Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Non-Neoplastic Bone Disorder

MedGen UID:: 277422
•Concept ID:: C1334997
•: Disease or Syndrome

Definition

A non-neoplastic disorder that affects the bone or articular cartilage. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNon-Neoplastic Bone Disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Connective and Soft Tissue Disorder
        Connective tissue disorder
        Non-Neoplastic Bone Disorder
        Achondroplasia
        Thanatophoric dysplasia
        Thanatophoric dysplasia type 1
        Thanatophoric dysplasia, Glasgow variant
        Thanatophoric dysplasia, type 2
        Acroosteolysis
        Hajdu-Cheney syndrome
        Osteolytic defect of thumb phalanx
        Osteolytic defects of the phalanges of the 2nd finger
        Osteolytic defects of the phalanges of the 3rd finger
        Osteolytic defects of the phalanges of the 4th finger
        Osteolytic defects of the phalanges of the 5th finger
        Bone development disease
        Congenital pectus excavatum
        Disappearing bone disease
        Dysostosis
        Acrofacial dysostosis
        Congenital pseudoarthrosis of clavicle
        Crouzon syndrome
        Focal dermal hypoplasia
        Klippel-Feil syndrome
        Orofaciodigital syndrome
        Rubinstein-Taybi syndrome
        Spondylocostal dysostosis
        Synostosis
        Gigantism
        Gorlin syndrome
        Basal cell nevus syndrome 1
        Basal cell nevus syndrome 2
        Lower limb asymmetry
        Hemiatrophy of lower limb
        Hemihypertrophy of lower limb
        Marfan syndrome
        Loeys-Dietz Syndrome Type 2
        Odontoid hypoplasia
        Osteochondrodysplasia
        Chondrodysplasia Blomstrand type
        Chondrodysplasia punctata
        Cleidocranial dysostosis
        Desbuquois syndrome
        Diaphyseal dysplasia
        Ellis-van Creveld syndrome
        Enchondromatosis
        FGFR3 Chondrodysplasia
        Fibrous dysplasia
        Hyperostosis interna frontalis
        Hypochondroplasia
        Increased bone mineral density
        Infantile cortical hyperostosis
        Kashin-Beck disease
        Langer-Giedion syndrome
        Mesomelic dysplasia
        Osteochondroma
        Osteogenesis imperfecta
        Proximal femoral epiphysiolysis
        Pyknodysostosis
        SAPHO syndrome
        Short rib-polydactyly syndrome
        Pectus carinatum
        Superior pectus carinatum
        Platybasia
        Proteus syndrome
        Severe short stature
        Cockayne syndrome
        Congenital hypothyroidism
        Laron-type isolated somatotropin defect
        Mulibrey nanism syndrome
        Pituitary dwarfism
        Russell-Silver syndrome
        Weill-Marchesani syndrome
        Bone Infarction
        Bone necrosis
        Aseptic Necrosis of Bone
        Aseptic Necrosis of Head and Neck of Femur
        Osteonecrosis of head of humerus
        Avascular necrosis
        Avascular Necrosis of Femur
        Avascular Necrosis of Humerus
        Avascular Necrosis of the Joint
        Juvenile aseptic necrosis
        Bisphosphonate-Associated Osteonecrosis
        Coxa plana
        Femur Head Necrosis
        Idiopathic phalangeal acro-osteolysis
        Mueller-weiss syndrome
        Osteochondritis dissecans
        Osteonecrosis of jaw caused by bisphosphonate
        Osteonecrosis of the jaw
        Osteoradionecrosis
        Osteoradionecrosis of the mandible
        Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans
        Bone Rosai-Dorfman-Destombes Disease
        Cartilage development disorder
        Congenital deformity of hip joint
        Congenital pseudoarthrosis of the tibia
        Deformity of spine
        Hyperlordosis
        Lumbar hyperlordosis
        Kyphosis
        Congenital kyphosis
        Juvenile osteochondrosis of spine
        Kyphoscoliosis
        Kyphosis of thoracic spine
        Lumbar Spine Kyphosis
        Scoliosis
        Compensatory scoliosis
        Progressive congenital scoliosis
        Thoracolumbar scoliosis
        Enthesitis
        Exostoses
        Exostoses of hand bones
        Exostoses of the forearm bones
        Exostoses of the radius
        Exostosis of external ear canal
        Heberden node
        Heel spur
        Multiple congenital exostosis
        Exostoses, multiple, type 2
        Exostoses, multiple, type III
        Multiple digital exostoses
        Multiple long-bone exostoses
        Osteophyte of bone
        Pelvic bone exostoses
