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Colon adenoma

MedGen UID:
1639098
•Concept ID:
C4551463
•
Neoplastic Process
Synonym: Colonic adenomas
 
Monarch Initiative: MONDO:0000527

Definition

An adenoma that arises from the colon. The group of colonic adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas, sessile serrated adenomas/polyps, and familial adenomatous polyposis. [from NCI]

Professional guidelines

PubMed

Effect of Insulin and Metformin Combination Treatment on Colon Adenoma and Advanced Adenoma Among DM II.
Jain D, Chhoda A, Uribe J
J Gastrointest Cancer 2016 Dec;47(4):404-408. doi: 10.1007/s12029-016-9842-4. PMID: 27256336
Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment.
DeStefano Shields CE, Van Meerbeke SW, Housseau F, Wang H, Huso DL, Casero RA Jr, O'Hagan HM, Sears CL
J Infect Dis 2016 Jul 1;214(1):122-9. Epub 2016 Feb 21 doi: 10.1093/infdis/jiw069. PMID: 26908749Free PMC Article
CYP2C9 and UGT1A6 genotypes modulate the protective effect of aspirin on colon adenoma risk.
Bigler J, Whitton J, Lampe JW, Fosdick L, Bostick RM, Potter JD
Cancer Res 2001 May 1;61(9):3566-9. PMID: 11325819

Recent clinical studies

Etiology

Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma.
Schoen RE, Boardman LA, Cruz-Correa M, Bansal A, Kastenberg D, Hur C, Dzubinski L, Kaufman SF, Rodriguez LM, Richmond E, Umar A, Szabo E, Salazar A, McKolanis J, Beatty P, Pai RK, Singhi AD, Jacqueline CM, Bao R, Diergaarde B, McMurray RP, Strand C, Foster NR, Zahrieh DM, Limburg PJ, Finn OJ
Clin Cancer Res 2023 May 1;29(9):1678-1688. doi: 10.1158/1078-0432.CCR-22-3168. PMID: 36892581Free PMC Article
Organoids Are Limited in Modeling the Colon Adenoma-Carcinoma Sequence.
Tokumaru Y, Oshi M, Patel A, Tian W, Yan L, Matsuhashi N, Futamura M, Yoshida K, Takabe K
Cells 2021 Feb 25;10(3) doi: 10.3390/cells10030488. PMID: 33668713Free PMC Article
Obesity, diabetes and the risk of colorectal adenoma and cancer.
Soltani G, Poursheikhani A, Yassi M, Hayatbakhsh A, Kerachian M, Kerachian MA
BMC Endocr Disord 2019 Oct 29;19(1):113. doi: 10.1186/s12902-019-0444-6. PMID: 31664994Free PMC Article
Pharmacological and dietary factors in prevention of colorectal cancer.
Waluga M, Zorniak M, Fichna J, Kukla M, Hartleb M
J Physiol Pharmacol 2018 Jun;69(3) Epub 2018 Aug 22 doi: 10.26402/jpp.2018.3.02. PMID: 30149368
Long-term use of progestogens: colon adenoma and colon carcinoma.
Schindler AE
Gynecol Endocrinol 2007 Oct;23 Suppl 1:42-4. doi: 10.1080/09513590701584899. PMID: 17943538

