U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Femur Head Necrosis

MedGen UID:
8811
•Concept ID:
C0015814
•
Disease or Syndrome
Synonyms: Femur Head Necroses; Head Necrosis, Femur; Necrosis, Femur Head

Definition

Aseptic or avascular necrosis of the femoral head. The major types are idiopathic (primary), as a complication of fractures or dislocations, and LEGG-CALVE-PERTHES DISEASE. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFemur Head Necrosis

Professional guidelines

PubMed

Osteonecrosis risk after steroids-related treatment of COVID-19 is not negligible: A cross sectional study.
Koutalos AA, Koskiniotis A, Rountas C, Konstantinou E, Georgiadou S, Stefos A, Gatselis NK, Dalekos GN, Malizos KN
Eur J Intern Med 2024 May;123:127-131. Epub 2024 Jan 28 doi: 10.1016/j.ejim.2024.01.006. PMID: 38281818
Epidemiological Characteristics and Trends of Primary Hip Arthroplasty in Five Tertiary Hospitals: A Multicenter Retrospective Study.
Sun W, Zhao K, Wang Y, Xu K, Jin L, Chen W, Hou Z, Zhang Y
Orthop Surg 2023 Sep;15(9):2267-2273. Epub 2023 Jul 11 doi: 10.1111/os.13756. PMID: 37431577Free PMC Article
Analysis of Bone Microarchitectural Changes and Structural Damage in Sickle Cell Disease-Induced Avascular Necrosis Using Raman Spectroscopy: Is there potential for medical management?
Al-Ghaithi A, Husband J, Al-Maskari S
Sultan Qaboos Univ Med J 2021 May;21(2):e297-e301. Epub 2021 Jun 21 doi: 10.18295/squmj.2021.21.02.020. PMID: 34221479Free PMC Article

Recent clinical studies

Etiology

Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today?: A 5-Year Update.
Mont MA, Salem HS, Piuzzi NS, Goodman SB, Jones LC
J Bone Joint Surg Am 2020 Jun 17;102(12):1084-1099. doi: 10.2106/JBJS.19.01271. PMID: 32282421Free PMC Article
Avascular necrosis of the hip.
Lamb JN, Holton C, O'Connor P, Giannoudis PV
BMJ 2019 May 30;365:l2178. doi: 10.1136/bmj.l2178. PMID: 31147356
Osteonecrosis of the Femoral Head.
Cohen-Rosenblum A, Cui Q
Orthop Clin North Am 2019 Apr;50(2):139-149. Epub 2019 Feb 12 doi: 10.1016/j.ocl.2018.10.001. PMID: 30850073
Are we evaluating osteonecrosis adequately?
Lee GC, Steinberg ME
Int Orthop 2012 Dec;36(12):2433-9. Epub 2012 Sep 26 doi: 10.1007/s00264-012-1658-7. PMID: 23011722Free PMC Article
Legg-Calvé-Perthes syndrome.
Catterall A
Clin Orthop Relat Res 1981 Jul-Aug;(158):41-52. PMID: 7023775

Diagnosis

Osteonecrosis of the Femoral Head.
George G, Lane JM
J Am Acad Orthop Surg Glob Res Rev 2022 May 1;6(5) doi: 10.5435/JAAOSGlobal-D-21-00176. PMID: 35511598Free PMC Article
Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today?: A 5-Year Update.
Mont MA, Salem HS, Piuzzi NS, Goodman SB, Jones LC
J Bone Joint Surg Am 2020 Jun 17;102(12):1084-1099. doi: 10.2106/JBJS.19.01271. PMID: 32282421Free PMC Article
Avascular necrosis of the hip.
Lamb JN, Holton C, O'Connor P, Giannoudis PV
BMJ 2019 May 30;365:l2178. doi: 10.1136/bmj.l2178. PMID: 31147356
Serpentine lines: Osteonecrosis.
Ridley LJ, Han J, Ridley WE, Xiang H
J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:153. doi: 10.1111/1754-9485.27_12786. PMID: 30309121
Osteonecrosis of the femoral head: evaluation and treatment.
Zalavras CG, Lieberman JR
J Am Acad Orthop Surg 2014 Jul;22(7):455-64. doi: 10.5435/JAAOS-22-07-455. PMID: 24966252

Therapy

Stem cell therapy combined with core decompression versus core decompression alone in the treatment of avascular necrosis of the femoral head: a systematic review and meta-analysis.
Li M, Chen D, Ma Y, Zheng M, Zheng Q
J Orthop Surg Res 2023 Aug 2;18(1):560. doi: 10.1186/s13018-023-04025-8. PMID: 37533122Free PMC Article
Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts.
Chen K, Liu Y, He J, Pavlos N, Wang C, Kenny J, Yuan J, Zhang Q, Xu J, He W
Int J Biol Sci 2020;16(11):1888-1900. Epub 2020 Apr 6 doi: 10.7150/ijbs.40917. PMID: 32398957Free PMC Article
Stem Cell Therapy for Osteonecrosis of the Femoral Head: Current Trends and Comprehensive Review.
Zhao L, Kaye AD, Kaye AJ, Abd-Elsayed A
Curr Pain Headache Rep 2018 May 3;22(6):41. doi: 10.1007/s11916-018-0700-x. PMID: 29725783
The physiopathology of avascular necrosis of the femoral head: an update.
Guerado E, Caso E
Injury 2016 Dec;47 Suppl 6:S16-S26. doi: 10.1016/S0020-1383(16)30835-X. PMID: 28040082
Experimental animal models of osteonecrosis.
Fan M, Peng J, Qin L, Lu S
Rheumatol Int 2011 Aug;31(8):983-94. Epub 2011 Feb 22 doi: 10.1007/s00296-011-1819-9. PMID: 21340568

