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Cecal disorder

MedGen UID:
2921
•Concept ID:
C0007527
•
Disease or Syndrome
Synonym: Cecal disease
SNOMED CT: Disorder of cecum (128525008)
 
Monarch Initiative: MONDO:0002031

Definition

Pathological developments in the cecum. [from MONDO]

Professional guidelines

PubMed

Update on the Diagnosis and Management of Acute Colonic Pseudo-obstruction (ACPO).
Sen A, Chokshi R
Curr Gastroenterol Rep 2023 Sep;25(9):191-197. Epub 2023 Jul 24 doi: 10.1007/s11894-023-00881-w. PMID: 37486594
European guideline on indications, performance, and clinical impact of hydrogen and methane breath tests in adult and pediatric patients: European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Neurogastroenterology and Motility, and European Society for Paediatric Gastroenterology Hepatology and Nutrition consensus.
Hammer HF, Fox MR, Keller J, Salvatore S, Basilisco G, Hammer J, Lopetuso L, Benninga M, Borrelli O, Dumitrascu D, Hauser B, Herszenyi L, Nakov R, Pohl D, Thapar N, Sonyi M; European H2-CH4-breath test group
United European Gastroenterol J 2022 Feb;10(1):15-40. Epub 2021 Aug 25 doi: 10.1002/ueg2.12133. PMID: 34431620Free PMC Article
Appendiceal Mucinous Neoplasms: Diagnosis and Management.
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article

Recent clinical studies

Etiology

The appendix and ulcerative colitis - an unsolved connection.
Agrawal M, Allin KH, Mehandru S, Faith J, Jess T, Colombel JF
Nat Rev Gastroenterol Hepatol 2023 Sep;20(9):615-624. Epub 2023 Apr 20 doi: 10.1038/s41575-023-00774-3. PMID: 37081213Free PMC Article
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial.
Stevens TW, Haasnoot ML, D'Haens GR, Buskens CJ, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Mol B, Stokkers PCF, Bemelman WA, Ponsioen CY; LIR!C study group
Lancet Gastroenterol Hepatol 2020 Oct;5(10):900-907. Epub 2020 Jun 30 doi: 10.1016/S2468-1253(20)30117-5. PMID: 32619413
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial.
Ponsioen CY, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Bossuyt PMM, Hart A, Warusavitarne J, Buskens CJ, van Bodegraven AA, Brink MA, Consten ECJ, van Wagensveld BA, Rijk MCM, Crolla RMPH, Noomen CG, Houdijk APJ, Mallant RC, Boom M, Marsman WA, Stockmann HB, Mol B, de Groof AJ, Stokkers PC, D'Haens GR, Bemelman WA; LIR!C study group
Lancet Gastroenterol Hepatol 2017 Nov;2(11):785-792. Epub 2017 Aug 31 doi: 10.1016/S2468-1253(17)30248-0. PMID: 28838644
Appendicitis.
D'Souza N
BMJ Clin Evid 2011 Jan 7;2011 PMID: 21477397Free PMC Article
Appendicitis.
Humes D, Speake WJ, Simpson J
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454096Free PMC Article

Diagnosis

Postoperative Crohn's Disease.
Bernstein CN, Regueiro M
J Clin Gastroenterol 2023 Sep 1;57(8):749-753. doi: 10.1097/MCG.0000000000001865. PMID: 37224283
Acute Colonic Pseudo-Obstruction.
Westfall KM, Cleary RK
Dis Colon Rectum 2022 Dec 1;65(12):1431-1434. Epub 2022 Oct 4 doi: 10.1097/DCR.0000000000002642. PMID: 36194654
American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the management of acute colonic pseudo-obstruction and colonic volvulus.
Naveed M, Jamil LH, Fujii-Lau LL, Al-Haddad M, Buxbaum JL, Fishman DS, Jue TL, Law JK, Lee JK, Qumseya BJ, Sawhney MS, Thosani N, Storm AC, Calderwood AH, Khashab MA, Wani SB
Gastrointest Endosc 2020 Feb;91(2):228-235. Epub 2019 Nov 30 doi: 10.1016/j.gie.2019.09.007. PMID: 31791596
Ilececum: A Comprehensive Review.
Tang SJ, Wu R
Can J Gastroenterol Hepatol 2019;2019:1451835. Epub 2019 Feb 3 doi: 10.1155/2019/1451835. PMID: 30854348Free PMC Article
Ultrasound diagnosis of typhlitis.
Tamburrini S, Setola FR, Belfiore MP, Saturnino PP, Della Casa MG, Sarti G, Abete R, Marano I
J Ultrasound 2019 Mar;22(1):103-106. Epub 2018 Oct 27 doi: 10.1007/s40477-018-0333-2. PMID: 30367357Free PMC Article

Therapy

The appendix and ulcerative colitis - an unsolved connection.
Agrawal M, Allin KH, Mehandru S, Faith J, Jess T, Colombel JF
Nat Rev Gastroenterol Hepatol 2023 Sep;20(9):615-624. Epub 2023 Apr 20 doi: 10.1038/s41575-023-00774-3. PMID: 37081213Free PMC Article
Treatment of Acute Uncomplicated Appendicitis.
Talan DA, Di Saverio S
N Engl J Med 2021 Sep 16;385(12):1116-1123. doi: 10.1056/NEJMcp2107675. PMID: 34525287
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial.
Stevens TW, Haasnoot ML, D'Haens GR, Buskens CJ, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Mol B, Stokkers PCF, Bemelman WA, Ponsioen CY; LIR!C study group
Lancet Gastroenterol Hepatol 2020 Oct;5(10):900-907. Epub 2020 Jun 30 doi: 10.1016/S2468-1253(20)30117-5. PMID: 32619413
Acute appendicitis.
Stringer MD
J Paediatr Child Health 2017 Nov;53(11):1071-1076. Epub 2017 Oct 17 doi: 10.1111/jpc.13737. PMID: 29044790
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial.
Ponsioen CY, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Bossuyt PMM, Hart A, Warusavitarne J, Buskens CJ, van Bodegraven AA, Brink MA, Consten ECJ, van Wagensveld BA, Rijk MCM, Crolla RMPH, Noomen CG, Houdijk APJ, Mallant RC, Boom M, Marsman WA, Stockmann HB, Mol B, de Groof AJ, Stokkers PC, D'Haens GR, Bemelman WA; LIR!C study group
Lancet Gastroenterol Hepatol 2017 Nov;2(11):785-792. Epub 2017 Aug 31 doi: 10.1016/S2468-1253(17)30248-0. PMID: 28838644

