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Crohn disease of large bowel

MedGen UID:
57618
•Concept ID:
C0156147
•
Disease or Syndrome
Synonyms: Crohn disease of colon; Crohn's colitis; Granulomatous colitis
SNOMED CT: CC - Crohn's colitis (50440006); GC - Granulomatous colitis (50440006); Crohn's disease of large bowel (7620006); Regional enteritis of the large bowel (7620006); Crohn disease of large bowel (7620006); Crohn disease of colon (50440006); Crohns disease, large intestine (7620006); Crohns disease, colon (50440006); Crohn's disease of colon (50440006); Regional colitis (50440006); Granulomatous colitis (50440006)
 
Monarch Initiative: MONDO:0005532

Definition

Inflammation of the colon that is characterized by the presence of granulomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCrohn disease of large bowel

Professional guidelines

PubMed

British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H; IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB
Gut 2019 Dec;68(Suppl 3):s1-s106. Epub 2019 Sep 27 doi: 10.1136/gutjnl-2019-318484. PMID: 31562236Free PMC Article
A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease.
Seyedian SS, Nokhostin F, Malamir MD
J Med Life 2019 Apr-Jun;12(2):113-122. doi: 10.25122/jml-2018-0075. PMID: 31406511Free PMC Article
Crohn's Disease: Diagnosis and Management.
Veauthier B, Hornecker JR
Am Fam Physician 2018 Dec 1;98(11):661-669. PMID: 30485038

Recent clinical studies

Etiology

Risankizumab Effectiveness and Safety in Crohn's Disease: Real-world Data From a Large Tertiary Center.
Zinger A, Choi D, Choi N, Cohen RD, Rubin DT
Clin Gastroenterol Hepatol 2024 Jun;22(6):1336-1338.e2. Epub 2023 Dec 7 doi: 10.1016/j.cgh.2023.11.033. PMID: 38065372
Mild Crohn's Disease: Definition and Management.
Claytor J, Kumar P, Ananthakrishnan AN, Colombel JF, Agrawal M, Ungaro RC
Curr Gastroenterol Rep 2023 Mar;25(3):45-51. Epub 2023 Feb 8 doi: 10.1007/s11894-023-00863-y. PMID: 36753033
Treatment of pouchitis, Crohn's disease, cuffitis, and other inflammatory disorders of the pouch: consensus guidelines from the International Ileal Pouch Consortium.
Shen B, Kochhar GS, Rubin DT, Kane SV, Navaneethan U, Bernstein CN, Cross RK, Sugita A, Schairer J, Kiran RP, Fleshner P, McCormick JT, D'Hoore A, Shah SA, Farraye FA, Kariv R, Liu X, Rosh J, Chang S, Scherl E, Schwartz DA, Kotze PG, Bruining DH, Philpott J, Abraham B, Segal J, Sedano R, Kayal M, Bentley-Hibbert S, Tarabar D, El-Hachem S, Sehgal P, Picoraro JA, Vermeire S, Sandborn WJ, Silverberg MS, Pardi DS
Lancet Gastroenterol Hepatol 2022 Jan;7(1):69-95. Epub 2021 Nov 10 doi: 10.1016/S2468-1253(21)00214-4. PMID: 34774224
The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy.
Mehto S, Jena KK, Nath P, Chauhan S, Kolapalli SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S
Mol Cell 2019 Feb 7;73(3):429-445.e7. Epub 2019 Jan 3 doi: 10.1016/j.molcel.2018.11.018. PMID: 30612879Free PMC Article
Crohn's disease.
Ballester Ferré MP, Boscá-Watts MM, Mínguez Pérez M
Med Clin (Barc) 2018 Jul 13;151(1):26-33. Epub 2017 Dec 13 doi: 10.1016/j.medcli.2017.10.036. PMID: 29246562

Diagnosis

Management of Perianal Fistulizing Crohn's Disease.
Singh A, Midha V, Kochhar GS, Shen B, Sood A
Inflamm Bowel Dis 2024 Sep 3;30(9):1579-1603. doi: 10.1093/ibd/izad195. PMID: 37672347
Mild Crohn's Disease: Definition and Management.
Claytor J, Kumar P, Ananthakrishnan AN, Colombel JF, Agrawal M, Ungaro RC
Curr Gastroenterol Rep 2023 Mar;25(3):45-51. Epub 2023 Feb 8 doi: 10.1007/s11894-023-00863-y. PMID: 36753033
Location-specific signatures of Crohn's disease at a multi-omics scale.
Gonzalez CG, Mills RH, Zhu Q, Sauceda C, Knight R, Dulai PS, Gonzalez DJ
Microbiome 2022 Aug 24;10(1):133. doi: 10.1186/s40168-022-01331-x. PMID: 35999575Free PMC Article
Dietary Inflammatory Potential and Risk of Crohn's Disease and Ulcerative Colitis.
Lo CH, Lochhead P, Khalili H, Song M, Tabung FK, Burke KE, Richter JM, Giovannucci EL, Chan AT, Ananthakrishnan AN
Gastroenterology 2020 Sep;159(3):873-883.e1. Epub 2020 May 7 doi: 10.1053/j.gastro.2020.05.011. PMID: 32389666Free PMC Article
Crohn's disease.
Ballester Ferré MP, Boscá-Watts MM, Mínguez Pérez M
Med Clin (Barc) 2018 Jul 13;151(1):26-33. Epub 2017 Dec 13 doi: 10.1016/j.medcli.2017.10.036. PMID: 29246562

