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Age-related cataract

MedGen UID:
11372
•Concept ID:
C0036646
•
Acquired Abnormality
Synonym: Senile cataract
SNOMED CT: Old-age related cataract (39450006); Senile cataract (39450006)
 
HPO: HP:0011141
Monarch Initiative: MONDO:0004847

Definition

A type of cataract (opacification of the lens) that forms during the course of aging. [from HPO]

Professional guidelines

PubMed

NSAIDs and Corticosteroids for the Postoperative Management of Age-Related Cataract Surgery: A Systematic Review and Meta-analysis.
Haddad JE, Sabbakh NA, Macaron MM, Shaaban H, Bourdakos NE, Shi A, Saad B, Nakanishi H, Than CA, Daoud YJ
Am J Ophthalmol 2024 Apr;260:1-13. Epub 2023 Oct 4 doi: 10.1016/j.ajo.2023.09.027. PMID: 37797866
Intractable Ocular Diseases and Treatment Progress.
Zhang X, Li S, Tang Y, Guo Y, Gao S
AAPS PharmSciTech 2020 Aug 14;21(6):236. doi: 10.1208/s12249-020-01774-1. PMID: 32803351
The quest for homeopathic and nonsurgical cataract treatment.
Lian RR, Afshari NA
Curr Opin Ophthalmol 2020 Jan;31(1):61-66. doi: 10.1097/ICU.0000000000000631. PMID: 31770163

Recent clinical studies

Etiology

Cataract and systemic disease: A review.
Ang MJ, Afshari NA
Clin Exp Ophthalmol 2021 Mar;49(2):118-127. Epub 2021 Jan 10 doi: 10.1111/ceo.13892. PMID: 33426783
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
The new epidemiology of cataract.
Abraham AG, Condon NG, West Gower E
Ophthalmol Clin North Am 2006 Dec;19(4):415-25. doi: 10.1016/j.ohc.2006.07.008. PMID: 17067897
Age-related cataract.
Asbell PA, Dualan I, Mindel J, Brocks D, Ahmad M, Epstein S
Lancet 2005 Feb 12-18;365(9459):599-609. doi: 10.1016/S0140-6736(05)17911-2. PMID: 15708105
The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group.
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY
Arch Ophthalmol 1993 Jun;111(6):831-6. doi: 10.1001/archopht.1993.01090060119035. PMID: 8512486

Diagnosis

Association of Behavioral and Clinical Risk Factors With Cataract: A Two-Sample Mendelian Randomization Study.
Jiang C, Melles RB, Sangani P, Hoffmann TJ, Hysi PG, Glymour MM, Jorgenson E, Lachke SA, Choquet H
Invest Ophthalmol Vis Sci 2023 Jul 3;64(10):19. doi: 10.1167/iovs.64.10.19. PMID: 37459064Free PMC Article
Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.
Mi Y, Wei C, Sun L, Liu H, Zhang J, Luo J, Yu X, He J, Ge H, Liu P
Biomed Pharmacother 2023 Jan;157:114048. Epub 2022 Dec 1 doi: 10.1016/j.biopha.2022.114048. PMID: 36463827
Comparison of posterior capsule opacification between a 1-piece and a 3-piece microincision intraocular lens.
Prinz A, Vecsei-Marlovits PV, Sonderhof D, Irsigler P, Findl O, Weingessel B
Br J Ophthalmol 2013 Jan;97(1):18-22. Epub 2012 Sep 5 doi: 10.1136/bjophthalmol-2012-301899. PMID: 22952402
Age-related cataract.
Asbell PA, Dualan I, Mindel J, Brocks D, Ahmad M, Epstein S
Lancet 2005 Feb 12-18;365(9459):599-609. doi: 10.1016/S0140-6736(05)17911-2. PMID: 15708105
Epidemiology of cataracts.
Nishikiori T, Yamamoto K
Dev Ophthalmol 1987;15:24-7. doi: 10.1159/000414688. PMID: 3691918

