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Colon Conventional Adenoma

MedGen UID:
1738948
•Concept ID:
C5419784
•
Neoplastic Process

Definition

A benign, premalignant colon neoplasm composed of dysplastic epithelium. The descriptor ""conventional"" distinguishes this from lesions in the serrated pathway. (WHO 2019) [from NCI]

Professional guidelines

PubMed

Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2024.
Ferlitsch M, Hassan C, Bisschops R, Bhandari P, Dinis-Ribeiro M, Risio M, Paspatis GA, Moss A, Libânio D, Lorenzo-Zúñiga V, Voiosu AM, Rutter MD, Pellisé M, Moons LMG, Probst A, Awadie H, Amato A, Takeuchi Y, Repici A, Rahmi G, Koecklin HU, Albéniz E, Rockenbauer LM, Waldmann E, Messmann H, Triantafyllou K, Jover R, Gralnek IM, Dekker E, Bourke MJ
Endoscopy 2024 Jul;56(7):516-545. Epub 2024 Apr 26 doi: 10.1055/a-2304-3219. PMID: 38670139
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Pathophysiology, clinical presentation, and management of colon cancer.
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

Recent clinical studies

Therapy

Impact of AI-aided colonoscopy in clinical practice: a prospective randomised controlled trial.
Schöler J, Alavanja M, de Lange T, Yamamoto S, Hedenström P, Varkey J
BMJ Open Gastroenterol 2024 Jan 30;11(1) doi: 10.1136/bmjgast-2023-001247. PMID: 38290758Free PMC Article
Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study.
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Artificial Intelligence-Assisted Colonoscopy for Colorectal Cancer Screening: A Multicenter Randomized Controlled Trial.
Xu H, Tang RSY, Lam TYT, Zhao G, Lau JYW, Liu Y, Wu Q, Rong L, Xu W, Li X, Wong SH, Cai S, Wang J, Liu G, Ma T, Liang X, Mak JWY, Xu H, Yuan P, Cao T, Li F, Ye Z, Shutian Z, Sung JJY
Clin Gastroenterol Hepatol 2023 Feb;21(2):337-346.e3. Epub 2022 Jul 19 doi: 10.1016/j.cgh.2022.07.006. PMID: 35863686
YYFZBJS ameliorates colorectal cancer progression in Apc(Min/+) mice by remodeling gut microbiota and inhibiting regulatory T-cell generation.
Sui H, Zhang L, Gu K, Chai N, Ji Q, Zhou L, Wang Y, Ren J, Yang L, Zhang B, Hu J, Li Q
Cell Commun Signal 2020 Jul 16;18(1):113. doi: 10.1186/s12964-020-00596-9. PMID: 32677955Free PMC Article
The Effect of Right Colon Retroflexion on Adenoma Detection: A Systematic Review and Meta-analysis.
Cohen J, Grunwald D, Grossberg LB, Sawhney MS
J Clin Gastroenterol 2017 Oct;51(9):818-824. doi: 10.1097/MCG.0000000000000695. PMID: 27683963Free PMC Article

Prognosis

Risk Factors for Colorectal Polyps and Cancer.
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
The Effect of Right Colon Retroflexion on Adenoma Detection: A Systematic Review and Meta-analysis.
Cohen J, Grunwald D, Grossberg LB, Sawhney MS
J Clin Gastroenterol 2017 Oct;51(9):818-824. doi: 10.1097/MCG.0000000000000695. PMID: 27683963Free PMC Article
Pathophysiology, clinical presentation, and management of colon cancer.
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537
Magnification chromo-colonoscopy.
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

Clinical prediction guides

Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study.
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Single-cell Transcriptomics Reveals Early Molecular and Immune Alterations Underlying the Serrated Neoplasia Pathway Toward Colorectal Cancer.
Zhou YJ, Lu XF, Chen H, Wang XY, Cheng W, Zhang QW, Chen JN, Wang XY, Jin JZ, Yan FR, Chen H, Li XB
Cell Mol Gastroenterol Hepatol 2023;15(2):393-424. Epub 2022 Oct 8 doi: 10.1016/j.jcmgh.2022.10.001. PMID: 36216310Free PMC Article
The Effect of Right Colon Retroflexion on Adenoma Detection: A Systematic Review and Meta-analysis.
Cohen J, Grunwald D, Grossberg LB, Sawhney MS
J Clin Gastroenterol 2017 Oct;51(9):818-824. doi: 10.1097/MCG.0000000000000695. PMID: 27683963Free PMC Article
Traditional serrated adenoma (TSA): morphological questions, queries and quandaries.
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Magnification chromo-colonoscopy.
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

Recent systematic reviews

Device-assisted endoscopic full-thickness resection in colorectum: Systematic review and meta-analysis.
Nabi Z, Samanta J, Dhar J, Mohan BP, Facciorusso A, Reddy DN
Dig Endosc 2024 Feb;36(2):116-128. Epub 2023 Aug 7 doi: 10.1111/den.14631. PMID: 37422920
Serrated Polyps and the Risk of Metachronous Colorectal Advanced Neoplasia: A Systematic Review and Meta-Analysis.
Jung YS, Park JH, Park CH
Clin Gastroenterol Hepatol 2022 Jan;20(1):31-43.e1. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.051. PMID: 33007512
New technologies improve adenoma detection rate, adenoma miss rate, and polyp detection rate: a systematic review and meta-analysis.
Castaneda D, Popov VB, Verheyen E, Wander P, Gross SA
Gastrointest Endosc 2018 Aug;88(2):209-222.e11. Epub 2018 Apr 1 doi: 10.1016/j.gie.2018.03.022. PMID: 29614263
The Effect of Right Colon Retroflexion on Adenoma Detection: A Systematic Review and Meta-analysis.
Cohen J, Grunwald D, Grossberg LB, Sawhney MS
J Clin Gastroenterol 2017 Oct;51(9):818-824. doi: 10.1097/MCG.0000000000000695. PMID: 27683963Free PMC Article
Colorectal endoscopic submucosal dissection: Systematic review of mid-term clinical outcomes.
Patel N, Patel K, Ashrafian H, Athanasiou T, Darzi A, Teare J
Dig Endosc 2016 May;28(4):405-416. Epub 2016 Apr 20 doi: 10.1111/den.12597. PMID: 26710317

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