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Skin sarcoidosis

MedGen UID:
19872
•Concept ID:
C0036203
•
Disease or Syndrome
Synonyms: cutaneous sarcoid; Cutaneous sarcoidosis; Cutaneous Sarcoidosis; cutaneous sarcoidosis; Sarcoidosis of skin; sarcoidosis of zone of skin; skin sarcoidosis; zone of skin sarcoidosis
SNOMED CT: Sarcoidosis of skin (55941000); Skin sarcoidosis (55941000); Cutaneous sarcoidosis (55941000)
 
Monarch Initiative: MONDO:0006611

Definition

Formation of non-necrotizing granulomas in the skin. It may be a manifestation of systemic sarcoidosis or may also arise in isolation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin sarcoidosis

Professional guidelines

PubMed

The treatment of lupus pernio: results of 116 treatment courses in 54 patients.
Stagaki E, Mountford WK, Lackland DT, Judson MA
Chest 2009 Feb;135(2):468-476. Epub 2008 Sep 23 doi: 10.1378/chest.08-1347. PMID: 18812454

Recent clinical studies

Etiology

Sarcoidosis among hospitalized patients in Poland: a study based on a national hospital registry.
Bogdan M, Nitsch-Osuch A, Kanecki K, Goryński P, Tyszko P, Barańska A, Samel-Kowalik P
Pol Arch Intern Med 2019 Sep 30;129(9):580-585. Epub 2019 Aug 8 doi: 10.20452/pamw.14927. PMID: 31436761
Clinical Features of Extrapulmonary Sarcoidosis Without Lung Involvement.
James WE, Koutroumpakis E, Saha B, Nathani A, Saavedra L, Yucel RM, Judson MA
Chest 2018 Aug;154(2):349-356. Epub 2018 Feb 14 doi: 10.1016/j.chest.2018.02.003. PMID: 29453944
How common is isolated cardiac sarcoidosis? Extra-cardiac and cardiac findings on clinical examination and whole-body (18)F-fluorodeoxyglucose positron emission tomography.
Juneau D, Nery P, Russo J, de Kemp RA, Leung E, Beanlands RSB, Birnie DH
Int J Cardiol 2018 Feb 15;253:189-193. doi: 10.1016/j.ijcard.2017.09.204. PMID: 29306462
Validation and important differences for the Sarcoidosis Assessment Tool. A new patient-reported outcome measure.
Judson MA, Mack M, Beaumont JL, Watt R, Barnathan ES, Victorson DE
Am J Respir Crit Care Med 2015 Apr 1;191(7):786-95. doi: 10.1164/rccm.201410-1785OC. PMID: 25594886
Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis.
Judson MA, Baughman RP, Costabel U, Drent M, Gibson KF, Raghu G, Shigemitsu H, Barney JB, Culver DA, Hamzeh NY, Wijsenbeek MS, Albera C, Huizar I, Agarwal P, Brodmerkel C, Watt R, Barnathan ES
Eur Respir J 2014 Nov;44(5):1296-307. Epub 2014 Jul 17 doi: 10.1183/09031936.00000914. PMID: 25034562

Diagnosis

Colon Sarcoidosis Mimicking Cancer at 18F-FDG PET/CT.
Mei R, Prediletto I, Nava S, Fanti S, Ambrosini V
Clin Nucl Med 2020 May;45(5):387-388. doi: 10.1097/RLU.0000000000002996. PMID: 32149791
A Rare Case of a Tuberculosis Patient with Sarcoidosis.
Muntean PE
Folia Med (Plovdiv) 2019 Jun 1;61(2):312-316. doi: 10.2478/folmed-2018-0055. PMID: 31301651
Systemic Sarcoidosis Revealed by Axillary Electrolysis.
Morand M, Beauregard S, Mathieu S
J Cutan Med Surg 2015 Jul-Aug;19(4):404-6. Epub 2015 Mar 2 doi: 10.1177/1203475415575016. PMID: 25775618
The "mystery" of cutaneous sarcoidosis: facts and controversies.
Tchernev G, Cardoso JC, Chokoeva AA, Verma SB, Tana C, Ananiev J, Gulubova M, Philipov S, Kanazawa N, Nenoff P, Lotti T, Wollina U
Int J Immunopathol Pharmacol 2014 Jul-Sep;27(3):321-30. doi: 10.1177/039463201402700302. PMID: 25280023
Cutaneous sarcoidosis.
Wilson NJ, King CM
Postgrad Med J 1998 Nov;74(877):649-52. doi: 10.1136/pgmj.74.877.649. PMID: 10197194Free PMC Article

