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Age-related cataract

MedGen UID:
11372
•Concept ID:
C0036646
•
Acquired Abnormality
Synonym: Senile cataract
SNOMED CT: Old-age related cataract (39450006); Senile cataract (39450006)
 
HPO: HP:0011141
Monarch Initiative: MONDO:0004847

Definition

A type of cataract (opacification of the lens) that forms during the course of aging. [from HPO]

Professional guidelines

PubMed

Intractable Ocular Diseases and Treatment Progress.
Zhang X, Li S, Tang Y, Guo Y, Gao S
AAPS PharmSciTech 2020 Aug 14;21(6):236. doi: 10.1208/s12249-020-01774-1. PMID: 32803351
The quest for homeopathic and nonsurgical cataract treatment.
Lian RR, Afshari NA
Curr Opin Ophthalmol 2020 Jan;31(1):61-66. doi: 10.1097/ICU.0000000000000631. PMID: 31770163
Management of patients with age-related cataract.
Elliott DB
Ophthalmic Physiol Opt 1999 Mar;19 Suppl 1:S10-5. doi: 10.1016/s0275-5408(98)00065-9. PMID: 10645395

Recent clinical studies

Etiology

Cataract and systemic disease: A review.
Ang MJ, Afshari NA
Clin Exp Ophthalmol 2021 Mar;49(2):118-127. Epub 2021 Jan 10 doi: 10.1111/ceo.13892. PMID: 33426783
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Nutritional effect on age-related cataract formation and progression.
Sella R, Afshari NA
Curr Opin Ophthalmol 2019 Jan;30(1):63-69. doi: 10.1097/ICU.0000000000000537. PMID: 30320615
Age-related cataract.
Asbell PA, Dualan I, Mindel J, Brocks D, Ahmad M, Epstein S
Lancet 2005 Feb 12-18;365(9459):599-609. doi: 10.1016/S0140-6736(05)17911-2. PMID: 15708105
The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group.
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY
Arch Ophthalmol 1993 Jun;111(6):831-6. doi: 10.1001/archopht.1993.01090060119035. PMID: 8512486

Diagnosis

Association of Behavioral and Clinical Risk Factors With Cataract: A Two-Sample Mendelian Randomization Study.
Jiang C, Melles RB, Sangani P, Hoffmann TJ, Hysi PG, Glymour MM, Jorgenson E, Lachke SA, Choquet H
Invest Ophthalmol Vis Sci 2023 Jul 3;64(10):19. doi: 10.1167/iovs.64.10.19. PMID: 37459064Free PMC Article
Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.
Mi Y, Wei C, Sun L, Liu H, Zhang J, Luo J, Yu X, He J, Ge H, Liu P
Biomed Pharmacother 2023 Jan;157:114048. Epub 2022 Dec 1 doi: 10.1016/j.biopha.2022.114048. PMID: 36463827
Association between age-related cataract and blepharoptosis in Korean adults: a population-based study.
Na KS, Jung SK, Jung Y, Han K, Lee J, Paik JS, Yang SW
Sci Rep 2022 Jan 10;12(1):389. doi: 10.1038/s41598-021-04381-7. PMID: 35013495Free PMC Article
N-acetylcarnosine (NAC) drops for age-related cataract.
Dubois VD, Bastawrous A
Cochrane Database Syst Rev 2017 Feb 28;2(2):CD009493. doi: 10.1002/14651858.CD009493.pub2. PMID: 28245346Free PMC Article
Age-related cataract.
Asbell PA, Dualan I, Mindel J, Brocks D, Ahmad M, Epstein S
Lancet 2005 Feb 12-18;365(9459):599-609. doi: 10.1016/S0140-6736(05)17911-2. PMID: 15708105

Therapy

Nutritional effect on age-related cataract formation and progression.
Sella R, Afshari NA
Curr Opin Ophthalmol 2019 Jan;30(1):63-69. doi: 10.1097/ICU.0000000000000537. PMID: 30320615
N-acetylcarnosine (NAC) drops for age-related cataract.
Dubois VD, Bastawrous A
Cochrane Database Syst Rev 2017 Feb 28;2(2):CD009493. doi: 10.1002/14651858.CD009493.pub2. PMID: 28245346Free PMC Article
Solar ultraviolet radiation cataract.
Löfgren S
Exp Eye Res 2017 Mar;156:112-116. Epub 2016 May 31 doi: 10.1016/j.exer.2016.05.026. PMID: 27260484
Age-related cataract.
Asbell PA, Dualan I, Mindel J, Brocks D, Ahmad M, Epstein S
Lancet 2005 Feb 12-18;365(9459):599-609. doi: 10.1016/S0140-6736(05)17911-2. PMID: 15708105
The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1.
Age-Related Eye Disease Study Research Group
Control Clin Trials 1999 Dec;20(6):573-600. doi: 10.1016/s0197-2456(99)00031-8. PMID: 10588299Free PMC Article

Prognosis

The impact of age-related cataract on measures of frailty in an aging global population.
Fukuoka H, Afshari NA
Curr Opin Ophthalmol 2017 Jan;28(1):93-97. doi: 10.1097/ICU.0000000000000338. PMID: 27820747
Myopia and age-related cataract: a systematic review and meta-analysis.
Pan CW, Cheng CY, Saw SM, Wang JJ, Wong TY
Am J Ophthalmol 2013 Nov;156(5):1021-1033.e1. Epub 2013 Aug 12 doi: 10.1016/j.ajo.2013.06.005. PMID: 23938120
Cataract.
Allen D
BMJ Clin Evid 2011 Feb 15;2011 PMID: 21718561Free PMC Article
Cataract.
Allen D
BMJ Clin Evid 2008 Aug 14;2008 PMID: 19445812Free PMC Article
The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1.
Age-Related Eye Disease Study Research Group
Control Clin Trials 1999 Dec;20(6):573-600. doi: 10.1016/s0197-2456(99)00031-8. PMID: 10588299Free PMC Article

Clinical prediction guides

Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.
Mi Y, Wei C, Sun L, Liu H, Zhang J, Luo J, Yu X, He J, Ge H, Liu P
Biomed Pharmacother 2023 Jan;157:114048. Epub 2022 Dec 1 doi: 10.1016/j.biopha.2022.114048. PMID: 36463827
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Cataract.
Allen D
BMJ Clin Evid 2011 Feb 15;2011 PMID: 21718561Free PMC Article
Cataract.
Allen D
BMJ Clin Evid 2008 Aug 14;2008 PMID: 19445812Free PMC Article
The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group.
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY
Arch Ophthalmol 1993 Jun;111(6):831-6. doi: 10.1001/archopht.1993.01090060119035. PMID: 8512486

Recent systematic reviews

Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
N-acetylcarnosine (NAC) drops for age-related cataract.
Dubois VD, Bastawrous A
Cochrane Database Syst Rev 2017 Feb 28;2(2):CD009493. doi: 10.1002/14651858.CD009493.pub2. PMID: 28245346Free PMC Article
Myopia and age-related cataract: a systematic review and meta-analysis.
Pan CW, Cheng CY, Saw SM, Wang JJ, Wong TY
Am J Ophthalmol 2013 Nov;156(5):1021-1033.e1. Epub 2013 Aug 12 doi: 10.1016/j.ajo.2013.06.005. PMID: 23938120
Cataract.
Allen D
BMJ Clin Evid 2011 Feb 15;2011 PMID: 21718561Free PMC Article
Cataract.
Allen D
BMJ Clin Evid 2008 Aug 14;2008 PMID: 19445812Free PMC Article

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