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Caplan syndrome

MedGen UID:
743
•Concept ID:
C0006915
•
Disease or Syndrome
Synonyms: Caplan Syndrome; Caplan Syndromes; Caplan's Syndrome; Caplans Syndrome
SNOMED CT: Rheumatoid pneumoconiosis (398640008); Caplan's syndrome (398640008); Caplans syndrome (398640008); Rheumatoid arthritis with pneumoconiosis (398640008)
 
Monarch Initiative: MONDO:0005690

Definition

A combination of rheumatoid arthritis (RA) and pneumoconiosis that manifests as intrapulmonary nodules, which appear homogenous and well-defined on chest X-ray. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCaplan syndrome

Professional guidelines

PubMed

"A Kratom Konundrum": Management of Kratom Withdrawal With Gabapentin in a Patient With a Left Ventricular Assist Device.
Giancola NB, Caplan JP, McKnight CA
J Acad Consult Liaison Psychiatry 2021 May-Jun;62(3):368-369. Epub 2020 Oct 13 doi: 10.1016/j.psym.2020.10.004. PMID: 33342583
12-month Success of Cracked Teeth Treated with Orthograde Root Canal Treatment.
Krell KV, Caplan DJ
J Endod 2018 Apr;44(4):543-548. Epub 2018 Feb 21 doi: 10.1016/j.joen.2017.12.025. PMID: 29429822
Prevention and management of glucocorticoid-induced side effects: A comprehensive review: Gastrointestinal and endocrinologic side effects.
Caplan A, Fett N, Rosenbach M, Werth VP, Micheletti RG
J Am Acad Dermatol 2017 Jan;76(1):11-16. doi: 10.1016/j.jaad.2016.02.1239. PMID: 27986133

Recent clinical studies

Etiology

Pulmonary manifestations of collagen diseases.
Gómez Carrera L, Bonilla Hernan G
Arch Bronconeumol 2013 Jun;49(6):249-60. Epub 2013 Feb 4 doi: 10.1016/j.arbres.2012.11.005. PMID: 23683373
Computed tomography findings of Caplan syndrome.
Arakawa H, Honma K, Shida H, Saito Y, Morikubo H
J Comput Assist Tomogr 2003 Sep-Oct;27(5):758-60. doi: 10.1097/00004728-200309000-00013. PMID: 14501367
Rheumatoid "pneumoconiosis" (Caplan's syndrome) in an asbestos worker: a 17 years' follow-up.
Greaves IA
Thorax 1979 Jun;34(3):404-5. doi: 10.1136/thx.34.3.404. PMID: 483218Free PMC Article
Caplan's syndrome in miners.
Kandus J, Sitaj S, Ondrásík M
Rev Czech Med 1977;23(4):236-45. PMID: 413171
Haemodilution as a cause of anaemia in coalworkers.
Chan BW
Br J Ind Med 1969 Jul;26(3):237-9. doi: 10.1136/oem.26.3.237. PMID: 5794949Free PMC Article

Diagnosis

What to do with all of these lung nodules?
Rozenberg D, Shapera S
Can Respir J 2014 May-Jun;21(3):e52-4. doi: 10.1155/2014/593430. PMID: 24914609Free PMC Article
Pulmonary manifestations of collagen diseases.
Gómez Carrera L, Bonilla Hernan G
Arch Bronconeumol 2013 Jun;49(6):249-60. Epub 2013 Feb 4 doi: 10.1016/j.arbres.2012.11.005. PMID: 23683373
Parkinsonism in Caplan's syndrome.
Rizzo G, Scaglione C, Lopane G, Pollini A, Tommasoni E, Martinelli P
Neurol Sci 2006 Apr;27(1):67-9. doi: 10.1007/s10072-006-0567-1. PMID: 16688603
Silicosis and coal workers' pneumoconiosis.
Scarisbrick D
Practitioner 2002 Feb;246(1631):114, 117-9. PMID: 11852619
Coal workers' pneumoconiosis.
Green FH, Laqueur WA
Pathol Annu 1980;15(Pt 2):333-410. PMID: 7005843

Therapy

Atypical presentation of rheumatoid arthritis: a case of massive bilateral pleural effusions in a patient with Caplan syndrome.
Wu Y, Dittmar PC
BMJ Case Rep 2019 Oct 25;12(10) doi: 10.1136/bcr-2019-231899. PMID: 31653636Free PMC Article
Parkinsonism in Caplan's syndrome.
Rizzo G, Scaglione C, Lopane G, Pollini A, Tommasoni E, Martinelli P
Neurol Sci 2006 Apr;27(1):67-9. doi: 10.1007/s10072-006-0567-1. PMID: 16688603
Coal workers' pneumoconiosis.
Green FH, Laqueur WA
Pathol Annu 1980;15(Pt 2):333-410. PMID: 7005843
Caplan's syndrome - a clinical study of 13 cases.
Unge G, Mellner C
Scand J Respir Dis 1975;56(6):287-91. PMID: 1221495
Treatment of rapidly progressive rheumatoid pneumoconiosis.
Davies D
Br J Ind Med 1973 Oct;30(4):396-401. doi: 10.1136/oem.30.4.396. PMID: 4753724Free PMC Article

Prognosis

Rheumatoid pneumoconiosis (Caplan's syndrome).
Schreiber J, Koschel D, Kekow J, Waldburg N, Goette A, Merget R
Eur J Intern Med 2010 Jun;21(3):168-72. Epub 2010 Mar 2 doi: 10.1016/j.ejim.2010.02.004. PMID: 20493416
Computed tomography findings of Caplan syndrome.
Arakawa H, Honma K, Shida H, Saito Y, Morikubo H
J Comput Assist Tomogr 2003 Sep-Oct;27(5):758-60. doi: 10.1097/00004728-200309000-00013. PMID: 14501367
Rheumatoid "pneumoconiosis" (Caplan's syndrome) in an asbestos worker: a 17 years' follow-up.
Greaves IA
Thorax 1979 Jun;34(3):404-5. doi: 10.1136/thx.34.3.404. PMID: 483218Free PMC Article
Caplan's syndrome in miners.
Kandus J, Sitaj S, Ondrásík M
Rev Czech Med 1977;23(4):236-45. PMID: 413171

Clinical prediction guides

Changes of the lung in rheumatoid arthritis--rheumatoid pneumonia. A clinicopathological study.
Bély M, Apáthy A
Acta Morphol Hung 1991;39(2):117-56. PMID: 1789145
Pulmonary function in coal workers with Caplan's syndrome and non-rheumatoid complicated pneumosoniosis.
Constantinidis K, Musk AW, Jenkins JP, Berry G
Thorax 1978 Dec;33(6):764-8. doi: 10.1136/thx.33.6.764. PMID: 746502Free PMC Article
Incidence of hepatitis associated antigen HAA and homologous antibody in patients with rheumatoid arthritis.
Marcolongo R, Debolini A
Vox Sang 1975;28(1):9-18. doi: 10.1111/j.1423-0410.1975.tb02735.x. PMID: 1114790

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