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Environmental allergy

MedGen UID:
84383
Concept ID:
C0282504
Disease or Syndrome
Synonyms: Environmental Hypersensitivities; Environmental Hypersensitivity; Environmental Illness; Environmental Illnesses; Hypersensitivities, Environmental; Hypersensitivity, Environmental; Illness, Environmental; Illnesses, Environmental
SNOMED CT: Environmental allergy (426232007)

Definition

A polysymptomatic condition believed by clinical ecologists to result from immune dysregulation induced by common foods, allergens, and chemicals, resulting in various physical and mental disorders. The medical community has remained largely skeptical of the existence of this ""disease"", given the plethora of symptoms attributed to environmental illness, the lack of reproducible laboratory abnormalities, and the use of unproven therapies to treat the condition. (From Segen, Dictionary of Modern Medicine, 1992) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEnvironmental allergy

Professional guidelines

PubMed

Garrean C, Hirano I
Curr Gastroenterol Rep 2009 Jun;11(3):175-81. doi: 10.1007/s11894-009-0028-0. PMID: 19463216

Recent clinical studies

Etiology

Heederik D, van Rooy F
Curr Opin Allergy Clin Immunol 2024 Apr 1;24(2):69-72. Epub 2024 Feb 5 doi: 10.1097/ACI.0000000000000963. PMID: 38359103Free PMC Article
Mahon M, Romo ND, de Vos G, Levanon D
Ann Allergy Asthma Immunol 2021 Sep;127(3):349-353. Epub 2021 May 15 doi: 10.1016/j.anai.2021.05.010. PMID: 34004276
Saif NT, Kleiner GI, Forster LQ, Hershorin ER, Colin AA, Mirsaeidi M, Kumar N
Int J Environ Res Public Health 2021 Apr 14;18(8) doi: 10.3390/ijerph18084142. PMID: 33919868Free PMC Article
Peng C, Van Meel ER, Cardenas A, Rifas-Shiman SL, Sonawane AR, Glass KR, Gold DR, Platts-Mills TA, Lin X, Oken E, Hivert MF, Baccarelli AA, De Jong NW, Felix JF, Jaddoe VW, Duijts L, Litonjua AA, DeMeo DL
Epigenetics 2019 May;14(5):445-466. Epub 2019 Mar 28 doi: 10.1080/15592294.2019.1590085. PMID: 30876376Free PMC Article
Ward BK, Ashry Y, Poe DS
Otol Neurotol 2017 Oct;38(9):1362-1369. doi: 10.1097/MAO.0000000000001543. PMID: 28796094

Diagnosis

Heederik D, van Rooy F
Curr Opin Allergy Clin Immunol 2024 Apr 1;24(2):69-72. Epub 2024 Feb 5 doi: 10.1097/ACI.0000000000000963. PMID: 38359103Free PMC Article
Rasmussen MLR, D'Souza M, Topal DG, Gradman J, Larsen DA, Lehrmann BB, Kjaer HF, Kessel L, Subhi Y
Acta Ophthalmol 2023 Feb;101(1):9-21. Epub 2022 Jul 18 doi: 10.1111/aos.15212. PMID: 35848379Free PMC Article
Chong AC, Chwa WJ, Ong PY
Curr Allergy Asthma Rep 2022 Jul;22(7):67-75. Epub 2022 Apr 1 doi: 10.1007/s11882-022-01033-2. PMID: 35362938
Saif NT, Kleiner GI, Forster LQ, Hershorin ER, Colin AA, Mirsaeidi M, Kumar N
Int J Environ Res Public Health 2021 Apr 14;18(8) doi: 10.3390/ijerph18084142. PMID: 33919868Free PMC Article
Ward BK, Ashry Y, Poe DS
Otol Neurotol 2017 Oct;38(9):1362-1369. doi: 10.1097/MAO.0000000000001543. PMID: 28796094

