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Langerhans Cell Histiocytosis, Disseminated

MedGen UID:
1651791
•Concept ID:
C4724714
•
Neoplastic Process

Definition

Langerhans cell histiocytosis presenting with disseminated disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLangerhans Cell Histiocytosis, Disseminated

Professional guidelines

PubMed

Disseminated Langerhans cell histocytosis in children: treatment outcome.
Kusumakumary P, James FV, Chellam VG, Ratheesan K, Nair MK
Am J Clin Oncol 1999 Apr;22(2):180-3. doi: 10.1097/00000421-199904000-00016. PMID: 10199456

Recent clinical studies

Etiology

Langerhans cell histiocytosis: Version 2021.
Gulati N, Allen CE
Hematol Oncol 2021 Jun;39 Suppl 1(Suppl 1):15-23. doi: 10.1002/hon.2857. PMID: 34105821Free PMC Article
Histiocytosis.
Emile JF, Cohen-Aubart F, Collin M, Fraitag S, Idbaih A, Abdel-Wahab O, Rollins BJ, Donadieu J, Haroche J
Lancet 2021 Jul 10;398(10295):157-170. Epub 2021 Apr 23 doi: 10.1016/S0140-6736(21)00311-1. PMID: 33901419Free PMC Article
Langerhans cell histiocytosis.
Rodriguez-Galindo C, Allen CE
Blood 2020 Apr 16;135(16):1319-1331. doi: 10.1182/blood.2019000934. PMID: 32106306
Langerhans cell histiocytosis in children: History, classification, pathobiology, clinical manifestations, and prognosis.
Krooks J, Minkov M, Weatherall AG
J Am Acad Dermatol 2018 Jun;78(6):1035-1044. doi: 10.1016/j.jaad.2017.05.059. PMID: 29754885
Pulmonary Langerhans' cell histiocytosis in adults.
Radzikowska E
Adv Respir Med 2017;85(5):277-289. Epub 2017 Oct 30 doi: 10.5603/ARM.a2017.0046. PMID: 29083024

Diagnosis

Pulmonary Langerhans-Cell Histiocytosis.
Qanneta R, Raventos-Estelle A
N Engl J Med 2022 Dec 29;387(26):2449. Epub 2022 Dec 24 doi: 10.1056/NEJMicm2203885. PMID: 36573701
Histiocytosis.
Emile JF, Cohen-Aubart F, Collin M, Fraitag S, Idbaih A, Abdel-Wahab O, Rollins BJ, Donadieu J, Haroche J
Lancet 2021 Jul 10;398(10295):157-170. Epub 2021 Apr 23 doi: 10.1016/S0140-6736(21)00311-1. PMID: 33901419Free PMC Article
Langerhans cell histiocytosis in children: History, classification, pathobiology, clinical manifestations, and prognosis.
Krooks J, Minkov M, Weatherall AG
J Am Acad Dermatol 2018 Jun;78(6):1035-1044. doi: 10.1016/j.jaad.2017.05.059. PMID: 29754885
Pulmonary Langerhans' cell histiocytosis in adults.
Radzikowska E
Adv Respir Med 2017;85(5):277-289. Epub 2017 Oct 30 doi: 10.5603/ARM.a2017.0046. PMID: 29083024
Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years.
Haupt R, Minkov M, Astigarraga I, Schäfer E, Nanduri V, Jubran R, Egeler RM, Janka G, Micic D, Rodriguez-Galindo C, Van Gool S, Visser J, Weitzman S, Donadieu J; Euro Histio Network
Pediatr Blood Cancer 2013 Feb;60(2):175-84. Epub 2012 Oct 25 doi: 10.1002/pbc.24367. PMID: 23109216Free PMC Article

Therapy

Langerhans cell histiocytosis: promises and caveats of targeted therapies in high-risk and CNS disease.
Abla O
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):386-395. doi: 10.1182/hematology.2023000439. PMID: 38066856Free PMC Article
International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults.
Goyal G, Tazi A, Go RS, Rech KL, Picarsic JL, Vassallo R, Young JR, Cox CW, Van Laar J, Hermiston ML, Cao XX, Makras P, Kaltsas G, Haroche J, Collin M, McClain KL, Diamond EL, Girschikofsky M
Blood 2022 Apr 28;139(17):2601-2621. doi: 10.1182/blood.2021014343. PMID: 35271698Free PMC Article
Langerhans cell histiocytosis.
Rodriguez-Galindo C, Allen CE
Blood 2020 Apr 16;135(16):1319-1331. doi: 10.1182/blood.2019000934. PMID: 32106306
Langerhans cell histiocytosis in adults: Advances in pathophysiology and treatment.
Kobayashi M, Tojo A
Cancer Sci 2018 Dec;109(12):3707-3713. Epub 2018 Oct 30 doi: 10.1111/cas.13817. PMID: 30281871Free PMC Article
Pulmonary Langerhans' cell histiocytosis in adults.
Radzikowska E
Adv Respir Med 2017;85(5):277-289. Epub 2017 Oct 30 doi: 10.5603/ARM.a2017.0046. PMID: 29083024

