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Bone Langerhans Cell Histiocytosis

MedGen UID:
1791592
•Concept ID:
C5555151
•
Neoplastic Process

Definition

Langerhans cell histiocytosis affecting the bone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone Langerhans Cell Histiocytosis

Professional guidelines

PubMed

Indomethacin is an effective treatment in adults and children with bone Langerhans cell histiocytosis (LCH).
De Benedittis D, Mohamed S, Rizzo L, Santopietro M, Palumbo G, Cardarelli L, Roggini M, Giona F
Br J Haematol 2020 Dec;191(5):e109-e113. Epub 2020 Aug 30 doi: 10.1111/bjh.17067. PMID: 32862434
Isolated Langerhans Cell Histiocytosis Bone Lesion in Pediatric Patients: Systematic Review and Treatment Algorithm.
Bezdjian A, Alarfaj AA, Varma N, Daniel SJ
Otolaryngol Head Neck Surg 2015 Nov;153(5):751-7. Epub 2015 Aug 4 doi: 10.1177/0194599815598969. PMID: 26243026

Recent clinical studies

Etiology

Cholesteatoma Masquerading as Recurrent Langerhans Cell Histiocytosis.
Gendre A, Dréno M, Boyer J, Thomas C, Michel G
J Int Adv Otol 2023 Jan;19(1):70-73. doi: 10.5152/iao.2023.22716. PMID: 36718041Free PMC Article
Relapses of multisystem/multifocal bone Langerhans cell histiocytosis in paediatric patients: Data analysis from the JLSG-96/02 study.
Sakamoto K, Morimoto A, Shioda Y, Imamura T, Imashuku S; Japan LCH Study Group (JLSG)
Br J Haematol 2023 Mar;200(6):769-775. Epub 2022 Dec 13 doi: 10.1111/bjh.18583. PMID: 36511451
Langerhans cell histiocytosis of the temporal bone: A review of 29 cases at a single center.
Modest MC, Garcia JJ, Arndt CS, Carlson ML
Laryngoscope 2016 Aug;126(8):1899-904. Epub 2015 Nov 4 doi: 10.1002/lary.25773. PMID: 26535795
Symptomatic bone langerhans cell histiocytosis treated at diagnosis or after reactivation with indomethacin alone.
Braier J, Rosso D, Pollono D, Rey G, Lagomarsino E, Latella A, Zubizarreta P
J Pediatr Hematol Oncol 2014 Jul;36(5):e280-4. doi: 10.1097/MPH.0000000000000165001. PMID: 24977402
Prognostic indicators for sensorineural hearing loss in temporal bone histiocytosis.
Saliba I, Sidani K
Int J Pediatr Otorhinolaryngol 2009 Dec;73(12):1616-20. Epub 2009 Aug 9 doi: 10.1016/j.ijporl.2009.07.010. PMID: 19671478

Diagnosis

Cholesteatoma Masquerading as Recurrent Langerhans Cell Histiocytosis.
Gendre A, Dréno M, Boyer J, Thomas C, Michel G
J Int Adv Otol 2023 Jan;19(1):70-73. doi: 10.5152/iao.2023.22716. PMID: 36718041Free PMC Article
Relapses of multisystem/multifocal bone Langerhans cell histiocytosis in paediatric patients: Data analysis from the JLSG-96/02 study.
Sakamoto K, Morimoto A, Shioda Y, Imamura T, Imashuku S; Japan LCH Study Group (JLSG)
Br J Haematol 2023 Mar;200(6):769-775. Epub 2022 Dec 13 doi: 10.1111/bjh.18583. PMID: 36511451
Solitary Bone Langerhans Cell Histiocytosis Demonstrated on Multimodality Imaging in an Adult.
Zhao Y, Zhou Y, Tian R, Su M
Clin Nucl Med 2020 Jan;45(1):78-80. doi: 10.1097/RLU.0000000000002845. PMID: 31789916
Langerhans cell histiocytosis of the temporal bone: A review of 29 cases at a single center.
Modest MC, Garcia JJ, Arndt CS, Carlson ML
Laryngoscope 2016 Aug;126(8):1899-904. Epub 2015 Nov 4 doi: 10.1002/lary.25773. PMID: 26535795
Symptomatic bone langerhans cell histiocytosis treated at diagnosis or after reactivation with indomethacin alone.
Braier J, Rosso D, Pollono D, Rey G, Lagomarsino E, Latella A, Zubizarreta P
J Pediatr Hematol Oncol 2014 Jul;36(5):e280-4. doi: 10.1097/MPH.0000000000000165001. PMID: 24977402

Therapy

Relapses of multisystem/multifocal bone Langerhans cell histiocytosis in paediatric patients: Data analysis from the JLSG-96/02 study.
Sakamoto K, Morimoto A, Shioda Y, Imamura T, Imashuku S; Japan LCH Study Group (JLSG)
Br J Haematol 2023 Mar;200(6):769-775. Epub 2022 Dec 13 doi: 10.1111/bjh.18583. PMID: 36511451
Radiologic Findings of Scapular Langerhans Cell Histiocytosis Successfully Treated with CT-Guided Corticosteroid Injection.
Sahin C, Ucpinar BA, Oc Y, Kabukcuoglu F
J Coll Physicians Surg Pak 2020 Jul;30(7):754-756. doi: 10.29271/jcpsp.2020.07.754. PMID: 32811609
Thoracic spine Langerhans cell histiocytosis in a child with achondroplasia.
Chan Z, Simpson L, Gallo P
BMJ Case Rep 2019 Jul 24;12(7) doi: 10.1136/bcr-2018-228801. PMID: 31345829Free PMC Article
Symptomatic bone langerhans cell histiocytosis treated at diagnosis or after reactivation with indomethacin alone.
Braier J, Rosso D, Pollono D, Rey G, Lagomarsino E, Latella A, Zubizarreta P
J Pediatr Hematol Oncol 2014 Jul;36(5):e280-4. doi: 10.1097/MPH.0000000000000165001. PMID: 24977402

Prognosis

Langerhans cell histiocytosis of the temporal bone: A review of 29 cases at a single center.
Modest MC, Garcia JJ, Arndt CS, Carlson ML
Laryngoscope 2016 Aug;126(8):1899-904. Epub 2015 Nov 4 doi: 10.1002/lary.25773. PMID: 26535795
Symptomatic bone langerhans cell histiocytosis treated at diagnosis or after reactivation with indomethacin alone.
Braier J, Rosso D, Pollono D, Rey G, Lagomarsino E, Latella A, Zubizarreta P
J Pediatr Hematol Oncol 2014 Jul;36(5):e280-4. doi: 10.1097/MPH.0000000000000165001. PMID: 24977402
Eosinophilic granuloma of the sternum in a child treated with closed biopsy.
Kontogeorgakos VA, Papachristou DJ, Malizos KN
Pediatr Int 2014 Jun;56(3):417-9. doi: 10.1111/ped.12263. PMID: 24894927
Prognostic indicators for sensorineural hearing loss in temporal bone histiocytosis.
Saliba I, Sidani K
Int J Pediatr Otorhinolaryngol 2009 Dec;73(12):1616-20. Epub 2009 Aug 9 doi: 10.1016/j.ijporl.2009.07.010. PMID: 19671478

Clinical prediction guides

Radiologic Findings of Scapular Langerhans Cell Histiocytosis Successfully Treated with CT-Guided Corticosteroid Injection.
Sahin C, Ucpinar BA, Oc Y, Kabukcuoglu F
J Coll Physicians Surg Pak 2020 Jul;30(7):754-756. doi: 10.29271/jcpsp.2020.07.754. PMID: 32811609

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