Therapy

Heederik D, van Rooy F
Curr Opin Allergy Clin Immunol 2024 Apr 1;24(2):69-72. Epub 2024 Feb 5 doi: 10.1097/ACI.0000000000000963. PMID: 38359103Free PMC Article
Pesek RD, Rettiganti M, O'Brien E, Beckwith S, Daniel C, Luo C, Scurlock AM, Chandler P, Levy RA, Perry TT, Kennedy JL, Chervinskiy S, Vonlanthen M, Casteel H, Fiedorek SC, Gibbons T, Jones SM
Ann Allergy Asthma Immunol 2017 Aug;119(2):177-183. Epub 2017 Jul 1 doi: 10.1016/j.anai.2017.06.006. PMID: 28676207Free PMC Article
Makhija MM, Robison RG, Caruso D, Cai M, Wang X, Pongracic JA
Ann Allergy Asthma Immunol 2016 Oct;117(4):382-386.e1. doi: 10.1016/j.anai.2016.07.042. PMID: 27742085Free PMC Article
Davies RJ
Allergy 1988;43 Suppl 8:23-5. doi: 10.1111/j.1398-9995.1988.tb02438.x. PMID: 3202278
West J Med 1986 Feb;144(2):239-45. PMID: 3953098Free PMC Article

Prognosis

Martin A, Bauer V, Datta A, Masi C, Mosnaim G, Solomonides A, Rao G
J Asthma 2020 Dec;57(12):1339-1346. Epub 2019 Aug 8 doi: 10.1080/02770903.2019.1648505. PMID: 31340688
Peng C, Van Meel ER, Cardenas A, Rifas-Shiman SL, Sonawane AR, Glass KR, Gold DR, Platts-Mills TA, Lin X, Oken E, Hivert MF, Baccarelli AA, De Jong NW, Felix JF, Jaddoe VW, Duijts L, Litonjua AA, DeMeo DL
Epigenetics 2019 May;14(5):445-466. Epub 2019 Mar 28 doi: 10.1080/15592294.2019.1590085. PMID: 30876376Free PMC Article
Makhija MM, Robison RG, Caruso D, Cai M, Wang X, Pongracic JA
Ann Allergy Asthma Immunol 2016 Oct;117(4):382-386.e1. doi: 10.1016/j.anai.2016.07.042. PMID: 27742085Free PMC Article
Simpson AB, Glutting J, Yousef E
Pediatr Pulmonol 2007 Jun;42(6):489-95. doi: 10.1002/ppul.20605. PMID: 17469157
Walusiak J, Hanke W, Górski P, Pałczyński C
Allergy 2004 Apr;59(4):442-50. doi: 10.1111/j.1398-9995.2003.00418.x. PMID: 15005769

Clinical prediction guides

Peng C, Van Meel ER, Cardenas A, Rifas-Shiman SL, Sonawane AR, Glass KR, Gold DR, Platts-Mills TA, Lin X, Oken E, Hivert MF, Baccarelli AA, De Jong NW, Felix JF, Jaddoe VW, Duijts L, Litonjua AA, DeMeo DL
Epigenetics 2019 May;14(5):445-466. Epub 2019 Mar 28 doi: 10.1080/15592294.2019.1590085. PMID: 30876376Free PMC Article
Ward BK, Ashry Y, Poe DS
Otol Neurotol 2017 Oct;38(9):1362-1369. doi: 10.1097/MAO.0000000000001543. PMID: 28796094
Makhija MM, Robison RG, Caruso D, Cai M, Wang X, Pongracic JA
Ann Allergy Asthma Immunol 2016 Oct;117(4):382-386.e1. doi: 10.1016/j.anai.2016.07.042. PMID: 27742085Free PMC Article
Nemet AY, Vinker S, Bahar I, Kaiserman I
Cornea 2010 Nov;29(11):1261-4. doi: 10.1097/ICO.0b013e3181cb410b. PMID: 20802320
Garrean C, Hirano I
Curr Gastroenterol Rep 2009 Jun;11(3):175-81. doi: 10.1007/s11894-009-0028-0. PMID: 19463216

Recent systematic reviews

Rasmussen MLR, D'Souza M, Topal DG, Gradman J, Larsen DA, Lehrmann BB, Kjaer HF, Kessel L, Subhi Y
Acta Ophthalmol 2023 Feb;101(1):9-21. Epub 2022 Jul 18 doi: 10.1111/aos.15212. PMID: 35848379Free PMC Article

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