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Disorder of orbital region

MedGen UID:
5092
•Concept ID:
C0015397
•
Disease or Syndrome
Synonym: Disease of orbital region
SNOMED CT: Disorder of eye (371405004); Disorder of eye region (371409005); Disease of eyeball (371405004); Disorder of globe (371405004); Disorder of eyeball (371405004); Ophthalmological disorder (371409005); Disorder of orbital region (371409005); Eye disorder (371405004); Disorder of eye proper (371405004)
 
Monarch Initiative: MONDO:0002022

Definition

A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Disorder of orbital region

Professional guidelines

PubMed

Glaucoma in Adults-Screening, Diagnosis, and Management: A Review.
Stein JD, Khawaja AP, Weizer JS
JAMA 2021 Jan 12;325(2):164-174. doi: 10.1001/jama.2020.21899. PMID: 33433580
Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.
Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I; Movement Disorder Society-endorsed PSP Study Group
Mov Disord 2017 Jun;32(6):853-864. Epub 2017 May 3 doi: 10.1002/mds.26987. PMID: 28467028Free PMC Article
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders.
Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG; International Panel for NMO Diagnosis
Neurology 2015 Jul 14;85(2):177-89. Epub 2015 Jun 19 doi: 10.1212/WNL.0000000000001729. PMID: 26092914Free PMC Article

Recent clinical studies

Etiology

Systemic lupus erythematosus and ocular involvement: an overview.
Dammacco R
Clin Exp Med 2018 May;18(2):135-149. Epub 2017 Dec 14 doi: 10.1007/s10238-017-0479-9. PMID: 29243035
Epidemiology of blindness in children.
Solebo AL, Teoh L, Rahi J
Arch Dis Child 2017 Sep;102(9):853-857. Epub 2017 May 2 doi: 10.1136/archdischild-2016-310532. PMID: 28465303
Vitreous floaters: Etiology, diagnostics, and management.
Milston R, Madigan MC, Sebag J
Surv Ophthalmol 2016 Mar-Apr;61(2):211-27. Epub 2015 Dec 8 doi: 10.1016/j.survophthal.2015.11.008. PMID: 26679984
Congenital stationary night blindness: an analysis and update of genotype-phenotype correlations and pathogenic mechanisms.
Zeitz C, Robson AG, Audo I
Prog Retin Eye Res 2015 Mar;45:58-110. Epub 2014 Oct 13 doi: 10.1016/j.preteyeres.2014.09.001. PMID: 25307992
The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole.
Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P
Ophthalmology 2013 Dec;120(12):2611-2619. Epub 2013 Sep 17 doi: 10.1016/j.ophtha.2013.07.042. PMID: 24053995

Diagnosis

Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Ocular Emergencies: Red Eye.
Tarff A, Behrens A
Med Clin North Am 2017 May;101(3):615-639. Epub 2017 Mar 8 doi: 10.1016/j.mcna.2016.12.013. PMID: 28372717
Vitreomacular traction syndrome.
Shao L, Wei W
Chin Med J (Engl) 2014;127(8):1566-71. PMID: 24762607
Symptomatic vitreomacular adhesion.
Jackson TL, Nicod E, Simpson A, Angelis A, Grimaccia F, Kanavos P
Retina 2013 Sep;33(8):1503-11. doi: 10.1097/IAE.0b013e31829232fd. PMID: 23714857
Vitreoschisis.
Sebag J
Graefes Arch Clin Exp Ophthalmol 2008 Mar;246(3):329-32. Epub 2008 Jan 29 doi: 10.1007/s00417-007-0743-x. PMID: 18228032Free PMC Article

Therapy

What do we know about COVID-19? A review article.
Vieira JM, Ricardo OMP, Hannas CM, Kanadani TCM, Prata TDS, Kanadani FN
Rev Assoc Med Bras (1992) 2020 Apr;66(4):534-540. doi: 10.1590/1806-9282.66.4.534. PMID: 32578792
Trehalose for Ocular Surface Health.
Laihia J, Kaarniranta K
Biomolecules 2020 May 25;10(5) doi: 10.3390/biom10050809. PMID: 32466265Free PMC Article
Retinal Neuroprotection: Overcoming the Translational Roadblocks.
Wubben TJ, Besirli CG, Johnson MW, Zacks DN
Am J Ophthalmol 2018 Aug;192:xv-xxii. Epub 2018 Apr 25 doi: 10.1016/j.ajo.2018.04.012. PMID: 29702074
The eye as a complement dysregulation hotspot.
Clark SJ, Bishop PN
Semin Immunopathol 2018 Jan;40(1):65-74. Epub 2017 Sep 25 doi: 10.1007/s00281-017-0649-6. PMID: 28948331Free PMC Article
Therapeutic potentials of short interfering RNAs.
Tam C, Wong JH, Cheung RCF, Zuo T, Ng TB
Appl Microbiol Biotechnol 2017 Oct;101(19):7091-7111. Epub 2017 Aug 8 doi: 10.1007/s00253-017-8433-z. PMID: 28791440

