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Polyradiculoneuropathy

MedGen UID:
46012
•Concept ID:
C0032587
•
Disease or Syndrome
Synonym: Polyradiculoneuropathies
SNOMED CT: Polyradiculoneuropathy (128078004)
 
Monarch Initiative: MONDO:0006915

Definition

Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (guillain-barre syndrome) and polyradiculoneuropathy, chronic inflammatory demyelinating. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots. [from MONDO]

Professional guidelines

PubMed

European Academy of Neurology/Peripheral Nerve Society Guideline on diagnosis and treatment of Guillain-Barré syndrome.
van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
Eur J Neurol 2023 Dec;30(12):3646-3674. Epub 2023 Oct 10 doi: 10.1111/ene.16073. PMID: 37814552
European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force-Second revision.
Van den Bergh PYK, van Doorn PA, Hadden RDM, Avau B, Vankrunkelsven P, Allen JA, Attarian S, Blomkwist-Markens PH, Cornblath DR, Eftimov F, Goedee HS, Harbo T, Kuwabara S, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Sommer C, Topaloglu HA
Eur J Neurol 2021 Nov;28(11):3556-3583. Epub 2021 Jul 30 doi: 10.1111/ene.14959. PMID: 34327760
European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force-Second revision.
Van den Bergh PYK, van Doorn PA, Hadden RDM, Avau B, Vankrunkelsven P, Allen JA, Attarian S, Blomkwist-Markens PH, Cornblath DR, Eftimov F, Goedee HS, Harbo T, Kuwabara S, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Sommer C, Topaloglu HA
J Peripher Nerv Syst 2021 Sep;26(3):242-268. Epub 2021 Jul 30 doi: 10.1111/jns.12455. PMID: 34085743

Recent clinical studies

Etiology

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): Current Therapies and Future Approaches.
Svačina MKR, Lehmann HC
Curr Pharm Des 2022;28(11):854-862. doi: 10.2174/1381612828666220325102840. PMID: 35339172
Novel Immunological and Therapeutic Insights in Guillain-Barré Syndrome and CIDP.
Querol L, Lleixà C
Neurotherapeutics 2021 Oct;18(4):2222-2235. Epub 2021 Sep 21 doi: 10.1007/s13311-021-01117-3. PMID: 34549385Free PMC Article
Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy.
Eftimov F, Lucke IM, Querol LA, Rajabally YA, Verhamme C
Brain 2020 Dec 5;143(11):3214-3224. doi: 10.1093/brain/awaa265. PMID: 33155018Free PMC Article
Atypical CIDP: diagnostic criteria, progression and treatment response. Data from the Italian CIDP Database.
Doneddu PE, Cocito D, Manganelli F, Fazio R, Briani C, Filosto M, Benedetti L, Mazzeo A, Marfia GA, Cortese A, Fierro B, Jann S, Beghi E, Clerici AM, Carpo M, Schenone A, Luigetti M, Lauria G, Antonini G, Rosso T, Siciliano G, Cavaletti G, Liberatore G, Santoro L, Peci E, Tronci S, Ruiz M, Cotti Piccinelli S, Toscano A, Mataluni G, Piccolo L, Cosentino G, Sabatelli M, Nobile-Orazio E; Italian CIDP Database study group
J Neurol Neurosurg Psychiatry 2019 Feb;90(2):125-132. Epub 2018 Oct 8 doi: 10.1136/jnnp-2018-318714. PMID: 30297520
Rehabilitation of Guillain-Barré syndrome.
Meythaler JM
Arch Phys Med Rehabil 1997 Aug;78(8):872-9. doi: 10.1016/s0003-9993(97)90203-3. PMID: 9344309

Diagnosis

Autoimmune polyneuropathies.
Naum R, Gwathmey KG
Handb Clin Neurol 2023;195:587-608. doi: 10.1016/B978-0-323-98818-6.00004-2. PMID: 37562888
Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP).
Querol L, Crabtree M, Herepath M, Priedane E, Viejo Viejo I, Agush S, Sommerer P
J Neurol 2021 Oct;268(10):3706-3716. Epub 2020 Jun 24 doi: 10.1007/s00415-020-09998-8. PMID: 32583051Free PMC Article
Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy.
Eftimov F, Lucke IM, Querol LA, Rajabally YA, Verhamme C
Brain 2020 Dec 5;143(11):3214-3224. doi: 10.1093/brain/awaa265. PMID: 33155018Free PMC Article
Progress in diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy.
Bunschoten C, Jacobs BC, Van den Bergh PYK, Cornblath DR, van Doorn PA
Lancet Neurol 2019 Aug;18(8):784-794. Epub 2019 May 7 doi: 10.1016/S1474-4422(19)30144-9. PMID: 31076244
Chronic inflammatory demyelinating polyneuropathy: update on diagnosis, immunopathogenesis and treatment.
Lehmann HC, Burke D, Kuwabara S
J Neurol Neurosurg Psychiatry 2019 Sep;90(9):981-987. Epub 2019 Apr 16 doi: 10.1136/jnnp-2019-320314. PMID: 30992333

