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Benign neoplasm of cornea

MedGen UID:
57579
Concept ID:
C0154026
Neoplastic Process
Synonyms: Benign Cornea Neoplasm; benign cornea neoplasm; Benign Cornea Tumor; benign cornea tumor; benign cornea tumour; Benign Corneal Neoplasm; benign corneal neoplasm; Benign Corneal Tumor; benign corneal tumor; benign corneal tumour; Benign Neoplasm of Cornea; benign neoplasm of cornea; Benign Neoplasm of the Cornea; benign neoplasm of the cornea; Benign tumor of cornea; Benign Tumor of Cornea; benign tumor of cornea; Benign Tumor of the Cornea; benign tumor of the cornea; benign tumour of cornea; benign tumour of the cornea; cornea benign neoplasm
SNOMED CT: Benign tumor of cornea (92070006); Benign neoplasm of cornea (92070006)
 
Monarch Initiative: MONDO:0021452

Definition

A neoplasm that arises from the cornea and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of cornea

Professional guidelines

PubMed

Carbonell D, Mahajan S, Chee SP, Sobolewska B, Agrawal R, Bülow T, Gupta V, Jones NP, Accorinti M, Agarwal M, Batchelor T, Biswas J, Cimino L, tenDam-van Loon NH, de-la-Torre A, Frenkel S, Pe'er J, Kramer M, Miserocchi E, Mochizuki M, Ness T, Rosenbaum JT, Sen HN, Simion M (VRL patient), Sitter H, Vasconcelos-Santos DV, Habot-Wilner Z, Coupland SE, Pulido JS, Smith J, Thorne JE, Zierhut M; Study Group for Vitreoretinal Lymphoma Diagnostics
Ocul Immunol Inflamm 2021 Apr 3;29(3):507-520. Epub 2021 May 19 doi: 10.1080/09273948.2021.1878233. PMID: 34009095
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Lima Cunha D, Arno G, Corton M, Moosajee M
Genes (Basel) 2019 Dec 17;10(12) doi: 10.3390/genes10121050. PMID: 31861090Free PMC Article

Recent clinical studies

Etiology

Wainberg ZA, Enzinger PC, Kang YK, Qin S, Yamaguchi K, Kim IH, Saeed A, Oh SC, Li J, Turk HM, Teixeira A, Borg C, Hitre E, Udrea AA, Cardellino GG, Sanchez RG, Collins H, Mitra S, Yang Y, Catenacci DVT, Lee KW
Lancet Oncol 2022 Nov;23(11):1430-1440. Epub 2022 Oct 14 doi: 10.1016/S1470-2045(22)00603-9. PMID: 36244398
Carbonell D, Mahajan S, Chee SP, Sobolewska B, Agrawal R, Bülow T, Gupta V, Jones NP, Accorinti M, Agarwal M, Batchelor T, Biswas J, Cimino L, tenDam-van Loon NH, de-la-Torre A, Frenkel S, Pe'er J, Kramer M, Miserocchi E, Mochizuki M, Ness T, Rosenbaum JT, Sen HN, Simion M (VRL patient), Sitter H, Vasconcelos-Santos DV, Habot-Wilner Z, Coupland SE, Pulido JS, Smith J, Thorne JE, Zierhut M; Study Group for Vitreoretinal Lymphoma Diagnostics
Ocul Immunol Inflamm 2021 Apr 3;29(3):507-520. Epub 2021 May 19 doi: 10.1080/09273948.2021.1878233. PMID: 34009095
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Mansour AM, Barber JC, Reinecke RD, Wang FM
Surv Ophthalmol 1989 Mar-Apr;33(5):339-58. doi: 10.1016/0039-6257(89)90011-8. PMID: 2655139

Diagnosis

Daher ND, Milman T, Syed ZA
J Fr Ophtalmol 2023 Nov;46(9):1122-1123. Epub 2023 Jul 4 doi: 10.1016/j.jfo.2023.01.039. PMID: 37414670
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Gueudry J, Majo F, Delcampe A, Muraine M
J Fr Ophtalmol 2019 Mar;42(3):e83-e94. Epub 2019 Mar 2 doi: 10.1016/j.jfo.2019.02.001. PMID: 30833005
Singh AD, Schoenfield LA, Bastian BC, Aziz HA, Marino MJ, Biscotti CV
Surv Ophthalmol 2016 Jan-Feb;61(1):59-64. Epub 2015 Aug 12 doi: 10.1016/j.survophthal.2015.07.005. PMID: 26277063

