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Chronic kidney disease mineral and bone disorder

MedGen UID:
885556
•Concept ID:
C4076240
•
Disease or Syndrome
Synonyms: Chronic Kidney Disease Mineral and Bone Disorder; Chronic Kidney Disease-Mineral and Bone Disorder; CKD-MBD
SNOMED CT: Chronic kidney disease mineral and bone disorder (713313000); CKD-MBD - chronic kidney disease mineral and bone disorder (713313000)

Definition

Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic kidney disease mineral and bone disorder

Professional guidelines

PubMed

Progress in pharmacotherapy for the treatment of hyperphosphatemia in renal failure.
Cernaro V, Longhitano E, Calabrese V, Casuscelli C, Di Carlo S, Spinella C, Gembillo G, Santoro D
Expert Opin Pharmacother 2023 Sep-Dec;24(15):1737-1746. Epub 2023 Aug 11 doi: 10.1080/14656566.2023.2243817. PMID: 37527180
Diagnosis and Management of Osteoporosis in Advanced Kidney Disease: A Review.
Ginsberg C, Ix JH
Am J Kidney Dis 2022 Mar;79(3):427-436. Epub 2021 Aug 20 doi: 10.1053/j.ajkd.2021.06.031. PMID: 34419519
Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters.
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995

Recent clinical studies

Etiology

Bone and Chronic Kidney Disease.
Lafage-Proust MH
Semin Musculoskelet Radiol 2023 Aug;27(4):463-470. Epub 2023 Sep 25 doi: 10.1055/s-0043-1770353. PMID: 37748470
Osteoporosis and Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD): Back to Basics.
Pazianas M, Miller PD
Am J Kidney Dis 2021 Oct;78(4):582-589. Epub 2021 Mar 25 doi: 10.1053/j.ajkd.2020.12.024. PMID: 33774081
Osteoporosis in Patients with Chronic Kidney Diseases: A Systemic Review.
Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters.
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995
Spontaneous fracture: multiple causes.
Wick JY
Consult Pharm 2009 Feb;24(2):100-2, 105-8, 110-2. doi: 10.4140/tcp.n.2009.100. PMID: 19275452

Diagnosis

Osteoporosis and Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD): Back to Basics.
Pazianas M, Miller PD
Am J Kidney Dis 2021 Oct;78(4):582-589. Epub 2021 Mar 25 doi: 10.1053/j.ajkd.2020.12.024. PMID: 33774081
Sagliker Syndrome.
Rubio-Manzanares Dorado M, Pino Díaz V, Fontillón Alberdi M, Padillo Ruíz J, Martos Martínez JM
Cir Esp (Engl Ed) 2020 Aug-Sep;98(7):414-416. Epub 2019 Dec 10 doi: 10.1016/j.ciresp.2019.11.002. PMID: 31836134
Executive summary of the 2017 KDIGO Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters.
Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L, Moe SM, Shroff R, Tonelli MA, Toussaint ND, Vervloet MG, Leonard MB
Kidney Int 2017 Jul;92(1):26-36. doi: 10.1016/j.kint.2017.04.006. PMID: 28646995
Renal osteodystrophy.
González EA, Martin KJ
Rev Endocr Metab Disord 2001 Apr;2(2):187-93. doi: 10.1023/a:1010058828232. PMID: 11705324
Renal hypophosphatemic rickets.
Chan JC, Alon U, Hirschman GM
J Pediatr 1985 Apr;106(4):533-44. doi: 10.1016/s0022-3476(85)80068-8. PMID: 3884759

Therapy

Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD).
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
Bisphosphonate therapy in renal osteodystrophy--a review.
Bergner R
J Nephrol 2013 May-Jun;26(3):450-5. Epub 2012 Jul 2 doi: 10.5301/jn.5000188. PMID: 22760876
Renal hypophosphatemic rickets.
Chan JC, Alon U, Hirschman GM
J Pediatr 1985 Apr;106(4):533-44. doi: 10.1016/s0022-3476(85)80068-8. PMID: 3884759
'One-alpha'.
Lancet 1978 May 6;1(8071):973-4. PMID: 76898
Renal bone disease.
Catto GR
J R Coll Physicians Lond 1976 Oct;11(1):75-85. PMID: 789876Free PMC Article

