam S, Islam MA, Shewade HD, Kamal SM, Husain A
PLoS One 2015;10(6):e0129155. Epub 2015 Jun 25 doi: 10.1371/journal.pone.0129155. PMID: 26110273Free PMC Article
Clinical aspects of farmer's lung: airway reactivity, treatment and prognosis.
Mönkäre S
Eur J Respir Dis Suppl 1984;137:1-68. PMID: 6426996

Recent clinical studies

Etiology

Agricultural lung disease.
Spurzem JR, Romberger DJ, Von Essen SG
Clin Chest Med 2002 Dec;23(4):795-810. doi: 10.1016/s0272-5231(02)00024-2. PMID: 12512166
Diffuse interstitial lung diseases: a histochemical approach.
Barbolini G, Bisetti A, Martinelli AM, Rivasi F, Saltini C
Respiration 1984;45(4):339-46. doi: 10.1159/000194640. PMID: 6236529
Leukocyte migration inhibition in farmer's lung.
Morell F, Jeanneret A, Aïache JM, Molina C
J Allergy Clin Immunol 1982 May;69(5):405-9. doi: 10.1016/0091-6749(82)90114-2. PMID: 7076981
Bronchial hyperreactivity to methacholine in farmers' lung disease.
Freedman PM, Ault B
J Allergy Clin Immunol 1981 Jan;67(1):59-63. doi: 10.1016/0091-6749(81)90046-4. PMID: 7451772
Immunological aspects of bagassosis.
Hearn CE, Holford-Strevens V
Br J Ind Med 1968 Oct;25(4):283-92. doi: 10.1136/oem.25.4.283. PMID: 4972748Free PMC Article

Diagnosis

Hypersensitivity pneumonitis: A new strategy for serodiagnosis and environmental surveys.
Bellanger AP, Reboux G, Rouzet A, Barrera C, Rocchi S, Scherer E, Millon L
Respir Med 2019 Apr;150:101-106. Epub 2019 Mar 5 doi: 10.1016/j.rmed.2019.02.019. PMID: 30961934
Agricultural lung disease.
Spurzem JR, Romberger DJ, Von Essen SG
Clin Chest Med 2002 Dec;23(4):795-810. doi: 10.1016/s0272-5231(02)00024-2. PMID: 12512166
Hypersensitivity pneumonitis.
Gurney JW
Radiol Clin North Am 1992 Nov;30(6):1219-30. PMID: 1410310
Lung disease in farmers.
Warren CP
Can Med Assoc J 1977 Feb 19;116(4):391-4. PMID: 321110Free PMC Article
Mushroom worker's lung.
Jackson E, Welch KM
Thorax 1970 Jan;25(1):25-30. doi: 10.1136/thx.25.1.25. PMID: 5461446Free PMC Article

Therapy

Prevalence of occupational hypersensitivity pneumonitis: a systematic review and meta-analysis.
Zhang X, Igor B, Elena D, Olga R, Glazachev O
Int J Environ Health Res 2024 Nov;34(11):3891-3908. Epub 2024 Mar 27 doi: 10.1080/09603123.2024.2333021. PMID: 38544315
Hypersensitivity pneumonitis: A new strategy for serodiagnosis and environmental surveys.
Bellanger AP, Reboux G, Rouzet A, Barrera C, Rocchi S, Scherer E, Millon L
Respir Med 2019 Apr;150:101-106. Epub 2019 Mar 5 doi: 10.1016/j.rmed.2019.02.019. PMID: 30961934
Mold and Human Health: a Reality Check.
Borchers AT, Chang C, Eric Gershwin M
Clin Rev Allergy Immunol 2017 Jun;52(3):305-322. doi: 10.1007/s12016-017-8601-z. PMID: 28299723
Agricultural lung disease.
Spurzem JR, Romberger DJ, Von Essen SG
Clin Chest Med 2002 Dec;23(4):795-810. doi: 10.1016/s0272-5231(02)00024-2. PMID: 12512166
Occupational reactions to foods.
Aresery M, Lehrer SB
Curr Allergy Asthma Rep 2002 Jan;2(1):78-86. doi: 10.1007/s11882-002-0044-8. PMID: 11895631

Prognosis

Hypersensitivity pneumonitis: A new strategy for serodiagnosis and environmental surveys.
Bellanger AP, Reboux G, Rouzet A, Barrera C, Rocchi S, Scherer E, Millon L
Respir Med 2019 Apr;150:101-106. Epub 2019 Mar 5 doi: 10.1016/j.rmed.2019.02.019. PMID: 30961934
Recovery of pulmonary function in farmer's lung. A five-year follow-up study.
Kokkarinen JI, Tukiainen HO, Terho EO
Am Rev Respir Dis 1993 Apr;147(4):793-6. doi: 10.1164/ajrccm/147.4.793. PMID: 8466111
Long-term physiologic outcome after acute farmer's lung.
Cormier Y, Bélanger J
Chest 1985 Jun;87(6):796-800. doi: 10.1378/chest.87.6.796. PMID: 3996070
Inhalation challenge and skin testing in farmer's lung.
Edwards JH, Davies BH
J Allergy Clin Immunol 1981 Jul;68(1):58-64. doi: 10.1016/0091-6749(81)90124-x. PMID: 7240600
The long-term prognosis in farmer's lung.
Barbee RA, Callies Q, Dickie HA, Rankin J
Am Rev Respir Dis 1968 Feb;97(2):223-31. doi: 10.1164/arrd.1968.97.2.223. PMID: 5637938

Clinical prediction guides

Prevalence of occupational hypersensitivity pneumonitis: a systematic review and meta-analysis.
Zhang X, Igor B, Elena D, Olga R, Glazachev O
Int J Environ Health Res 2024 Nov;34(11):3891-3908. Epub 2024 Mar 27 doi: 10.1080/09603123.2024.2333021. PMID: 38544315
Hypersensitivity pneumonitis: A new strategy for serodiagnosis and environmental surveys.
Bellanger AP, Reboux G, Rouzet A, Barrera C, Rocchi S, Scherer E, Millon L
Respir Med 2019 Apr;150:101-106. Epub 2019 Mar 5 doi: 10.1016/j.rmed.2019.02.019. PMID: 30961934
Allergic alveolitis due to wood-rot fungi.
Bryant DH, Rogers P
Allergy Proc 1991 Mar-Apr;12(2):89-94. doi: 10.2500/108854191779011855. PMID: 2060786
Diffuse interstitial lung diseases: a histochemical approach.
Barbolini G, Bisetti A, Martinelli AM, Rivasi F, Saltini C
Respiration 1984;45(4):339-46. doi: 10.1159/000194640. PMID: 6236529
Precipitating antibodies to farmer's lung antigens in a Wisconsin farming population.
Gruchow HW, Hoffmann RG, Marx JJ Jr, Emanuel DA, Rimm AA
Am Rev Respir Dis 1981 Oct;124(4):411-5. doi: 10.1164/arrd.1981.124.4.411. PMID: 7027852

Recent systematic reviews

Prevalence of occupational hypersensitivity pneumonitis: a systematic review and meta-analysis.
Zhang X, Igor B, Elena D, Olga R, Glazachev O
Int J Environ Health Res 2024 Nov;34(11):3891-3908. Epub 2024 Mar 27 doi: 10.1080/09603123.2024.2333021. PMID: 38544315

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