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Spontaneous intestinal perforation

MedGen UID:
856598
•Concept ID:
C3897004
•
Finding
Synonyms: Spontaneous Intestinal Perforation; spontaneous intestinal perforation
 
Monarch Initiative: MONDO:0957460

Definition

A focal intestinal perforation without a definite cause, commonly located in the terminal ileum, lacking the transmural inflammation and/or pneumatosis typically seen in necrotizing enterocolitis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpontaneous intestinal perforation

Professional guidelines

PubMed

Management of neonatal spontaneous intestinal perforation by peritoneal needle aspiration.
Gébus M, Michel JL, Samperiz S, Harper L, Alessandri JL, Ramful D
J Perinatol 2018 Feb;38(2):159-163. Epub 2017 Nov 9 doi: 10.1038/jp.2017.170. PMID: 29120457
Peritoneal drainage as the initial management of intestinal perforation in premature infants.
Stokes SM, Iocono JA, Draus JM Jr
Am Surg 2014 Sep;80(9):851-4. PMID: 25197869
Hydrocortisone administration for the treatment of refractory hypotension in critically ill newborns.
Baker CF, Barks JD, Engmann C, Vazquez DM, Neal CR Jr, Schumacher RE, Bhatt-Mehta V
J Perinatol 2008 Jun;28(6):412-9. Epub 2008 Mar 13 doi: 10.1038/jp.2008.16. PMID: 18337742

Recent clinical studies

Etiology

Re-feeding versus discarding gastric residuals to improve growth in preterm infants.
Abiramalatha T, Thanigainathan S, Ramaswamy VV, Rajaiah B, Ramakrishnan S
Cochrane Database Syst Rev 2023 Jun 30;6(6):CD012940. doi: 10.1002/14651858.CD012940.pub3. PMID: 37387544Free PMC Article
Consequences of early-onset preeclampsia on neonatal morbidity and mortality.
Rocha G
Minerva Pediatr (Torino) 2023 Feb;75(1):87-97. Epub 2022 Apr 4 doi: 10.23736/S2724-5276.22.06714-3. PMID: 35373936
Initial surgical treatment of necrotizing enterocolitis: a meta-analysis of peritoneal drainage versus laparotomy.
Li W, Tang J, Zhu Z, Tang W
Eur J Pediatr 2022 Jul;181(7):2593-2601. Epub 2022 Apr 22 doi: 10.1007/s00431-022-04454-3. PMID: 35451633
Model for severe intracranial hemorrhage and role of early indomethacin in extreme preterm infants.
Chawla S, Natarajan G, Laptook AR, Chowdhury D, Bell EF, Ambalavanan N, Carlo WA, Gantz M, Das A, Tapia JL, Harmon HM, Shankaran S; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Pediatr Res 2022 Dec;92(6):1648-1656. Epub 2022 Mar 17 doi: 10.1038/s41390-022-02012-z. PMID: 35301420Free PMC Article
The role of magnesium sulfate (MgSO(4)) in fetal neuroprotection.
Bachnas MA, Akbar MIA, Dachlan EG, Dekker G
J Matern Fetal Neonatal Med 2021 Mar;34(6):966-978. Epub 2019 May 27 doi: 10.1080/14767058.2019.1619688. PMID: 31092073

