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Graft versus host disease(GVHD)

MedGen UID:
9082
Concept ID:
C0018133
Disease or Syndrome
Synonyms: Graft vs Host Disease; GVHD; Late acute graft versus host disease
SNOMED CT: Graft versus host disease (234646005); GVHD - Graft-versus-host disease (234646005); Graft-versus-host disease (234646005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0013730
Orphanet: ORPHA39812

Definition

A rare disease that occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen. [from ORDO]

Professional guidelines

PubMed

Penack O, Marchetti M, Aljurf M, Arat M, Bonifazi F, Duarte RF, Giebel S, Greinix H, Hazenberg MD, Kröger N, Mielke S, Mohty M, Nagler A, Passweg J, Patriarca F, Ruutu T, Schoemans H, Solano C, Vrhovac R, Wolff D, Zeiser R, Sureda A, Peric Z
Lancet Haematol 2024 Feb;11(2):e147-e159. Epub 2024 Jan 3 doi: 10.1016/S2352-3026(23)00342-3. PMID: 38184001
Malard F, Mohty M
Am J Hematol 2023 Oct;98(10):1637-1644. Epub 2023 Jul 22 doi: 10.1002/ajh.27040. PMID: 37483142
Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte RF, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socié G, Solano C, Vrhovac R, Zeiser R, Kröger N, Basak GW
Lancet Haematol 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485

Recent clinical studies

Etiology

Watkins B, Qayed M
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):155-163. doi: 10.1182/hematology.2023000426. PMID: 38066861Free PMC Article
Choe H, Ferrara JLM
Expert Opin Ther Targets 2021 Sep;25(9):761-771. Epub 2021 Nov 1 doi: 10.1080/14728222.2021.1992383. PMID: 34669521Free PMC Article
Hill GR, Betts BC, Tkachev V, Kean LS, Blazar BR
Annu Rev Immunol 2021 Apr 26;39:19-49. Epub 2021 Jan 11 doi: 10.1146/annurev-immunol-102119-073227. PMID: 33428454Free PMC Article
Aladağ E, Kelkitli E, Göker H
Turk J Haematol 2020 Feb 20;37(1):1-4. Epub 2019 Sep 2 doi: 10.4274/tjh.galenos.2019.2019.0157. PMID: 31475512Free PMC Article
Kornik RI, Rustagi AS
Obstet Gynecol Clin North Am 2017 Sep;44(3):475-492. doi: 10.1016/j.ogc.2017.05.007. PMID: 28778644

Diagnosis

Baumrin E, Loren AW, Falk SJ, Mays JW, Cowen EW
J Am Acad Dermatol 2024 Jan;90(1):1-16. Epub 2022 Dec 23 doi: 10.1016/j.jaad.2022.12.024. PMID: 36572065Free PMC Article
Soleimani M, Mahdavi Sharif P, Cheraqpour K, Koganti R, Masoumi A, Baharnoori SM, Salabati M, Djalilian AR
Surv Ophthalmol 2023 Jul-Aug;68(4):697-712. Epub 2023 Mar 2 doi: 10.1016/j.survophthal.2023.02.006. PMID: 36870423Free PMC Article
Aladağ E, Kelkitli E, Göker H
Turk J Haematol 2020 Feb 20;37(1):1-4. Epub 2019 Sep 2 doi: 10.4274/tjh.galenos.2019.2019.0157. PMID: 31475512Free PMC Article
Ramachandran V, Kolli SS, Strowd LC
Dermatol Clin 2019 Oct;37(4):569-582. Epub 2019 Jul 10 doi: 10.1016/j.det.2019.05.014. PMID: 31466596
Moreno DF, Cid J
Med Clin (Barc) 2019 Jan 4;152(1):22-28. Epub 2018 Oct 9 doi: 10.1016/j.medcli.2018.07.012. PMID: 30309668

Therapy

Martinez-Cibrian N, Zeiser R, Perez-Simon JA
Blood Rev 2021 Jul;48:100792. Epub 2020 Dec 26 doi: 10.1016/j.blre.2020.100792. PMID: 33386151
Ooijevaar RE, Terveer EM, Verspaget HW, Kuijper EJ, Keller JJ
Annu Rev Med 2019 Jan 27;70:335-351. Epub 2018 Nov 7 doi: 10.1146/annurev-med-111717-122956. PMID: 30403550
Maertens JA, Girmenia C, Brüggemann RJ, Duarte RF, Kibbler CC, Ljungman P, Racil Z, Ribaud P, Slavin MA, Cornely OA, Peter Donnelly J, Cordonnier C; European Conference on Infections in Leukaemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS) and; European Conference on Infections in Leukaemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS) and the European LeukemiaNet (ELN)
J Antimicrob Chemother 2018 Dec 1;73(12):3221-3230. doi: 10.1093/jac/dky286. PMID: 30085172
Trounson A, McDonald C
Cell Stem Cell 2015 Jul 2;17(1):11-22. doi: 10.1016/j.stem.2015.06.007. PMID: 26140604
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article

