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Colorectal Benign Granular Cell Tumor

MedGen UID:
474471
•Concept ID:
C3272838
•
Neoplastic Process

Definition

A granular cell tumor that arises from the colon or rectum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Benign Granular Cell Tumor

Professional guidelines

PubMed

Colorectal Leiomyosarcoma: Demographics Patterns, Treatment Characteristics, and Survival Analysis in the U.S. Population.
Yasinzai AQK, Lee KT, Khan I, Tareen B, Sohail AH, Iqbal A, Khan I, Waheed A, Ramamoorthy BU, Ullah A, Blakely AM
J Gastrointest Cancer 2024 Dec;55(4):1588-1597. Epub 2024 Aug 27 doi: 10.1007/s12029-024-01110-x. PMID: 39190114Free PMC Article
Gastrointestinal (GI) leiomyosarcoma (LMS) case series and review on diagnosis, management, and prognosis.
Hilal L, Barada K, Mukherji D, Temraz S, Shamseddine A
Med Oncol 2016 Feb;33(2):20. Epub 2016 Jan 20 doi: 10.1007/s12032-016-0730-3. PMID: 26786155
Genetic testing by cancer site: uterus.
Daniels MS
Cancer J 2012 Jul-Aug;18(4):338-42. doi: 10.1097/PPO.0b013e3182610cc2. PMID: 22846735

Recent clinical studies

Etiology

High intramuscular adipose tissue content associated with prognosis and postoperative complications of cancers.
Liu R, Qiu Z, Zhang L, Ma W, Zi L, Wang K, Kuang T, Zhao K, Wang W
J Cachexia Sarcopenia Muscle 2023 Dec;14(6):2509-2519. Epub 2023 Nov 22 doi: 10.1002/jcsm.13371. PMID: 37990969Free PMC Article
Role of ion channels in gastrointestinal cancer.
Anderson KJ, Cormier RT, Scott PM
World J Gastroenterol 2019 Oct 14;25(38):5732-5772. doi: 10.3748/wjg.v25.i38.5732. PMID: 31636470Free PMC Article
Multitarget stool DNA testing for colorectal-cancer screening.
Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, Ahlquist DA, Berger BM
N Engl J Med 2014 Apr 3;370(14):1287-97. Epub 2014 Mar 19 doi: 10.1056/NEJMoa1311194. PMID: 24645800
Screening for uterine tumours.
Van den Bosch T, Coosemans A, Morina M, Timmerman D, Amant F
Best Pract Res Clin Obstet Gynaecol 2012 Apr;26(2):257-66. Epub 2011 Nov 9 doi: 10.1016/j.bpobgyn.2011.08.002. PMID: 22078749
Hepatic artery chemoembolization.
Sullivan KL
Semin Oncol 2002 Apr;29(2):145-51. doi: 10.1053/sonc.2002.31671. PMID: 11951212

Diagnosis

Tumor loss-of-function mutations in STK11/LKB1 induce cachexia.
Iyengar P, Gandhi AY, Granados J, Guo T, Gupta A, Yu J, Llano EM, Zhang F, Gao A, Kandathil A, Williams D, Gao B, Girard L, Malladi VS, Shelton JM, Evers BM, Hannan R, Ahn C, Minna JD, Infante RE
JCI Insight 2023 Apr 24;8(8) doi: 10.1172/jci.insight.165419. PMID: 37092555Free PMC Article
Leiomyosarcoma of the Mesentery.
Arhin MA, DeMatos P
Am Surg 2022 Sep;88(9):2210-2211. Epub 2022 Apr 14 doi: 10.1177/00031348221087921. PMID: 35420902
The Role of Tumor Microenvironment Cells in Colorectal Cancer (CRC) Cachexia.
Kasprzak A
Int J Mol Sci 2021 Feb 4;22(4) doi: 10.3390/ijms22041565. PMID: 33557173Free PMC Article
Multitarget stool DNA testing for colorectal-cancer screening.
Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, Ahlquist DA, Berger BM
N Engl J Med 2014 Apr 3;370(14):1287-97. Epub 2014 Mar 19 doi: 10.1056/NEJMoa1311194. PMID: 24645800
Screening for uterine tumours.
Van den Bosch T, Coosemans A, Morina M, Timmerman D, Amant F
Best Pract Res Clin Obstet Gynaecol 2012 Apr;26(2):257-66. Epub 2011 Nov 9 doi: 10.1016/j.bpobgyn.2011.08.002. PMID: 22078749

