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Juvenile aseptic necrosis

MedGen UID:
892393
•Concept ID:
C4022146
•
Disease or Syndrome
Synonym: Aseptic epiphyseal necrosis
 
HPO: HP:0100323

Definition

Juvenile aseptic necrosis comprises a group of orthopedic diseases characterized by interruption of the blood supply of a bone, followed by localized bony necrosis most often of the epiphyses of bones of children or teenagers. [from HPO]

Professional guidelines

PubMed

Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.
Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623
A classification-based treatment algorithm for Kienböck disease: current and future considerations.
Saunders BM, Lichtman D
Tech Hand Up Extrem Surg 2011 Mar;15(1):38-40. doi: 10.1097/BTH.0b013e31820e82d2. PMID: 21358524
Differential diagnosis and management of hip pain in childhood.
Hollingworth P
Br J Rheumatol 1995 Jan;34(1):78-82. doi: 10.1093/rheumatology/34.1.78. PMID: 7881844

Recent clinical studies

Etiology

Do Bisphosphonates Alleviate Pain in Children? A Systematic Review.
Celin MR, Simon JC, Krzak JJ, Fial AV, Kruger KM, Smith PA, Harris GF
Curr Osteoporos Rep 2020 Oct;18(5):486-504. doi: 10.1007/s11914-020-00621-3. PMID: 32960409
Kienböck Disease in the Skeletally Immature Patient.
Afshar A
J Hand Surg Am 2018 May;43(5):465-469. Epub 2018 Mar 21 doi: 10.1016/j.jhsa.2018.02.029. PMID: 29573896
Total hip arthroplasty in the very young patient.
Polkowski GG, Callaghan JJ, Mont MA, Clohisy JC
J Am Acad Orthop Surg 2012 Aug;20(8):487-97. doi: 10.5435/JAAOS-20-08-487. PMID: 22855851
Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.
Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623
Bisphosphonate use in conditions other than osteoporosis.
Silverman SL
Ann N Y Acad Sci 2011 Feb;1218:33-7. Epub 2010 Sep 28 doi: 10.1111/j.1749-6632.2010.05769.x. PMID: 20946575

Diagnosis

Evaluating the Limping Child: A Rheumatology Perspective.
Syed R
Mo Med 2016 Mar-Apr;113(2):131-5. PMID: 27311224Free PMC Article
Pediatric hip: pearls and pitfalls.
Gill KG
Semin Musculoskelet Radiol 2013 Jul;17(3):328-38. Epub 2013 Jun 20 doi: 10.1055/s-0033-1348099. PMID: 23787987
Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.
Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623
Avascular necrosis of the metacarpals in juvenile dermatomyositis.
Robinson AB, Rabinovich CE
J Clin Rheumatol 2010 Aug;16(5):233-6. doi: 10.1097/RHU.0b013e3181e9345d. PMID: 20577093
Arthritis in children.
Wilkinson RH, Weissman BN
Radiol Clin North Am 1988 Nov;26(6):1247-65. PMID: 3051095

Therapy

Neridronate for transient osteoporosis of the hip in a child.
Gaggiano C, Bardelli M, Tarsia M, Gentileschi S, Maselli A, Grosso S, Cantarini L, Frediani B
Osteoporos Int 2022 Jul;33(7):1619-1624. Epub 2022 Feb 1 doi: 10.1007/s00198-022-06324-y. PMID: 35106625Free PMC Article
Do Bisphosphonates Alleviate Pain in Children? A Systematic Review.
Celin MR, Simon JC, Krzak JJ, Fial AV, Kruger KM, Smith PA, Harris GF
Curr Osteoporos Rep 2020 Oct;18(5):486-504. doi: 10.1007/s11914-020-00621-3. PMID: 32960409
Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.
Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623
Bisphosphonate use in conditions other than osteoporosis.
Silverman SL
Ann N Y Acad Sci 2011 Feb;1218:33-7. Epub 2010 Sep 28 doi: 10.1111/j.1749-6632.2010.05769.x. PMID: 20946575
Intra-articular corticosteroid injections in juvenile idiopathic arthritis.
Cleary AG, Murphy HD, Davidson JE
Arch Dis Child 2003 Mar;88(3):192-6. doi: 10.1136/adc.88.3.192. PMID: 12598375Free PMC Article

