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Intestinal disorder

MedGen UID:: 7130
•Concept ID:: C0021831
•: Disease or Syndrome

Synonym:	Intestinal disease
SNOMED CT:	Enteropathy (85919009); Disorder of intestine (85919009); Intestinal disease (85919009)

Monarch Initiative:	MONDO:0005020

Definition

A non-neoplastic or neoplastic disorder that affects the small or large intestine. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIntestinal disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of gastrointestinal tract
        Intestinal disorder
        Cecal disorder
        Appendicitis
        Acute perforated appendicitis
        Cecal neoplasm
        Appendiceal neoplasm
        Benign neoplasm of cecum
        Cecum cancer
        Cecum neuroendocrine tumor G1
        Typhlitis
        Colonic disorder
        Chilaiditi syndrome
        Colitis
        Acute colitis
        Aggravated Colitis
        Antibiotic enterocolitis
        Chronic Active Colitis
        Chronic colitis
        Colitis due to radiation
        Crohn disease of large bowel
        Enterocolitis
        Focal active colitis
        Infectious colitis
        Ischemic colitis
        Microscopic colitis
        Pancolitis
        Proctocolitis
        Ulcerative colitis
        Colonic diverticula
        Diverticulitis of colon
        Functional colonic disease
        Colonic pseudo-obstruction
        Irritable bowel syndrome
        Neurogenic bowel
        Megacolon
        Aganglionic megacolon
        Toxic megacolon
        Neoplasm of the large intestine
        Adenocarcinoma of the large intestine
        Anal canal neoplasm
        Benign neoplasm of large intestine
        Colonic neoplasm
        Colorectal cancer
        Colorectal gastrointestinal stromal tumor
        Colorectal Intraepithelial Neoplasia
        Colorectal Neuroendocrine Neoplasm
        Familial multiple polyposis syndrome
        Hereditary nonpolyposis colorectal carcinoma
        Hereditary nonpolyposis colorectal neoplasms
        Rectal neoplasm
        Rectosigmoid junction neoplasm
        Sigmoid disease
        Sigmoid neoplasm
        Colorectal polyposis
        Colorectal Adenomatous Polyp
        Adenomatous polyp of colon
        Rectal Adenomatous Polyp
        Colorectal hamartoma
        Colorectal Cowden-Associated Polyp
        Colorectal juvenile polyp
        Colorectal Peutz-Jeghers Polyp
        Colorectal Inflammatory Polyp
        Colon inflammatory polyp
        Colorectal Sporadic Serrated Polyp
        Colorectal Hyperplastic Polyp
        Hyperplastic polyposis syndrome
        Colon serrated polyposis
        Polyp of colon
        Colon Hyperplastic Polyp
        Colon juvenile polyp
        Colon sessile serrated adenoma/polyp
        Rectal polyposis
        Rectal hyperplastic polyp
        Rectal Juvenile Polyp
        Rectal Serrated Lesions and Polyps
        Duodenal disorder
        Duodenal obstruction
        Superior mesenteric artery syndrome
        Duodenitis
        Duodenogastric reflux
        Bile reflux
        Peptic ulcer
        Active Peptic Ulcer
        Duodenal ulcer
        Gastric ulcer
        Peptic esophagitis
        Peptic ulcer perforation
        Stress ulcer
        Zollinger-Ellison syndrome
        Tumor of duodenum
        Benign duodenal neoplasm
        Duodenal neuroendocrine tumor, well differentiated, low or intermediate grade
        Duodenum cancer
        Dysentery
        Amebic dysentery
        Bacillary dysentery
        Enteritis
        Crohn disease
        Small bowel Crohn disease
        Ileitis
        Necrotizing ileitis