        Rib exostoses
        Scapular exostoses
        Hyperostosis
        Cranial hyperostosis
        Calvarial hyperostosis
        Hyperostosis cranialis interna
        Craniodiaphyseal dysplasia
        Craniotubular Hyperostosis
        Diffuse idiopathic skeletal hyperostosis
        Hyperostosis, Sternocostoclavicular
        Hyperphosphatasemia tarda
        Increased skull ossification
        Dense calvaria
        Increased spinal bone density
        Vertebral hyperostosis
        Infection of bone
        Infectious disorder of joint
        Osteomyelitis
        Chronic multifocal osteomyelitis
        Foot osteomyelitis
        Mandibular osteomyelitis
        Mastoiditis
        Osteomyelitis leading to amputation due to slow healing fractures
        Petrositis
        Pott puffy tumor
        Salmonella osteomyelitis
        Metabolic bone disorder
        Bone Demineralization, Pathologic
        Decalcification, Pathologic
        Bone Paget disease
        Hyperphosphatasemia with bone disease
        Sternal Paget Disease
        Mucolipidosis
        Deficiency of N-acetylglucosamine-1-phosphotransferase
        GNPTG-mucolipidosis
        Mucolipidosis type II
        Mucolipidosis Type IIIA
        Mucolipidosis type IV
        Sialidosis
        Osteomalacia
        Tumor-induced osteomalacia
        Osteoporosis
        Generalized osteoporosis
        Idiopathic juvenile osteoporosis
        Localized osteoporosis
        Nephrolithiasis/osteoporosis, hypophosphatemic
        Postmenopausal osteoporosis
        Pregnancy associated osteoporosis
        X-linked osteoporosis with fractures
        Pseudogout
        Pseudohypoparathyroidism
        Pseudohypoparathyroidism type 1B
        Pseudohypoparathyroidism type 1C
        Pseudohypoparathyroidism type I A
        Pseudohypoparathyroidism type II
        Pseudopseudohypoparathyroidism
        Rickets
        Acquired Rickets
        Adult Rickets
        Calcium Deficiency Rickets
        Childhood Rickets
        Chronic kidney disease mineral and bone disorder
        Dent disease
        Familial X-linked hypophosphatemic vitamin D refractory rickets
        Hypocalcemic rickets
        Hypophosphatemic rickets
        Nutritional Rickets
        Vitamin D Dependent Rickets 2
        Vitamin D-dependent rickets
        Vitamin D-dependent rickets type II with alopecia
        Vitamin D-dependent rickets, type 2
        Osteitis fibrosa
        Osteochondritis
        Osteochondrosis
        Familial osteoarthropathy of the fingers
        Freiberg disease
        Juvenile osteochondritis
        Morbus Osgood-Schlatter
        Legg-Calve-Perthes disease
        Medial condensing osteitis of the clavicle
        Morbus Kienboeck
        Osteochondritis of tarsal/metatarsal bone
        Osteochondrosis of Spine
        Panner disease
        Sinding-Larsen-Johansson disease
        Osteopetrosis
        12q14 microdeletion syndrome
        Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome
        Autosomal dominant osteopetrosis
        Autosomal dominant osteopetrosis 1
        Autosomal dominant osteopetrosis 2
        Autosomal recessive osteopetrosis
        Autosomal recessive osteopetrosis 1
        Autosomal recessive osteopetrosis 8
        Autosomal recessive osteopetrosis 6
        Autosomal recessive osteopetrosis 7
        Axial osteosclerosis
        Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness
        Dermatofibrosis lenticularis disseminata
        Dysosteosclerosis
        Early-onset calcifying leukoencephalopathy-skeletal dysplasia
        Infantile osteopetrosis with neuroaxonal dysplasia
        Isolated osteopoikilosis
        Leukocyte adhesion deficiency 3
        Melorheostosis
        Melorheostosis with osteopoikilosis
        Osteoclast-Rich Osteopetrosis
        Osteopathia striata with cranial sclerosis
        Osteopetrosis with renal tubular acidosis
        Osteosclerotic metaphyseal dysplasia
        Osteopoikilosis
        Spinal Degenerative Disorder
        Intervertebral disk degeneration
        Cervical disk degenerative disorder
        Degeneration of lumbar intervertebral disc
        Thoracic disk degenerative disorder
        Spinal arthritis deformans
        Spondylolisthesis
        Spondylolisthesis at L5-S1
        Spondylolysis
        Congenital Spondylolysis
        Congenital spondylolysis of lumbosacral region
        Tibia vara

Professional guidelines

PubMed

Differential diagnosis of hip pain in children referred to a specialist bone tumour service.