Prognosis

Histiocytosis.
Emile JF, Cohen-Aubart F, Collin M, Fraitag S, Idbaih A, Abdel-Wahab O, Rollins BJ, Donadieu J, Haroche J
Lancet 2021 Jul 10;398(10295):157-170. Epub 2021 Apr 23 doi: 10.1016/S0140-6736(21)00311-1. PMID: 33901419Free PMC Article
Pulmonary Langerhans Cell Histiocytosis.
Shaw B, Borchers M, Zander D, Gupta N
Semin Respir Crit Care Med 2020 Apr;41(2):269-279. Epub 2020 Apr 12 doi: 10.1055/s-0039-1700996. PMID: 32279297
Langerhans cell histiocytosis in children: History, classification, pathobiology, clinical manifestations, and prognosis.
Krooks J, Minkov M, Weatherall AG
J Am Acad Dermatol 2018 Jun;78(6):1035-1044. doi: 10.1016/j.jaad.2017.05.059. PMID: 29754885
Pulmonary Langerhans' cell histiocytosis in adults.
Radzikowska E
Adv Respir Med 2017;85(5):277-289. Epub 2017 Oct 30 doi: 10.5603/ARM.a2017.0046. PMID: 29083024
Langerhans cell histiocytosis.
Margo CE, Goldman DR
Surv Ophthalmol 2008 Jul-Aug;53(4):332-58. doi: 10.1016/j.survophthal.2008.04.007. PMID: 18572052

Clinical prediction guides

Bronchoalveolar cytokine profile differentiates Pulmonary Langerhans cell histiocytosis patients from other smoking-related interstitial lung diseases.
Barril S, Acebo P, Millan-Billi P, Luque A, Sibila O, Tarín C, Tazi A, Castillo D, Hortelano S
Respir Res 2023 Dec 18;24(1):320. doi: 10.1186/s12931-023-02622-z. PMID: 38111019Free PMC Article
Langerhans cell histiocytosis: promises and caveats of targeted therapies in high-risk and CNS disease.
Abla O
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):386-395. doi: 10.1182/hematology.2023000439. PMID: 38066856Free PMC Article
Histiocytosis.
Emile JF, Cohen-Aubart F, Collin M, Fraitag S, Idbaih A, Abdel-Wahab O, Rollins BJ, Donadieu J, Haroche J
Lancet 2021 Jul 10;398(10295):157-170. Epub 2021 Apr 23 doi: 10.1016/S0140-6736(21)00311-1. PMID: 33901419Free PMC Article
Merkel cell polyomavirus and Langerhans cell neoplasm.
Murakami I, Wada N, Nakashima J, Iguchi M, Toi M, Hashida Y, Higuchi T, Daibata M, Matsushita M, Iwasaki T, Kuwamoto S, Horie Y, Nagata K, Hayashi K, Oka T, Yoshino T, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F
Cell Commun Signal 2018 Aug 22;16(1):49. doi: 10.1186/s12964-018-0261-y. PMID: 30134914Free PMC Article
Multiple cystic lung disease.
Ferreira Francisco FA, Soares Souza A Jr, Zanetti G, Marchiori E
Eur Respir Rev 2015 Dec;24(138):552-64. doi: 10.1183/16000617.0046-2015. PMID: 26621970Free PMC Article

Recent systematic reviews

Systemic therapy of necrobiotic xanthogranuloma: a systematic review.
Steinhelfer L, Kühnel T, Jägle H, Mayer S, Karrer S, Haubner F, Schreml S
Orphanet J Rare Dis 2022 Mar 24;17(1):132. doi: 10.1186/s13023-022-02291-z. PMID: 35331271Free PMC Article
Otologic Manifestations of Langerhans Cell Histiocytosis: A Systematic Review.
Chen T, Ashman PE, Bojrab DI 2nd, Johnson AP, Benson B, Hong RS, Svider PF
Otolaryngol Head Neck Surg 2022 Jan;166(1):48-59. Epub 2021 May 4 doi: 10.1177/01945998211004590. PMID: 33945752
Periodontal manifestations of Langerhans cell histiocytosis: a systematic review.
Difloe-Geisert JC, Bernauer SA, Schneeberger N, Bornstein MM, Walter C
Clin Oral Investig 2021 Jun;25(6):3341-3349. Epub 2021 Mar 22 doi: 10.1007/s00784-021-03873-0. PMID: 33751219Free PMC Article
Treatment of necrobiotic xanthogranuloma - a systematic review.
Miguel D, Lukacs J, Illing T, Elsner P
J Eur Acad Dermatol Venereol 2017 Feb;31(2):221-235. Epub 2016 Jul 19 doi: 10.1111/jdv.13786. PMID: 27436448
Langerhans cell sarcoma: a systematic review.
Howard JE, Dwivedi RC, Masterson L, Jani P
Cancer Treat Rev 2015 Apr;41(4):320-31. Epub 2015 Mar 9 doi: 10.1016/j.ctrv.2015.02.011. PMID: 25805533

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