Prognosis

Unravelling the enigma of Perthes disease.
Perry DC
Ann R Coll Surg Engl 2013 Jul;95(5):311-6. doi: 10.1308/003588413X13629960046192. PMID: 23838491Free PMC Article
Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.
Kim HK
J Bone Joint Surg Am 2012 Apr 4;94(7):659-69. doi: 10.2106/JBJS.J.01834. PMID: 22488623
Infantile and juvenile lunatomalacia.
Irisarri C, Kalb K, Ribak S
J Hand Surg Eur Vol 2010 Sep;35(7):544-8. Epub 2010 Mar 17 doi: 10.1177/1753193410364913. PMID: 20237187
Hip pathology in the trichorhinophalangeal syndrome.
Dunbar JD, Sussman MD, Aiona MD
J Pediatr Orthop 1995 May-Jun;15(3):381-5. doi: 10.1097/01241398-199505000-00023. PMID: 7790499
The characterization of "transient synovitis of the hip" in children.
Haueisen DC, Weiner DS, Weiner SD
J Pediatr Orthop 1986 Jan-Feb;6(1):11-7. doi: 10.1097/01241398-198601000-00003. PMID: 3941171

Clinical prediction guides

The pediatric glucocorticoid toxicity index.
Brogan P, Naden R, Ardoin SP, Cooper JC, De Benedetti F, Dicaire JF, Eleftheriou D, Feldman B, Goldin J, Karol SE, Price-Kuehne F, Skuse D, Stratakis CA, Webb N, Stone JH
Semin Arthritis Rheum 2022 Oct;56:152068. Epub 2022 Jul 14 doi: 10.1016/j.semarthrit.2022.152068. PMID: 35917759
Implant degradation of low-alloyed Mg-Zn-Ca in osteoporotic, old and juvenile rats.
Sommer NG, Hirzberger D, Paar L, Berger L, Ćwieka H, Schwarze UY, Herber V, Okutan B, Bodey AJ, Willumeit-Römer R, Zeller-Plumhoff B, Löffler JF, Weinberg AM
Acta Biomater 2022 Jul 15;147:427-438. Epub 2022 May 27 doi: 10.1016/j.actbio.2022.05.041. PMID: 35644328
Wear of XLPE liner against zirconium heads in cementless total hip arthroplasty for patients under 40 years of age.
Sonohata M, Kitajima M, Kawano S, Mawatari M
Hip Int 2017 Nov 21;27(6):532-536. Epub 2017 May 27 doi: 10.5301/hipint.5000513. PMID: 28574118
Unravelling the enigma of Perthes disease.
Perry DC
Ann R Coll Surg Engl 2013 Jul;95(5):311-6. doi: 10.1308/003588413X13629960046192. PMID: 23838491Free PMC Article
The classic: On juvenile arthritis deformans. 1910.
Perthes G
Clin Orthop Relat Res 2012 Sep;470(9):2349-68. doi: 10.1007/s11999-012-2433-1. PMID: 22744201Free PMC Article

Recent systematic reviews

Do Bisphosphonates Alleviate Pain in Children? A Systematic Review.
Celin MR, Simon JC, Krzak JJ, Fial AV, Kruger KM, Smith PA, Harris GF
Curr Osteoporos Rep 2020 Oct;18(5):486-504. doi: 10.1007/s11914-020-00621-3. PMID: 32960409
Effects of the use of growth hormone in children and adolescents with juvenile idiopathic arthritis: a systematic review.
Frittoli RB, Longhi BS, Silva AM, Filho AAB, Monteiro MÂRG, Appenzeller S
Rev Bras Reumatol Engl Ed 2017 Mar-Apr;57(2):100-106. Epub 2016 Oct 24 doi: 10.1016/j.rbre.2016.07.009. PMID: 28343613
Evidence for using bisphosphonate to treat Legg-Calvé-Perthes disease.
Young ML, Little DG, Kim HK
Clin Orthop Relat Res 2012 Sep;470(9):2462-75. doi: 10.1007/s11999-011-2240-0. PMID: 22270467Free PMC Article

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