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Intestinal Intraepithelial Neoplasia

MedGen UID:
235222
•Concept ID:
C1334229
•
Neoplastic Process
Synonyms: Bowel Dysplasia; Intestinal Dysplasia

Definition

A precancerous neoplastic process that affects the small or large intestine. It is characterized by low or high grade dysplasia of the mucosal epithelium. There is no evidence of invasion. [from NCI]

Professional guidelines

PubMed

Colorectal Cancer Screening Methods and Molecular Markers for Early Detection.
Wu Z, Li Y, Zhang Y, Hu H, Wu T, Liu S, Chen W, Xie S, Lu Z
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820980426. doi: 10.1177/1533033820980426. PMID: 33353503Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent clinical studies

Etiology

Anal intraepithelial neoplasia: a review of terminology, differential diagnoses, and patient management.
Vyas M, Gonzalez RS
Hum Pathol 2023 Feb;132:56-64. Epub 2022 Jul 16 doi: 10.1016/j.humpath.2022.07.005. PMID: 35843339
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
An overview of anal intraepithelial neoplasia.
Buzard CL, Rizzolo D
JAAPA 2018 Jul;31(7):1-5. doi: 10.1097/01.JAA.0000534979.69236.e7. PMID: 29957613
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Diagnosis

Anal and Perianal Preneoplastic Lesions.
Loughrey MB, Shepherd NA
Gastroenterol Clin North Am 2024 Mar;53(1):201-220. Epub 2023 Oct 16 doi: 10.1016/j.gtc.2023.09.007. PMID: 38280748
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
Colorectal Cancer Screening Methods and Molecular Markers for Early Detection.
Wu Z, Li Y, Zhang Y, Hu H, Wu T, Liu S, Chen W, Xie S, Lu Z
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820980426. doi: 10.1177/1533033820980426. PMID: 33353503Free PMC Article
A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Therapy

Establishment and validation of a clinical diagnostic model for gastric low-grade intraepithelial neoplasia.
Sun T, Ke XQ, Wang M, Wang QZ
Medicine (Baltimore) 2023 Nov 17;102(46):e35515. doi: 10.1097/MD.0000000000035515. PMID: 37986403Free PMC Article
Whether long-term use of proton pump inhibitor increases the risk of precancerous lesions in the stomach: A systematic review and meta-analysis of randomized controlled trials.
Lv F, Wang J, Mao L, Zhou X, Zhang T, Zhou S
Medicine (Baltimore) 2023 Sep 22;102(38):e35062. doi: 10.1097/MD.0000000000035062. PMID: 37747015Free PMC Article
Clonally expanded EOMES(+) Tr1-like cells in primary and metastatic tumors are associated with disease progression.
Bonnal RJP, Rossetti G, Lugli E, De Simone M, Gruarin P, Brummelman J, Drufuca L, Passaro M, Bason R, Gervasoni F, Della Chiara G, D'Oria C, Martinovic M, Curti S, Ranzani V, Cordiglieri C, Alvisi G, Mazza EMC, Oliveto S, Silvestri Y, Carelli E, Mazzara S, Bosotti R, Sarnicola ML, Godano C, Bevilacqua V, Lorenzo M, Siena S, Bonoldi E, Sartore-Bianchi A, Amatu A, Veronesi G, Novellis P, Alloisio M, Giani A, Zucchini N, Opocher E, Ceretti AP, Mariani N, Biffo S, Prati D, Bardelli A, Geginat J, Lanzavecchia A, Abrignani S, Pagani M
Nat Immunol 2021 Jun;22(6):735-745. Epub 2021 May 20 doi: 10.1038/s41590-021-00930-4. PMID: 34017124
A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Chemoprevention of colorectal cancer.
Niitsu Y, Takayama T, Miyanishi K, Nobuoka A, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Abe T, Kogawa T, Takahashi M, Matsunaga T, Kato J
Cancer Chemother Pharmacol 2004 Sep;54 Suppl 1:S40-3. doi: 10.1007/s00280-004-0885-z. PMID: 15309513

