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Indeterminate colitis

MedGen UID:
87418
•Concept ID:
C0341332
•
Disease or Syndrome
Synonyms: Colitis of Indeterminate Type; colitis of indeterminate type; indeterminate colitis
SNOMED CT: Indeterminate colitis (235746007)
 
Monarch Initiative: MONDO:0006038

Definition

It describes patients in whom a diagnosis of ulcerative colitis or Crohn's disease cannot be made based on standard clinical testing, including colonoscopy, imaging, laboratory tests, and biopsy. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIndeterminate colitis

Professional guidelines

PubMed

Diagnosis and Treatment of Iron Deficiency and Anemia in Youth With Inflammatory Bowel Disease.
Smith J, Jacobson-Kelly A, Donegan A, Boyle B, Maltz RM, Michel HK, Dotson JL
J Pediatr Gastroenterol Nutr 2023 Mar 1;76(3):313-318. Epub 2022 Nov 30 doi: 10.1097/MPG.0000000000003673. PMID: 36730097
Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease.
Balderramo D
World J Gastroenterol 2022 Dec 21;28(47):6743-6751. doi: 10.3748/wjg.v28.i47.6743. PMID: 36620336Free PMC Article
Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview.
M'Koma AE
Medicina (Kaunas) 2022 Apr 21;58(5) doi: 10.3390/medicina58050567. PMID: 35629984Free PMC Article

Recent clinical studies

Etiology

Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease.
Balderramo D
World J Gastroenterol 2022 Dec 21;28(47):6743-6751. doi: 10.3748/wjg.v28.i47.6743. PMID: 36620336Free PMC Article
Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview.
M'Koma AE
Medicina (Kaunas) 2022 Apr 21;58(5) doi: 10.3390/medicina58050567. PMID: 35629984Free PMC Article
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Indeterminate colitis.
Mitchell PJ, Rabau MY, Haboubi NY
Tech Coloproctol 2007 Jun;11(2):91-6. Epub 2007 May 25 doi: 10.1007/s10151-007-0337-y. PMID: 17510748
Inflammatory bowel disease.
Chutkan RK
Prim Care 2001 Sep;28(3):539-56, vi. doi: 10.1016/s0095-4543(05)70052-x. PMID: 11483443

Diagnosis

Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease.
Balderramo D
World J Gastroenterol 2022 Dec 21;28(47):6743-6751. doi: 10.3748/wjg.v28.i47.6743. PMID: 36620336Free PMC Article
Inflammatory Bowel Disease: Clinical Diagnosis and Surgical Treatment-Overview.
M'Koma AE
Medicina (Kaunas) 2022 Apr 21;58(5) doi: 10.3390/medicina58050567. PMID: 35629984Free PMC Article
Clinical presentation of Crohn's, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifestations, and disease phenotypes.
Yu YR, Rodriguez JR
Semin Pediatr Surg 2017 Dec;26(6):349-355. Epub 2017 Oct 5 doi: 10.1053/j.sempedsurg.2017.10.003. PMID: 29126502
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Indeterminate colitis.
Geboes K, De Hertogh G
Inflamm Bowel Dis 2003 Sep;9(5):324-31. doi: 10.1097/00054725-200309000-00007. PMID: 14555917

Therapy

Prevalence of Extraintestinal Manifestations in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Kilic Y, Kamal S, Jaffar F, Sriranganathan D, Quraishi MN, Segal JP
Inflamm Bowel Dis 2024 Feb 1;30(2):230-239. doi: 10.1093/ibd/izad061. PMID: 37042969
Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease.
Balderramo D
World J Gastroenterol 2022 Dec 21;28(47):6743-6751. doi: 10.3748/wjg.v28.i47.6743. PMID: 36620336Free PMC Article
A Comprehensive Approach to Pouch Disorders.
Quinn KP, Lightner AL, Faubion WA, Raffals LE
Inflamm Bowel Dis 2019 Feb 21;25(3):460-471. doi: 10.1093/ibd/izy267. PMID: 30124882
Indications of capsule endoscopy in Crohn´s disease.
Luján-Sanchis M, Sanchis-Artero L, Suárez-Callol P, Medina-Chuliá E
Rev Esp Enferm Dig 2014 Jan;106(1):37-44. doi: 10.4321/s1130-01082014000100006. PMID: 24689714
Inflammatory bowel disease.
Chutkan RK
Prim Care 2001 Sep;28(3):539-56, vi. doi: 10.1016/s0095-4543(05)70052-x. PMID: 11483443