Prognosis

Role of Chronic Kidney Disease (CKD)-Mineral and Bone Disorder (MBD) in the Pathogenesis of Cardiovascular Disease in CKD.
Yamada S, Nakano T
J Atheroscler Thromb 2023 Aug 1;30(8):835-850. Epub 2023 May 30 doi: 10.5551/jat.RV22006. PMID: 37258233Free PMC Article
Bone Disease in Chronic Kidney Disease and Kidney Transplant.
Bellorin-Font E, Rojas E, Martin KJ
Nutrients 2022 Dec 29;15(1) doi: 10.3390/nu15010167. PMID: 36615824Free PMC Article
Mineral Bone Disorders in Kidney Disease Patients: The Ever-Current Topic.
Hu L, Napoletano A, Provenzano M, Garofalo C, Bini C, Comai G, La Manna G
Int J Mol Sci 2022 Oct 13;23(20) doi: 10.3390/ijms232012223. PMID: 36293076Free PMC Article
Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD).
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
TYROSINEMIA.
GENTZ J, JAGENBURG R, ZETTERSTROEM R
J Pediatr 1965 Apr;66:670-96. doi: 10.1016/s0022-3476(65)80002-6. PMID: 14271358

Clinical prediction guides

Inflammation and gut dysbiosis as drivers of CKD-MBD.
Evenepoel P, Stenvinkel P, Shanahan C, Pacifici R
Nat Rev Nephrol 2023 Oct;19(10):646-657. Epub 2023 Jul 24 doi: 10.1038/s41581-023-00736-7. PMID: 37488276
Management of osteoporosis in patients with chronic kidney disease.
Abdalbary M, Sobh M, Elnagar S, Elhadedy MA, Elshabrawy N, Abdelsalam M, Asadipooya K, Sabry A, Halawa A, El-Husseini A
Osteoporos Int 2022 Nov;33(11):2259-2274. Epub 2022 Jun 24 doi: 10.1007/s00198-022-06462-3. PMID: 35748896
Clinical features of CKD-MBD in Japan: cohort studies and registry.
Hamano T, Sakaguchi Y, Fujii N, Isaka Y
Clin Exp Nephrol 2017 Mar;21(Suppl 1):9-20. Epub 2016 Dec 9 doi: 10.1007/s10157-016-1367-4. PMID: 27942882
Bisphosphonate therapy in renal osteodystrophy--a review.
Bergner R
J Nephrol 2013 May-Jun;26(3):450-5. Epub 2012 Jul 2 doi: 10.5301/jn.5000188. PMID: 22760876
Spontaneous fracture: multiple causes.
Wick JY
Consult Pharm 2009 Feb;24(2):100-2, 105-8, 110-2. doi: 10.4140/tcp.n.2009.100. PMID: 19275452

Recent systematic reviews

Effects of Plant-Based Protein Consumption on Kidney Function and Mineral Bone Disorder Outcomes in Adults With Stage 3-5 Chronic Kidney Disease: A Systematic Review.
Burstad KM, Cladis DP, Wiese GN, Butler M, Hill Gallant KM
J Ren Nutr 2023 Nov;33(6):717-730. Epub 2023 Apr 26 doi: 10.1053/j.jrn.2023.04.004. PMID: 37116624
Osteoporosis in Patients with Chronic Kidney Diseases: A Systemic Review.
Hsu CY, Chen LR, Chen KH
Int J Mol Sci 2020 Sep 18;21(18) doi: 10.3390/ijms21186846. PMID: 32961953Free PMC Article
Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD).
Ruospo M, Palmer SC, Natale P, Craig JC, Vecchio M, Elder GJ, Strippoli GF
Cochrane Database Syst Rev 2018 Aug 22;8(8):CD006023. doi: 10.1002/14651858.CD006023.pub3. PMID: 30132304Free PMC Article
Impact of surgical parathyroidectomy on chronic kidney disease-mineral and bone disorder (CKD-MBD) - A systematic review and meta-analysis.
Apetrii M, Goldsmith D, Nistor I, Siriopol D, Voroneanu L, Scripcariu D, Vervloet M, Covic A
PLoS One 2017;12(11):e0187025. Epub 2017 Nov 6 doi: 10.1371/journal.pone.0187025. PMID: 29107998Free PMC Article
Dietary interventions for mineral and bone disorder in people with chronic kidney disease.
Liu Z, Su G, Guo X, Wu Y, Liu X, Zou C, Zhang L, Yang Q, Xu Y, Ma W
Cochrane Database Syst Rev 2015 Sep 16;2015(9):CD010350. doi: 10.1002/14651858.CD010350.pub2. PMID: 26376110Free PMC Article

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