Prognosis

The inflammatory potential of diet is associated with the risk of age-related eye diseases.
Vergroesen JE, Thee EF, de Crom TOE, Kiefte-de Jong JC, Meester-Smoor MA, Voortman T, Klaver CCW, Ramdas WD
Clin Nutr 2023 Dec;42(12):2404-2413. Epub 2023 Oct 12 doi: 10.1016/j.clnu.2023.10.008. PMID: 37865012
Toxic anterior segment syndrome-an updated review.
Park CY, Lee JK, Chuck RS
BMC Ophthalmol 2018 Oct 25;18(1):276. doi: 10.1186/s12886-018-0939-3. PMID: 30359246Free PMC Article
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Ocular leprosy.
Grzybowski A, Nita M, Virmond M
Clin Dermatol 2015 Jan-Feb;33(1):79-89. doi: 10.1016/j.clindermatol.2014.07.003. PMID: 25432813
Ocular emergencies.
Hodge C, Lawless M
Aust Fam Physician 2008 Jul;37(7):506-9. PMID: 18592066

Clinical prediction guides

Genetic prediction of myopia: prospects and challenges.
Guggenheim JA, Ghorbani Mojarrad N, Williams C, Flitcroft DI
Ophthalmic Physiol Opt 2017 Sep;37(5):549-556. doi: 10.1111/opo.12403. PMID: 28836387
International photographic classification and grading system for myopic maculopathy.
Ohno-Matsui K, Kawasaki R, Jonas JB, Cheung CM, Saw SM, Verhoeven VJ, Klaver CC, Moriyama M, Shinohara K, Kawasaki Y, Yamazaki M, Meuer S, Ishibashi T, Yasuda M, Yamashita H, Sugano A, Wang JJ, Mitchell P, Wong TY; META-analysis for Pathologic Myopia (META-PM) Study Group
Am J Ophthalmol 2015 May;159(5):877-83.e7. Epub 2015 Jan 26 doi: 10.1016/j.ajo.2015.01.022. PMID: 25634530
Vitreomacular traction syndrome.
Shao L, Wei W
Chin Med J (Engl) 2014;127(8):1566-71. PMID: 24762607
Understanding and using sensitivity, specificity and predictive values.
Parikh R, Mathai A, Parikh S, Chandra Sekhar G, Thomas R
Indian J Ophthalmol 2008 Jan-Feb;56(1):45-50. doi: 10.4103/0301-4738.37595. PMID: 18158403Free PMC Article
Criteria for diagnosis of Behçet's disease. International Study Group for Behçet's Disease.
Lancet 1990 May 5;335(8697):1078-80. PMID: 1970380

Recent systematic reviews

Vernal Keratoconjunctivitis: A Systematic Review.
Bruschi G, Ghiglioni DG, Cozzi L, Osnaghi S, Viola F, Marchisio P
Clin Rev Allergy Immunol 2023 Aug;65(2):277-329. Epub 2023 Sep 2 doi: 10.1007/s12016-023-08970-4. PMID: 37658939Free PMC Article
Vitamin D and Ocular Diseases: A Systematic Review.
Chan HN, Zhang XJ, Ling XT, Bui CH, Wang YM, Ip P, Chu WK, Chen LJ, Tham CC, Yam JC, Pang CP
Int J Mol Sci 2022 Apr 11;23(8) doi: 10.3390/ijms23084226. PMID: 35457041Free PMC Article
A Global Assessment of Eye Health and Quality of Life: A Systematic Review of Systematic Reviews.
Assi L, Chamseddine F, Ibrahim P, Sabbagh H, Rosman L, Congdon N, Evans J, Ramke J, Kuper H, Burton MJ, Ehrlich JR, Swenor BK
JAMA Ophthalmol 2021 May 1;139(5):526-541. doi: 10.1001/jamaophthalmol.2021.0146. PMID: 33576772Free PMC Article
Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study.
GBD 2019 Blindness and Vision Impairment Collaborators; Vision Loss Expert Group of the Global Burden of Disease Study
Lancet Glob Health 2021 Feb;9(2):e144-e160. Epub 2020 Dec 1 doi: 10.1016/S2214-109X(20)30489-7. PMID: 33275949Free PMC Article
Conjunctivitis: a systematic review of diagnosis and treatment.
Azari AA, Barney NP
JAMA 2013 Oct 23;310(16):1721-9. doi: 10.1001/jama.2013.280318. PMID: 24150468Free PMC Article

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