Therapy

A Rare Case of a Tuberculosis Patient with Sarcoidosis.
Muntean PE
Folia Med (Plovdiv) 2019 Jun 1;61(2):312-316. doi: 10.2478/folmed-2018-0055. PMID: 31301651
How common is isolated cardiac sarcoidosis? Extra-cardiac and cardiac findings on clinical examination and whole-body (18)F-fluorodeoxyglucose positron emission tomography.
Juneau D, Nery P, Russo J, de Kemp RA, Leung E, Beanlands RSB, Birnie DH
Int J Cardiol 2018 Feb 15;253:189-193. doi: 10.1016/j.ijcard.2017.09.204. PMID: 29306462
Validation and important differences for the Sarcoidosis Assessment Tool. A new patient-reported outcome measure.
Judson MA, Mack M, Beaumont JL, Watt R, Barnathan ES, Victorson DE
Am J Respir Crit Care Med 2015 Apr 1;191(7):786-95. doi: 10.1164/rccm.201410-1785OC. PMID: 25594886
Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis.
Judson MA, Baughman RP, Costabel U, Drent M, Gibson KF, Raghu G, Shigemitsu H, Barney JB, Culver DA, Hamzeh NY, Wijsenbeek MS, Albera C, Huizar I, Agarwal P, Brodmerkel C, Watt R, Barnathan ES
Eur Respir J 2014 Nov;44(5):1296-307. Epub 2014 Jul 17 doi: 10.1183/09031936.00000914. PMID: 25034562
Two cases of interferon-alpha-induced sarcoidosis Koebnerized along venous drainage lines: new pathogenic insights and review of the literature of interferon-induced sarcoidosis.
Buss G, Cattin V, Spring P, Malinverni R, Gilliet M
Dermatology 2013;226(4):289-97. Epub 2013 Jul 23 doi: 10.1159/000346244. PMID: 23886768

Prognosis

Spontaneous Remission Without Steroid Therapy in Isolated Cardiac Sarcoidosis with Severe Left Ventricular Systolic Dysfunction.
Ozawa T, Goto K, Miura K, Kobayashi K, Kikuta Y, Sato K, Taniguchi M, Hiramatsu S, Takebayashi H, Haruta S
Int Heart J 2024 Mar 30;65(2):359-362. Epub 2024 Mar 12 doi: 10.1536/ihj.23-399. PMID: 38479849
Sarcoidosis among hospitalized patients in Poland: a study based on a national hospital registry.
Bogdan M, Nitsch-Osuch A, Kanecki K, Goryński P, Tyszko P, Barańska A, Samel-Kowalik P
Pol Arch Intern Med 2019 Sep 30;129(9):580-585. Epub 2019 Aug 8 doi: 10.20452/pamw.14927. PMID: 31436761
Immunogenetics of Disease-Causing Inflammation in Sarcoidosis.
Grunewald J, Spagnolo P, Wahlström J, Eklund A
Clin Rev Allergy Immunol 2015 Aug;49(1):19-35. doi: 10.1007/s12016-015-8477-8. PMID: 25791751
Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis.
Judson MA, Baughman RP, Costabel U, Drent M, Gibson KF, Raghu G, Shigemitsu H, Barney JB, Culver DA, Hamzeh NY, Wijsenbeek MS, Albera C, Huizar I, Agarwal P, Brodmerkel C, Watt R, Barnathan ES
Eur Respir J 2014 Nov;44(5):1296-307. Epub 2014 Jul 17 doi: 10.1183/09031936.00000914. PMID: 25034562
Cutaneous sarcoidosis.
Wilson NJ, King CM
Postgrad Med J 1998 Nov;74(877):649-52. doi: 10.1136/pgmj.74.877.649. PMID: 10197194Free PMC Article

Clinical prediction guides

Sarcoidosis among hospitalized patients in Poland: a study based on a national hospital registry.
Bogdan M, Nitsch-Osuch A, Kanecki K, Goryński P, Tyszko P, Barańska A, Samel-Kowalik P
Pol Arch Intern Med 2019 Sep 30;129(9):580-585. Epub 2019 Aug 8 doi: 10.20452/pamw.14927. PMID: 31436761
Clinical Features of Extrapulmonary Sarcoidosis Without Lung Involvement.
James WE, Koutroumpakis E, Saha B, Nathani A, Saavedra L, Yucel RM, Judson MA
Chest 2018 Aug;154(2):349-356. Epub 2018 Feb 14 doi: 10.1016/j.chest.2018.02.003. PMID: 29453944
Validation and important differences for the Sarcoidosis Assessment Tool. A new patient-reported outcome measure.
Judson MA, Mack M, Beaumont JL, Watt R, Barnathan ES, Victorson DE
Am J Respir Crit Care Med 2015 Apr 1;191(7):786-95. doi: 10.1164/rccm.201410-1785OC. PMID: 25594886
Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis.
Judson MA, Baughman RP, Costabel U, Drent M, Gibson KF, Raghu G, Shigemitsu H, Barney JB, Culver DA, Hamzeh NY, Wijsenbeek MS, Albera C, Huizar I, Agarwal P, Brodmerkel C, Watt R, Barnathan ES
Eur Respir J 2014 Nov;44(5):1296-307. Epub 2014 Jul 17 doi: 10.1183/09031936.00000914. PMID: 25034562
Biochemical and immunohistochemical comparison of collagen in granuloma annulare and skin sarcoidosis.
Oikarinen A, Kinnunen T, Kallioinen M
Acta Derm Venereol 1989;69(4):277-83. PMID: 2568042

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