Choraria A, O'Donnell P, Saifuddin A
Br J Radiol 2022 Jun 1;95(1134):20211397. Epub 2022 Mar 28 doi: 10.1259/bjr.20211397. PMID: 35343784 Free PMC Article

Differential diagnosis of T2 hypointense masses in musculoskeletal MRI.

Finkelstein D, Foremny G, Singer A, Clifford P, Pretell-Mazzini J, Kerr DA, Subhawong TK
Skeletal Radiol 2021 Oct;50(10):1981-1994. Epub 2021 Mar 2 doi: 10.1007/s00256-021-03711-0. PMID: 33651128

Tumor-like Lesions of Bone and Soft Tissues and Imaging Tips for Differential Diagnosis.

Örgüç S, Arkun R
Semin Musculoskelet Radiol 2020 Dec;24(6):613-626. Epub 2020 Dec 11 doi: 10.1055/s-0040-1721378. PMID: 33307580

See all (14)

Recent clinical studies

Etiology

Percutaneous spine biopsy: reaching those hard-to-reach places.

Saththianathan M, Mallinson PI, Munk PL, Heran MKS
Skeletal Radiol 2023 Oct;52(10):1803-1814. Epub 2022 Jul 15 doi: 10.1007/s00256-022-04120-7. PMID: 35840815

A review on the role of PRNCR1 in human disorders with an especial focus on cancer.

Ghafouri-Fard S, Khoshbakht T, Hussen BM, Baniahmad A, Taheri M, Salimi A
Pathol Res Pract 2022 Sep;237:154026. Epub 2022 Jul 13 doi: 10.1016/j.prp.2022.154026. PMID: 35849867

Marrow outside marrow: imaging of extramedullary haematopoiesis.

Malla S, Razik A, Das CJ, Naranje P, Kandasamy D, Kumar R
Clin Radiol 2020 Aug;75(8):565-578. Epub 2020 Jan 20 doi: 10.1016/j.crad.2019.12.016. PMID: 31973940

Antiestrogens--tamoxifen, SERMs and beyond.

Dhingra K
Invest New Drugs 1999;17(3):285-311. doi: 10.1023/a:1006348907994. PMID: 10665480

Cherubism: clinicopathologic features.

Yamaguchi T, Dorfman HD, Eisig S
Skeletal Radiol 1999 Jun;28(6):350-3. doi: 10.1007/s002560050530. PMID: 10450884

See all (112)

Diagnosis

Pediatric focal calvarial lesions: an illustrated review.

McDermott T, Amarneh M, Sato Y, Watal P, Charmi V, Fuortes M, Faruqui S, Sato TS
Pediatr Radiol 2023 Dec;53(13):2699-2711. Epub 2023 Nov 15 doi: 10.1007/s00247-023-05795-3. PMID: 37964037

Lipocalin-2: Structure, function, distribution and role in metabolic disorders.

Jaberi SA, Cohen A, D'Souza C, Abdulrazzaq YM, Ojha S, Bastaki S, Adeghate EA
Biomed Pharmacother 2021 Oct;142:112002. Epub 2021 Aug 27 doi: 10.1016/j.biopha.2021.112002. PMID: 34463264

Distinguishing autoimmune myelofibrosis from primary myelofibrosis.

Marcellino B, El Jamal SM, Mascarenhas JO
Clin Adv Hematol Oncol 2018 Sep;16(9):619-626. PMID: 30256778

Endocrine pathology: past, present and future.

Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721

Gorham-Stout disease.

Mavrogenis AF, Zambirinis CP, Dimitriadis PA, Tsakanikas A, Papagelopoulos PJ
J Surg Orthop Adv 2010 Summer;19(2):85-90. PMID: 20727303

See all (244)

Therapy

Systematic review of proximal femoral arthroplasty for non-neoplastic conditions.

Korim MT, Esler CN, Ashford RU
J Arthroplasty 2014 Nov;29(11):2117-21. Epub 2014 Jun 21 doi: 10.1016/j.arth.2014.06.012. PMID: 25115232

Gorham-Stout disease.

Mavrogenis AF, Zambirinis CP, Dimitriadis PA, Tsakanikas A, Papagelopoulos PJ
J Surg Orthop Adv 2010 Summer;19(2):85-90. PMID: 20727303

Current and emerging concepts in tumour metastasis.

