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Calcium Deficiency Rickets

MedGen UID:
1384003
Concept ID:
C4329608
Disease or Syndrome

Definition

Rickets due to low calcium concentrations, the cause of which can be nutritional or genetic. [from NCI]

Professional guidelines

PubMed

Uday S, Högler W
Indian J Med Res 2020 Oct;152(4):356-367. doi: 10.4103/ijmr.IJMR_1961_19. PMID: 33380700Free PMC Article
Haffner D, Emma F, Eastwood DM, Duplan MB, Bacchetta J, Schnabel D, Wicart P, Bockenhauer D, Santos F, Levtchenko E, Harvengt P, Kirchhoff M, Di Rocco F, Chaussain C, Brandi ML, Savendahl L, Briot K, Kamenicky P, Rejnmark L, Linglart A
Nat Rev Nephrol 2019 Jul;15(7):435-455. doi: 10.1038/s41581-019-0152-5. PMID: 31068690Free PMC Article
Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W
J Clin Endocrinol Metab 2016 Feb;101(2):394-415. Epub 2016 Jan 8 doi: 10.1210/jc.2015-2175. PMID: 26745253Free PMC Article

Recent clinical studies

Etiology

Bourassa MW, Abrams SA, Belizán JM, Boy E, Cormick G, Quijano CD, Gibson S, Gomes F, Hofmeyr GJ, Humphrey J, Kraemer K, Lividini K, Neufeld LM, Palacios C, Shlisky J, Thankachan P, Villalpando S, Weaver CM
Ann N Y Acad Sci 2022 May;1511(1):40-58. Epub 2022 Jan 31 doi: 10.1111/nyas.14743. PMID: 35103316Free PMC Article
Wesselsky V, Kitz C, Jakob F, Eulert J, Raab P
Int Orthop 2016 Apr;40(4):653-8. Epub 2015 Jul 30 doi: 10.1007/s00264-015-2911-7. PMID: 26224615
Thacher TD, Fischer PR, Pettifor JM
Arch Dis Child 2014 Sep;99(9):807-11. Epub 2014 Apr 19 doi: 10.1136/archdischild-2013-305275. PMID: 24748637Free PMC Article
Pettifor JM
Pediatr Endocrinol Rev 2013 Jun;10 Suppl 2:347-53. PMID: 23858618
Pettifor JM
Indian J Med Res 2008 Mar;127(3):245-9. PMID: 18497438

Diagnosis

Jones KDJ, Hachmeister CU, Khasira M, Cox L, Schoenmakers I, Munyi C, Nassir HS, Hünten-Kirsch B, Prentice A, Berkley JA
Matern Child Nutr 2018 Jan;14(1) Epub 2017 May 3 doi: 10.1111/mcn.12452. PMID: 28470840Free PMC Article
Braithwaite VS, Freeman R, Greenwood CL, Summers DM, Nigdikar S, Lavy CBD, Offiah AC, Bishop NJ, Cashman J, Prentice A
Osteoporos Int 2016 Jul;27(7):2367-2372. Epub 2016 Apr 8 doi: 10.1007/s00198-016-3541-7. PMID: 27059923Free PMC Article
Thacher TD
Endocr Dev 2003;6:105-25. doi: 10.1159/000072773. PMID: 12964429
Teotia M, Teotia SP, Singh KP
Indian J Pediatr 1998 May-Jun;65(3):371-81. doi: 10.1007/BF02761130. PMID: 10771988
Maltz HE, Fish MB, Holliday MA
Pediatrics 1970 Dec;46(6):865-70. PMID: 5491440

Therapy

Bouillon R, Antonio L
J Steroid Biochem Mol Biol 2020 Apr;198:105563. Epub 2019 Dec 3 doi: 10.1016/j.jsbmb.2019.105563. PMID: 31809867
Sharp CA, Magnusson P, Davie MW, Oginni LM
Trop Med Int Health 2015 Apr;20(4):408-10. Epub 2014 Dec 19 doi: 10.1111/tmi.12444. PMID: 25430923
Allgrove J, Mughal MZ
Arch Dis Child 2014 Sep;99(9):794-5. Epub 2014 Jun 19 doi: 10.1136/archdischild-2014-306465. PMID: 24947283
Thacher TD, Fischer PR, Pettifor JM
Arch Dis Child 2014 Sep;99(9):807-11. Epub 2014 Apr 19 doi: 10.1136/archdischild-2013-305275. PMID: 24748637Free PMC Article
Pettifor JM
Pediatr Endocrinol Rev 2013 Jun;10 Suppl 2:347-53. PMID: 23858618

Prognosis

Wesselsky V, Kitz C, Jakob F, Eulert J, Raab P
Int Orthop 2016 Apr;40(4):653-8. Epub 2015 Jul 30 doi: 10.1007/s00264-015-2911-7. PMID: 26224615
Braithwaite V, Jarjou LM, Goldberg GR, Jones H, Pettifor JM, Prentice A
Bone 2012 Jan;50(1):218-25. Epub 2011 Oct 17 doi: 10.1016/j.bone.2011.10.009. PMID: 22023931Free PMC Article
Prentice A, Ceesay M, Nigdikar S, Allen SJ, Pettifor JM
Bone 2008 Apr;42(4):788-97. Epub 2007 Dec 8 doi: 10.1016/j.bone.2007.11.014. PMID: 18234575
Thacher TD
Endocr Dev 2003;6:105-25. doi: 10.1159/000072773. PMID: 12964429
Teotia M, Teotia SP, Singh KP
Indian J Pediatr 1998 May-Jun;65(3):371-81. doi: 10.1007/BF02761130. PMID: 10771988

Clinical prediction guides

Thacher TD, Bommersbach TJ, Pettifor JM, Isichei CO, Fischer PR
J Pediatr 2015 Jul;167(1):148-54.e1. Epub 2015 Mar 19 doi: 10.1016/j.jpeds.2015.02.008. PMID: 25799193
Thacher TD, Fischer PR, Pettifor JM
Arch Dis Child 2014 Sep;99(9):807-11. Epub 2014 Apr 19 doi: 10.1136/archdischild-2013-305275. PMID: 24748637Free PMC Article
Braithwaite V, Jarjou LM, Goldberg GR, Jones H, Pettifor JM, Prentice A
Bone 2012 Jan;50(1):218-25. Epub 2011 Oct 17 doi: 10.1016/j.bone.2011.10.009. PMID: 22023931Free PMC Article
Arnaud J, Pettifor JM, Cimma JP, Fischer PR, Craviari T, Meisner C, Haque S; Convergence Rickets Group
Ann Trop Paediatr 2007 Sep;27(3):185-91. doi: 10.1179/146532807X220299. PMID: 17716446

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