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Osteonecrosis of the jaw

MedGen UID:
751019
Concept ID:
C2711248
Disease or Syndrome
Synonyms: Aseptic necrosis of bone of jaw; Avascular necrosis of bone of jaw; Jaw Osteonecrosis; jaw osteonecrosis; ONJ; Osteonecrosis of Jaw; Osteonecrosis of jaw; osteonecrosis of jaw; osteonecrosis of the jaw
SNOMED CT: Osteonecrosis of jaw (1231151009); Avascular necrosis of bone of jaw (1231151009); Aseptic necrosis of bone of jaw (1231151009)
 
Monarch Initiative: MONDO:0018378
Orphanet: ORPHA399293

Definition

A rare osteonecrosis with characteristics of an exposed necrotic lesion in the mandible or maxilla present for more than eight weeks, arising as a complication of antiresorptive medication, dental intervention, trauma and infection. Patients may present with pain, altered neurosensory functions, secondary infections, and (in advanced stages) pathological fractures or fistulae. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteonecrosis of the jaw

Professional guidelines

PubMed

Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
Muñoz M, Robinson K, Shibli-Rahhal A
Clin Obstet Gynecol 2020 Dec;63(4):770-787. doi: 10.1097/GRF.0000000000000572. PMID: 33017332
Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah-Pollack R, McClung M, Wimalawansa SJ, Watts NB
Endocr Pract 2020 May;26(Suppl 1):1-46. doi: 10.4158/GL-2020-0524SUPPL. PMID: 32427503

Recent clinical studies

Etiology

Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D
J Oral Maxillofac Surg 2022 May;80(5):920-943. Epub 2022 Feb 21 doi: 10.1016/j.joms.2022.02.008. PMID: 35300956
Anastasilakis AD, Pepe J, Napoli N, Palermo A, Magopoulos C, Khan AA, Zillikens MC, Body JJ
J Clin Endocrinol Metab 2022 Apr 19;107(5):1441-1460. doi: 10.1210/clinem/dgab888. PMID: 34922381Free PMC Article
Kawahara M, Kuroshima S, Sawase T
Int J Implant Dent 2021 May 14;7(1):47. doi: 10.1186/s40729-021-00323-0. PMID: 33987769Free PMC Article
Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert T
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb;127(2):117-135. Epub 2018 Oct 9 doi: 10.1016/j.oooo.2018.09.008. PMID: 30393090
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052

Diagnosis

Bedogni A, Mauceri R, Fusco V, Bertoldo F, Bettini G, Di Fede O, Lo Casto A, Marchetti C, Panzarella V, Saia G, Vescovi P, Campisi G
Oral Dis 2024 Sep;30(6):3679-3709. Epub 2024 Feb 5 doi: 10.1111/odi.14887. PMID: 38317291
Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D
J Oral Maxillofac Surg 2022 May;80(5):920-943. Epub 2022 Feb 21 doi: 10.1016/j.joms.2022.02.008. PMID: 35300956
Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert T
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb;127(2):117-135. Epub 2018 Oct 9 doi: 10.1016/j.oooo.2018.09.008. PMID: 30393090
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052
Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O'Ryan F; American Association of Oral and Maxillofacial Surgeons
J Oral Maxillofac Surg 2014 Oct;72(10):1938-56. Epub 2014 May 5 doi: 10.1016/j.joms.2014.04.031. PMID: 25234529

Therapy

Billington E, Aghajafari F, Skulsky E, Kline GA
BMJ 2024 Aug 21;386:e076898. doi: 10.1136/bmj-2023-076898. PMID: 39168493
Anastasilakis AD, Pepe J, Napoli N, Palermo A, Magopoulos C, Khan AA, Zillikens MC, Body JJ
J Clin Endocrinol Metab 2022 Apr 19;107(5):1441-1460. doi: 10.1210/clinem/dgab888. PMID: 34922381Free PMC Article
Kawahara M, Kuroshima S, Sawase T
Int J Implant Dent 2021 May 14;7(1):47. doi: 10.1186/s40729-021-00323-0. PMID: 33987769Free PMC Article
Ferreira Jr LH Jr, Mendonça Jr KD Jr, Chaves de Souza J, Soares Dos Reis DC, do Carmo Faleiros Veloso Guedes C, de Souza Castro Filice L, Bruzadelli Macedo S, Soares Rocha F
Minerva Dent Oral Sci 2021 Feb;70(1):49-57. Epub 2020 Sep 22 doi: 10.23736/S2724-6329.20.04306-X. PMID: 32960522
Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert T
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb;127(2):117-135. Epub 2018 Oct 9 doi: 10.1016/j.oooo.2018.09.008. PMID: 30393090