Prognosis

Hyperbaric oxygen therapy for the treatment of Steinberg I and II avascular necrosis of the femoral head: a report of fifteen cases and literature review.
Salameh M, Moghamis IS, Kokash O, Ahmed GO
Int Orthop 2021 Oct;45(10):2519-2523. Epub 2021 Jul 4 doi: 10.1007/s00264-021-05120-3. PMID: 34218337Free PMC Article
Systematic Review and Meta-Analysis of Avascular Necrosis and Posttraumatic Arthritis After Traumatic Hip Dislocation.
Kellam P, Ostrum RF
J Orthop Trauma 2016 Jan;30(1):10-6. doi: 10.1097/BOT.0000000000000419. PMID: 26849386
Complications following young femoral neck fractures.
Slobogean GP, Sprague SA, Scott T, Bhandari M
Injury 2015 Mar;46(3):484-91. Epub 2014 Oct 31 doi: 10.1016/j.injury.2014.10.010. PMID: 25480307
Avascular necrosis of the femoral head following trochanteric fractures in adults: a systematic review.
Barquet A, Mayora G, Guimaraes JM, Suárez R, Giannoudis PV
Injury 2014 Dec;45(12):1848-58. doi: 10.1016/j.injury.2014.10.054. PMID: 25467713
Slipped capital femoral epiphysis: prevalence, pathogenesis, and natural history.
Novais EN, Millis MB
Clin Orthop Relat Res 2012 Dec;470(12):3432-8. doi: 10.1007/s11999-012-2452-y. PMID: 23054509Free PMC Article

Clinical prediction guides

Methods to predict osteonecrosis of femoral head after femoral neck fracture: a systematic review of the literature.
Hu Y, Yang Q, Zhang J, Peng Y, Guang Q, Li K
J Orthop Surg Res 2023 May 22;18(1):377. doi: 10.1186/s13018-023-03858-7. PMID: 37217998Free PMC Article
Hyperbaric oxygen therapy for the treatment of Steinberg I and II avascular necrosis of the femoral head: a report of fifteen cases and literature review.
Salameh M, Moghamis IS, Kokash O, Ahmed GO
Int Orthop 2021 Oct;45(10):2519-2523. Epub 2021 Jul 4 doi: 10.1007/s00264-021-05120-3. PMID: 34218337Free PMC Article
Clinical acupuncture therapy for femur head necrosis: A protocol for systematic review and meta analysis.
Wang H, Yang F, Cao Z, Luo Y, Liu J, Yang Z, Xia H, Li F, Mao Z, Yang W
Medicine (Baltimore) 2021 Jun 25;100(25):e26400. doi: 10.1097/MD.0000000000026400. PMID: 34160424Free PMC Article
Italian experience on use of E.S.W. therapy for avascular necrosis of femoral head.
Russo S, Sadile F, Esposito R, Mosillo G, Aitanti E, Busco G, Wang CJ
Int J Surg 2015 Dec;24(Pt B):188-90. Epub 2015 Nov 27 doi: 10.1016/j.ijsu.2015.11.038. PMID: 26644278
Slipped capital femoral epiphysis: prevalence, pathogenesis, and natural history.
Novais EN, Millis MB
Clin Orthop Relat Res 2012 Dec;470(12):3432-8. doi: 10.1007/s11999-012-2452-y. PMID: 23054509Free PMC Article

Recent systematic reviews

Conservative Treatment in Avascular Necrosis of the Femoral Head: A Systematic Review.
Goncharov EN, Koval OA, Nikolaevich Bezuglov E, Aleksandrovich Vetoshkin A, Gavriilovich Goncharov N, Encarnación Ramirez MJ, Montemurro N
Med Sci (Basel) 2024 Jul 2;12(3) doi: 10.3390/medsci12030032. PMID: 39051378Free PMC Article
Regenerative therapies for femoral head necrosis in the past two decades: a systematic review and network meta-analysis.
Wang X, Hu L, Wei B, Wang J, Hou D, Deng X
Stem Cell Res Ther 2024 Jan 25;15(1):21. doi: 10.1186/s13287-024-03635-1. PMID: 38273397Free PMC Article
Femoral head avascular necrosis in COVID-19 survivors: a systematic review.
Hassan AAA, Khalifa AA
Rheumatol Int 2023 Sep;43(9):1583-1595. Epub 2023 Jun 20 doi: 10.1007/s00296-023-05373-8. PMID: 37338665Free PMC Article
Bone grafting for femoral head necrosis in the past decade: a systematic review and network meta-analysis.
Lou P, Zhou G, Wei B, Deng X, Hou D
Int J Surg 2023 Mar 1;109(3):412-418. doi: 10.1097/JS9.0000000000000231. PMID: 36906744Free PMC Article
Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment.
Mathieu D, Marroni A, Kot J
Diving Hyperb Med 2017 Mar;47(1):24-32. doi: 10.28920/dhm47.1.24-32. PMID: 28357821Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...