Prognosis

The appendix and ulcerative colitis - an unsolved connection.
Agrawal M, Allin KH, Mehandru S, Faith J, Jess T, Colombel JF
Nat Rev Gastroenterol Hepatol 2023 Sep;20(9):615-624. Epub 2023 Apr 20 doi: 10.1038/s41575-023-00774-3. PMID: 37081213Free PMC Article
Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1.
Gao M, Yu T, Liu D, Shi Y, Yang P, Zhang J, Wang J, Liu Y, Zhang X
Clin Sci (Lond) 2021 Jan 29;135(2):347-365. doi: 10.1042/CS20200573. PMID: 33416075Free PMC Article
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial.
Stevens TW, Haasnoot ML, D'Haens GR, Buskens CJ, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Mol B, Stokkers PCF, Bemelman WA, Ponsioen CY; LIR!C study group
Lancet Gastroenterol Hepatol 2020 Oct;5(10):900-907. Epub 2020 Jun 30 doi: 10.1016/S2468-1253(20)30117-5. PMID: 32619413
The immunological functions of the Appendix: An example of redundancy?
Girard-Madoux MJH, Gomez de Agüero M, Ganal-Vonarburg SC, Mooser C, Belz GT, Macpherson AJ, Vivier E
Semin Immunol 2018 Apr;36:31-44. Epub 2018 Mar 2 doi: 10.1016/j.smim.2018.02.005. PMID: 29503124
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.
Salminen P, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, Tuominen R, Hurme S, Virtanen J, Mecklin JP, Sand J, Jartti A, Rinta-Kiikka I, Grönroos JM
JAMA 2015 Jun 16;313(23):2340-8. doi: 10.1001/jama.2015.6154. PMID: 26080338

Clinical prediction guides

The appendix and ulcerative colitis - an unsolved connection.
Agrawal M, Allin KH, Mehandru S, Faith J, Jess T, Colombel JF
Nat Rev Gastroenterol Hepatol 2023 Sep;20(9):615-624. Epub 2023 Apr 20 doi: 10.1038/s41575-023-00774-3. PMID: 37081213Free PMC Article
Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1.
Gao M, Yu T, Liu D, Shi Y, Yang P, Zhang J, Wang J, Liu Y, Zhang X
Clin Sci (Lond) 2021 Jan 29;135(2):347-365. doi: 10.1042/CS20200573. PMID: 33416075Free PMC Article
The immunological functions of the Appendix: An example of redundancy?
Girard-Madoux MJH, Gomez de Agüero M, Ganal-Vonarburg SC, Mooser C, Belz GT, Macpherson AJ, Vivier E
Semin Immunol 2018 Apr;36:31-44. Epub 2018 Mar 2 doi: 10.1016/j.smim.2018.02.005. PMID: 29503124
Acute appendicitis.
Stringer MD
J Paediatr Child Health 2017 Nov;53(11):1071-1076. Epub 2017 Oct 17 doi: 10.1111/jpc.13737. PMID: 29044790
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial.
Ponsioen CY, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Bossuyt PMM, Hart A, Warusavitarne J, Buskens CJ, van Bodegraven AA, Brink MA, Consten ECJ, van Wagensveld BA, Rijk MCM, Crolla RMPH, Noomen CG, Houdijk APJ, Mallant RC, Boom M, Marsman WA, Stockmann HB, Mol B, de Groof AJ, Stokkers PC, D'Haens GR, Bemelman WA; LIR!C study group
Lancet Gastroenterol Hepatol 2017 Nov;2(11):785-792. Epub 2017 Aug 31 doi: 10.1016/S2468-1253(17)30248-0. PMID: 28838644

Recent systematic reviews

Non-culture-based studies of the appendiceal microbiota: a systematic review.
Antonsen J, Winther-Jensen M, Krogsbøll LT, Jess T, Jorgensen LN, Allin KH
Future Microbiol 2023 Feb;18:205-216. Epub 2023 Mar 14 doi: 10.2217/fmb-2022-0194. PMID: 36916537
Association between prior appendectomy and the risk and course of Crohn's disease: A systematic review and meta-analysis.
Zhang L, Hu C, Zhang Z, Liu R, Liu G, Xue D, Wang Z, Wu C, Wu X, She J, Shi F
Clin Res Hepatol Gastroenterol 2023 Mar;47(3):102090. Epub 2023 Feb 4 doi: 10.1016/j.clinre.2023.102090. PMID: 36746236
Appendicitis.
D'Souza N, Nugent K
BMJ Clin Evid 2014 Dec 8;2014 PMID: 25486014Free PMC Article
Appendicitis.
D'Souza N
BMJ Clin Evid 2011 Jan 7;2011 PMID: 21477397Free PMC Article
Appendicitis.
Humes D, Speake WJ, Simpson J
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454096Free PMC Article

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