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Colorectal Adenoma with Moderate Dysplasia

MedGen UID:
232091
•Concept ID:
C1333107
•
Neoplastic Process

Definition

An adenoma that arises from the colon or rectum. It is characterized by the presence of moderate epithelial dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Adenoma with Moderate Dysplasia

Professional guidelines

PubMed

Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2024.
Ferlitsch M, Hassan C, Bisschops R, Bhandari P, Dinis-Ribeiro M, Risio M, Paspatis GA, Moss A, Libânio D, Lorenzo-Zúñiga V, Voiosu AM, Rutter MD, Pellisé M, Moons LMG, Probst A, Awadie H, Amato A, Takeuchi Y, Repici A, Rahmi G, Koecklin HU, Albéniz E, Rockenbauer LM, Waldmann E, Messmann H, Triantafyllou K, Jover R, Gralnek IM, Dekker E, Bourke MJ
Endoscopy 2024 Jul;56(7):516-545. Epub 2024 Apr 26 doi: 10.1055/a-2304-3219. PMID: 38670139
Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics.
Rau TT, Agaimy A, Gehoff A, Geppert C, Jung K, Knobloch K, Langner C, Lugli A, Groenbus-Lurkin I, Nagtegaal ID, Rüschoff J, Saegert X, Sarbia M, Schneider-Stock R, Vieth M, Zwarthoff EC, Hartmann A
Virchows Arch 2014 Jun;464(6):663-72. Epub 2014 Apr 12 doi: 10.1007/s00428-014-1569-7. PMID: 24728704
Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Hassan C, Quintero E, Dumonceau JM, Regula J, Brandão C, Chaussade S, Dekker E, Dinis-Ribeiro M, Ferlitsch M, Gimeno-García A, Hazewinkel Y, Jover R, Kalager M, Loberg M, Pox C, Rembacken B, Lieberman D; European Society of Gastrointestinal Endoscopy
Endoscopy 2013 Oct;45(10):842-51. Epub 2013 Sep 12 doi: 10.1055/s-0033-1344548. PMID: 24030244

Recent clinical studies

Etiology

Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2024.
Ferlitsch M, Hassan C, Bisschops R, Bhandari P, Dinis-Ribeiro M, Risio M, Paspatis GA, Moss A, Libânio D, Lorenzo-Zúñiga V, Voiosu AM, Rutter MD, Pellisé M, Moons LMG, Probst A, Awadie H, Amato A, Takeuchi Y, Repici A, Rahmi G, Koecklin HU, Albéniz E, Rockenbauer LM, Waldmann E, Messmann H, Triantafyllou K, Jover R, Gralnek IM, Dekker E, Bourke MJ
Endoscopy 2024 Jul;56(7):516-545. Epub 2024 Apr 26 doi: 10.1055/a-2304-3219. PMID: 38670139
Real-Time Computer-Aided Detection of Colorectal Neoplasia During Colonoscopy : A Systematic Review and Meta-analysis.
Hassan C, Spadaccini M, Mori Y, Foroutan F, Facciorusso A, Gkolfakis P, Tziatzios G, Triantafyllou K, Antonelli G, Khalaf K, Rizkala T, Vandvik PO, Fugazza A, Rondonotti E, Glissen-Brown JR, Kamba S, Maida M, Correale L, Bhandari P, Jover R, Sharma P, Rex DK, Repici A
Ann Intern Med 2023 Sep;176(9):1209-1220. Epub 2023 Aug 29 doi: 10.7326/M22-3678. PMID: 37639719
Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study.
Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
Clinicopathological characterization of colonic polyps.
Qari YA
Niger J Clin Pract 2020 Aug;23(8):1048-1053. doi: 10.4103/njcp.njcp_490_19. PMID: 32788480
DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia.
Takiyama A, Tanaka T, Kazama S, Nagata H, Kawai K, Hata K, Otani K, Nishikawa T, Sasaki K, Kaneko M, Emoto S, Murono K, Takiyama H, Nozawa H
In Vivo 2018 Mar-Apr;32(2):365-371. doi: 10.21873/invivo.11247. PMID: 29475922Free PMC Article

Diagnosis

Real-Time Computer-Aided Detection of Colorectal Neoplasia During Colonoscopy : A Systematic Review and Meta-analysis.
Hassan C, Spadaccini M, Mori Y, Foroutan F, Facciorusso A, Gkolfakis P, Tziatzios G, Triantafyllou K, Antonelli G, Khalaf K, Rizkala T, Vandvik PO, Fugazza A, Rondonotti E, Glissen-Brown JR, Kamba S, Maida M, Correale L, Bhandari P, Jover R, Sharma P, Rex DK, Repici A
Ann Intern Med 2023 Sep;176(9):1209-1220. Epub 2023 Aug 29 doi: 10.7326/M22-3678. PMID: 37639719
Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study.
Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia.
Takiyama A, Tanaka T, Kazama S, Nagata H, Kawai K, Hata K, Otani K, Nishikawa T, Sasaki K, Kaneko M, Emoto S, Murono K, Takiyama H, Nozawa H
In Vivo 2018 Mar-Apr;32(2):365-371. doi: 10.21873/invivo.11247. PMID: 29475922Free PMC Article
Long-term colorectal-cancer mortality after adenoma removal.
Løberg M, Kalager M, Holme Ø, Hoff G, Adami HO, Bretthauer M
N Engl J Med 2014 Aug 28;371(9):799-807. doi: 10.1056/NEJMoa1315870. PMID: 25162886
Colorectal polyps and their relationship to cancer.
Kim EC, Lance P
Gastroenterol Clin North Am 1997 Mar;26(1):1-17. doi: 10.1016/s0889-8553(05)70280-6. PMID: 9119435

