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Postmenopausal osteoporosis

MedGen UID:
10498
•Concept ID:
C0029458
•
Disease or Syndrome
Synonyms: BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS; OSTEOPOROSIS, INVOLUTIONAL
SNOMED CT: Postmenopausal osteoporosis (102447009); Type I osteoporosis (32369003); Type 1 osteoporosis (32369003); Menopausal osteoporosis (32369003)
 
Monarch Initiative: MONDO:0008159
OMIM®: 120160; 166710

Definition

Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency. [from MONDO]

Professional guidelines

PubMed

Long-Term Treatment of Postmenopausal Osteoporosis.
Brown JP
Endocrinol Metab (Seoul) 2021 Jun;36(3):544-552. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.301. PMID: 34154042Free PMC Article
Bone Health and Osteoporosis Prevention and Treatment.
Muñoz M, Robinson K, Shibli-Rahhal A
Clin Obstet Gynecol 2020 Dec;63(4):770-787. doi: 10.1097/GRF.0000000000000572. PMID: 33017332
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/AMERICAN COLLEGE OF ENDOCRINOLOGY CLINICAL PRACTICE GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS-2020 UPDATE.
Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah-Pollack R, McClung M, Wimalawansa SJ, Watts NB
Endocr Pract 2020 May;26(Suppl 1):1-46. doi: 10.4158/GL-2020-0524SUPPL. PMID: 32427503

Recent clinical studies

Etiology

Interaction between bone and immune cells: Implications for postmenopausal osteoporosis.
Fischer V, Haffner-Luntzer M
Semin Cell Dev Biol 2022 Mar;123:14-21. Epub 2021 May 20 doi: 10.1016/j.semcdb.2021.05.014. PMID: 34024716
Long-Term Treatment of Postmenopausal Osteoporosis.
Brown JP
Endocrinol Metab (Seoul) 2021 Jun;36(3):544-552. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.301. PMID: 34154042Free PMC Article
Postmenopausal Osteoporosis: Latest Guidelines.
Arceo-Mendoza RM, Camacho PM
Endocrinol Metab Clin North Am 2021 Jun;50(2):167-178. doi: 10.1016/j.ecl.2021.03.009. PMID: 34023036
Bone Health and Osteoporosis Prevention and Treatment.
Muñoz M, Robinson K, Shibli-Rahhal A
Clin Obstet Gynecol 2020 Dec;63(4):770-787. doi: 10.1097/GRF.0000000000000572. PMID: 33017332
Osteoporosis in Older Adults.
Johnston CB, Dagar M
Med Clin North Am 2020 Sep;104(5):873-884. Epub 2020 Jul 15 doi: 10.1016/j.mcna.2020.06.004. PMID: 32773051

Diagnosis

Management of Postmenopausal Osteoporosis: ACOG Clinical Practice Guideline No. 2.
ACOG Committee on Clinical Practice Guidelines–Gynecology
Obstet Gynecol 2022 Apr 1;139(4):698-717. doi: 10.1097/AOG.0000000000004730. PMID: 35594133
Management of osteoporosis in postmenopausal women: the 2021 position statement of The North American Menopause Society.
Menopause 2021 Sep 1;28(9):973-997. doi: 10.1097/GME.0000000000001831. PMID: 34448749
Postmenopausal Osteoporosis: Latest Guidelines.
Arceo-Mendoza RM, Camacho PM
Endocrinol Metab Clin North Am 2021 Jun;50(2):167-178. doi: 10.1016/j.ecl.2021.03.009. PMID: 34023036
Bone Health and Osteoporosis Prevention and Treatment.
Muñoz M, Robinson K, Shibli-Rahhal A
Clin Obstet Gynecol 2020 Dec;63(4):770-787. doi: 10.1097/GRF.0000000000000572. PMID: 33017332
Use of bone turnover markers in postmenopausal osteoporosis.
Eastell R, Szulc P
Lancet Diabetes Endocrinol 2017 Nov;5(11):908-923. Epub 2017 Jul 7 doi: 10.1016/S2213-8587(17)30184-5. PMID: 28689768

Therapy

Drug efficacy and safety of denosumab, teriparatide, zoledronic acid, and ibandronic acid for the treatment of postmenopausal osteoporosis: a network meta-analysis of randomized controlled trials.
Wang WY, Chen LH, Ma WJ, You RX
Eur Rev Med Pharmacol Sci 2023 Sep;27(17):8253-8268. doi: 10.26355/eurrev_202309_33586. PMID: 37750653
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials.
Ma ML, Ma ZJ, He YL, Sun H, Yang B, Ruan BJ, Zhan WD, Li SX, Dong H, Wang YX
Front Public Health 2022;10:979649. Epub 2022 Aug 11 doi: 10.3389/fpubh.2022.979649. PMID: 36033779Free PMC Article
Effects of physical exercise on bone mineral density in older postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.
Hejazi K, Askari R, Hofmeister M
Arch Osteoporos 2022 Jul 27;17(1):102. doi: 10.1007/s11657-022-01140-7. PMID: 35896850
Postmenopausal osteoporosis: Assessment and management.
Rizzoli R
Best Pract Res Clin Endocrinol Metab 2018 Oct;32(5):739-757. Epub 2018 Sep 22 doi: 10.1016/j.beem.2018.09.005. PMID: 30449552
Exercise for preventing and treating osteoporosis in postmenopausal women.
Howe TE, Shea B, Dawson LJ, Downie F, Murray A, Ross C, Harbour RT, Caldwell LM, Creed G
Cochrane Database Syst Rev 2011 Jul 6;(7):CD000333. doi: 10.1002/14651858.CD000333.pub2. PMID: 21735380