Coghlin C, Murray GI
J Pathol 2010 Sep;222(1):1-15. doi: 10.1002/path.2727. PMID: 20681009

The central nervous system complications of bone marrow transplantation in children.

Yoshida S, Hayakawa K, Yamamoto A, Kuroda H, Imashuku S
Eur Radiol 2008 Oct;18(10):2048-59. Epub 2008 May 20 doi: 10.1007/s00330-008-1000-3. PMID: 18491111

Antiestrogens--tamoxifen, SERMs and beyond.

Dhingra K
Invest New Drugs 1999;17(3):285-311. doi: 10.1023/a:1006348907994. PMID: 10665480

See all (49)

Prognosis

A Rare Skeletal Disorder, Fibrous Dysplasia: A Review of Its Pathogenesis and Therapeutic Prospects.

Kim HY, Shim JH, Heo CY
Int J Mol Sci 2023 Oct 26;24(21) doi: 10.3390/ijms242115591. PMID: 37958575 Free PMC Article

Mechanisms and clinical implications of intervertebral disc calcification.

Zehra U, Tryfonidou M, Iatridis JC, Illien-Jünger S, Mwale F, Samartzis D
Nat Rev Rheumatol 2022 Jun;18(6):352-362. Epub 2022 May 9 doi: 10.1038/s41584-022-00783-7. PMID: 35534553 Free PMC Article

An update on imaging of Paget's sarcoma.

Tilden W, Saifuddin A
Skeletal Radiol 2021 Jul;50(7):1275-1290. Epub 2021 Jan 2 doi: 10.1007/s00256-020-03682-8. PMID: 33386903

Distinguishing autoimmune myelofibrosis from primary myelofibrosis.

Marcellino B, El Jamal SM, Mascarenhas JO
Clin Adv Hematol Oncol 2018 Sep;16(9):619-626. PMID: 30256778

Endocrine pathology: past, present and future.

Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721

See all (100)

Clinical prediction guides

Mechanisms and clinical implications of intervertebral disc calcification.

Zehra U, Tryfonidou M, Iatridis JC, Illien-Jünger S, Mwale F, Samartzis D
Nat Rev Rheumatol 2022 Jun;18(6):352-362. Epub 2022 May 9 doi: 10.1038/s41584-022-00783-7. PMID: 35534553 Free PMC Article

Differential diagnosis of T2 hypointense masses in musculoskeletal MRI.

Finkelstein D, Foremny G, Singer A, Clifford P, Pretell-Mazzini J, Kerr DA, Subhawong TK
Skeletal Radiol 2021 Oct;50(10):1981-1994. Epub 2021 Mar 2 doi: 10.1007/s00256-021-03711-0. PMID: 33651128

microRNA-140: A miRNA with diverse roles in human diseases.

Ghafouri-Fard S, Bahroudi Z, Shoorei H, Abak A, Ahin M, Taheri M
Biomed Pharmacother 2021 Mar;135:111256. Epub 2021 Feb 1 doi: 10.1016/j.biopha.2021.111256. PMID: 33434855

Endocrine pathology: past, present and future.

Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721

Systematic review of proximal femoral arthroplasty for non-neoplastic conditions.

Korim MT, Esler CN, Ashford RU
J Arthroplasty 2014 Nov;29(11):2117-21. Epub 2014 Jun 21 doi: 10.1016/j.arth.2014.06.012. PMID: 25115232

See all (78)

Recent systematic reviews

Nasal glial heterotopia: a systematic review of the literature and case report.

Gallego Compte M, Menter T, Guertler N, Negoias S
Acta Otorhinolaryngol Ital 2022 Aug;42(4):317-324. doi: 10.14639/0392-100X-N1977. PMID: 36254649 Free PMC Article

Sarcoidosis of the Skull: A Systematic Review.

Robles LA, Matilla AF, Covarrubias MP
World Neurosurg 2020 Jul;139:387-394. Epub 2020 Apr 24 doi: 10.1016/j.wneu.2020.04.114. PMID: 32339731

Systematic review of proximal femoral arthroplasty for non-neoplastic conditions.

Korim MT, Esler CN, Ashford RU
J Arthroplasty 2014 Nov;29(11):2117-21. Epub 2014 Jun 21 doi: 10.1016/j.arth.2014.06.012. PMID: 25115232

See all (3)

MedGen

National Center for Biotechnology Information

Send to:

Non-Neoplastic Bone Disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Recent activity