Therapy

Ravisankar R, Mohankumar A, Shivananda N
Indian J Ophthalmol 2023 Apr;71(4):1657-1658. doi: 10.4103/IJO.IJO_2582_22. PMID: 37026321Free PMC Article
Wainberg ZA, Enzinger PC, Kang YK, Qin S, Yamaguchi K, Kim IH, Saeed A, Oh SC, Li J, Turk HM, Teixeira A, Borg C, Hitre E, Udrea AA, Cardellino GG, Sanchez RG, Collins H, Mitra S, Yang Y, Catenacci DVT, Lee KW
Lancet Oncol 2022 Nov;23(11):1430-1440. Epub 2022 Oct 14 doi: 10.1016/S1470-2045(22)00603-9. PMID: 36244398
Loustau M, Anna F, Dréan R, Lecomte M, Langlade-Demoyen P, Caumartin J
Front Immunol 2020;11:1685. Epub 2020 Aug 14 doi: 10.3389/fimmu.2020.01685. PMID: 32922387Free PMC Article
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Midena E, Frizziero L, Parrozzani R
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):121-131. doi: 10.22608/APO.201751. PMID: 28399343

Prognosis

Loustau M, Anna F, Dréan R, Lecomte M, Langlade-Demoyen P, Caumartin J
Front Immunol 2020;11:1685. Epub 2020 Aug 14 doi: 10.3389/fimmu.2020.01685. PMID: 32922387Free PMC Article
Parekh PH, Boente CS, Boente RD, Meeker JW, Carlos WG
Ann Am Thorac Soc 2019 Aug;16(8):957-966. doi: 10.1513/AnnalsATS.201812-848CME. PMID: 31091984
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Słowik M, Biernat MM, Urbaniak-Kujda D, Kapelko-Słowik K, Misiuk-Hojło M
Adv Clin Exp Med 2015 Nov-Dec;24(6):1113-7. doi: 10.17219/acem/50572. PMID: 26771986
Spraul CW, Grossniklaus HE
Curr Opin Ophthalmol 1996 Aug;7(4):28-34. doi: 10.1097/00055735-199608000-00006. PMID: 10163636

Clinical prediction guides

Gross C, Guérin LP, Socol BG, Germain L, Guérin SL
Int J Mol Sci 2023 Aug 24;24(17) doi: 10.3390/ijms241713182. PMID: 37685987Free PMC Article
Magan T, Rapuano CJ, Ayres BD, Skeens HM, Goyal V, Heersink S, Meghpara BB, Syed ZA, Eagle RC Jr, Milman T
Am J Ophthalmol 2021 Sep;229:120-126. Epub 2021 Apr 22 doi: 10.1016/j.ajo.2021.04.006. PMID: 33895150
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Słowik M, Biernat MM, Urbaniak-Kujda D, Kapelko-Słowik K, Misiuk-Hojło M
Adv Clin Exp Med 2015 Nov-Dec;24(6):1113-7. doi: 10.17219/acem/50572. PMID: 26771986
Wollensak G, Green WR, Seiler T
Jpn J Ophthalmol 2002 Mar-Apr;46(2):193-7. doi: 10.1016/s0021-5155(01)00493-2. PMID: 12062226

Recent systematic reviews

Bachert SE, Cornea V, Bocklage T
Breast 2023 Oct;71:99-105. Epub 2023 Aug 7 doi: 10.1016/j.breast.2023.08.002. PMID: 37566996Free PMC Article
Huang S, Yang Y, Ouyang Z, Guo X, Zhan Z, Liu X, Chen Z, Xu J, Yu M
Eur J Dermatol 2022 Sep 1;32(5):589-596. doi: 10.1684/ejd.2022.4317. PMID: 36468718
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119
Chinnery HR, Rajan R, Jiao H, Wu M, Zhang AC, De Silva MEH, Makrai E, Stepp MA, Di Girolamo N, Downie LE
Br J Ophthalmol 2022 Jun;106(6):765-771. Epub 2021 Feb 10 doi: 10.1136/bjophthalmol-2020-318156. PMID: 33568390Free PMC Article
Toro MD, Reibaldi M, Longo A, Avitabile T, Lionetti ME, Tripodi S, Posarelli C, Palomba S
Reprod Biomed Online 2019 Apr;38(4):621-633. Epub 2018 Dec 7 doi: 10.1016/j.rbmo.2018.11.007. PMID: 30795976

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