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Recurrent Langerhans Cell Histiocytosis

MedGen UID:
1628116
•Concept ID:
C4525079
•
Neoplastic Process

Definition

The reemergence of Langerhans cell histiocytosis after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Langerhans Cell Histiocytosis

Professional guidelines

PubMed

Treatment of recurrent Langerhans cell histiocytosis in children with 2-chlorodeoxyadenosine.
Mottl H, Starý J, Chánová M, Nekolná M, Drahokoupilová E, Smelhaus V
Leuk Lymphoma 2006 Sep;47(9):1881-4. doi: 10.1080/10428190600687281. PMID: 17065001

Recent clinical studies

Therapy

Pilot study to estimate the safety and effectiveness of hydroxyurea and methotrexate recurrent langerhans cell histiocytosis (LCH-HU-pilot).
Sakamoto K, Kikuchi K, Sako M, Kato M, Takimoto T, Shioda Y
Medicine (Baltimore) 2022 Dec 16;101(50):e31475. doi: 10.1097/MD.0000000000031475. PMID: 36550910Free PMC Article
Resorption of PDLLA plates as a nidus for recurrent langerhans cell histiocytosis.
Yee KS, Combs PD, Kelley PK, George TM, Harshbarger RJ
Pediatr Neurosurg 2013;49(4):243-7. Epub 2014 Jun 5 doi: 10.1159/000362341. PMID: 24902626
Recurrent Langerhans cell histiocytosis of the mandible.
Felstead AM, Main BG, Thomas SJ, Hughes CW
Br J Oral Maxillofac Surg 2013 Apr;51(3):264-5. Epub 2012 Nov 3 doi: 10.1016/j.bjoms.2012.10.005. PMID: 23131794
Treatment of recurrent Langerhans cell histiocytosis in children with 2-chlorodeoxyadenosine.
Mottl H, Starý J, Chánová M, Nekolná M, Drahokoupilová E, Smelhaus V
Leuk Lymphoma 2006 Sep;47(9):1881-4. doi: 10.1080/10428190600687281. PMID: 17065001
Etoposide in recurrent childhood Langerhans' cell histiocytosis: an Italian cooperative study.
Ceci A, de Terlizzi M, Colella R, Balducci D, Toma MG, Zurlo MG, Macchia P, Mancini A, Indolfi P, Locurto M
Cancer 1988 Dec 15;62(12):2528-31. doi: 10.1002/1097-0142(19881215)62:12<2528::aid-cncr2820621213>3.0.co;2-#. PMID: 3056605

Prognosis

EBV+ lymphoproliferative disease following prolonged chemotherapy for refractory LCH.
Lee DA, Tatevian N, Herring RA, McClain KL
Pediatr Blood Cancer 2008 Mar;50(3):728-30. doi: 10.1002/pbc.21121. PMID: 17243127
Treatment of recurrent Langerhans cell histiocytosis in children with 2-chlorodeoxyadenosine.
Mottl H, Starý J, Chánová M, Nekolná M, Drahokoupilová E, Smelhaus V
Leuk Lymphoma 2006 Sep;47(9):1881-4. doi: 10.1080/10428190600687281. PMID: 17065001
2-Chlorodeoxyadenosine (2-CDA) for the treatment of refractory or recurrent Langerhans cell histiocytosis (LCH) in pediatric patients.
Stine KC, Saylors RL, Williams LL, Becton DL
Med Pediatr Oncol 1997 Oct;29(4):288-92. doi: 10.1002/(sici)1096-911x(199710)29:4<288::aid-mpo9>3.0.co;2-i. PMID: 9251735

Supplemental Content

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