Prognosis

Goldsmith SR, Abid MB, Auletta JJ, Bashey A, Beitinjaneh A, Castillo P, Chemaly RF, Chen M, Ciurea S, Dandoy CE, Díaz MÁ, Fuchs E, Ganguly S, Kanakry CG, Kanakry JA, Kim S, Komanduri KV, Krem MM, Lazarus HM, Liu H, Ljungman P, Masiarz R, Mulroney C, Nathan S, Nishihori T, Page KM, Perales MA, Taplitz R, Romee R, Riches M
Blood 2021 Jun 10;137(23):3291-3305. doi: 10.1182/blood.2020009362. PMID: 33657221Free PMC Article
Cordeiro A, Bezerra ED, Hirayama AV, Hill JA, Wu QV, Voutsinas J, Sorror ML, Turtle CJ, Maloney DG, Bar M
Biol Blood Marrow Transplant 2020 Jan;26(1):26-33. Epub 2019 Aug 13 doi: 10.1016/j.bbmt.2019.08.003. PMID: 31419568Free PMC Article
Totani A, Amin H, Bacchi S, Lewis I
Bone Marrow Transplant 2020 Feb;55(2):332-340. Epub 2019 Jul 29 doi: 10.1038/s41409-019-0626-x. PMID: 31358916
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article
Sunul H, Erguven N
Transfus Apher Sci 2013 Oct;49(2):331-3. Epub 2013 Jul 23 doi: 10.1016/j.transci.2013.07.001. PMID: 23890576

Clinical prediction guides

DeFilipp Z, Kim HT, Yang Z, Noonan J, Blazar BR, Lee SJ, Pavletic SZ, Cutler C
Blood Adv 2022 Dec 27;6(24):6263-6270. doi: 10.1182/bloodadvances.2022008095. PMID: 36083121Free PMC Article
Hidalgo Calleja C, Martín Hidalgo D, Román Curto C, Vázquez López L, Pérez López E, Cabrero Calvo M, Martín López AÁ, Caballero Barrigón MD, Lopez-Corral L
Adv Rheumatol 2022 Aug 23;62(1):33. doi: 10.1186/s42358-022-00262-3. PMID: 35999577
Elhage A, Sligar C, Cuthbertson P, Watson D, Sluyter R
Biosci Rep 2022 Sep 30;42(9) doi: 10.1042/BSR20211986. PMID: 35993192Free PMC Article
Crossland RE, Perutelli F, Bogunia-Kubik K, Mooney N, Milutin Gašperov N, Pučić-Baković M, Greinix H, Weber D, Holler E, Pulanić D, Wolff D, Dickinson AM, Inngjerdingen M, Grce M
Front Immunol 2020;11:602547. Epub 2020 Dec 23 doi: 10.3389/fimmu.2020.602547. PMID: 33424849Free PMC Article
Aguilar PR, Michelson AP, Isakow W
Transplantation 2016 Feb;100(2):272-83. doi: 10.1097/TP.0000000000000892. PMID: 26335918

Recent systematic reviews

Kneifel F, Vogel T, Bormann E, Becker F, Houben P, Flammang I, Slepecka P, Eichelmann AK, Brockmann JG, Pascher A
Hepatol Commun 2023 Oct 1;7(10) Epub 2023 Sep 27 doi: 10.1097/HC9.0000000000000260. PMID: 37755878Free PMC Article
Appeldoorn TYJ, Munnink THO, Morsink LM, Hooge MNL, Touw DJ
Clin Pharmacokinet 2023 Apr;62(4):559-571. Epub 2023 Mar 31 doi: 10.1007/s40262-023-01225-7. PMID: 37000342Free PMC Article
Fan S, Huo WX, Yang Y, Shen MZ, Mo XD
Front Immunol 2022;13:954268. Epub 2022 Aug 4 doi: 10.3389/fimmu.2022.954268. PMID: 35990629Free PMC Article
Arnold DD, Yalamanoglu A, Boyman O
Front Immunol 2022;13:888392. Epub 2022 Jul 6 doi: 10.3389/fimmu.2022.888392. PMID: 35874710Free PMC Article
Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, Axéll T, Bruce AJ, Carpenter W, Eisenberg E, Epstein JB, Holmstrup P, Jontell M, Lozada-Nur F, Nair R, Silverman B, Thongprasom K, Thornhill M, Warnakulasuriya S, van der Waal I
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Mar;103 Suppl:S25.e1-12. Epub 2007 Jan 29 doi: 10.1016/j.tripleo.2006.11.001. PMID: 17261375

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