Diagnosis

Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma.
Schoen RE, Boardman LA, Cruz-Correa M, Bansal A, Kastenberg D, Hur C, Dzubinski L, Kaufman SF, Rodriguez LM, Richmond E, Umar A, Szabo E, Salazar A, McKolanis J, Beatty P, Pai RK, Singhi AD, Jacqueline CM, Bao R, Diergaarde B, McMurray RP, Strand C, Foster NR, Zahrieh DM, Limburg PJ, Finn OJ
Clin Cancer Res 2023 May 1;29(9):1678-1688. doi: 10.1158/1078-0432.CCR-22-3168. PMID: 36892581Free PMC Article
Insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: A retrospective, hospital-based study.
Shin HS, Cho YJ
Medicine (Baltimore) 2022 Aug 26;101(34):e30200. doi: 10.1097/MD.0000000000030200. PMID: 36042665Free PMC Article
Comparing right colon adenoma detection rate during water exchange and air insufflation: a double-blind randomized controlled trial.
Tseng CW, Hsieh YH, Koo M, Leung FW
Tech Coloproctol 2022 Jan;26(1):35-44. Epub 2021 Oct 27 doi: 10.1007/s10151-021-02537-1. PMID: 34705136
Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum.
Brennan CA, Nakatsu G, Gallini Comeau CA, Drew DA, Glickman JN, Schoen RE, Chan AT, Garrett WS
mBio 2021 Apr 6;12(2) doi: 10.1128/mBio.00547-21. PMID: 33824205Free PMC Article
Obesity, diabetes and the risk of colorectal adenoma and cancer.
Soltani G, Poursheikhani A, Yassi M, Hayatbakhsh A, Kerachian M, Kerachian MA
BMC Endocr Disord 2019 Oct 29;19(1):113. doi: 10.1186/s12902-019-0444-6. PMID: 31664994Free PMC Article

Therapy

Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma.
Schoen RE, Boardman LA, Cruz-Correa M, Bansal A, Kastenberg D, Hur C, Dzubinski L, Kaufman SF, Rodriguez LM, Richmond E, Umar A, Szabo E, Salazar A, McKolanis J, Beatty P, Pai RK, Singhi AD, Jacqueline CM, Bao R, Diergaarde B, McMurray RP, Strand C, Foster NR, Zahrieh DM, Limburg PJ, Finn OJ
Clin Cancer Res 2023 May 1;29(9):1678-1688. doi: 10.1158/1078-0432.CCR-22-3168. PMID: 36892581Free PMC Article
Pharmacological and dietary factors in prevention of colorectal cancer.
Waluga M, Zorniak M, Fichna J, Kukla M, Hartleb M
J Physiol Pharmacol 2018 Jun;69(3) Epub 2018 Aug 22 doi: 10.26402/jpp.2018.3.02. PMID: 30149368
Endoscopic management of mucosal lesions in the gastrointestinal tract.
Chen WC, Wallace MB
Expert Rev Gastroenterol Hepatol 2016;10(4):481-95. Epub 2015 Dec 11 doi: 10.1586/17474124.2016.1122520. PMID: 26581857
Long-term use of progestogens: colon adenoma and colon carcinoma.
Schindler AE
Gynecol Endocrinol 2007 Oct;23 Suppl 1:42-4. doi: 10.1080/09513590701584899. PMID: 17943538
Estrogen replacement therapy and colon cancer: a clinical review.
Crandall CJ
J Womens Health Gend Based Med 1999 Nov;8(9):1155-66. doi: 10.1089/jwh.1.1999.8.1155. PMID: 10595328

Prognosis

Significance of long non-coding RNA IFNG-AS1 in the progression and clinical prognosis in colon adenocarcinoma.
Wang Z, Cao Z, Wang Z
Bioengineered 2021 Dec;12(2):11342-11350. doi: 10.1080/21655979.2021.2003944. PMID: 34872454Free PMC Article
Comparison of Right Colon Adenoma Miss Rates Between Water Exchange and Carbon Dioxide Insufflation: A Prospective Randomized Controlled Trial.
Cheng CL, Kuo YL, Hsieh YH, Tang JH, Leung FW
J Clin Gastroenterol 2021 Nov-Dec 01;55(10):869-875. doi: 10.1097/MCG.0000000000001454. PMID: 33074950
Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer.
Abdel Raouf SM, Ibrahim TR, Abdelaziz LA, Farid MI, Mohamed SY
J Gastrointest Cancer 2021 Mar;52(1):90-98. doi: 10.1007/s12029-019-00344-4. PMID: 31823218
Obesity, diabetes and the risk of colorectal adenoma and cancer.
Soltani G, Poursheikhani A, Yassi M, Hayatbakhsh A, Kerachian M, Kerachian MA
BMC Endocr Disord 2019 Oct 29;19(1):113. doi: 10.1186/s12902-019-0444-6. PMID: 31664994Free PMC Article
Estrogen and colon cancer: current issues.
al-Azzawi F, Wahab M
Climacteric 2002 Mar;5(1):3-14. PMID: 11974557

