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Conjunctival tumor

MedGen UID:
3208
•Concept ID:
C0009761
•
Neoplastic Process
Synonyms: Conjunctival Neoplasm; Conjunctival Neoplasms; Neoplasm, Conjunctival; Neoplasms, Conjunctival
SNOMED CT: Neoplasm of conjunctiva (126996004); Tumor of conjunctiva (126996004)
 
Monarch Initiative: MONDO:0020204

Definition

A benign or malignant neoplasm that affects the conjunctiva. Representative examples include papilloma, squamous cell carcinoma, and melanoma. [from NCI]

Professional guidelines

PubMed

Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.
Sripawadkul W, Reyes-Capo D, Zein M, Wylegala A, Albayyat G, Galor A, Karp CL
Ocul Surf 2023 Apr;28:108-114. Epub 2022 Dec 30 doi: 10.1016/j.jtos.2022.12.009. PMID: 36592780Free PMC Article
Interventional Radiotherapy (Brachytherapy) in Eyelid and Ocular Surface Tumors: A Review for Treatment of Naïve and Recurrent Malignancies.
Pagliara MM, Kakkassery V, Fionda B, Lepore D, Kovács G, Tagliaferri L, Blasi MA
Neurosignals 2022 Mar 25;30(S1):1-10. doi: 10.33594/000000505. PMID: 35333486
Topical mitomycin C for the treatment of conjunctival tumor.
Ozcan AA, Sizmaz S, Yagmur M
Ophthalmologica 2007;221(1):14-7. doi: 10.1159/000096516. PMID: 17183195

Recent clinical studies

Etiology

Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.
Sripawadkul W, Reyes-Capo D, Zein M, Wylegala A, Albayyat G, Galor A, Karp CL
Ocul Surf 2023 Apr;28:108-114. Epub 2022 Dec 30 doi: 10.1016/j.jtos.2022.12.009. PMID: 36592780Free PMC Article
Epidemiology and clinical characteristics of congenital choristomas in the ocular adnexa of pediatric patients.
Turanzas NJ, von Holstein SL, Wiencke AK, Toft PB, Heegaard S, Kessel L
Graefes Arch Clin Exp Ophthalmol 2022 Sep;260(9):3069-3074. Epub 2022 Apr 21 doi: 10.1007/s00417-022-05652-3. PMID: 35445875
Interventional Radiotherapy (Brachytherapy) in Eyelid and Ocular Surface Tumors: A Review for Treatment of Naïve and Recurrent Malignancies.
Pagliara MM, Kakkassery V, Fionda B, Lepore D, Kovács G, Tagliaferri L, Blasi MA
Neurosignals 2022 Mar 25;30(S1):1-10. doi: 10.33594/000000505. PMID: 35333486
Fibrous histiocytoma of the conjunctiva.
Kim HJ, Shields CL, Eagle RC Jr, Shields JA
Am J Ophthalmol 2006 Dec;142(6):1036-43. Epub 2006 Sep 1 doi: 10.1016/j.ajo.2006.07.025. PMID: 17157587
Amniotic membrane transplantation for conjunctival tumor.
Chen Z, Yan J, Yang H, Wu Z, Pang Y, Ai S, Mao Y
Yan Ke Xue Bao 2003 Sep;19(3):165-7, 145. PMID: 14574973

Diagnosis

Interventional Radiotherapy (Brachytherapy) in Eyelid and Ocular Surface Tumors: A Review for Treatment of Naïve and Recurrent Malignancies.
Pagliara MM, Kakkassery V, Fionda B, Lepore D, Kovács G, Tagliaferri L, Blasi MA
Neurosignals 2022 Mar 25;30(S1):1-10. doi: 10.33594/000000505. PMID: 35333486
Conjunctival myxoma: A systematic review of a rare tumor.
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119
Ocular Oncology-Primary and Metastatic Malignancies.
Williams BK Jr, Di Nicola M
Med Clin North Am 2021 May;105(3):531-550. Epub 2021 Apr 2 doi: 10.1016/j.mcna.2021.02.005. PMID: 33926645
Swept-Source and Spectral-Domain OCT Imaging of Conjunctival Tumors.
Nahon-Estève S, Martel A, Maschi C, Baillif S, Lassalle S, Caujolle JP
Ophthalmology 2021 Jun;128(6):947-950. Epub 2020 Sep 29 doi: 10.1016/j.ophtha.2020.09.036. PMID: 33007339
Salmon Patch Conjunctival Tumor.
Yong GY, Ab-Ghani S, Hanafi H
J Pediatr 2020 Oct;225:277-278. Epub 2020 Jun 5 doi: 10.1016/j.jpeds.2020.05.062. PMID: 32511962