Therapy

Association of Behavioral and Clinical Risk Factors With Cataract: A Two-Sample Mendelian Randomization Study.
Jiang C, Melles RB, Sangani P, Hoffmann TJ, Hysi PG, Glymour MM, Jorgenson E, Lachke SA, Choquet H
Invest Ophthalmol Vis Sci 2023 Jul 3;64(10):19. doi: 10.1167/iovs.64.10.19. PMID: 37459064Free PMC Article
Prospective comparison of apex-centered vs standard pupil-centered femtosecond laser-assisted capsulotomy in cataract surgery.
Mursch-Edlmayr AS, Pomberger LJ, Hermann P, Wagner H, Beka S, Waser K, Wendelstein J, Podkowinski D, Laubichler P, Siska R, Bolz M
J Cataract Refract Surg 2021 May 1;47(5):606-611. doi: 10.1097/j.jcrs.0000000000000496. PMID: 33196566
Age-related cataract.
Asbell PA, Dualan I, Mindel J, Brocks D, Ahmad M, Epstein S
Lancet 2005 Feb 12-18;365(9459):599-609. doi: 10.1016/S0140-6736(05)17911-2. PMID: 15708105
The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1.
Age-Related Eye Disease Study Research Group
Control Clin Trials 1999 Dec;20(6):573-600. doi: 10.1016/s0197-2456(99)00031-8. PMID: 10588299Free PMC Article
UV radiation ocular exposure dosimetry.
Sliney DH
Doc Ophthalmol 1994-1995;88(3-4):243-54. doi: 10.1007/BF01203678. PMID: 7634993

Prognosis

Cataract.
Allen D
BMJ Clin Evid 2011 Feb 15;2011 PMID: 21718561Free PMC Article
Phacoemulsification in eyes with extreme axial myopia.
Zuberbuhler B, Seyedian M, Tuft S
J Cataract Refract Surg 2009 Feb;35(2):335-40. doi: 10.1016/j.jcrs.2008.10.044. PMID: 19185252
Cataract.
Allen D
BMJ Clin Evid 2008 Aug 14;2008 PMID: 19445812Free PMC Article
The new epidemiology of cataract.
Abraham AG, Condon NG, West Gower E
Ophthalmol Clin North Am 2006 Dec;19(4):415-25. doi: 10.1016/j.ohc.2006.07.008. PMID: 17067897
The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1.
Age-Related Eye Disease Study Research Group
Control Clin Trials 1999 Dec;20(6):573-600. doi: 10.1016/s0197-2456(99)00031-8. PMID: 10588299Free PMC Article

Clinical prediction guides

Association of Behavioral and Clinical Risk Factors With Cataract: A Two-Sample Mendelian Randomization Study.
Jiang C, Melles RB, Sangani P, Hoffmann TJ, Hysi PG, Glymour MM, Jorgenson E, Lachke SA, Choquet H
Invest Ophthalmol Vis Sci 2023 Jul 3;64(10):19. doi: 10.1167/iovs.64.10.19. PMID: 37459064Free PMC Article
Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.
Mi Y, Wei C, Sun L, Liu H, Zhang J, Luo J, Yu X, He J, Ge H, Liu P
Biomed Pharmacother 2023 Jan;157:114048. Epub 2022 Dec 1 doi: 10.1016/j.biopha.2022.114048. PMID: 36463827
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Structure, function and disease relevance of Omega-class glutathione transferases.
Board PG, Menon D
Arch Toxicol 2016 May;90(5):1049-67. Epub 2016 Mar 18 doi: 10.1007/s00204-016-1691-1. PMID: 26993125
The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group.
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY
Arch Ophthalmol 1993 Jun;111(6):831-6. doi: 10.1001/archopht.1993.01090060119035. PMID: 8512486

Recent systematic reviews

Influence of Diet, Dietary Products and Vitamins on Age-Related Cataract Incidence: A Systematic Review.
Falkowska M, Młynarczyk M, Micun Z, Konopińska J, Socha K
Nutrients 2023 Oct 28;15(21) doi: 10.3390/nu15214585. PMID: 37960238Free PMC Article
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
N-acetylcarnosine (NAC) drops for age-related cataract.
Dubois VD, Bastawrous A
Cochrane Database Syst Rev 2017 Feb 28;2(2):CD009493. doi: 10.1002/14651858.CD009493.pub2. PMID: 28245346Free PMC Article
Cataract.
Allen D
BMJ Clin Evid 2011 Feb 15;2011 PMID: 21718561Free PMC Article
Cataract.
Allen D
BMJ Clin Evid 2008 Aug 14;2008 PMID: 19445812Free PMC Article

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