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Langerhans Cell Histiocytosis, Monostotic

MedGen UID:
727088
•Concept ID:
C1306599
•
Neoplastic Process
Synonyms: Langerhans cell granulomatosis, unifocal; Langerhans cell histiocytosis, unifocal; Langerhans cell histiocytosis, unifocal (clinical); Mono-ostotic Langerhans cell histiocytosis; Monostotic Langerhans cell histiocytosis
SNOMED CT: Langerhans cell granulomatosis, unifocal (128810002); Langerhans cell histiocytosis, unifocal (128810002); Langerhans cell histiocytosis, unifocal (clinical) (129000002); Langerhans cell histiocytosis, unifocal (129000002); Monostotic Langerhans cell histiocytosis (1187283003); Mono-ostotic Langerhans cell histiocytosis (1187283003)

Definition

Langerhans cell histiocytosis presenting as a solitary lesion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLangerhans Cell Histiocytosis, Monostotic

Recent clinical studies

Etiology

Monostotic Langerhans' cell histiocytosis in a child with central diabetes insipidus.
Soares EC, Quidute AR, Costa FW, Gurgel MH, Alves AP, Fonteles CS
J Clin Pediatr Dent 2012 Summer;36(4):377-81. doi: 10.17796/jcpd.36.4.aq167251703n767u. PMID: 23019836
Tumours and tumour-like lesions of the hip in the paediatric age: a review of the Rizzoli experience.
Ruggieri P, Angelini A, Montalti M, Pala E, Calabrò T, Ussia G, Abati CN, Mercuri M
Hip Int 2009 Jan-Mar;19 Suppl 6:S35-45. doi: 10.1177/112070000901906s07. PMID: 19306246
Disease course and late sequelae of Langerhans' cell histiocytosis: 25-year experience at the University of California, San Francisco.
Willis B, Ablin A, Weinberg V, Zoger S, Wara WM, Matthay KK
J Clin Oncol 1996 Jul;14(7):2073-82. doi: 10.1200/JCO.1996.14.7.2073. PMID: 8683239
Histiocytosis X: a review of 114 cases with oral involvement.
Hartman KS
Oral Surg Oral Med Oral Pathol 1980;49(1):38-54. doi: 10.1016/0030-4220(80)90030-4. PMID: 6965322
Idiopathic differentiated histiocytosis.
Daneshbod K, Kissane JM
Am J Clin Pathol 1978 Sep;70(3):381-9. doi: 10.1093/ajcp/70.3.381. PMID: 309279

Diagnosis

Immunogenetic heterogeneity in single-system and multisystem langerhans cell histiocytosis.
Bernstrand C, Carstensen H, Jakobsen B, Svejgaard A, Henter JI, Olerup O
Pediatr Res 2003 Jul;54(1):30-6. Epub 2003 Apr 16 doi: 10.1203/01.PDR.0000069844.50684.7D. PMID: 12700369
Langerhans cell histiocytosis mimicking malignancy: a radiological appraisal.
Potepan P, Tesoro-Tess JD, Laffranchi A, Danesini GM, Gianni C, Uslenghi E, Spagnoli I
Tumori 1996 Nov-Dec;82(6):603-9. doi: 10.1177/030089169608200619. PMID: 9061074
Disease course and late sequelae of Langerhans' cell histiocytosis: 25-year experience at the University of California, San Francisco.
Willis B, Ablin A, Weinberg V, Zoger S, Wara WM, Matthay KK
J Clin Oncol 1996 Jul;14(7):2073-82. doi: 10.1200/JCO.1996.14.7.2073. PMID: 8683239
Primary rib tumours in children (report of 27 cases with short literature review).
Kozlowski K, Campbell J, Morris L, Sprague P, Taccone A, Beluffi G, Marcinski A, Porta F, Stevens M
Australas Radiol 1989 Aug;33(3):210-22. doi: 10.1111/j.1440-1673.1989.tb03277.x. PMID: 2690801
Idiopathic differentiated histiocytosis.
Daneshbod K, Kissane JM
Am J Clin Pathol 1978 Sep;70(3):381-9. doi: 10.1093/ajcp/70.3.381. PMID: 309279

Therapy

Monostotic Langerhans' cell histiocytosis in a child with central diabetes insipidus.
Soares EC, Quidute AR, Costa FW, Gurgel MH, Alves AP, Fonteles CS
J Clin Pediatr Dent 2012 Summer;36(4):377-81. doi: 10.17796/jcpd.36.4.aq167251703n767u. PMID: 23019836
Polyostotic monosystemic calvarial and spinal langerhans' cell histiocytosis treated by surgery and chemotherapy.
Karagoz Guzey F, Bas NS, Emel E, Alatas I, Kebudi R
Pediatr Neurosurg 2003 Apr;38(4):206-11. doi: 10.1159/000069100. PMID: 12646740

Prognosis

Spontaneous remission of eosinophilic granuloma of the maxilla after incisional biopsy: a case report.
Vargas A, Ramírez H, Ramírez P, Foncea C, Venegas B, Astorga P
Head Face Med 2016 Jun 2;12(1):21. doi: 10.1186/s13005-016-0118-9. PMID: 27251410Free PMC Article
Langerhans cell histiocytosis mimicking malignancy: a radiological appraisal.
Potepan P, Tesoro-Tess JD, Laffranchi A, Danesini GM, Gianni C, Uslenghi E, Spagnoli I
Tumori 1996 Nov-Dec;82(6):603-9. doi: 10.1177/030089169608200619. PMID: 9061074
Disease course and late sequelae of Langerhans' cell histiocytosis: 25-year experience at the University of California, San Francisco.
Willis B, Ablin A, Weinberg V, Zoger S, Wara WM, Matthay KK
J Clin Oncol 1996 Jul;14(7):2073-82. doi: 10.1200/JCO.1996.14.7.2073. PMID: 8683239
Histiocytosis X: a review of 114 cases with oral involvement.
Hartman KS
Oral Surg Oral Med Oral Pathol 1980;49(1):38-54. doi: 10.1016/0030-4220(80)90030-4. PMID: 6965322
Idiopathic differentiated histiocytosis.
Daneshbod K, Kissane JM
Am J Clin Pathol 1978 Sep;70(3):381-9. doi: 10.1093/ajcp/70.3.381. PMID: 309279

Clinical prediction guides

Tumours and tumour-like lesions of the hip in the paediatric age: a review of the Rizzoli experience.
Ruggieri P, Angelini A, Montalti M, Pala E, Calabrò T, Ussia G, Abati CN, Mercuri M
Hip Int 2009 Jan-Mar;19 Suppl 6:S35-45. doi: 10.1177/112070000901906s07. PMID: 19306246
Spontaneous regression of orbital Langerhans cell granulomatosis in a three-year-old girl.
Smith JH, Fulton L, O'Brien JM
Am J Ophthalmol 1999 Jul;128(1):119-21. doi: 10.1016/s0002-9394(99)00055-0. PMID: 10482114

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