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Immune system disorder

MedGen UID:
5759
•Concept ID:
C0021053
•
Disease or Syndrome
Synonym: Immune system disease
SNOMED CT: Immunity disorders (41266007); Disorder of immune system (41266007)
 
Monarch Initiative: MONDO:0005046

Definition

A disorder resulting from an abnormality in the immune system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmune system disorder

Professional guidelines

PubMed

International consensus statement on allergy and rhinology: Allergic rhinitis - 2023.
Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban MR, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
International consensus statement on allergy and rhinology: rhinosinusitis 2021.
Orlandi RR, Kingdom TT, Smith TL, Bleier B, DeConde A, Luong AU, Poetker DM, Soler Z, Welch KC, Wise SK, Adappa N, Alt JA, Anselmo-Lima WT, Bachert C, Baroody FM, Batra PS, Bernal-Sprekelsen M, Beswick D, Bhattacharyya N, Chandra RK, Chang EH, Chiu A, Chowdhury N, Citardi MJ, Cohen NA, Conley DB, DelGaudio J, Desrosiers M, Douglas R, Eloy JA, Fokkens WJ, Gray ST, Gudis DA, Hamilos DL, Han JK, Harvey R, Hellings P, Holbrook EH, Hopkins C, Hwang P, Javer AR, Jiang RS, Kennedy D, Kern R, Laidlaw T, Lal D, Lane A, Lee HM, Lee JT, Levy JM, Lin SY, Lund V, McMains KC, Metson R, Mullol J, Naclerio R, Oakley G, Otori N, Palmer JN, Parikh SR, Passali D, Patel Z, Peters A, Philpott C, Psaltis AJ, Ramakrishnan VR, Ramanathan M Jr, Roh HJ, Rudmik L, Sacks R, Schlosser RJ, Sedaghat AR, Senior BA, Sindwani R, Smith K, Snidvongs K, Stewart M, Suh JD, Tan BK, Turner JH, van Drunen CM, Voegels R, Wang Y, Woodworth BA, Wormald PJ, Wright ED, Yan C, Zhang L, Zhou B
Int Forum Allergy Rhinol 2021 Mar;11(3):213-739. doi: 10.1002/alr.22741. PMID: 33236525
Hashimoto thyroiditis: clinical and diagnostic criteria.
Caturegli P, De Remigis A, Rose NR
Autoimmun Rev 2014 Apr-May;13(4-5):391-7. Epub 2014 Jan 13 doi: 10.1016/j.autrev.2014.01.007. PMID: 24434360

Recent clinical studies

Etiology

Assessing the causal relationship between immune cell traits and depression by Mendelian randomization analysis.
Xue H, Chen J, Fan W
J Affect Disord 2024 Jul 1;356:48-53. Epub 2024 Apr 7 doi: 10.1016/j.jad.2024.04.006. PMID: 38593939
Antigen-specific immunotherapies in type 1 diabetes.
Zhang X, Dong Y, Liu D, Yang L, Xu J, Wang Q
J Trace Elem Med Biol 2022 Sep;73:127040. Epub 2022 Jul 15 doi: 10.1016/j.jtemb.2022.127040. PMID: 35868165
Graves' disease: pathophysiological aspects and considerations about using the chemometric analysis in the study of the disease.
Koseva PM, Kamenov ZA, Nikolova MM, Andreeva-Gateva PA
Folia Med (Plovdiv) 2021 Aug 31;63(4):467-474. doi: 10.3897/folmed.63.e57193. PMID: 35851162
Autoimmune diseases in patients undergoing percutaneous coronary intervention: A risk factor for in-stent restenosis?
Pepe M, Napoli G, Carulli E, Moscarelli M, Forleo C, Nestola PL, Biondi-Zoccai G, Giordano A, Favale S
Atherosclerosis 2021 Sep;333:24-31. Epub 2021 Aug 5 doi: 10.1016/j.atherosclerosis.2021.08.007. PMID: 34418682
The incidence and type of cancer in patients with ataxia-telangiectasia via a retrospective single-centre study.
Bakhtiar S, Salzmann-Manrique E, Donath H, Woelke S, Duecker RP, Fritzemeyer S, Schubert R, Huenecke S, Kieslich M, Klingebiel T, Bader P, Zielen S
Br J Haematol 2021 Sep;194(5):879-887. Epub 2021 Aug 1 doi: 10.1111/bjh.17736. PMID: 34337741

Diagnosis

Antigen-specific immunotherapies in type 1 diabetes.
Zhang X, Dong Y, Liu D, Yang L, Xu J, Wang Q
J Trace Elem Med Biol 2022 Sep;73:127040. Epub 2022 Jul 15 doi: 10.1016/j.jtemb.2022.127040. PMID: 35868165
The incidence and type of cancer in patients with ataxia-telangiectasia via a retrospective single-centre study.
Bakhtiar S, Salzmann-Manrique E, Donath H, Woelke S, Duecker RP, Fritzemeyer S, Schubert R, Huenecke S, Kieslich M, Klingebiel T, Bader P, Zielen S
Br J Haematol 2021 Sep;194(5):879-887. Epub 2021 Aug 1 doi: 10.1111/bjh.17736. PMID: 34337741
An inflammation classification system using cytokine parameters.
Roe K
Scand J Immunol 2021 Feb;93(2):e12970. Epub 2020 Sep 18 doi: 10.1111/sji.12970. PMID: 32892387
Chronic Nonbacterial Osteomyelitis and Chronic Recurrent Multifocal Osteomyelitis in Children.
Zhao Y, Ferguson PJ
Pediatr Clin North Am 2018 Aug;65(4):783-800. doi: 10.1016/j.pcl.2018.04.003. PMID: 30031498
Radiological manifestations of sarcoidosis.
Vagal AS, Shipley R, Meyer CA
Clin Dermatol 2007 May-Jun;25(3):312-25. doi: 10.1016/j.clindermatol.2007.03.009. PMID: 17560309