Diagnosis

Development of necrotizing enterocolitis after blood transfusion in very premature neonates.
Odom TL, Eubanks J, Redpath N, Davenport E, Tumin D, Akpan US
World J Pediatr 2023 Jan;19(1):68-75. Epub 2022 Oct 13 doi: 10.1007/s12519-022-00627-0. PMID: 36227506
Review of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation Clinical Presentation, Treatment, and Outcomes.
Rausch LA, Hanna DN, Patel A, Blakely ML
Clin Perinatol 2022 Dec;49(4):955-964. Epub 2022 Oct 9 doi: 10.1016/j.clp.2022.07.005. PMID: 36328610
Necrotizing Enterocolitis: Long Term Complications.
Bazacliu C, Neu J
Curr Pediatr Rev 2019;15(2):115-124. doi: 10.2174/1573396315666190312093119. PMID: 30864508
Transumbilical minilaparotomy in low-birthweight newborns for complicated conditions.
Chia-Yu Chang P, Fu YW, Hsu YJ, Huang H, Wei CH
Pediatr Neonatol 2019 Jun;60(3):318-323. Epub 2018 Aug 2 doi: 10.1016/j.pedneo.2018.07.014. PMID: 30145106
Spontaneous intestinal perforation.
Khan RA, Narasimhan KL
Ann Ital Chir 2012 Sep-Oct;83(5):437-9; discussion 439-40. PMID: 23064306

Therapy

Re-feeding versus discarding gastric residuals to improve growth in preterm infants.
Abiramalatha T, Thanigainathan S, Ramaswamy VV, Rajaiah B, Ramakrishnan S
Cochrane Database Syst Rev 2023 Jun 30;6(6):CD012940. doi: 10.1002/14651858.CD012940.pub3. PMID: 37387544Free PMC Article
Mortality and neurodevelopmental outcomes of infants with spontaneous intestinal perforation: a systematic review and meta-analysis.
Ang JL, Rath CP, Tan H, Patole S, Rao SC
Arch Dis Child Fetal Neonatal Ed 2023 May;108(3):256-266. Epub 2022 Nov 3 doi: 10.1136/archdischild-2022-324157. PMID: 36328412
Review of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation Clinical Presentation, Treatment, and Outcomes.
Rausch LA, Hanna DN, Patel A, Blakely ML
Clin Perinatol 2022 Dec;49(4):955-964. Epub 2022 Oct 9 doi: 10.1016/j.clp.2022.07.005. PMID: 36328610
Initial surgical treatment of necrotizing enterocolitis: a meta-analysis of peritoneal drainage versus laparotomy.
Li W, Tang J, Zhu Z, Tang W
Eur J Pediatr 2022 Jul;181(7):2593-2601. Epub 2022 Apr 22 doi: 10.1007/s00431-022-04454-3. PMID: 35451633
The role of magnesium sulfate (MgSO(4)) in fetal neuroprotection.
Bachnas MA, Akbar MIA, Dachlan EG, Dekker G
J Matern Fetal Neonatal Med 2021 Mar;34(6):966-978. Epub 2019 May 27 doi: 10.1080/14767058.2019.1619688. PMID: 31092073

Prognosis

Antenatal Magnesium Sulfate and adverse gastrointestinal outcomes in Preterm infants-a systematic review and meta-analysis.
Prasath A, Aronoff N, Chandrasekharan P, Diggikar S
J Perinatol 2023 Sep;43(9):1087-1100. Epub 2023 Jun 30 doi: 10.1038/s41372-023-01710-8. PMID: 37391507
Model for severe intracranial hemorrhage and role of early indomethacin in extreme preterm infants.
Chawla S, Natarajan G, Laptook AR, Chowdhury D, Bell EF, Ambalavanan N, Carlo WA, Gantz M, Das A, Tapia JL, Harmon HM, Shankaran S; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Pediatr Res 2022 Dec;92(6):1648-1656. Epub 2022 Mar 17 doi: 10.1038/s41390-022-02012-z. PMID: 35301420Free PMC Article
Necrotizing Enterocolitis: Long Term Complications.
Bazacliu C, Neu J
Curr Pediatr Rev 2019;15(2):115-124. doi: 10.2174/1573396315666190312093119. PMID: 30864508
Changing the paradigm of defining, detecting, and diagnosing NEC: Perspectives on Bell's stages and biomarkers for NEC.
Gephart SM, Gordon PV, Penn AH, Gregory KE, Swanson JR, Maheshwari A, Sylvester K
Semin Pediatr Surg 2018 Feb;27(1):3-10. Epub 2017 Nov 6 doi: 10.1053/j.sempedsurg.2017.11.002. PMID: 29275814
Spontaneous Intestinal Perforation: The Long-Term Outcome.
Houben CH, Feng XN, Chan KWE, Mou JWC, Tam YH, Lee KH
Eur J Pediatr Surg 2017 Aug;27(4):346-351. Epub 2016 Nov 15 doi: 10.1055/s-0036-1593990. PMID: 27846663

