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Colorectal Tubular Adenoma

MedGen UID:
232095
•Concept ID:
C1333117
•
Neoplastic Process

Definition

A usually polypoid neoplasm that arises from the glandular epithelium of the colonic and rectal mucosa. It is characterized by a tubular architectural pattern. The neoplastic glandular cells have dysplastic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Tubular Adenoma

Professional guidelines

PubMed

Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Follow-up of patients with curatively resected colorectal cancer: a practice guideline.
Figueredo A, Rumble RB, Maroun J, Earle CC, Cummings B, McLeod R, Zuraw L, Zwaal C; Gastrointestinal Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care
BMC Cancer 2003 Oct 6;3:26. doi: 10.1186/1471-2407-3-26. PMID: 14529575Free PMC Article
Initial management and follow-up surveillance of patients with colorectal adenomas.
Zauber AG, Winawer SJ
Gastroenterol Clin North Am 1997 Mar;26(1):85-101. doi: 10.1016/s0889-8553(05)70285-5. PMID: 9119442

Recent clinical studies

Etiology

Microsatellite Status of Primary Colorectal Cancer Predicts the Incidence of Postoperative Colorectal Neoplasms.
Takiyama A, Tanaka T, Yamamoto Y, Hata K, Ishihara S, Nozawa H, Kawai K, Kiyomatsu T, Nishikawa T, Otani K, Sasaki K, Watanabe T
Anticancer Res 2017 Oct;37(10):5785-5790. doi: 10.21873/anticanres.12020. PMID: 28982902
Genetic instability, CpG island methylator phenotype, and proliferative activity are distinct differences between diminutive and small tubular adenoma of the colorectum.
Nando Y, Watari J, Ito C, Hara K, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Tomita T, Ohda Y, Oshima T, Fukui H, Matsubara N, Tomita N, Hirota S, Miwa H
Hum Pathol 2017 Feb;60:37-45. Epub 2016 Oct 13 doi: 10.1016/j.humpath.2016.09.022. PMID: 27746269
Expression of RUNX3 and β-catenin in the carcinogenesis of sporadic colorectal tubular adenoma.
Wang L, Li D, Liu Y, Wang Y, Cui J, Cui A, Wu W
Tumour Biol 2014 Jun;35(6):6039-46. Epub 2014 Mar 14 doi: 10.1007/s13277-014-1800-9. PMID: 24622886
Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men.
Tabuchi M, Kitayama J, Nagawa H
World J Gastroenterol 2006 Feb 28;12(8):1261-4. doi: 10.3748/wjg.v12.i8.1261. PMID: 16534881Free PMC Article

Diagnosis

Colon adenoma and adenocarcinoma with clear cell components - two case reports.
Oyama Y, Nishida H, Kusaba T, Kadowaki H, Arakane M, Okamoto K, Wada J, Urabe S, Daa T
Diagn Pathol 2019 May 10;14(1):37. doi: 10.1186/s13000-019-0819-z. PMID: 31077226Free PMC Article
Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men.
Tabuchi M, Kitayama J, Nagawa H
World J Gastroenterol 2006 Feb 28;12(8):1261-4. doi: 10.3748/wjg.v12.i8.1261. PMID: 16534881Free PMC Article

Therapy

Microsatellite Status of Primary Colorectal Cancer Predicts the Incidence of Postoperative Colorectal Neoplasms.
Takiyama A, Tanaka T, Yamamoto Y, Hata K, Ishihara S, Nozawa H, Kawai K, Kiyomatsu T, Nishikawa T, Otani K, Sasaki K, Watanabe T
Anticancer Res 2017 Oct;37(10):5785-5790. doi: 10.21873/anticanres.12020. PMID: 28982902

Prognosis

Microsatellite Status of Primary Colorectal Cancer Predicts the Incidence of Postoperative Colorectal Neoplasms.
Takiyama A, Tanaka T, Yamamoto Y, Hata K, Ishihara S, Nozawa H, Kawai K, Kiyomatsu T, Nishikawa T, Otani K, Sasaki K, Watanabe T
Anticancer Res 2017 Oct;37(10):5785-5790. doi: 10.21873/anticanres.12020. PMID: 28982902
Genetic instability, CpG island methylator phenotype, and proliferative activity are distinct differences between diminutive and small tubular adenoma of the colorectum.
Nando Y, Watari J, Ito C, Hara K, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Tomita T, Ohda Y, Oshima T, Fukui H, Matsubara N, Tomita N, Hirota S, Miwa H
Hum Pathol 2017 Feb;60:37-45. Epub 2016 Oct 13 doi: 10.1016/j.humpath.2016.09.022. PMID: 27746269
Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men.
Tabuchi M, Kitayama J, Nagawa H
World J Gastroenterol 2006 Feb 28;12(8):1261-4. doi: 10.3748/wjg.v12.i8.1261. PMID: 16534881Free PMC Article

Clinical prediction guides

Microsatellite Status of Primary Colorectal Cancer Predicts the Incidence of Postoperative Colorectal Neoplasms.
Takiyama A, Tanaka T, Yamamoto Y, Hata K, Ishihara S, Nozawa H, Kawai K, Kiyomatsu T, Nishikawa T, Otani K, Sasaki K, Watanabe T
Anticancer Res 2017 Oct;37(10):5785-5790. doi: 10.21873/anticanres.12020. PMID: 28982902
Genetic instability, CpG island methylator phenotype, and proliferative activity are distinct differences between diminutive and small tubular adenoma of the colorectum.
Nando Y, Watari J, Ito C, Hara K, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Tomita T, Ohda Y, Oshima T, Fukui H, Matsubara N, Tomita N, Hirota S, Miwa H
Hum Pathol 2017 Feb;60:37-45. Epub 2016 Oct 13 doi: 10.1016/j.humpath.2016.09.022. PMID: 27746269
Expression of RUNX3 and β-catenin in the carcinogenesis of sporadic colorectal tubular adenoma.
Wang L, Li D, Liu Y, Wang Y, Cui J, Cui A, Wu W
Tumour Biol 2014 Jun;35(6):6039-46. Epub 2014 Mar 14 doi: 10.1007/s13277-014-1800-9. PMID: 24622886

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