Therapy

Management of Perianal Fistulizing Crohn's Disease.
Singh A, Midha V, Kochhar GS, Shen B, Sood A
Inflamm Bowel Dis 2024 Sep 3;30(9):1579-1603. doi: 10.1093/ibd/izad195. PMID: 37672347
Mild Crohn's Disease: Definition and Management.
Claytor J, Kumar P, Ananthakrishnan AN, Colombel JF, Agrawal M, Ungaro RC
Curr Gastroenterol Rep 2023 Mar;25(3):45-51. Epub 2023 Feb 8 doi: 10.1007/s11894-023-00863-y. PMID: 36753033
Treatment of pouchitis, Crohn's disease, cuffitis, and other inflammatory disorders of the pouch: consensus guidelines from the International Ileal Pouch Consortium.
Shen B, Kochhar GS, Rubin DT, Kane SV, Navaneethan U, Bernstein CN, Cross RK, Sugita A, Schairer J, Kiran RP, Fleshner P, McCormick JT, D'Hoore A, Shah SA, Farraye FA, Kariv R, Liu X, Rosh J, Chang S, Scherl E, Schwartz DA, Kotze PG, Bruining DH, Philpott J, Abraham B, Segal J, Sedano R, Kayal M, Bentley-Hibbert S, Tarabar D, El-Hachem S, Sehgal P, Picoraro JA, Vermeire S, Sandborn WJ, Silverberg MS, Pardi DS
Lancet Gastroenterol Hepatol 2022 Jan;7(1):69-95. Epub 2021 Nov 10 doi: 10.1016/S2468-1253(21)00214-4. PMID: 34774224
The Crohn's disease exclusion diet for induction and maintenance of remission in adults with mild-to-moderate Crohn's disease (CDED-AD): an open-label, pilot, randomised trial.
Yanai H, Levine A, Hirsch A, Boneh RS, Kopylov U, Eran HB, Cohen NA, Ron Y, Goren I, Leibovitzh H, Wardi J, Zittan E, Ziv-Baran T, Abramas L, Fliss-Isakov N, Raykhel B, Gik TP, Dotan I, Maharshak N
Lancet Gastroenterol Hepatol 2022 Jan;7(1):49-59. Epub 2021 Nov 2 doi: 10.1016/S2468-1253(21)00299-5. PMID: 34739863
Development of antifibrotic therapy for stricturing Crohn's disease: lessons from randomized trials in other fibrotic diseases.
Lin SN, Mao R, Qian C, Bettenworth D, Wang J, Li J, Bruining DH, Jairath V, Feagan BG, Chen MH; Stenosis Therapy and Antifibrotic Research (STAR) Consortium, Rieder F
Physiol Rev 2022 Apr 1;102(2):605-652. Epub 2021 Sep 27 doi: 10.1152/physrev.00005.2021. PMID: 34569264Free PMC Article

Prognosis

Mild Crohn's Disease: Definition and Management.
Claytor J, Kumar P, Ananthakrishnan AN, Colombel JF, Agrawal M, Ungaro RC
Curr Gastroenterol Rep 2023 Mar;25(3):45-51. Epub 2023 Feb 8 doi: 10.1007/s11894-023-00863-y. PMID: 36753033
The Burden of Inflammatory Bowel Disease in Europe in 2020.
Zhao M, Gönczi L, Lakatos PL, Burisch J
J Crohns Colitis 2021 Sep 25;15(9):1573-1587. doi: 10.1093/ecco-jcc/jjab029. PMID: 33582812
Crohn's disease.
Ballester Ferré MP, Boscá-Watts MM, Mínguez Pérez M
Med Clin (Barc) 2018 Jul 13;151(1):26-33. Epub 2017 Dec 13 doi: 10.1016/j.medcli.2017.10.036. PMID: 29246562
A comprehensive review and update on Crohn's disease.
Gajendran M, Loganathan P, Catinella AP, Hashash JG
Dis Mon 2018 Feb;64(2):20-57. Epub 2017 Aug 18 doi: 10.1016/j.disamonth.2017.07.001. PMID: 28826742
Epidemiology and natural history of inflammatory bowel diseases.
Cosnes J, Gower-Rousseau C, Seksik P, Cortot A
Gastroenterology 2011 May;140(6):1785-94. doi: 10.1053/j.gastro.2011.01.055. PMID: 21530745