Therapy

Assessing the causal relationship between immune cell traits and depression by Mendelian randomization analysis.
Xue H, Chen J, Fan W
J Affect Disord 2024 Jul 1;356:48-53. Epub 2024 Apr 7 doi: 10.1016/j.jad.2024.04.006. PMID: 38593939
Autoimmune diseases in patients undergoing percutaneous coronary intervention: A risk factor for in-stent restenosis?
Pepe M, Napoli G, Carulli E, Moscarelli M, Forleo C, Nestola PL, Biondi-Zoccai G, Giordano A, Favale S
Atherosclerosis 2021 Sep;333:24-31. Epub 2021 Aug 5 doi: 10.1016/j.atherosclerosis.2021.08.007. PMID: 34418682
Chronic Nonbacterial Osteomyelitis and Chronic Recurrent Multifocal Osteomyelitis in Children.
Zhao Y, Ferguson PJ
Pediatr Clin North Am 2018 Aug;65(4):783-800. doi: 10.1016/j.pcl.2018.04.003. PMID: 30031498
Advances in mechanisms of systemic lupus erythematosus.
Dema B, Charles N
Discov Med 2014 May;17(95):247-55. PMID: 24882716
Vascular complications and gene therapy.
Roy S, Rothschild JG, Chen A
Expert Opin Biol Ther 2003 Feb;3(1):71-83. doi: 10.1517/14712598.3.1.71. PMID: 12718732

Prognosis

Unraveling the complex relationship: Multiple sclerosis, urinary tract infections, and infertility.
Seyedolmohadesin M, Ashkani M, Ghadikolaei TS, Mirshekar M, Bostanghadiri N, Aminzadeh S
Mult Scler Relat Disord 2024 Apr;84:105512. Epub 2024 Feb 20 doi: 10.1016/j.msard.2024.105512. PMID: 38428292
Systemic immune responses after ischemic stroke: From the center to the periphery.
Wu F, Liu Z, Zhou L, Ye D, Zhu Y, Huang K, Weng Y, Xiong X, Zhan R, Shen J
Front Immunol 2022;13:911661. Epub 2022 Sep 20 doi: 10.3389/fimmu.2022.911661. PMID: 36211352Free PMC Article
The incidence and type of cancer in patients with ataxia-telangiectasia via a retrospective single-centre study.
Bakhtiar S, Salzmann-Manrique E, Donath H, Woelke S, Duecker RP, Fritzemeyer S, Schubert R, Huenecke S, Kieslich M, Klingebiel T, Bader P, Zielen S
Br J Haematol 2021 Sep;194(5):879-887. Epub 2021 Aug 1 doi: 10.1111/bjh.17736. PMID: 34337741
Chronic Nonbacterial Osteomyelitis and Chronic Recurrent Multifocal Osteomyelitis in Children.
Zhao Y, Ferguson PJ
Pediatr Clin North Am 2018 Aug;65(4):783-800. doi: 10.1016/j.pcl.2018.04.003. PMID: 30031498
Primary open-angle glaucoma: neuroendocrine-immune disorder?
Zhang T, Xie X, Lu F
Med Hypotheses 2014 Oct;83(4):514-5. Epub 2014 Aug 20 doi: 10.1016/j.mehy.2014.08.017. PMID: 25175405

Clinical prediction guides

Assessing the causal relationship between immune cell traits and depression by Mendelian randomization analysis.
Xue H, Chen J, Fan W
J Affect Disord 2024 Jul 1;356:48-53. Epub 2024 Apr 7 doi: 10.1016/j.jad.2024.04.006. PMID: 38593939
Stratified distribution of Th17 and Treg cells in patients with multi-stage rheumatoid arthritis.
Su R, Li B, Wu R, Xie Y, Gao A, Gao C, Li X, Wang C
Arthritis Res Ther 2023 Apr 4;25(1):55. doi: 10.1186/s13075-023-03041-7. PMID: 37016395Free PMC Article
Graves' disease: pathophysiological aspects and considerations about using the chemometric analysis in the study of the disease.
Koseva PM, Kamenov ZA, Nikolova MM, Andreeva-Gateva PA
Folia Med (Plovdiv) 2021 Aug 31;63(4):467-474. doi: 10.3897/folmed.63.e57193. PMID: 35851162
Primary open-angle glaucoma: neuroendocrine-immune disorder?
Zhang T, Xie X, Lu F
Med Hypotheses 2014 Oct;83(4):514-5. Epub 2014 Aug 20 doi: 10.1016/j.mehy.2014.08.017. PMID: 25175405
An investigation of immune system disorder as a "marker" for anomalous dominance.
Rich DA, McKeever WF
Brain Cogn 1990 Jan;12(1):55-72. doi: 10.1016/0278-2626(90)90004-8. PMID: 2297435

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