Clinical prediction guides

Antenatal Magnesium Sulfate and adverse gastrointestinal outcomes in Preterm infants-a systematic review and meta-analysis.
Prasath A, Aronoff N, Chandrasekharan P, Diggikar S
J Perinatol 2023 Sep;43(9):1087-1100. Epub 2023 Jun 30 doi: 10.1038/s41372-023-01710-8. PMID: 37391507
Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates.
Kinoshita M, Stempel KS, Borges do Nascimento IJ, Bruschettini M
Cochrane Database Syst Rev 2023 Mar 3;3(3):CD014876. doi: 10.1002/14651858.CD014876.pub2. PMID: 36870076Free PMC Article
Consequences of early-onset preeclampsia on neonatal morbidity and mortality.
Rocha G
Minerva Pediatr (Torino) 2023 Feb;75(1):87-97. Epub 2022 Apr 4 doi: 10.23736/S2724-5276.22.06714-3. PMID: 35373936
Model for severe intracranial hemorrhage and role of early indomethacin in extreme preterm infants.
Chawla S, Natarajan G, Laptook AR, Chowdhury D, Bell EF, Ambalavanan N, Carlo WA, Gantz M, Das A, Tapia JL, Harmon HM, Shankaran S; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Pediatr Res 2022 Dec;92(6):1648-1656. Epub 2022 Mar 17 doi: 10.1038/s41390-022-02012-z. PMID: 35301420Free PMC Article
Spontaneous localized intestinal perforation in very-low-birth-weight infants: a distinct clinical entity different from necrotizing enterocolitis.
Pumberger W, Mayr M, Kohlhauser C, Weninger M
J Am Coll Surg 2002 Dec;195(6):796-803. doi: 10.1016/s1072-7515(02)01344-3. PMID: 12495312

Recent systematic reviews

Antenatal Magnesium Sulfate and adverse gastrointestinal outcomes in Preterm infants-a systematic review and meta-analysis.
Prasath A, Aronoff N, Chandrasekharan P, Diggikar S
J Perinatol 2023 Sep;43(9):1087-1100. Epub 2023 Jun 30 doi: 10.1038/s41372-023-01710-8. PMID: 37391507
Re-feeding versus discarding gastric residuals to improve growth in preterm infants.
Abiramalatha T, Thanigainathan S, Ramaswamy VV, Rajaiah B, Ramakrishnan S
Cochrane Database Syst Rev 2023 Jun 30;6(6):CD012940. doi: 10.1002/14651858.CD012940.pub3. PMID: 37387544Free PMC Article
Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates.
Kinoshita M, Stempel KS, Borges do Nascimento IJ, Bruschettini M
Cochrane Database Syst Rev 2023 Mar 3;3(3):CD014876. doi: 10.1002/14651858.CD014876.pub2. PMID: 36870076Free PMC Article
Mortality and neurodevelopmental outcomes of infants with spontaneous intestinal perforation: a systematic review and meta-analysis.
Ang JL, Rath CP, Tan H, Patole S, Rao SC
Arch Dis Child Fetal Neonatal Ed 2023 May;108(3):256-266. Epub 2022 Nov 3 doi: 10.1136/archdischild-2022-324157. PMID: 36328412
Role of Nutrition in Prevention of Neonatal Spontaneous Intestinal Perforation and Its Complications: A Systematic Review.
Olaloye O, Swatski M, Konnikova L
Nutrients 2020 May 8;12(5) doi: 10.3390/nu12051347. PMID: 32397283Free PMC Article

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