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Nutritional Rickets

MedGen UID:
1385792
•Concept ID:
C4330845
•
Disease or Syndrome

Definition

Rickets due to dietary deficiency of calcium, phosphate, or vitamin D. [from NCI]

Professional guidelines

PubMed

Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline.
Demay MB, Pittas AG, Bikle DD, Diab DL, Kiely ME, Lazaretti-Castro M, Lips P, Mitchell DM, Murad MH, Powers S, Rao SD, Scragg R, Tayek JA, Valent AM, Walsh JME, McCartney CR
J Clin Endocrinol Metab 2024 Jul 12;109(8):1907-1947. doi: 10.1210/clinem/dgae290. PMID: 38828931
Nutritional rickets & osteomalacia: A practical approach to management.
Uday S, Högler W
Indian J Med Res 2020 Oct;152(4):356-367. doi: 10.4103/ijmr.IJMR_1961_19. PMID: 33380700Free PMC Article
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W
J Clin Endocrinol Metab 2016 Feb;101(2):394-415. Epub 2016 Jan 8 doi: 10.1210/jc.2015-2175. PMID: 26745253Free PMC Article

Recent clinical studies

Therapy

Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline.
Demay MB, Pittas AG, Bikle DD, Diab DL, Kiely ME, Lazaretti-Castro M, Lips P, Mitchell DM, Murad MH, Powers S, Rao SD, Scragg R, Tayek JA, Valent AM, Walsh JME, McCartney CR
J Clin Endocrinol Metab 2024 Jul 12;109(8):1907-1947. doi: 10.1210/clinem/dgae290. PMID: 38828931
Refractory Rickets.
Chinoy A, Padidela R
Indian J Pediatr 2023 Jun;90(6):574-581. Epub 2023 Apr 19 doi: 10.1007/s12098-023-04538-4. PMID: 37074534Free PMC Article
Rickets guidance: part II-management.
Haffner D, Leifheit-Nestler M, Grund A, Schnabel D
Pediatr Nephrol 2022 Oct;37(10):2289-2302. Epub 2022 Mar 29 doi: 10.1007/s00467-022-05505-5. PMID: 35352187Free PMC Article
The health effects of vitamin D supplementation: evidence from human studies.
Bouillon R, Manousaki D, Rosen C, Trajanoska K, Rivadeneira F, Richards JB
Nat Rev Endocrinol 2022 Feb;18(2):96-110. Epub 2021 Nov 23 doi: 10.1038/s41574-021-00593-z. PMID: 34815552Free PMC Article
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W
J Clin Endocrinol Metab 2016 Feb;101(2):394-415. Epub 2016 Jan 8 doi: 10.1210/jc.2015-2175. PMID: 26745253Free PMC Article

Prognosis

Nutritional rickets under 16 years: UK surveillance results.
Julies P, Lynn RM, Pall K, Leoni M, Calder A, Mughal Z, Shaw N, McDonnell C, McDevitt H, Blair M
Arch Dis Child 2020 Jun;105(6):587-592. Epub 2020 Jan 16 doi: 10.1136/archdischild-2019-317934. PMID: 31949032
Nutritional rickets: vitamin D, calcium, and the genetic make-up.
El Kholy M, Elsedfy H, Fernández-Cancio M, Hamza RT, Amr NH, Ahmed AY, Toaima NN, Audí L
Pediatr Res 2017 Feb;81(2):356-363. Epub 2016 Nov 3 doi: 10.1038/pr.2016.222. PMID: 27973470
Prevention and treatment of nutritional rickets.
Shaw NJ
J Steroid Biochem Mol Biol 2016 Nov;164:145-147. Epub 2015 Oct 19 doi: 10.1016/j.jsbmb.2015.10.014. PMID: 26493853
A reliable and cost effective approach for radiographic monitoring in nutritional rickets.
Chatterjee D, Gupta V, Sharma V, Sinha B, Samanta S
Br J Radiol 2014 Apr;87(1036):20130648. Epub 2014 Feb 3 doi: 10.1259/bjr.20130648. PMID: 24593231Free PMC Article
Rickets in Denmark.
Beck-Nielsen SS
Dan Med J 2012 Feb;59(2):B4384. PMID: 22293055

Clinical prediction guides

Calcifediol (25OH Vitamin D(3)) Deficiency: A Risk Factor from Early to Old Age.
Bouillon R, Antonio L, Olarte OR
Nutrients 2022 Mar 10;14(6) doi: 10.3390/nu14061168. PMID: 35334824Free PMC Article
The health effects of vitamin D supplementation: evidence from human studies.
Bouillon R, Manousaki D, Rosen C, Trajanoska K, Rivadeneira F, Richards JB
Nat Rev Endocrinol 2022 Feb;18(2):96-110. Epub 2021 Nov 23 doi: 10.1038/s41574-021-00593-z. PMID: 34815552Free PMC Article
Vitamin D in pregnancy: Where we are and where we should go.
Kiely ME, Wagner CL, Roth DE
J Steroid Biochem Mol Biol 2020 Jul;201:105669. Epub 2020 Apr 14 doi: 10.1016/j.jsbmb.2020.105669. PMID: 32302652
Screening for nutritional rickets in a community.
Pettifor JM
J Steroid Biochem Mol Biol 2016 Nov;164:139-144. Epub 2015 Sep 10 doi: 10.1016/j.jsbmb.2015.09.008. PMID: 26365554
Nutritional and metabolic rickets.
Teotia M, Teotia SP
Indian J Pediatr 1997 Mar-Apr;64(2):153-7. doi: 10.1007/BF02752435. PMID: 10771831

Recent systematic reviews

Serum 25-hydroxyvitamin D threshold and risk of rickets in young children: a systematic review and individual participant data meta-analysis to inform the development of dietary requirements for vitamin D.
Rios-Leyvraz M, Thacher TD, Dabas A, Elsedfy HH, Baroncelli GI, Cashman KD
Eur J Nutr 2024 Apr;63(3):673-695. Epub 2024 Jan 27 doi: 10.1007/s00394-023-03299-2. PMID: 38280944Free PMC Article
Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health.
Tan ML, Abrams SA, Osborn DA
Cochrane Database Syst Rev 2020 Dec 11;12(12):CD013046. doi: 10.1002/14651858.CD013046.pub2. PMID: 33305822Free PMC Article
Nutritional rickets around the world: an update.
Creo AL, Thacher TD, Pettifor JM, Strand MA, Fischer PR
Paediatr Int Child Health 2017 May;37(2):84-98. Epub 2016 Dec 6 doi: 10.1080/20469047.2016.1248170. PMID: 27922335
Nutritional rickets around the world: causes and future directions.
Thacher TD, Fischer PR, Strand MA, Pettifor JM
Ann Trop Paediatr 2006 Mar;26(1):1-16. doi: 10.1179/146532806X90556. PMID: 16494699
A systematic review of nutritional rickets in Ethiopia: status and prospects.
Wondale Y, Shiferaw F, Lulseged S
Ethiop Med J 2005 Jul;43(3):203-10. PMID: 16370553

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