        Pouchitis
        Radiation enteritis of intestine
        HIV enteropathy
        Ileal Diseases
        Ileal neoplasm
        Ileal neuroendocrine tumor, well differentiated, low or intermediate grade
        Inflammatory bowel disease
        ALPI-related inflammatory bowel disease
        Cap polyposis
        Chronic granulomatous disease
        Granulomatous disease, chronic, autosomal recessive, cytochrome b-negative
        Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 1
        Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 2
        Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 3
        Granulomatous disease, chronic, X-linked
        Cutaneous photosensitivity-lethal colitis syndrome
        IL21-related infantile inflammatory bowel disease
        Indeterminate colitis
        Inflammatory bowel disease 28
        Necrotizing enterocolitis
        Neonatal inflammatory skin and bowel disease
        Non-infective Inflammatory Bowel Disease
        Protein-losing enteropathy
        TRIM22-related inflammatory bowel disease
        Undetermined colitis
        X-linked lymphoproliferative disease due to XIAP deficiency
        Insufficiency, Mesenteric Vascular
        Intestinal atresia
        Atresia of small intestine
        Duodenal atresia
        Ileal atresia
        Jejunal atresia
        Congenital atresia of colon
        Congenital atresia of large intestine
        Multiple small bowel atresias
        Rectal atresia
        Intestinal Failure
        Intestinal fistula
        Anal fistula
        Anoperineal fistula
        Colonic fistula
        Colovesical fistula
        Duodenal fistula
        Enterocutaneous fistula
        Ileal Fistula
        Intestinal Fistula excluding Rectum and Anus
        Jejunal fistula
        Rectal fistula
        Rectoperineal fistula
        Rectoureteral fistula
        Rectourethral fistula
        Rectovaginal fistula
        Rectovesical fistula
        Rectovestibular fistula
        Intestinal neoplasm
        Alpha-heavy chain disease
        Intestinal benign neoplasm
        Benign neoplasm of small intestine
        Intestinal cancer
        Intestinal Neuroendocrine Carcinoma
        Intestinal T-Cell Lymphoma
        Malignant tumor of small intestine
        Intestinal Intraepithelial Neoplasia
        Small intestinal intraepithelial neoplasia
        Intestinal neuroendocrine neoplasm
        Intestinal Neuroendocrine Tumor
        Small intestine neuroendocrine neoplasm
        Intestinal Soft Tissue Neoplasm
        Colorectal leiomyoma
        Colorectal lipoma
        Small Intestinal Lipoma
        Small intestine leiomyoma
        Jejunal neoplasm
        Jejunal cancer
        Jejunal neuroendocrine tumor, well differentiated, low or intermediate grade
        Neoplasm of the small intestine
        Duodenal gastrin-producing neuroendocrine tumor
        Gastrointestinal stromal tumor of small intestine
        Small intestinal adenoma
        Small intestinal hamartoma
        Small intestinal polyp
        Small intestine adenocarcinoma
        Small intestine carcinoid
        Intestinal obstruction
        Afferent loop syndrome
        Fecal impaction
        Functional intestinal obstruction
        High intestinal obstruction
        Ileus
        Intestinal pseudo-obstruction
        Mechanical ileus
        Meconium ileus
        Paralytic ileus
        Intestinal Stoma Obstruction
        Intussusception
        Ileoileal intussusception
        Malignant Bowel Obstruction
        Neonatal intestinal obstruction
        Obstruction of colon