Clinical prediction guides

Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma.
Schoen RE, Boardman LA, Cruz-Correa M, Bansal A, Kastenberg D, Hur C, Dzubinski L, Kaufman SF, Rodriguez LM, Richmond E, Umar A, Szabo E, Salazar A, McKolanis J, Beatty P, Pai RK, Singhi AD, Jacqueline CM, Bao R, Diergaarde B, McMurray RP, Strand C, Foster NR, Zahrieh DM, Limburg PJ, Finn OJ
Clin Cancer Res 2023 May 1;29(9):1678-1688. doi: 10.1158/1078-0432.CCR-22-3168. PMID: 36892581Free PMC Article
Comparing right colon adenoma detection rate during water exchange and air insufflation: a double-blind randomized controlled trial.
Tseng CW, Hsieh YH, Koo M, Leung FW
Tech Coloproctol 2022 Jan;26(1):35-44. Epub 2021 Oct 27 doi: 10.1007/s10151-021-02537-1. PMID: 34705136
Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer.
Abdel Raouf SM, Ibrahim TR, Abdelaziz LA, Farid MI, Mohamed SY
J Gastrointest Cancer 2021 Mar;52(1):90-98. doi: 10.1007/s12029-019-00344-4. PMID: 31823218
Obesity, diabetes and the risk of colorectal adenoma and cancer.
Soltani G, Poursheikhani A, Yassi M, Hayatbakhsh A, Kerachian M, Kerachian MA
BMC Endocr Disord 2019 Oct 29;19(1):113. doi: 10.1186/s12902-019-0444-6. PMID: 31664994Free PMC Article
Cell-surface markers for colon adenoma and adenocarcinoma.
Sewda K, Coppola D, Enkemann S, Yue B, Kim J, Lopez AS, Wojtkowiak JW, Stark VE, Morse B, Shibata D, Vignesh S, Morse DL
Oncotarget 2016 Apr 5;7(14):17773-89. doi: 10.18632/oncotarget.7402. PMID: 26894861Free PMC Article

Recent systematic reviews

Endocuff-assisted versus Cap-assisted Colonoscopy in Increasing Adenoma Detection Rate. A Meta-analysis.
Facciorusso A, Buccino VR, Sacco R
J Gastrointestin Liver Dis 2020 Sep 9;29(3):415-420. doi: 10.15403/jgld-1239. PMID: 32830810
Compared Abilities of Endoscopic Techniques to Increase Colon Adenoma Detection Rates: A Network Meta-analysis.
Facciorusso A, Triantafyllou K, Murad MH, Prokop LJ, Tziatzios G, Muscatiello N, Singh S
Clin Gastroenterol Hepatol 2019 Nov;17(12):2439-2454.e25. Epub 2018 Dec 6 doi: 10.1016/j.cgh.2018.11.058. PMID: 30529731
The benefit of adding oral simethicone in bowel preparation regimen for the detection of colon adenoma: A systematic review and meta-analysis.
Yeh JH, Hsu MH, Tseng CM, Chen TH, Huang RY, Lee CT, Lin CW, Wang WL
J Gastroenterol Hepatol 2019 May;34(5):830-836. Epub 2018 Nov 4 doi: 10.1111/jgh.14508. PMID: 30311262
Comparative Efficacy of Colonoscope Distal Attachment Devices in Increasing Rates of Adenoma Detection: A Network Meta-analysis.
Facciorusso A, Del Prete V, Buccino RV, Della Valle N, Nacchiero MC, Monica F, Cannizzaro R, Muscatiello N
Clin Gastroenterol Hepatol 2018 Aug;16(8):1209-1219.e9. Epub 2017 Nov 11 doi: 10.1016/j.cgh.2017.11.007. PMID: 29133257
Physical activity and risk of colon adenoma: a meta-analysis.
Wolin KY, Yan Y, Colditz GA
Br J Cancer 2011 Mar 1;104(5):882-5. Epub 2011 Feb 8 doi: 10.1038/sj.bjc.6606045. PMID: 21304525Free PMC Article

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