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Benign neoplasm of large intestine

MedGen UID:
91125
•Concept ID:
C0347272
•
Neoplastic Process
Synonyms: Benign Colorectal Neoplasm; benign colorectal neoplasm; Benign Colorectal Neoplasms; benign colorectal neoplasms; Benign Colorectal Tumor; benign colorectal tumor; Benign Colorectal Tumors; benign colorectal tumors; benign colorectal tumour; benign colorectal tumours; Benign Large Bowel Neoplasm; benign large bowel neoplasm; Benign Large Bowel Tumor; benign large bowel tumor; benign large bowel tumour; Benign Large Intestine Neoplasm; benign large intestine neoplasm; Benign Large Intestine Tumor; benign large intestine tumor; benign large intestine tumour; Benign Neoplasm of Large Bowel; benign neoplasm of large bowel; Benign Neoplasm of Large Intestine; benign neoplasm of large intestine; Benign Neoplasm of the Large Bowel; benign neoplasm of the large bowel; Benign Neoplasm of the Large Intestine; benign neoplasm of the large intestine; Benign Tumor of Large Bowel; benign tumor of large bowel; Benign tumor of large intestine; Benign Tumor of Large Intestine; benign tumor of large intestine; Benign Tumor of the Large Bowel; benign tumor of the large bowel; Benign Tumor of the Large Intestine; benign tumor of the large intestine; benign tumour of large bowel; benign tumour of large intestine; benign tumour of the large bowel; benign tumour of the large intestine; Colorectal Neoplasms, Benign; colorectal neoplasms, benign; Colorectal Tumors, Benign; colorectal tumors, benign; large intestine benign neoplasm; Neoplasms, Colorectal, Benign; neoplasms, colorectal, benign; Tumors, Colorectal, Benign; tumors, colorectal, benign
SNOMED CT: Benign tumor of large intestine (92170008); Benign neoplasm of large intestine (92170008)
 
Monarch Initiative: MONDO:0021444

Definition

A neoplasm that arises from the colon or rectum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

MRI of Rectal Cancer: Tumor Staging, Imaging Techniques, and Management.
Horvat N, Carlos Tavares Rocha C, Clemente Oliveira B, Petkovska I, Gollub MJ
Radiographics 2019 Mar-Apr;39(2):367-387. Epub 2019 Feb 15 doi: 10.1148/rg.2019180114. PMID: 30768361Free PMC Article
Appendiceal Mucinous Neoplasms: Diagnosis and Management.
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845

Recent clinical studies

Etiology

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Colorectal Cancer Screening for the Serrated Pathway.
Anderson JC, Srivastava A
Gastrointest Endosc Clin N Am 2020 Jul;30(3):457-478. Epub 2020 Apr 8 doi: 10.1016/j.giec.2020.02.007. PMID: 32439082
The Intestinal Microbiota in Colorectal Cancer.
Tilg H, Adolph TE, Gerner RR, Moschen AR
Cancer Cell 2018 Jun 11;33(6):954-964. Epub 2018 Apr 12 doi: 10.1016/j.ccell.2018.03.004. PMID: 29657127
Large intestine.
Kelly CP
Curr Opin Gastroenterol 2010 Jan;26(1):45-6. doi: 10.1097/MOG.0b013e328333b040. PMID: 19881344
Diet and metabolism: large-bowel cancer.
Reddy BS, Mastromarino A, Wynder E
Cancer 1977 Apr;39(4 Suppl):1815-9. doi: 10.1002/1097-0142(197704)39:4+<1815::aid-cncr2820390812>3.0.co;2-w. PMID: 851954

Diagnosis

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Colorectal Cancer Screening for the Serrated Pathway.
Anderson JC, Srivastava A
Gastrointest Endosc Clin N Am 2020 Jul;30(3):457-478. Epub 2020 Apr 8 doi: 10.1016/j.giec.2020.02.007. PMID: 32439082
Unusual causes of large bowel obstruction.
Farkas NG, Welman TJP, Ross T, Brown S, Smith JJ, Pawa N
Curr Probl Surg 2019 Feb;56(2):49-90. Epub 2018 Dec 22 doi: 10.1067/j.cpsurg.2018.12.001. PMID: 30777150
Colonoscopy.
Kaminski MF, Zagorowicz E
Gastrointest Endosc 2014 Sep;80(3):400-3. doi: 10.1016/j.gie.2014.07.005. PMID: 25127944
Large intestine.
Kelly CP
Curr Opin Gastroenterol 2010 Jan;26(1):45-6. doi: 10.1097/MOG.0b013e328333b040. PMID: 19881344

