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Human T-lymphotropic virus 1 infectious disease

MedGen UID:
6919
•Concept ID:
C0020097
•
Disease or Syndrome
Synonyms: HTLV I Infections; HTLV-I Infection; HTLV-I Infections; Human T lymphotropic Virus 1 Infection; Human T lymphotropic Virus 1 Infections; Human T-lymphotropic Virus 1 Infection; Human T-lymphotropic Virus 1 Infections; Infection, HTLV-I; Infections, HTLV I; Infections, HTLV-I
SNOMED CT: Human T-cell lymphotropic virus (HTLV) 1 infection (429659006); Human T-cell lymphotropic virus 1 infection (429659006); HTLV 1 infection (429659006); HTLV I infection (429659006); Human T-lymphotropic virus 1 infection (429659006)
 
Monarch Initiative: MONDO:0005801

Definition

An infection that is caused by HTLV-1. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHuman T-lymphotropic virus 1 infectious disease

Professional guidelines

PubMed

Treatment of Adult T-Cell Leukemia/Lymphoma: Established Paradigms and Emerging Directions.
Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Molecular epidemiology, genetic variability and evolution of HTLV-1 with special emphasis on African genotypes.
Afonso PV, Cassar O, Gessain A
Retrovirology 2019 Dec 16;16(1):39. doi: 10.1186/s12977-019-0504-z. PMID: 31842895Free PMC Article

Recent clinical studies

Etiology

HTLV in Sweden.
Vesterbacka J, Svensson AK, Nowak P
AIDS Rev 2024;26(1):41-47. doi: 10.24875/AIDSRev.24000002. PMID: 38530748
Treatment of Adult T-Cell Leukemia/Lymphoma: Established Paradigms and Emerging Directions.
Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis.
Penner J, Hernstadt H, Burns JE, Randell P, Lyall H
Arch Dis Child 2021 Feb;106(2):117-124. Epub 2020 Jun 25 doi: 10.1136/archdischild-2020-318841. PMID: 32586930
Sexual transmission of human T-cell lymphotropic virus type 1.
Paiva A, Casseb J
Rev Soc Bras Med Trop 2014 May-Jun;47(3):265-74. doi: 10.1590/0037-8682-0232-2013. PMID: 25075475

Diagnosis

Treatment of Adult T-Cell Leukemia/Lymphoma: Established Paradigms and Emerging Directions.
Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
HTLV-1 encephalitis.
King-Robson J, Hampton T, Rosadas C, Taylor GP, Stanton B
Pract Neurol 2022 Feb;22(1):60-63. Epub 2021 Aug 30 doi: 10.1136/practneurol-2021-003053. PMID: 34462338
Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis.
Penner J, Hernstadt H, Burns JE, Randell P, Lyall H
Arch Dis Child 2021 Feb;106(2):117-124. Epub 2020 Jun 25 doi: 10.1136/archdischild-2020-318841. PMID: 32586930
Reducing the global burden of HTLV-1 infection: An agenda for research and action.
Willems L, Hasegawa H, Accolla R, Bangham C, Bazarbachi A, Bertazzoni U, Carneiro-Proietti AB, Cheng H, Chieco-Bianchi L, Ciminale V, Coelho-Dos-Reis J, Esparza J, Gallo RC, Gessain A, Gotuzzo E, Hall W, Harford J, Hermine O, Jacobson S, Macchi B, Macpherson C, Mahieux R, Matsuoka M, Murphy E, Peloponese JM, Simon V, Tagaya Y, Taylor GP, Watanabe T, Yamano Y
Antiviral Res 2017 Jan;137:41-48. Epub 2016 Nov 11 doi: 10.1016/j.antiviral.2016.10.015. PMID: 27840202

Therapy

HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Adult T-cell leukemia-lymphoma as a viral disease: Subtypes based on viral aspects.
Nosaka K, Matsuoka M
Cancer Sci 2021 May;112(5):1688-1694. Epub 2021 Mar 30 doi: 10.1111/cas.14869. PMID: 33630351Free PMC Article
Mogamulizumab (Anti-CCR4) in HTLV-1-Associated Myelopathy.
Sato T, Coler-Reilly ALG, Yagishita N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y, Yamano Y
N Engl J Med 2018 Feb 8;378(6):529-538. doi: 10.1056/NEJMoa1704827. PMID: 29414279
Human T-lymphotropic virus/HIV co-infection: a clinical review.
Dhasmana D, Taylor GP
Curr Opin Infect Dis 2014 Feb;27(1):16-28. doi: 10.1097/QCO.0000000000000027. PMID: 24305042
Adult T-cell leukemia/lymphoma and HTLV-1.
Mahieux R, Gessain A
Curr Hematol Malig Rep 2007 Oct;2(4):257-64. doi: 10.1007/s11899-007-0035-x. PMID: 20425378