Therapy

Role of ion channels in gastrointestinal cancer.
Anderson KJ, Cormier RT, Scott PM
World J Gastroenterol 2019 Oct 14;25(38):5732-5772. doi: 10.3748/wjg.v25.i38.5732. PMID: 31636470Free PMC Article
Multitarget stool DNA testing for colorectal-cancer screening.
Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, Ahlquist DA, Berger BM
N Engl J Med 2014 Apr 3;370(14):1287-97. Epub 2014 Mar 19 doi: 10.1056/NEJMoa1311194. PMID: 24645800
Screening for uterine tumours.
Van den Bosch T, Coosemans A, Morina M, Timmerman D, Amant F
Best Pract Res Clin Obstet Gynaecol 2012 Apr;26(2):257-66. Epub 2011 Nov 9 doi: 10.1016/j.bpobgyn.2011.08.002. PMID: 22078749
Non-contraceptive benefits of oral contraceptives.
Huber JC, Bentz EK, Ott J, Tempfer CB
Expert Opin Pharmacother 2008 Sep;9(13):2317-25. doi: 10.1517/14656566.9.13.2317. PMID: 18710356
Hepatic artery chemoembolization.
Sullivan KL
Semin Oncol 2002 Apr;29(2):145-51. doi: 10.1053/sonc.2002.31671. PMID: 11951212

Prognosis

High intramuscular adipose tissue content associated with prognosis and postoperative complications of cancers.
Liu R, Qiu Z, Zhang L, Ma W, Zi L, Wang K, Kuang T, Zhao K, Wang W
J Cachexia Sarcopenia Muscle 2023 Dec;14(6):2509-2519. Epub 2023 Nov 22 doi: 10.1002/jcsm.13371. PMID: 37990969Free PMC Article
The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis.
Kobayashi H, Gieniec KA, Lannagan TRM, Wang T, Asai N, Mizutani Y, Iida T, Ando R, Thomas EM, Sakai A, Suzuki N, Ichinose M, Wright JA, Vrbanac L, Ng JQ, Goyne J, Radford G, Lawrence MJ, Sammour T, Hayakawa Y, Klebe S, Shin AE, Asfaha S, Bettington ML, Rieder F, Arpaia N, Danino T, Butler LM, Burt AD, Leedham SJ, Rustgi AK, Mukherjee S, Takahashi M, Wang TC, Enomoto A, Woods SL, Worthley DL
Gastroenterology 2022 Mar;162(3):890-906. Epub 2021 Dec 6 doi: 10.1053/j.gastro.2021.11.037. PMID: 34883119Free PMC Article
The Role of Tumor Microenvironment Cells in Colorectal Cancer (CRC) Cachexia.
Kasprzak A
Int J Mol Sci 2021 Feb 4;22(4) doi: 10.3390/ijms22041565. PMID: 33557173Free PMC Article
Role of ion channels in gastrointestinal cancer.
Anderson KJ, Cormier RT, Scott PM
World J Gastroenterol 2019 Oct 14;25(38):5732-5772. doi: 10.3748/wjg.v25.i38.5732. PMID: 31636470Free PMC Article
The Role of PDGFs and PDGFRs in Colorectal Cancer.
Manzat Saplacan RM, Balacescu L, Gherman C, Chira RI, Craiu A, Mircea PA, Lisencu C, Balacescu O
Mediators Inflamm 2017;2017:4708076. Epub 2017 Jan 10 doi: 10.1155/2017/4708076. PMID: 28163397Free PMC Article