Prognosis

A Comprehensive Approach to Pouch Disorders.
Quinn KP, Lightner AL, Faubion WA, Raffals LE
Inflamm Bowel Dis 2019 Feb 21;25(3):460-471. doi: 10.1093/ibd/izy267. PMID: 30124882
Allergic and Immunologic Perspectives of Inflammatory Bowel Disease.
Clarke K, Chintanaboina J
Clin Rev Allergy Immunol 2019 Oct;57(2):179-193. doi: 10.1007/s12016-018-8690-3. PMID: 29754190
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Ileal pouch-anal anastomosis: Points of controversy.
Trigui A, Frikha F, Rejab H, Ben Ameur H, Triki H, Ben Amar M, Mzali R
J Visc Surg 2014 Sep;151(4):281-8. Epub 2014 Jul 3 doi: 10.1016/j.jviscsurg.2014.05.004. PMID: 24999229
Is indeterminate colitis determinable?
Tremaine WJ
Curr Gastroenterol Rep 2012 Apr;14(2):162-5. doi: 10.1007/s11894-012-0244-x. PMID: 22314810

Clinical prediction guides

Diagnostic Modalities for Inflammatory Bowel Disease: Serologic Markers and Endoscopy.
Clark C, Turner J
Surg Clin North Am 2015 Dec;95(6):1123-41, v. Epub 2015 Oct 21 doi: 10.1016/j.suc.2015.07.008. PMID: 26596918
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article
Is indeterminate colitis determinable?
Tremaine WJ
Curr Gastroenterol Rep 2012 Apr;14(2):162-5. doi: 10.1007/s11894-012-0244-x. PMID: 22314810
Indeterminate colitis.
Guindi M, Riddell RH
J Clin Pathol 2004 Dec;57(12):1233-44. doi: 10.1136/jcp.2003.015214. PMID: 15563659Free PMC Article
NOD2/CARD15: relevance in clinical practice.
Vermeire S
Best Pract Res Clin Gastroenterol 2004 Jun;18(3):569-75. doi: 10.1016/j.bpg.2003.12.008. PMID: 15157828

Recent systematic reviews

Prevalence of Extraintestinal Manifestations in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Kilic Y, Kamal S, Jaffar F, Sriranganathan D, Quraishi MN, Segal JP
Inflamm Bowel Dis 2024 Feb 1;30(2):230-239. doi: 10.1093/ibd/izad061. PMID: 37042969
Systematic Review of Diagnostic Delay for Children With Inflammatory Bowel Disease.
Vernon-Roberts A, Aluzaite K, Khalilipour B, Day AS
J Pediatr Gastroenterol Nutr 2023 Mar 1;76(3):304-312. Epub 2022 Dec 1 doi: 10.1097/MPG.0000000000003670. PMID: 36730088
COVID-19 and Outcomes in Patients With Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.
Tripathi K, Godoy Brewer G, Thu Nguyen M, Singh Y, Saleh Ismail M, Sauk JS, Parian AM, Limketkai BN
Inflamm Bowel Dis 2022 Aug 1;28(8):1265-1279. doi: 10.1093/ibd/izab236. PMID: 34718595Free PMC Article
Outcome of Ileal Pouch-anal Anastomosis in Patients With Indeterminate Colitis: A Systematic Review and Meta-analysis.
Emile SH, Gilshtein H, Wexner SD
J Crohns Colitis 2020 Jul 30;14(7):1010-1020. doi: 10.1093/ecco-jcc/jjaa002. PMID: 31912129
Serological antibodies in inflammatory bowel disease: a systematic review.
Prideaux L, De Cruz P, Ng SC, Kamm MA
Inflamm Bowel Dis 2012 Jul;18(7):1340-55. Epub 2011 Nov 8 doi: 10.1002/ibd.21903. PMID: 22069240

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