Therapy

Treatment of CIDP.
Fehmi J, Bellanti R, Misbah SA, Bhattacharjee A, Rinaldi S
Pract Neurol 2023 Feb;23(1):46-53. Epub 2022 Sep 15 doi: 10.1136/pn-2021-002991. PMID: 36109154
Therapeutic Monoclonal Antibody Therapies in Chronic Autoimmune Demyelinating Neuropathies.
Briani C, Visentin A
Neurotherapeutics 2022 Apr;19(3):874-884. Epub 2022 Mar 28 doi: 10.1007/s13311-022-01222-x. PMID: 35349079Free PMC Article
Novel Immunological and Therapeutic Insights in Guillain-Barré Syndrome and CIDP.
Querol L, Lleixà C
Neurotherapeutics 2021 Oct;18(4):2222-2235. Epub 2021 Sep 21 doi: 10.1007/s13311-021-01117-3. PMID: 34549385Free PMC Article
Immunoglobulin administration for the treatment of CIDP: IVIG or SCIG?
Allen JA, Gelinas DF, Freimer M, Runken MC, Wolfe GI
J Neurol Sci 2020 Jan 15;408:116497. Epub 2019 Nov 9 doi: 10.1016/j.jns.2019.116497. PMID: 31765922
Progress in diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy.
Bunschoten C, Jacobs BC, Van den Bergh PYK, Cornblath DR, van Doorn PA
Lancet Neurol 2019 Aug;18(8):784-794. Epub 2019 May 7 doi: 10.1016/S1474-4422(19)30144-9. PMID: 31076244

Prognosis

Current Biomarker Strategies in Autoimmune Neuromuscular Diseases.
Oeztuerk M, Henes A, Schroeter CB, Nelke C, Quint P, Theissen L, Meuth SG, Ruck T
Cells 2023 Oct 15;12(20) doi: 10.3390/cells12202456. PMID: 37887300Free PMC Article
Guillain-Barré syndrome mimics.
Tham SL, Prasad K, Umapathi T
Brain Behav 2018 May;8(5):e00960. Epub 2018 Apr 10 doi: 10.1002/brb3.960. PMID: 29761013Free PMC Article
Peripheral neuropathies.
Hanewinckel R, Ikram MA, Van Doorn PA
Handb Clin Neurol 2016;138:263-82. doi: 10.1016/B978-0-12-802973-2.00015-X. PMID: 27637963
Guillain-Barré syndrome.
Walling AD, Dickson G
Am Fam Physician 2013 Feb 1;87(3):191-7. PMID: 23418763
Guillain-Barré syndrome.
Hughes RA, Cornblath DR
Lancet 2005 Nov 5;366(9497):1653-66. doi: 10.1016/S0140-6736(05)67665-9. PMID: 16271648

Clinical prediction guides

Current Biomarker Strategies in Autoimmune Neuromuscular Diseases.
Oeztuerk M, Henes A, Schroeter CB, Nelke C, Quint P, Theissen L, Meuth SG, Ruck T
Cells 2023 Oct 15;12(20) doi: 10.3390/cells12202456. PMID: 37887300Free PMC Article
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): Current Therapies and Future Approaches.
Svačina MKR, Lehmann HC
Curr Pharm Des 2022;28(11):854-862. doi: 10.2174/1381612828666220325102840. PMID: 35339172
Rituximab in refractory chronic inflammatory demyelinating polyneuropathy.
Muley SA, Jacobsen B, Parry G, Usman U, Ortega E, Walk D, Allen J, Pasnoor M, Varon M, Dimachkie MM
Muscle Nerve 2020 May;61(5):575-579. Epub 2020 Jan 21 doi: 10.1002/mus.26804. PMID: 31922613
POEMS syndrome.
Keddie S, Lunn MP
Curr Opin Neurol 2018 Oct;31(5):551-558. doi: 10.1097/WCO.0000000000000610. PMID: 30138145
Rehabilitation of Guillain-Barré syndrome.
Meythaler JM
Arch Phys Med Rehabil 1997 Aug;78(8):872-9. doi: 10.1016/s0003-9993(97)90203-3. PMID: 9344309

Recent systematic reviews

Guidelines for Neuroprognostication in Adults with Guillain-Barré Syndrome.
Busl KM, Fried H, Muehlschlegel S, Wartenberg KE, Rajajee V, Alexander SA, Creutzfeldt CJ, Fontaine GV, Hocker SE, Hwang DY, Kim KS, Madzar D, Mahanes D, Mainali S, Meixensberger J, Sakowitz OW, Varelas PN, Westermaier T, Weimar C
Neurocrit Care 2023 Jun;38(3):564-583. Epub 2023 Mar 25 doi: 10.1007/s12028-023-01707-3. PMID: 36964442Free PMC Article
Triggers of Guillain-Barré Syndrome: Campylobacter jejuni Predominates.
Finsterer J
Int J Mol Sci 2022 Nov 17;23(22) doi: 10.3390/ijms232214222. PMID: 36430700Free PMC Article
Efficacy of rituximab treatment in chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review and meta-analysis.
Hu J, Sun C, Lu J, Zhao C, Lin J
J Neurol 2022 Mar;269(3):1250-1263. Epub 2021 Jun 12 doi: 10.1007/s00415-021-10646-y. PMID: 34120208
Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP).
Querol L, Crabtree M, Herepath M, Priedane E, Viejo Viejo I, Agush S, Sommerer P
J Neurol 2021 Oct;268(10):3706-3716. Epub 2020 Jun 24 doi: 10.1007/s00415-020-09998-8. PMID: 32583051Free PMC Article
Incidence and Prevalence of Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Systematic Review and Meta-Analysis.
Broers MC, Bunschoten C, Nieboer D, Lingsma HF, Jacobs BC
Neuroepidemiology 2019;52(3-4):161-172. Epub 2019 Jan 22 doi: 10.1159/000494291. PMID: 30669140Free PMC Article

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