Therapy

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Macroscopic assessment of mesorectal excision.
Enker WE, Levi GS
Cancer 2009 Nov 1;115(21):4890-4. doi: 10.1002/cncr.24655. PMID: 19777545
Sigmoidoscopy.
Nicholls RJ
Br J Hosp Med 1982 Jul;28(1):59-60, 64-6. PMID: 7126974
Dietary fibre and large bowel cancer.
Cummings JH
Proc Nutr Soc 1981 Jan;40(1):7-14. doi: 10.1079/pns19810003. PMID: 6259640
Transexual surgery.
Markland C
Obstet Gynecol Annu 1975;4:309-30. PMID: 1095990

Prognosis

The Evolving Field of Neoadjuvant Therapy in Locally-advanced Rectal Cancer: Evidence and Prospects.
Ominelli J, Valadão M, Araujo ROC, Cristina de Melo A, Araujo LH
Clin Colorectal Cancer 2021 Dec;20(4):288-298. Epub 2021 Jul 8 doi: 10.1016/j.clcc.2021.06.005. PMID: 34340916
Tissue-specific mutation accumulation in human adult stem cells during life.
Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R
Nature 2016 Oct 13;538(7624):260-264. Epub 2016 Oct 3 doi: 10.1038/nature19768. PMID: 27698416Free PMC Article
Large intestine.
Kelly CP
Curr Opin Gastroenterol 2010 Jan;26(1):45-6. doi: 10.1097/MOG.0b013e328333b040. PMID: 19881344
The indication of local excision for T2 rectal carcinomas.
Masaki T, Sugiyama M, Atomi Y, Matsuoka H, Abe N, Watanabe T, Nagawa H, Muto T
Am J Surg 2001 Feb;181(2):133-7. doi: 10.1016/s0002-9610(00)00559-6. PMID: 11425053
Pseudo-obstruction of the large bowel.
Caves PK, Crockard HA
Br Med J 1970 Jun 6;2(5709):583-6. doi: 10.1136/bmj.2.5709.583. PMID: 5526616Free PMC Article

Clinical prediction guides

Volvulus of the Appendix.
Bhojwani D, Gourgiotis S, Simillis C
Gastroenterology 2021 Dec;161(6):1809-1810. Epub 2021 Aug 27 doi: 10.1053/j.gastro.2021.08.038. PMID: 34461051
AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review.
Murthy SK, Feuerstein JD, Nguyen GC, Velayos FS
Gastroenterology 2021 Sep;161(3):1043-1051.e4. doi: 10.1053/j.gastro.2021.05.063. PMID: 34416977
Abnormal Polypoid Finding During Colonoscopy.
Peng FB, Kim HS, Agarwal SK
Gastroenterology 2019 Oct;157(4):940-941. Epub 2019 May 31 doi: 10.1053/j.gastro.2019.05.063. PMID: 31158372
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma.
Castellarin M, Warren RL, Freeman JD, Dreolini L, Krzywinski M, Strauss J, Barnes R, Watson P, Allen-Vercoe E, Moore RA, Holt RA
Genome Res 2012 Feb;22(2):299-306. Epub 2011 Oct 18 doi: 10.1101/gr.126516.111. PMID: 22009989Free PMC Article
Histopathology reporting in large bowel cancer.
Blenkinsopp WK, Stewart-Brown S, Blesovsky L, Kearney G, Fielding LP
J Clin Pathol 1981 May;34(5):509-13. doi: 10.1136/jcp.34.5.509. PMID: 7251893Free PMC Article

Recent systematic reviews

Robotic rectal resection preserves anorectal function: Systematic review and meta-analysis.
Grass JK, Chen CC, Melling N, Lingala B, Kemper M, Scognamiglio P, Persiani R, Tirelli F, Caricato M, Capolupo GT, Izbicki JR, Perez DR
Int J Med Robot 2021 Dec;17(6):e2329. Epub 2021 Sep 9 doi: 10.1002/rcs.2329. PMID: 34463416
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Immunotherapy of Colon Cancer.
Stein A, Folprecht G
Oncol Res Treat 2018;41(5):282-285. Epub 2018 Apr 26 doi: 10.1159/000488918. PMID: 29705788
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845
A systematic review: effectiveness of rectal emptying preparation in prostate cancer patients.
McNair HA, Wedlake L, Lips IM, Andreyev J, Van Vulpen M, Dearnaley D
Pract Radiat Oncol 2014 Nov-Dec;4(6):437-47. Epub 2014 Aug 3 doi: 10.1016/j.prro.2014.06.005. PMID: 25407867

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