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Allergic contact dermatitis

MedGen UID:
102474
•Concept ID:
C0162820
•
Disease or Syndrome
Synonyms: Allergic Contact Dermatitides; Allergic Contact Dermatitis; Allergic Eczematous Dermatitides; Allergic Eczematous Dermatitis; Contact Dermatitides, Allergic; Contact Dermatitis, Allergic; Dermatitides, Allergic Contact; Dermatitides, Allergic Eczematous; Dermatitis, Allergic Contact; Dermatitis, Allergic Eczematous; Dermatitis, Contact, Allergic; Eczematous Dermatitides, Allergic; Eczematous Dermatitis, Allergic
SNOMED CT: Allergic contact dermatitis (238575004); ACD - Allergic contact dermatitis (238575004)
 
Monarch Initiative: MONDO:0006525

Definition

An inflammatory skin condition caused by an immune response to direct contact between the skin and an allergen. It consists of a delayed type of allergic reaction at the affected site with resulting red, swollen, and blistered skin that may itch or leak. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAllergic contact dermatitis

Professional guidelines

PubMed

Stasis Dermatitis: An Overview of Its Clinical Presentation, Pathogenesis, and Management.
Yosipovitch G, Nedorost ST, Silverberg JI, Friedman AJ, Canosa JM, Cha A
Am J Clin Dermatol 2023 Mar;24(2):275-286. Epub 2023 Feb 17 doi: 10.1007/s40257-022-00753-5. PMID: 36800152Free PMC Article
Guidelines for diagnosis, prevention, and treatment of hand eczema.
Thyssen JP, Schuttelaar MLA, Alfonso JH, Andersen KE, Angelova-Fischer I, Arents BWM, Bauer A, Brans R, Cannavo A, Christoffers WA, Crépy MN, Elsner P, Fartasch M, Filon FL, Giménez-Arnau AM, Gonçalo M, Guzmán-Perera MG, Hamann CR, Hoetzenecker W, Johansen JD, John SM, Kunkeler ACM, Hadzavdic SL, Molin S, Nixon R, Oosterhaven JAF, Rustemeyer T, Serra-Baldrich E, Shah M, Simon D, Skudlik C, Spiewak R, Valiukevičienė S, Voorberg AN, Weisshaar E, Agner T
Contact Dermatitis 2022 May;86(5):357-378. Epub 2022 Mar 3 doi: 10.1111/cod.14035. PMID: 34971008
Contact Dermatitis: Classifications and Management.
Li Y, Li L
Clin Rev Allergy Immunol 2021 Dec;61(3):245-281. Epub 2021 Jul 15 doi: 10.1007/s12016-021-08875-0. PMID: 34264448

Recent clinical studies

Etiology

Role of Innate Immunity in Allergic Contact Dermatitis: An Update.
Yamaguchi HL, Yamaguchi Y, Peeva E
Int J Mol Sci 2023 Aug 19;24(16) doi: 10.3390/ijms241612975. PMID: 37629154Free PMC Article
Pitfalls in Patch Testing: Minimizing the Risk of Avoidable False-Negative Reactions.
Ophaug S, Schwarzenberger K
Dermatol Clin 2020 Jul;38(3):293-300. Epub 2020 May 4 doi: 10.1016/j.det.2020.02.007. PMID: 32475507
Irritant Contact Dermatitis.
Bains SN, Nash P, Fonacier L
Clin Rev Allergy Immunol 2019 Feb;56(1):99-109. doi: 10.1007/s12016-018-8713-0. PMID: 30293200
Computer-related skin diseases.
Wintzen M, Van Zuuren EJ
Contact Dermatitis 2003 May;48(5):241-3. doi: 10.1034/j.1600-0536.2003.00085.x. PMID: 12868962
Sesquiterpene lactone allergy.
Warshaw EM, Zug KA
Am J Contact Dermat 1996 Mar;7(1):1-23. doi: 10.1016/s1046-199x(96)90028-7. PMID: 8796737

Diagnosis

Cinnamon allergic contact cheilitis.
Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F
Contact Dermatitis 2023 May;88(5):418-419. Epub 2023 Feb 14 doi: 10.1111/cod.14290. PMID: 36753046
Laboratory Techniques for Identifying Causes of Allergic Dermatitis.
Chipinda I, Anderson SE, Siegel PD
Immunol Allergy Clin North Am 2021 Aug;41(3):423-438. Epub 2021 Jun 5 doi: 10.1016/j.iac.2021.04.003. PMID: 34225898Free PMC Article
Contact dermatitis to minoxidil.
Nagarajan H, Rai R
Contact Dermatitis 2021 Jan;84(1):57. Epub 2020 Sep 30 doi: 10.1111/cod.13670. PMID: 32700369
The Importance of Education When Patch Testing.
Wu PA
Dermatol Clin 2020 Jul;38(3):351-360. Epub 2020 May 4 doi: 10.1016/j.det.2020.02.004. PMID: 32475513
Allergic Contact Dermatitis.
Nassau S, Fonacier L
Med Clin North Am 2020 Jan;104(1):61-76. Epub 2019 Oct 28 doi: 10.1016/j.mcna.2019.08.012. PMID: 31757238