Clinical prediction guides

Immunoglobulin A Glycosylation Differs between Crohn's Disease and Ulcerative Colitis.
Clerc F, Reiding KR, de Haan N, Koeleman CAM, Hipgrave Ederveen AL, Manetti N; IBD-BIOM Consortium, Dotz V, Annese V, Wuhrer M
J Proteome Res 2023 Oct 6;22(10):3213-3224. Epub 2023 Aug 28 doi: 10.1021/acs.jproteome.3c00260. PMID: 37641533Free PMC Article
Differentiating Crohn's disease from intestinal tuberculosis.
Kedia S, Das P, Madhusudhan KS, Dattagupta S, Sharma R, Sahni P, Makharia G, Ahuja V
World J Gastroenterol 2019 Jan 28;25(4):418-432. doi: 10.3748/wjg.v25.i4.418. PMID: 30700939Free PMC Article
Monitoring of small bowel Crohn's disease.
Kopylov U, Koulaouzidis A, Klang E, Carter D, Ben-Horin S, Eliakim R
Expert Rev Gastroenterol Hepatol 2017 Nov;11(11):1047-1058. Epub 2017 Jul 30 doi: 10.1080/17474124.2017.1359541. PMID: 28737951
Imaging of perianal fistulizing Crohn's disease.
Chidi VN, Schwartz DA
Expert Rev Gastroenterol Hepatol 2015 Jun;9(6):797-806. Epub 2015 Mar 30 doi: 10.1586/17474124.2015.1031110. PMID: 25816833
Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD.
Daperno M, D'Haens G, Van Assche G, Baert F, Bulois P, Maunoury V, Sostegni R, Rocca R, Pera A, Gevers A, Mary JY, Colombel JF, Rutgeerts P
Gastrointest Endosc 2004 Oct;60(4):505-12. doi: 10.1016/s0016-5107(04)01878-4. PMID: 15472670

Recent systematic reviews

High-Fiber Diet and Crohn's Disease: Systematic Review and Meta-Analysis.
Serrano Fernandez V, Seldas Palomino M, Laredo-Aguilera JA, Pozuelo-Carrascosa DP, Carmona-Torres JM
Nutrients 2023 Jul 12;15(14) doi: 10.3390/nu15143114. PMID: 37513532Free PMC Article
Dietary Interventions for the Treatment of Inflammatory Bowel Diseases: An Updated Systematic Review and Meta-analysis.
Limketkai BN, Godoy-Brewer G, Parian AM, Noorian S, Krishna M, Shah ND, White J, Mullin GE
Clin Gastroenterol Hepatol 2023 Sep;21(10):2508-2525.e10. Epub 2022 Dec 5 doi: 10.1016/j.cgh.2022.11.026. PMID: 36470529
Global Hospitalization Trends for Crohn's Disease and Ulcerative Colitis in the 21st Century: A Systematic Review With Temporal Analyses.
Buie MJ, Quan J, Windsor JW, Coward S, Hansen TM, King JA, Kotze PG, Gearry RB, Ng SC, Mak JWY, Abreu MT, Rubin DT, Bernstein CN, Banerjee R, Yamamoto-Furusho JK, Panaccione R, Seow CH, Ma C, Underwood FE, Ahuja V, Panaccione N, Shaheen AA, Holroyd-Leduc J, Kaplan GG; Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES-21) Research Group, Balderramo D, Chong VH, Juliao-Baños F, Dutta U, Simadibrata M, Kaibullayeva J, Sun Y, Hilmi I, Raja Ali RA, Paudel MS, Altuwaijri M, Hartono JL, Wei SC, Limsrivilai J, El Ouali S, Vergara BI, Dao VH, Kelly P, Hodges P, Miao Y, Li M
Clin Gastroenterol Hepatol 2023 Aug;21(9):2211-2221. Epub 2022 Jul 19 doi: 10.1016/j.cgh.2022.06.030. PMID: 35863682
STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.
Turner D, Ricciuto A, Lewis A, D'Amico F, Dhaliwal J, Griffiths AM, Bettenworth D, Sandborn WJ, Sands BE, Reinisch W, Schölmerich J, Bemelman W, Danese S, Mary JY, Rubin D, Colombel JF, Peyrin-Biroulet L, Dotan I, Abreu MT, Dignass A; International Organization for the Study of IBD
Gastroenterology 2021 Apr;160(5):1570-1583. Epub 2021 Feb 19 doi: 10.1053/j.gastro.2020.12.031. PMID: 33359090
Crohn's disease.
Mills SC, von Roon AC, Tekkis PP, Orchard TR
BMJ Clin Evid 2011 Apr 27;2011 PMID: 21524318Free PMC Article

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