U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Langerhans Cell Histiocytosis, Polyostotic

MedGen UID:
1669950
•Concept ID:
C4727834
•
Neoplastic Process
Synonyms: Polyostotic Langerhans cell histiocytosis; Polystotic Langerhans cell histiocytosis
SNOMED CT: Polystotic Langerhans cell histiocytosis (1187282008); Polyostotic Langerhans cell histiocytosis (1187282008)

Definition

Langerhans cell histiocytosis presenting with multiple sites of involvement. [from NCI]

Professional guidelines

PubMed

Langerhans' cell histiocytosis: pathology, imaging and treatment of skeletal involvement.
Azouz EM, Saigal G, Rodriguez MM, Podda A
Pediatr Radiol 2005 Feb;35(2):103-15. Epub 2004 Jul 28 doi: 10.1007/s00247-004-1262-0. PMID: 15289942

Recent clinical studies

Therapy

Monosystem multifocal Langerhans cell histiocytosis (multifocal eosinophilic granulomas of the bone) in a 36-year old patient: case report, therapeutic doubts and review of literature.
Roginić S, Buković D, Pesek K, Trsinski D
Coll Antropol 2013 Jun;37(2):521-5. PMID: 23940999
Polyostotic monosystemic calvarial and spinal langerhans' cell histiocytosis treated by surgery and chemotherapy.
Karagoz Guzey F, Bas NS, Emel E, Alatas I, Kebudi R
Pediatr Neurosurg 2003 Apr;38(4):206-11. doi: 10.1159/000069100. PMID: 12646740
The prognosis of polyostotic eosinophilic granuloma.
Daneshbod K, Kissane JM
Am J Clin Pathol 1976 May;65(5):601-11. doi: 10.1093/ajcp/65.5.601. PMID: 16535802

Prognosis

Langerhans' cell histiocytosis: pathology, imaging and treatment of skeletal involvement.
Azouz EM, Saigal G, Rodriguez MM, Podda A
Pediatr Radiol 2005 Feb;35(2):103-15. Epub 2004 Jul 28 doi: 10.1007/s00247-004-1262-0. PMID: 15289942
Disease course and late sequelae of Langerhans' cell histiocytosis: 25-year experience at the University of California, San Francisco.
Willis B, Ablin A, Weinberg V, Zoger S, Wara WM, Matthay KK
J Clin Oncol 1996 Jul;14(7):2073-82. doi: 10.1200/JCO.1996.14.7.2073. PMID: 8683239
Langerhans' cell histiocytosis (histiocytosis X) of bone. A clinicopathologic analysis of 263 pediatric and adult cases.
Kilpatrick SE, Wenger DE, Gilchrist GS, Shives TC, Wollan PC, Unni KK
Cancer 1995 Dec 15;76(12):2471-84. doi: 10.1002/1097-0142(19951215)76:12<2471::aid-cncr2820761211>3.0.co;2-z. PMID: 8625073
Histiocytosis X: a review of 114 cases with oral involvement.
Hartman KS
Oral Surg Oral Med Oral Pathol 1980;49(1):38-54. doi: 10.1016/0030-4220(80)90030-4. PMID: 6965322
Idiopathic differentiated histiocytosis.
Daneshbod K, Kissane JM
Am J Clin Pathol 1978 Sep;70(3):381-9. doi: 10.1093/ajcp/70.3.381. PMID: 309279

Clinical prediction guides

Childhood Langerhans cell histiocytosis increased during El Niño 1997-98: a report from the Taiwan Pediatric Oncology Group.
Chen RL, Lin KS, Chang WH, Hsieh YL, Chen BW, Jaing TH, Yang CP, Hung IJ, Peng CT, Shu SG, Lu MY, Jou ST, Lin KH, Lin DT, Lin MT, Chen JS, Liu HC, Chen SH, Liang DC, Chiou SS, Chang TT, Sheen JM, Hsiao CC, Cheng SN, Lin JC
Acta Paediatr Taiwan 2003 Jan-Feb;44(1):14-20. PMID: 12800378
The prognosis of polyostotic eosinophilic granuloma.
Daneshbod K, Kissane JM
Am J Clin Pathol 1976 May;65(5):601-11. doi: 10.1093/ajcp/65.5.601. PMID: 16535802

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...