Prognosis

CAR-iNKT cells targeting clonal TCRVβ chains as a precise strategy to treat T cell lymphoma.
Rowan AG, Ponnusamy K, Ren H, Taylor GP, Cook LBM, Karadimitris A
Front Immunol 2023;14:1118681. Epub 2023 Mar 2 doi: 10.3389/fimmu.2023.1118681. PMID: 36936927Free PMC Article
Effect of HTLV-1 Infection on the Clinical Course of Patients with Rheumatoid Arthritis.
Umekita K
Viruses 2022 Jul 1;14(7) doi: 10.3390/v14071460. PMID: 35891440Free PMC Article
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Extracellular Vesicles in HTLV-1 Communication: The Story of an Invisible Messenger.
Al Sharif S, Pinto DO, Mensah GA, Dehbandi F, Khatkar P, Kim Y, Branscome H, Kashanchi F
Viruses 2020 Dec 10;12(12) doi: 10.3390/v12121422. PMID: 33322043Free PMC Article
Human T-lymphotropic virus 1: recent knowledge about an ancient infection.
Verdonck K, González E, Van Dooren S, Vandamme AM, Vanham G, Gotuzzo E
Lancet Infect Dis 2007 Apr;7(4):266-81. doi: 10.1016/S1473-3099(07)70081-6. PMID: 17376384

Clinical prediction guides

Viral, genetic, and immune factors in the oncogenesis of adult T-cell leukemia/lymphoma.
Yasunaga JI
Int J Hematol 2023 Apr;117(4):504-511. Epub 2023 Jan 27 doi: 10.1007/s12185-023-03547-5. PMID: 36705848
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
HTLV, a multi organ oncovirus.
Ramezani S, Rezaee SA, Farjami Z, Ebrahimi N, Abdullabass HK, Ibrahim Jebur MI, Rafatpanah H, Akbarin MM
Microb Pathog 2022 Aug;169:105622. Epub 2022 Jun 7 doi: 10.1016/j.micpath.2022.105622. PMID: 35688412
Mogamulizumab (Anti-CCR4) in HTLV-1-Associated Myelopathy.
Sato T, Coler-Reilly ALG, Yagishita N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y, Yamano Y
N Engl J Med 2018 Feb 8;378(6):529-538. doi: 10.1056/NEJMoa1704827. PMID: 29414279
Human T-lymphotropic virus/HIV co-infection: a clinical review.
Dhasmana D, Taylor GP
Curr Opin Infect Dis 2014 Feb;27(1):16-28. doi: 10.1097/QCO.0000000000000027. PMID: 24305042

Recent systematic reviews

Human T Cell Lymphotropic Virus Type 1 Global Prevalence Associated with the Human Development Index: Systematic Review with Meta-Analysis.
Sampaio GCL, Ribeiro JR, de Almeida CN, Boa-Sorte N, Galvão-Castro B, Grassi MFR, Nunes Sá K, Dias CMCC
AIDS Res Hum Retroviruses 2023 Apr;39(4):145-165. Epub 2023 Feb 15 doi: 10.1089/AID.2021.0230. PMID: 36571250
Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa.
Oloumbou EF, Engone-Ondo JD, Mamimandjiami Idam I, Moussavou-Boudzanga P, Mfouo-Tynga I, Mouinga-Ondeme A
Viruses 2022 Dec 16;14(12) doi: 10.3390/v14122808. PMID: 36560812Free PMC Article
Clinical and Laboratory Outcomes in HIV-1 and HTLV-1/2 Coinfection: A Systematic Review.
Montaño-Castellón I, Marconi CSC, Saffe C, Brites C
Front Public Health 2022;10:820727. Epub 2022 Mar 7 doi: 10.3389/fpubh.2022.820727. PMID: 35359787Free PMC Article
The Effect of Early Postnatal Nutrition on Human T Cell Leukemia Virus Type 1 Mother-to-Child Transmission: A Systematic Review and Meta-Analysis.
Miyazawa T, Hasebe Y, Murase M, Sakurai M, Itabashi K, Yonemoto N
Viruses 2021 May 1;13(5) doi: 10.3390/v13050819. PMID: 34062915Free PMC Article
Seroprevalence of HTLV-1 and HTLV-2 amongst mothers and children in Malawi within the context of a systematic review and meta-analysis of HTLV seroprevalence in Africa.
Fox JM, Mutalima N, Molyneux E, Carpenter LM, Taylor GP, Bland M, Newton R, Martin F
Trop Med Int Health 2016 Mar;21(3):312-24. Epub 2016 Feb 3 doi: 10.1111/tmi.12659. PMID: 26700941Free PMC Article

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