        Rectal Obstruction
        Small bowel obstruction
        Ileal Obstruction
        Jejunal Obstruction
        Volvulus
        Intestinal perforation
        Colon perforation
        In Utero Bowel Perforation
        Rectal perforation
        Small intestinal perforation
        Duodenal perforation
        Perforation of ileum
        Perforation of jejunum
        Spontaneous intestinal perforation
        Intestinal polyposis
        Discrete intestinal polyps
        Large intestinal polyposis
        Hyperplastic colonic polyposis
        Juvenile colonic polyposis
        Peutz-Jeghers syndrome
        Serrated intestinal polyps
        Small intestinal polyposis
        Duodenal polyposis
        Intestinal Precancerous Condition
        Jejunal Diseases
        Malabsorption syndrome
        Autoimmune enteropathy
        MHC class II deficiency
        Primary autoimmune enteropathy
        Severe combined immunodeficiency due to LCK deficiency
        TCR-alpha-beta-positive T-cell deficiency
        Blind loop syndrome
        Celiac disease
        Celiac disease, susceptibility to, 1
        Celiac disease, susceptibility to, 2
        Celiac disease, susceptibility to, 3
        Celiac disease, susceptibility to, 4
        Celiac disease, susceptibility to, 5
        Celiac disease, susceptibility to, 6
        Celiac disease, susceptibility to, 7
        Celiac disease, susceptibility to, 8
        Celiac disease, susceptibility to, 9
        Celiac disease, susceptibility to, 10
        Celiac disease, susceptibility to, 11
        Celiac disease, susceptibility to, 12
        Celiac disease, susceptibility to, 13
        Collagenous sprue
        Hyperhomocysteinemia
        Homocystinuria
        Intestinal Disaccharidase Deficiency and Disaccharide Malabsorption
        Lactose intolerance
        Short bowel syndrome
        Secondary short bowel syndrome
        Steatorrhea
        Tropical sprue
        Whipple disease
        Mesenteric vascular occlusion
        Non-Neoplastic Intestinal Disorder
        Abdominal colic
        Infantile colic
        Renal colic
        Cecal Infection
        Congenital Abnormality of the Large Intestine
        Diverticulitis
        Esophageal diverticulosis
        Gastric Diverticulitis
        Meckel diverticulitis
        Stomach diverticulosis
        Duodenal web
        Ileal Web
        Intestinal duplication
        Duplicated colon
        Intestinal malrotation
        Malrotation of colon
        Malrotation of small bowel
        Midgut malrotation
        Ischemic bowel disorder
        Acute intestinal ischemia
        Jejunal Web
        Large Intestinal Mucositis
        Rectal Mucositis
        Microcolon
        Small Intestinal Infection
        Campylobacter Jejuni Infection
        Duodenal Infection
        Small Intestinal Mucositis
        Ulcer of rectum
        Ulceration of large intestine
        Ulceration of small intestine
        Ileal ulcer
        Parasitic intestinal disease
        Anisakiasis
        Balantidiasis
        Cryptosporidiosis
        Chronic Intestinal Cryptosporidiosis
        Dientamoebiasis
        Giardiasis
        Infection caused by Blastocystis
        Pneumatosis cystoides intestinalis
        Rectal disorder
        Anus disorder
        Anal fissure
        Anal polyp
        Anal Precancerous Condition
        Anus neoplasm
        Non-Neoplastic Anal Disorder
        Pruritus ani
        Bowel incontinence
        Encopresis
        Hemorrhoid
        External hemorrhoids
        Internal hemorrhoid
        Proctitis
        Rectal prolapse
        Rectocele