Prognosis

One Year of Romosozumab Followed by Two Years of Denosumab Maintains Fracture Risk Reductions: Results of the FRAME Extension Study.
Lewiecki EM, Dinavahi RV, Lazaretti-Castro M, Ebeling PR, Adachi JD, Miyauchi A, Gielen E, Milmont CE, Libanati C, Grauer A
J Bone Miner Res 2019 Mar;34(3):419-428. Epub 2018 Dec 3 doi: 10.1002/jbmr.3622. PMID: 30508316
Menopause in CKD.
Vellanki K, Hou S
Am J Kidney Dis 2018 May;71(5):710-719. Epub 2018 Mar 9 doi: 10.1053/j.ajkd.2017.12.019. PMID: 29530509
10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension.
Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwiński E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster JY, Roux C, Malouf J, Bradley MN, Daizadeh NS, Wang A, Dakin P, Pannacciulli N, Dempster DW, Papapoulos S
Lancet Diabetes Endocrinol 2017 Jul;5(7):513-523. Epub 2017 May 22 doi: 10.1016/S2213-8587(17)30138-9. PMID: 28546097
Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures.
Marshall D, Johnell O, Wedel H
BMJ 1996 May 18;312(7041):1254-9. doi: 10.1136/bmj.312.7041.1254. PMID: 8634613Free PMC Article
Vertebral fracture assessment using a semiquantitative technique.
Genant HK, Wu CY, van Kuijk C, Nevitt MC
J Bone Miner Res 1993 Sep;8(9):1137-48. doi: 10.1002/jbmr.5650080915. PMID: 8237484

Clinical prediction guides

Denosumab versus romosozumab for postmenopausal osteoporosis treatment.
Kobayakawa T, Miyazaki A, Saito M, Suzuki T, Takahashi J, Nakamura Y
Sci Rep 2021 Jun 3;11(1):11801. doi: 10.1038/s41598-021-91248-6. PMID: 34083636Free PMC Article
Effects of prior osteoporosis treatment on 12-month treatment response of romosozumab in patients with postmenopausal osteoporosis.
Ebina K, Tsuboi H, Nagayama Y, Kashii M, Kaneshiro S, Miyama A, Nakaya H, Kunugiza Y, Hirao M, Okamura G, Etani Y, Takami K, Goshima A, Miura T, Nakata K, Okada S
Joint Bone Spine 2021 Oct;88(5):105219. Epub 2021 May 19 doi: 10.1016/j.jbspin.2021.105219. PMID: 34020048
Determinants of imminent fracture risk in postmenopausal women with osteoporosis.
Barron RL, Oster G, Grauer A, Crittenden DB, Weycker D
Osteoporos Int 2020 Nov;31(11):2103-2111. Epub 2020 Jul 1 doi: 10.1007/s00198-020-05294-3. PMID: 32613410Free PMC Article
Clinical Practice. Postmenopausal Osteoporosis.
Black DM, Rosen CJ
N Engl J Med 2016 Jan 21;374(3):254-62. doi: 10.1056/NEJMcp1513724. PMID: 26789873
Vertebral fracture assessment using a semiquantitative technique.
Genant HK, Wu CY, van Kuijk C, Nevitt MC
J Bone Miner Res 1993 Sep;8(9):1137-48. doi: 10.1002/jbmr.5650080915. PMID: 8237484

Recent systematic reviews

Fracture risk reduction and safety by osteoporosis treatment compared with placebo or active comparator in postmenopausal women: systematic review, network meta-analysis, and meta-regression analysis of randomised clinical trials.
Händel MN, Cardoso I, von Bülow C, Rohde JF, Ussing A, Nielsen SM, Christensen R, Body JJ, Brandi ML, Diez-Perez A, Hadji P, Javaid MK, Lems WF, Nogues X, Roux C, Minisola S, Kurth A, Thomas T, Prieto-Alhambra D, Ferrari SL, Langdahl B, Abrahamsen B
BMJ 2023 May 2;381:e068033. doi: 10.1136/bmj-2021-068033. PMID: 37130601Free PMC Article
Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.
Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
A systematic review and meta-analysis of efficacy and safety of Romosozumab in postmenopausal osteoporosis.
Singh S, Dutta S, Khasbage S, Kumar T, Sachin J, Sharma J, Varthya SB
Osteoporos Int 2022 Jan;33(1):1-12. Epub 2021 Aug 25 doi: 10.1007/s00198-021-06095-y. PMID: 34432115Free PMC Article
Swimming as Treatment for Osteoporosis: A Systematic Review and Meta-analysis.
Su Y, Chen Z, Xie W
Biomed Res Int 2020;2020:6210201. Epub 2020 May 15 doi: 10.1155/2020/6210201. PMID: 32509864Free PMC Article
Exercise for preventing and treating osteoporosis in postmenopausal women.
Howe TE, Shea B, Dawson LJ, Downie F, Murray A, Ross C, Harbour RT, Caldwell LM, Creed G
Cochrane Database Syst Rev 2011 Jul 6;(7):CD000333. doi: 10.1002/14651858.CD000333.pub2. PMID: 21735380

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