Clinical prediction guides

High intramuscular adipose tissue content associated with prognosis and postoperative complications of cancers.
Liu R, Qiu Z, Zhang L, Ma W, Zi L, Wang K, Kuang T, Zhao K, Wang W
J Cachexia Sarcopenia Muscle 2023 Dec;14(6):2509-2519. Epub 2023 Nov 22 doi: 10.1002/jcsm.13371. PMID: 37990969Free PMC Article
Tumor loss-of-function mutations in STK11/LKB1 induce cachexia.
Iyengar P, Gandhi AY, Granados J, Guo T, Gupta A, Yu J, Llano EM, Zhang F, Gao A, Kandathil A, Williams D, Gao B, Girard L, Malladi VS, Shelton JM, Evers BM, Hannan R, Ahn C, Minna JD, Infante RE
JCI Insight 2023 Apr 24;8(8) doi: 10.1172/jci.insight.165419. PMID: 37092555Free PMC Article
The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis.
Kobayashi H, Gieniec KA, Lannagan TRM, Wang T, Asai N, Mizutani Y, Iida T, Ando R, Thomas EM, Sakai A, Suzuki N, Ichinose M, Wright JA, Vrbanac L, Ng JQ, Goyne J, Radford G, Lawrence MJ, Sammour T, Hayakawa Y, Klebe S, Shin AE, Asfaha S, Bettington ML, Rieder F, Arpaia N, Danino T, Butler LM, Burt AD, Leedham SJ, Rustgi AK, Mukherjee S, Takahashi M, Wang TC, Enomoto A, Woods SL, Worthley DL
Gastroenterology 2022 Mar;162(3):890-906. Epub 2021 Dec 6 doi: 10.1053/j.gastro.2021.11.037. PMID: 34883119Free PMC Article
The Role of PDGFs and PDGFRs in Colorectal Cancer.
Manzat Saplacan RM, Balacescu L, Gherman C, Chira RI, Craiu A, Mircea PA, Lisencu C, Balacescu O
Mediators Inflamm 2017;2017:4708076. Epub 2017 Jan 10 doi: 10.1155/2017/4708076. PMID: 28163397Free PMC Article
Granular cell tumours of the colorectum: histopathological and immunohistochemical evaluation of 30 cases.
Na JI, Kim HJ, Jung JJ, Kim Y, Kim SS, Lee JH, Lee KH, Park JT
Histopathology 2014 Dec;65(6):764-74. Epub 2014 Aug 26 doi: 10.1111/his.12487. PMID: 25040719

Recent systematic reviews

High intramuscular adipose tissue content associated with prognosis and postoperative complications of cancers.
Liu R, Qiu Z, Zhang L, Ma W, Zi L, Wang K, Kuang T, Zhao K, Wang W
J Cachexia Sarcopenia Muscle 2023 Dec;14(6):2509-2519. Epub 2023 Nov 22 doi: 10.1002/jcsm.13371. PMID: 37990969Free PMC Article
Special features of sarcomas developed in patients with Lynch syndrome: A systematic review.
Poumeaud F, Valentin T, Vande Perre P, Jaffrelot M, Bonnet D, Chibon F, Chevreau C, Selves J, Guimbaud R, Fares N
Crit Rev Oncol Hematol 2023 Aug;188:104055. Epub 2023 Jun 8 doi: 10.1016/j.critrevonc.2023.104055. PMID: 37301271
Body Composition and Dose-limiting Toxicity in Colorectal Cancer Chemotherapy Treatment; a Systematic Review of the Literature. Could Muscle Mass be the New Body Surface Area in Chemotherapy Dosing?
Drami I, Pring ET, Gould L, Malietzis G, Naghibi M, Athanasiou T, Glynne-Jones R, Jenkins JT
Clin Oncol (R Coll Radiol) 2021 Dec;33(12):e540-e552. Epub 2021 Jun 17 doi: 10.1016/j.clon.2021.05.011. PMID: 34147322
Myosteatosis and prognosis in cancer: Systematic review and meta-analysis.
Aleixo GFP, Shachar SS, Nyrop KA, Muss HB, Malpica L, Williams GR
Crit Rev Oncol Hematol 2020 Jan;145:102839. Epub 2019 Dec 20 doi: 10.1016/j.critrevonc.2019.102839. PMID: 31877534
A systematic review: perivascular epithelioid cell tumor of gastrointestinal tract.
Chen Z, Han S, Wu J, Xiong M, Huang Y, Chen J, Yuan Y, Peng J, Song W
Medicine (Baltimore) 2016 Jul;95(28):e3890. doi: 10.1097/MD.0000000000003890. PMID: 27428182Free PMC Article

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