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Benign neoplasm of small intestine

MedGen UID:
56324
•Concept ID:
C0153944
•
Neoplastic Process
Synonyms: Benign Neoplasm of Small Intestine; benign neoplasm of small intestine; Benign Neoplasm of the Small Intestine; benign neoplasm of the small intestine; Benign Small Intestinal Neoplasm; benign small intestinal neoplasm; Benign Small Intestinal Neoplasm NOS; Benign Small Intestinal Tumor; benign small intestinal tumor; benign small intestinal tumour; Benign Small Intestine Neoplasm; benign small intestine neoplasm; Benign Small Intestine Tumor; benign small intestine tumor; benign small intestine tumour; Benign tumor of small intestine; Benign Tumor of Small Intestine; benign tumor of small intestine; Benign Tumor of the Small Intestine; benign tumor of the small intestine; benign tumour of small intestine; benign tumour of the small intestine; small intestine benign neoplasm
SNOMED CT: Benign tumor of small intestine (92385005); Benign neoplasm of small intestine (92385005)
 
Monarch Initiative: MONDO:0021501

Definition

A neoplasm that arises from the small intestine and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Management of Incidentalomas.
Reidelberger K, Fingeret A
Surg Clin North Am 2021 Dec;101(6):1081-1096. doi: 10.1016/j.suc.2021.06.006. PMID: 34774270
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845

Recent clinical studies

Etiology

Updates in the diagnosis and management of small-bowel tumors.
Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
Imaging and Screening of Cancer of the Small Bowel.
Kim JS, Park SH, Hansel S, Fletcher JG
Radiol Clin North Am 2017 Nov;55(6):1273-1291. Epub 2017 Sep 13 doi: 10.1016/j.rcl.2017.06.008. PMID: 28991566
Tissue-specific mutation accumulation in human adult stem cells during life.
Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R
Nature 2016 Oct 13;538(7624):260-264. Epub 2016 Oct 3 doi: 10.1038/nature19768. PMID: 27698416Free PMC Article
Small Bowel Neoplasms and Polyps.
Pourmand K, Itzkowitz SH
Curr Gastroenterol Rep 2016 May;18(5):23. doi: 10.1007/s11894-016-0497-x. PMID: 27086004
Small intestinal neoplasms.
Gill SS, Heuman DM, Mihas AA
J Clin Gastroenterol 2001 Oct;33(4):267-82. doi: 10.1097/00004836-200110000-00004. PMID: 11588539

Diagnosis

Updates in the diagnosis and management of non-ampullary small-bowel polyposis.
Lucaciu L, Yano T, Saurin JC
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101852. Epub 2023 Jul 22 doi: 10.1016/j.bpg.2023.101852. PMID: 37652652
Updates in the diagnosis and management of small-bowel tumors.
Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
Progress in the Treatment of Small Intestine Cancer.
Symons R, Daly D, Gandy R, Goldstein D, Aghmesheh M
Curr Treat Options Oncol 2023 Apr;24(4):241-261. Epub 2023 Feb 24 doi: 10.1007/s11864-023-01058-3. PMID: 36826686
The Small Bowel Cancer Incidence Enigma.
Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R
Pathol Oncol Res 2020 Apr;26(2):635-639. Epub 2019 Jun 5 doi: 10.1007/s12253-019-00682-5. PMID: 31165996
Small bowel tumours: update in diagnosis and management.
Rondonotti E, Koulaouzidis A, Georgiou J, Pennazio M
Curr Opin Gastroenterol 2018 May;34(3):159-164. doi: 10.1097/MOG.0000000000000428. PMID: 29438117

Therapy

Progress in the Treatment of Small Intestine Cancer.
Symons R, Daly D, Gandy R, Goldstein D, Aghmesheh M
Curr Treat Options Oncol 2023 Apr;24(4):241-261. Epub 2023 Feb 24 doi: 10.1007/s11864-023-01058-3. PMID: 36826686
Tissue-specific mutation accumulation in human adult stem cells during life.
Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R
Nature 2016 Oct 13;538(7624):260-264. Epub 2016 Oct 3 doi: 10.1038/nature19768. PMID: 27698416Free PMC Article
Small bowel adenocarcinoma.
Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ
Curr Treat Options Oncol 2008 Dec;9(4-6):388-99. Epub 2009 Apr 14 doi: 10.1007/s11864-009-0098-0. PMID: 19365735
Enteroscopy.
Mönkemüller K, Bellutti M, Fry LC, Malfertheiner P
Best Pract Res Clin Gastroenterol 2008;22(5):789-811. doi: 10.1016/j.bpg.2008.05.005. PMID: 18790433
Abdominal surgery.
Welch CE
N Engl J Med 1969 Feb 20;280(8):419-25 contd. doi: 10.1056/NEJM196902202800805. PMID: 4883944