Professional guidelines

PubMed

Bile Acid Diarrhea: From Molecular Mechanisms to Clinical Diagnosis and Treatment in the Era of Precision Medicine.

Yang D, Lyu C, He K, Pang K, Guo Z, Wu D
Int J Mol Sci 2024 Jan 26;25(3) doi: 10.3390/ijms25031544. PMID: 38338820 Free PMC Article

Enterogenous Microbiotic Markers in the Differential Diagnosis of Crohn's Disease and Intestinal Tuberculosis.

Jiang M, Zeng Z, Chen K, Dang Y, Li L, Ma C, Cheng R, Hu K, Li X, Zhang H
Front Immunol 2022;13:820891. Epub 2022 Mar 16 doi: 10.3389/fimmu.2022.820891. PMID: 35371004 Free PMC Article

Functional heartburn: definition and management strategies.

Zerbib F, Bruley des Varannes S, Simon M, Galmiche JP
Curr Gastroenterol Rep 2012 Jun;14(3):181-8. doi: 10.1007/s11894-012-0255-7. PMID: 22451252

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Recent clinical studies

Etiology

Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice.

Sodhi CP, Ahmad R, Fulton WB, Lopez CM, Eke BO, Scheese D, Duess JW, Steinway SN, Raouf Z, Moore H, Tsuboi K, Sampah ME, Jang HS, Buck RH, Hill DR, Niemiro GM, Prindle T Jr, Wang S, Wang M, Jia H, Catazaro J, Lu P, Hackam DJ
Am J Physiol Gastrointest Liver Physiol 2023 Jul 1;325(1):G23-G41. Epub 2023 Apr 25 doi: 10.1152/ajpgi.00233.2022. PMID: 37120853 Free PMC Article

A mini-review of advances in intestinal flora and necrotizing enterocolitis.

Zhao Q, Shi Q, Zhu Q, Hu Y, Zhang X
Lett Appl Microbiol 2022 Jul;75(1):2-9. Epub 2022 Mar 2 doi: 10.1111/lam.13670. PMID: 35138661

The Specific Carbohydrate Diet and Diet Modification as Induction Therapy for Pediatric Crohn's Disease: A Randomized Diet Controlled Trial.

Suskind DL, Lee D, Kim YM, Wahbeh G, Singh N, Braly K, Nuding M, Nicora CD, Purvine SO, Lipton MS, Jansson JK, Nelson WC
Nutrients 2020 Dec 6;12(12) doi: 10.3390/nu12123749. PMID: 33291229 Free PMC Article

Celiac disease-on-chip: Modeling a multifactorial disease in vitro.

Moerkens R, Mooiweer J, Withoff S, Wijmenga C
United European Gastroenterol J 2019 May;7(4):467-476. Epub 2019 Mar 14 doi: 10.1177/2050640619836057. PMID: 31065364 Free PMC Article

Irritable bowel syndrome and visceral hypersensitivity : risk factors and pathophysiological mechanisms.

Deiteren A, de Wit A, van der Linden L, De Man JG, Pelckmans PA, De Winter BY
Acta Gastroenterol Belg 2016 Mar;79(1):29-38. PMID: 26852761

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Diagnosis

Intramural diverticulosis and diverticulitis of the colon: Pictorial essay.

Ghahremani GG
Clin Imaging 2022 Jan;81:150-156. Epub 2021 Nov 2 doi: 10.1016/j.clinimag.2021.10.006. PMID: 34743065

Hypoxia-sensitive pathways in intestinal inflammation.

Brown E, Taylor CT
J Physiol 2018 Aug;596(15):2985-2989. Epub 2017 Nov 28 doi: 10.1113/JP274350. PMID: 29114885 Free PMC Article

Irritable bowel syndrome and visceral hypersensitivity : risk factors and pathophysiological mechanisms.

Deiteren A, de Wit A, van der Linden L, De Man JG, Pelckmans PA, De Winter BY
Acta Gastroenterol Belg 2016 Mar;79(1):29-38. PMID: 26852761

Functional gastro-intestinal disorder algorithms focus on early recognition, parental reassurance and nutritional strategies.

Vandenplas Y, Benninga M, Broekaert I, Falconer J, Gottrand F, Guarino A, Lifschitz C, Lionetti P, Orel R, Papadopoulou A, Ribes-Koninckx C, Ruemmele FM, Salvatore S, Shamir R, Schäppi M, Staiano A, Szajewska H, Thapar N, Wilschanski M
Acta Paediatr 2016 Mar;105(3):244-52. Epub 2015 Dec 21 doi: 10.1111/apa.13270. PMID: 26584953

Functional heartburn: definition and management strategies.

Zerbib F, Bruley des Varannes S, Simon M, Galmiche JP
Curr Gastroenterol Rep 2012 Jun;14(3):181-8. doi: 10.1007/s11894-012-0255-7. PMID: 22451252

See all (69)

Therapy

Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice.

A mini-review of advances in intestinal flora and necrotizing enterocolitis.

Zhao Q, Shi Q, Zhu Q, Hu Y, Zhang X
Lett Appl Microbiol 2022 Jul;75(1):2-9. Epub 2022 Mar 2 doi: 10.1111/lam.13670. PMID: 35138661

Phytochemicals as regulators of Th17/Treg balance in inflammatory bowel diseases.