Prognosis

A faecal microbiota signature with high specificity for pancreatic cancer.
Kartal E, Schmidt TSB, Molina-Montes E, Rodríguez-Perales S, Wirbel J, Maistrenko OM, Akanni WA, Alashkar Alhamwe B, Alves RJ, Carrato A, Erasmus HP, Estudillo L, Finkelmeier F, Fullam A, Glazek AM, Gómez-Rubio P, Hercog R, Jung F, Kandels S, Kersting S, Langheinrich M, Márquez M, Molero X, Orakov A, Van Rossum T, Torres-Ruiz R, Telzerow A, Zych K; MAGIC Study investigators; PanGenEU Study investigators, Benes V, Zeller G, Trebicka J, Real FX, Malats N, Bork P
Gut 2022 Jul;71(7):1359-1372. Epub 2022 Mar 8 doi: 10.1136/gutjnl-2021-324755. PMID: 35260444Free PMC Article
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Clinical prediction guides

A faecal microbiota signature with high specificity for pancreatic cancer.
Kartal E, Schmidt TSB, Molina-Montes E, Rodríguez-Perales S, Wirbel J, Maistrenko OM, Akanni WA, Alashkar Alhamwe B, Alves RJ, Carrato A, Erasmus HP, Estudillo L, Finkelmeier F, Fullam A, Glazek AM, Gómez-Rubio P, Hercog R, Jung F, Kandels S, Kersting S, Langheinrich M, Márquez M, Molero X, Orakov A, Van Rossum T, Torres-Ruiz R, Telzerow A, Zych K; MAGIC Study investigators; PanGenEU Study investigators, Benes V, Zeller G, Trebicka J, Real FX, Malats N, Bork P
Gut 2022 Jul;71(7):1359-1372. Epub 2022 Mar 8 doi: 10.1136/gutjnl-2021-324755. PMID: 35260444Free PMC Article
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
A comprehensive review and update on ulcerative colitis().
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent systematic reviews

Whether long-term use of proton pump inhibitor increases the risk of precancerous lesions in the stomach: A systematic review and meta-analysis of randomized controlled trials.
Lv F, Wang J, Mao L, Zhou X, Zhang T, Zhou S
Medicine (Baltimore) 2023 Sep 22;102(38):e35062. doi: 10.1097/MD.0000000000035062. PMID: 37747015Free PMC Article
The incidence of malignancy in the residual rectum of IBD patients after colectomy: a systematic review and meta-analysis.
Georganta I, McIntosh S, Boldovjakova D, Parnaby CN, Watson AJM, Ramsay G
Tech Coloproctol 2023 Sep;27(9):699-712. Epub 2023 Mar 12 doi: 10.1007/s10151-023-02762-w. PMID: 36906886Free PMC Article
Use of folic acid supplementation to halt and even reverse the progression of gastric precancerous conditions: a meta-analysis.
Lei J, Ren F, Li W, Guo X, Liu Q, Gao H, Pang Y, He Y, Guo J, Zeng J
BMC Gastroenterol 2022 Aug 2;22(1):370. doi: 10.1186/s12876-022-02390-y. PMID: 35918654Free PMC Article
Interventions for anal canal intraepithelial neoplasia.
Macaya A, Muñoz-Santos C, Balaguer A, Barberà MJ
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD009244. doi: 10.1002/14651858.CD009244.pub2. PMID: 23235673Free PMC Article
Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis.
Machalek DA, Poynten M, Jin F, Fairley CK, Farnsworth A, Garland SM, Hillman RJ, Petoumenos K, Roberts J, Tabrizi SN, Templeton DJ, Grulich AE
Lancet Oncol 2012 May;13(5):487-500. Epub 2012 Mar 23 doi: 10.1016/S1470-2045(12)70080-3. PMID: 22445259

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