Prognosis

Management of Small Bowel Neuroendocrine Tumors.
Scott AT, Howe JR
Surg Oncol Clin N Am 2020 Apr;29(2):223-241. doi: 10.1016/j.soc.2019.11.006. PMID: 32151357
The Small Bowel Cancer Incidence Enigma.
Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R
Pathol Oncol Res 2020 Apr;26(2):635-639. Epub 2019 Jun 5 doi: 10.1007/s12253-019-00682-5. PMID: 31165996
Tissue-specific mutation accumulation in human adult stem cells during life.
Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R
Nature 2016 Oct 13;538(7624):260-264. Epub 2016 Oct 3 doi: 10.1038/nature19768. PMID: 27698416Free PMC Article
Risk stratification of patients diagnosed with gastrointestinal stromal tumor.
Joensuu H
Hum Pathol 2008 Oct;39(10):1411-9. doi: 10.1016/j.humpath.2008.06.025. PMID: 18774375
Small intestinal neoplasms.
Gill SS, Heuman DM, Mihas AA
J Clin Gastroenterol 2001 Oct;33(4):267-82. doi: 10.1097/00004836-200110000-00004. PMID: 11588539

Clinical prediction guides

Small Bowel Neuroendocrine Neoplasms-A Review.
Vulasala SS, Virarkar M, Gopireddy D, Waters R, Alkhasawneh A, Awad Z, Maxwell J, Ramani N, Kumar S, Onteddu N, Morani AC
J Comput Assist Tomogr 2024 Jul-Aug 01;48(4):563-576. Epub 2023 Dec 17 doi: 10.1097/RCT.0000000000001541. PMID: 38110305
Metabolic programs of T cell tissue residency empower tumour immunity.
Reina-Campos M, Heeg M, Kennewick K, Mathews IT, Galletti G, Luna V, Nguyen Q, Huang H, Milner JJ, Hu KH, Vichaidit A, Santillano N, Boland BS, Chang JT, Jain M, Sharma S, Krummel MF, Chi H, Bensinger SJ, Goldrath AW
Nature 2023 Sep;621(7977):179-187. Epub 2023 Aug 30 doi: 10.1038/s41586-023-06483-w. PMID: 37648857Free PMC Article
Pathogenesis of Gastrointestinal Follicular Lymphomas: Consideration Based on Histopathology and Endoscopic Findings.
Takahashi Y, Taniguchi H, Haruhi F, Hattori D, Sasaki H, Makita S, Iwaki N, Fukuhara S, Munakata W, Saito Y, Izutsu K, Maeshima AM
Am J Surg Pathol 2023 Oct 1;47(10):1134-1143. Epub 2023 Jul 27 doi: 10.1097/PAS.0000000000002095. PMID: 37493666
The Small Bowel Cancer Incidence Enigma.
Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R
Pathol Oncol Res 2020 Apr;26(2):635-639. Epub 2019 Jun 5 doi: 10.1007/s12253-019-00682-5. PMID: 31165996
Enteroscopy.
Mönkemüller K, Bellutti M, Fry LC, Malfertheiner P
Best Pract Res Clin Gastroenterol 2008;22(5):789-811. doi: 10.1016/j.bpg.2008.05.005. PMID: 18790433

Recent systematic reviews

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Xiao Z, Xiao P, Wang Y, Fang C, Li Y
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Somatostatinoma of the Ampulla of Vater: A Systematic Review.
Giannakodimos I, Giannakodimos A, Ziogou A, Frountzas M, Kritikos N, Vlachos K, Toutouzas KG, Schizas D
J Gastrointestin Liver Dis 2022 Dec 17;31(4):459-466. doi: 10.15403/jgld-4383. PMID: 36535044
A systematic review of symptomatic hamartomas of the jejunum and ileum.
Farkas N, Conroy M, Baig M
Ann R Coll Surg Engl 2022 Jan;104(1):18-23. Epub 2021 Sep 21 doi: 10.1308/rcsann.2021.0038. PMID: 34545759Free PMC Article
A systematic review of the possible carcinogenic role of the aristolochic acid.
Bara T Jr, Gurzu S, Sugimura H, Bara T, Beleaua MA, Jung I
Rom J Morphol Embryol 2017;58(1):41-44. PMID: 28523296
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845

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