Prognosis

Aguirre JI, Castillo EJ, Kimmel DB
Bone 2021 Dec;153:116184. Epub 2021 Sep 11 doi: 10.1016/j.bone.2021.116184. PMID: 34520898Free PMC Article
Kün-Darbois JD, Fauvel F
Morphologie 2021 Jun;105(349):170-187. Epub 2020 Dec 3 doi: 10.1016/j.morpho.2020.11.008. PMID: 33281055
Saag KG, Petersen J, Brandi ML, Karaplis AC, Lorentzon M, Thomas T, Maddox J, Fan M, Meisner PD, Grauer A
N Engl J Med 2017 Oct 12;377(15):1417-1427. Epub 2017 Sep 11 doi: 10.1056/NEJMoa1708322. PMID: 28892457
Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwiński E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster JY, Roux C, Malouf J, Bradley MN, Daizadeh NS, Wang A, Dakin P, Pannacciulli N, Dempster DW, Papapoulos S
Lancet Diabetes Endocrinol 2017 Jul;5(7):513-523. Epub 2017 May 22 doi: 10.1016/S2213-8587(17)30138-9. PMID: 28546097
Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C; FREEDOM Trial
N Engl J Med 2009 Aug 20;361(8):756-65. Epub 2009 Aug 11 doi: 10.1056/NEJMoa0809493. PMID: 19671655

Clinical prediction guides

Aguirre JI, Castillo EJ, Kimmel DB
Bone 2021 Dec;153:116184. Epub 2021 Sep 11 doi: 10.1016/j.bone.2021.116184. PMID: 34520898Free PMC Article
Dunphy L, Salzano G, Gerber B, Graystone J
BMJ Case Rep 2020 Jan 5;13(1) doi: 10.1136/bcr-2018-224455. PMID: 31907213Free PMC Article
Beth-Tasdogan NH, Mayer B, Hussein H, Zolk O
Cochrane Database Syst Rev 2017 Oct 6;10(10):CD012432. doi: 10.1002/14651858.CD012432.pub2. PMID: 28983908Free PMC Article
Black DM, Rosen CJ
N Engl J Med 2016 Jan 21;374(3):254-62. doi: 10.1056/NEJMcp1513724. PMID: 26789873
Adler RA, El-Hajj Fuleihan G, Bauer DC, Camacho PM, Clarke BL, Clines GA, Compston JE, Drake MT, Edwards BJ, Favus MJ, Greenspan SL, McKinney R Jr, Pignolo RJ, Sellmeyer DE
J Bone Miner Res 2016 Jan;31(1):16-35. doi: 10.1002/jbmr.2708. PMID: 26350171Free PMC Article

Recent systematic reviews

Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
Beth-Tasdogan NH, Mayer B, Hussein H, Zolk O, Peter JU
Cochrane Database Syst Rev 2022 Jul 12;7(7):CD012432. doi: 10.1002/14651858.CD012432.pub3. PMID: 35866376Free PMC Article
Ferreira Jr LH Jr, Mendonça Jr KD Jr, Chaves de Souza J, Soares Dos Reis DC, do Carmo Faleiros Veloso Guedes C, de Souza Castro Filice L, Bruzadelli Macedo S, Soares Rocha F
Minerva Dent Oral Sci 2021 Feb;70(1):49-57. Epub 2020 Sep 22 doi: 10.23736/S2724-6329.20.04306-X. PMID: 32960522
Beth-Tasdogan NH, Mayer B, Hussein H, Zolk O
Cochrane Database Syst Rev 2017 Oct 6;10(10):CD012432. doi: 10.1002/14651858.CD012432.pub2. PMID: 28983908Free PMC Article
Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw
J Bone Miner Res 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. PMID: 25414052

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