Chang Y, Zhai L, Peng J, Wu H, Bian Z, Xiao H
Biomed Pharmacother 2021 Sep;141:111931. Epub 2021 Jul 20 doi: 10.1016/j.biopha.2021.111931. PMID: 34328111

The Specific Carbohydrate Diet and Diet Modification as Induction Therapy for Pediatric Crohn's Disease: A Randomized Diet Controlled Trial.

Parenteral nutrition associated liver disease.

Kaufman SS, Gondolesi GE, Fishbein TM
Semin Neonatol 2003 Oct;8(5):375-81. doi: 10.1016/S1084-2756(03)00094-0. PMID: 15001125

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Prognosis

Delayed diagnosis in inflammatory bowel disease: Time to consider solutions.

Lv H, Li HY, Zhang HN, Liu Y
World J Gastroenterol 2024 Sep 21;30(35):3954-3958. doi: 10.3748/wjg.v30.i35.3954. PMID: 39351057 Free PMC Article

The Specific Carbohydrate Diet and Diet Modification as Induction Therapy for Pediatric Crohn's Disease: A Randomized Diet Controlled Trial.

Spontaneous free perforation of the small intestine in adults.

Freeman HJ
World J Gastroenterol 2014 Aug 7;20(29):9990-7. doi: 10.3748/wjg.v20.i29.9990. PMID: 25110427 Free PMC Article

Gluten: a two-edged sword. Immunopathogenesis of celiac disease.

Koning F, Gilissen L, Wijmenga C
Springer Semin Immunopathol 2005 Sep;27(2):217-32. Epub 2005 Aug 10 doi: 10.1007/s00281-005-0203-9. PMID: 16091925

Parenteral nutrition associated liver disease.

Kaufman SS, Gondolesi GE, Fishbein TM
Semin Neonatol 2003 Oct;8(5):375-81. doi: 10.1016/S1084-2756(03)00094-0. PMID: 15001125

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Clinical prediction guides

Therapeutic Implications of Phenolic Acids for Ameliorating Inflammatory Bowel Disease.

Lu Y, Han X
Nutrients 2024 Apr 29;16(9) doi: 10.3390/nu16091347. PMID: 38732594 Free PMC Article

Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice.

The Specific Carbohydrate Diet and Diet Modification as Induction Therapy for Pediatric Crohn's Disease: A Randomized Diet Controlled Trial.

Spontaneous free perforation of the small intestine in adults.

Freeman HJ
World J Gastroenterol 2014 Aug 7;20(29):9990-7. doi: 10.3748/wjg.v20.i29.9990. PMID: 25110427 Free PMC Article

Parenteral nutrition associated liver disease.

Kaufman SS, Gondolesi GE, Fishbein TM
Semin Neonatol 2003 Oct;8(5):375-81. doi: 10.1016/S1084-2756(03)00094-0. PMID: 15001125

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Recent systematic reviews

Association between irritable bowel syndrome and Parkinson's disease: A systematic review and meta-analysis.

Lu S, Jiang HY, Shi YD
Acta Neurol Scand 2022 Apr;145(4):442-448. Epub 2021 Dec 15 doi: 10.1111/ane.13570. PMID: 34908158

Fecal microbiota transplantation for Crohn's disease: a systematic review and meta-analysis.

Cheng F, Huang Z, Wei W, Li Z
Tech Coloproctol 2021 May;25(5):495-504. Epub 2021 Mar 23 doi: 10.1007/s10151-020-02395-3. PMID: 33759066

Safety of TNF-α inhibitors during IBD pregnancy: a systematic review.

Nielsen OH, Loftus EV Jr, Jess T
BMC Med 2013 Jul 31;11:174. doi: 10.1186/1741-7015-11-174. PMID: 23902720 Free PMC Article

NIH Consensus Development Conference on Celiac Disease.

NIH Consens State Sci Statements 2004 Jun 28-30;21(1):1-23. PMID: 17308551

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Intestinal disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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