Therapy

Corneal Microaneurysm-A Vascular Feature of Conjunctival Squamous Intraepithelial Neoplasia.
Stöckl V, Franchi A, Palme C, Steger B
Cornea 2024 Aug 1;43(8):1062-1064. Epub 2024 Apr 18 doi: 10.1097/ICO.0000000000003549. PMID: 38635480
Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.
Sripawadkul W, Reyes-Capo D, Zein M, Wylegala A, Albayyat G, Galor A, Karp CL
Ocul Surf 2023 Apr;28:108-114. Epub 2022 Dec 30 doi: 10.1016/j.jtos.2022.12.009. PMID: 36592780Free PMC Article
Clinical Management of Squamous Cell Carcinoma of the Conjunctiva.
Röck T, Bartz-Schmidt KU, Bramkamp M, Milla J, Bösmüller HC, Röck D
Am J Case Rep 2020 Feb 1;21:e919751. doi: 10.12659/AJCR.919751. PMID: 32005796Free PMC Article
Unilateral conjunctival infiltration of Adult T-cell leukemia/lymphoma. Case report and literature review.
Shimono J, Kaino S, Okada K, Oshimi K, Ishida Y, Takahashi T, Miyagishima T, Teshima T
J Clin Exp Hematop 2017;57(3):143-146. doi: 10.3960/jslrt.17027. PMID: 29279551Free PMC Article
Topical mitomycin C for extensive, recurrent conjunctival-corneal squamous cell carcinoma.
Shields CL, Naseripour M, Shields JA
Am J Ophthalmol 2002 May;133(5):601-6. doi: 10.1016/s0002-9394(02)01400-9. PMID: 11992855

Prognosis

Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.
Sripawadkul W, Reyes-Capo D, Zein M, Wylegala A, Albayyat G, Galor A, Karp CL
Ocul Surf 2023 Apr;28:108-114. Epub 2022 Dec 30 doi: 10.1016/j.jtos.2022.12.009. PMID: 36592780Free PMC Article
Epidemiology and clinical characteristics of congenital choristomas in the ocular adnexa of pediatric patients.
Turanzas NJ, von Holstein SL, Wiencke AK, Toft PB, Heegaard S, Kessel L
Graefes Arch Clin Exp Ophthalmol 2022 Sep;260(9):3069-3074. Epub 2022 Apr 21 doi: 10.1007/s00417-022-05652-3. PMID: 35445875
Ocular Oncology-Primary and Metastatic Malignancies.
Williams BK Jr, Di Nicola M
Med Clin North Am 2021 May;105(3):531-550. Epub 2021 Apr 2 doi: 10.1016/j.mcna.2021.02.005. PMID: 33926645
Unilateral conjunctival infiltration of Adult T-cell leukemia/lymphoma. Case report and literature review.
Shimono J, Kaino S, Okada K, Oshimi K, Ishida Y, Takahashi T, Miyagishima T, Teshima T
J Clin Exp Hematop 2017;57(3):143-146. doi: 10.3960/jslrt.17027. PMID: 29279551Free PMC Article
Fibrous histiocytoma of the conjunctiva.
Kim HJ, Shields CL, Eagle RC Jr, Shields JA
Am J Ophthalmol 2006 Dec;142(6):1036-43. Epub 2006 Sep 1 doi: 10.1016/j.ajo.2006.07.025. PMID: 17157587

Clinical prediction guides

Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.
Sripawadkul W, Reyes-Capo D, Zein M, Wylegala A, Albayyat G, Galor A, Karp CL
Ocul Surf 2023 Apr;28:108-114. Epub 2022 Dec 30 doi: 10.1016/j.jtos.2022.12.009. PMID: 36592780Free PMC Article
Unilateral conjunctival infiltration of Adult T-cell leukemia/lymphoma. Case report and literature review.
Shimono J, Kaino S, Okada K, Oshimi K, Ishida Y, Takahashi T, Miyagishima T, Teshima T
J Clin Exp Hematop 2017;57(3):143-146. doi: 10.3960/jslrt.17027. PMID: 29279551Free PMC Article
Conjunctival tumors in children: histopathologic diagnosis in 165 cases.
Zimmermann-Paiz MA, García de la Riva JC
Arq Bras Oftalmol 2015 Nov-Dec;78(6):337-9. doi: 10.5935/0004-2749.20150089. PMID: 26677032
Fibrous histiocytoma of the conjunctiva.
Kim HJ, Shields CL, Eagle RC Jr, Shields JA
Am J Ophthalmol 2006 Dec;142(6):1036-43. Epub 2006 Sep 1 doi: 10.1016/j.ajo.2006.07.025. PMID: 17157587
Amniotic membrane transplantation for conjunctival tumor.
Chen Z, Yan J, Yang H, Wu Z, Pang Y, Ai S, Mao Y
Yan Ke Xue Bao 2003 Sep;19(3):165-7, 145. PMID: 14574973

Recent systematic reviews

Conjunctival myxoma: A systematic review of a rare tumor.
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119

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