Therapy

Off-label Uses of Topical Pimecrolimus.
Ladda M, Sandhu V, Ighani A, Yeung J
J Cutan Med Surg 2019 Jul/Aug;23(4):442-448. Epub 2019 May 3 doi: 10.1177/1203475419847950. PMID: 31053034
Nickel by proxy.
Lian BSY, McFadden JP, Lee SX
Contact Dermatitis 2019 Jul;81(1):69. Epub 2019 Mar 13 doi: 10.1111/cod.13232. PMID: 30677153
Allergic skin diseases.
Lang DM, Fineman SM, Khan DA, Tilles SA
Ann Allergy Asthma Immunol 2018 Jun;120(6):580-582. Epub 2018 Apr 26 doi: 10.1016/j.anai.2018.04.019. PMID: 29705380
Hair colour shampoo dermatitis.
Kosumi H, Yanagi T, Izumi K, Ito T, Shimizu H
Contact Dermatitis 2017 Dec;77(6):419-421. doi: 10.1111/cod.12851. PMID: 29164693
Eucalyptus oil: contact allergy and safety.
Higgins C, Palmer A, Nixon R
Contact Dermatitis 2015 May;72(5):344-6. Epub 2015 Mar 6 doi: 10.1111/cod.12376. PMID: 25752915

Prognosis

Tattoos: Very Popular, Not So Innocent.
Hermida MD, Cabrera HN
Skinmed 2017;15(1):37-42. Epub 2017 Feb 1 PMID: 28270308
Skin diseases in musicians.
Crépy MN
Eur J Dermatol 2015 Sep-Oct;25(5):375-83. doi: 10.1684/ejd.2015.2559. PMID: 25905552
Diagnosis and management of contact dermatitis.
Usatine RP, Riojas M
Am Fam Physician 2010 Aug 1;82(3):249-55. PMID: 20672788
Gentamicin-induced anaphylaxis.
Connolly M, McAdoo J, Bourke JF
Ir J Med Sci 2007 Dec;176(4):317-8. Epub 2007 Aug 28 doi: 10.1007/s11845-007-0077-z. PMID: 17724569
Contact dermatitis.
Friedlander SF
Pediatr Rev 1998 May;19(5):166-71. doi: 10.1542/pir.19-5-166. PMID: 9584526

Clinical prediction guides

Effects of aluminium chloride added to common patch test substances.
Comstedt LR, Siemund I, Dahlin J, Bruze M, Svedman C
Contact Dermatitis 2023 Jun;88(6):456-462. Epub 2023 Mar 14 doi: 10.1111/cod.14299. PMID: 36840428
Immune-competent in vitro co-culture models as an approach for skin sensitisation assessment.
Thélu A, Catoire S, Kerdine-Römer S
Toxicol In Vitro 2020 Feb;62:104691. Epub 2019 Oct 22 doi: 10.1016/j.tiv.2019.104691. PMID: 31648045
Conctact dermatitis: some important topics.
Pigatto PD
Eur Ann Allergy Clin Immunol 2015 Nov;47(6):188-91. PMID: 26549335
Interactions of chemicals and metal ions with proteins and role for immune responses.
Martin SF, Merfort I, Thierse HJ
Mini Rev Med Chem 2006 Mar;6(3):247-55. doi: 10.2174/138955706776073493. PMID: 16515463
Contact sensitization to N-(cyclohexylthio)phthalimide.
Geier J, Lessmann H, Frosch PJ, Schnuch A
Contact Dermatitis 2003 Jan;48(1):1-6. PMID: 12641571

Recent systematic reviews

Allergens in Common Brands of Clobetasol.
Ramani L, Haidari W, Hall S, Amin S, Chisolm S, Feldman S
J Drugs Dermatol 2023 May 1;22(5):491-495. doi: 10.36849/JDD.4651. PMID: 37133477
Nipple eczema: A systematic review and practical recommendations.
Reynaert V, Gutermuth J, Wollenberg A
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1149-1159. Epub 2023 Feb 16 doi: 10.1111/jdv.18920. PMID: 36695082
Hand hygiene and hand eczema: A systematic review and meta-analysis.
Loh EW, Yew YW
Contact Dermatitis 2022 Oct;87(4):303-314. Epub 2022 May 2 doi: 10.1111/cod.14133. PMID: 35460528Free PMC Article
Dupilumab ocular side effects in patients with atopic dermatitis: a systematic review.
Neagu N, Dianzani C, Avallone G, Dell'Aquila C, Morariu SH, Zalaudek I, Conforti C
J Eur Acad Dermatol Venereol 2022 Jun;36(6):820-835. Epub 2022 Feb 17 doi: 10.1111/jdv.17981. PMID: 35122335
Facial and neck erythema associated with dupilumab treatment: A systematic review.
Jo CE, Finstad A, Georgakopoulos JR, Piguet V, Yeung J, Drucker AM
J Am Acad Dermatol 2021 May;84(5):1339-1347. Epub 2021 Jan 8 doi: 10.1016/j.jaad.2021.01.012. PMID: 33428978

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