Therapy

Real-Time Computer-Aided Detection of Colorectal Neoplasia During Colonoscopy : A Systematic Review and Meta-analysis.
Hassan C, Spadaccini M, Mori Y, Foroutan F, Facciorusso A, Gkolfakis P, Tziatzios G, Triantafyllou K, Antonelli G, Khalaf K, Rizkala T, Vandvik PO, Fugazza A, Rondonotti E, Glissen-Brown JR, Kamba S, Maida M, Correale L, Bhandari P, Jover R, Sharma P, Rex DK, Repici A
Ann Intern Med 2023 Sep;176(9):1209-1220. Epub 2023 Aug 29 doi: 10.7326/M22-3678. PMID: 37639719
Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study.
Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
Systematic review with meta-analysis: the incidence of advanced neoplasia after polypectomy in patients with and without low-risk adenomas.
Hassan C, Gimeno-García A, Kalager M, Spada C, Zullo A, Costamagna G, Senore C, Rex DK, Quintero E
Aliment Pharmacol Ther 2014 May;39(9):905-12. Epub 2014 Mar 4 doi: 10.1111/apt.12682. PMID: 24593121
Colorectal adenoma characteristics as predictors of recurrence.
Bonithon-Kopp C, Piard F, Fenger C, Cabeza E, O'Morain C, Kronborg O, Faivre J; European Cancer Prevention Organisation Study Group
Dis Colon Rectum 2004 Mar;47(3):323-33. doi: 10.1007/s10350-003-0054-1. PMID: 14991494
Bile acid concentrations, cytotoxicity, and pH of fecal water from patients with colorectal adenomas.
de Kok TM, van Faassen A, Glinghammar B, Pachen DM, Eng M, Rafter JJ, Baeten CG, Engels LG, Kleinjans JC
Dig Dis Sci 1999 Nov;44(11):2218-25. doi: 10.1023/a:1026644418142. PMID: 10573365

Prognosis

Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.
Bains L, Lal P, Vindal A, Singh M
World J Surg Oncol 2019 Jun 25;17(1):109. doi: 10.1186/s12957-019-1650-4. PMID: 31238922Free PMC Article
Long-term colorectal-cancer mortality after adenoma removal.
Løberg M, Kalager M, Holme Ø, Hoff G, Adami HO, Bretthauer M
N Engl J Med 2014 Aug 28;371(9):799-807. doi: 10.1056/NEJMoa1315870. PMID: 25162886
Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome.
Flanagan L, Schmid J, Ebert M, Soucek P, Kunicka T, Liska V, Bruha J, Neary P, Dezeeuw N, Tommasino M, Jenab M, Prehn JH, Hughes DJ
Eur J Clin Microbiol Infect Dis 2014 Aug;33(8):1381-90. Epub 2014 Mar 6 doi: 10.1007/s10096-014-2081-3. PMID: 24599709
Systematic review with meta-analysis: the incidence of advanced neoplasia after polypectomy in patients with and without low-risk adenomas.
Hassan C, Gimeno-García A, Kalager M, Spada C, Zullo A, Costamagna G, Senore C, Rex DK, Quintero E
Aliment Pharmacol Ther 2014 May;39(9):905-12. Epub 2014 Mar 4 doi: 10.1111/apt.12682. PMID: 24593121
Pathology of colorectal cancer.
Ponz de Leon M, Di Gregorio C
Dig Liver Dis 2001 May;33(4):372-88. doi: 10.1016/s1590-8658(01)80095-5. PMID: 11432519

Clinical prediction guides

c-MET immunohistochemical expression in sporadic and inflammatory bowel disease associated lesions.
Halliday G, Porter RJ, Black CJ, Arends MJ, Din S
World J Gastroenterol 2022 Apr 7;28(13):1338-1346. doi: 10.3748/wjg.v28.i13.1338. PMID: 35645542Free PMC Article
DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia.
Takiyama A, Tanaka T, Kazama S, Nagata H, Kawai K, Hata K, Otani K, Nishikawa T, Sasaki K, Kaneko M, Emoto S, Murono K, Takiyama H, Nozawa H
In Vivo 2018 Mar-Apr;32(2):365-371. doi: 10.21873/invivo.11247. PMID: 29475922Free PMC Article
Long-term colorectal-cancer mortality after adenoma removal.
Løberg M, Kalager M, Holme Ø, Hoff G, Adami HO, Bretthauer M
N Engl J Med 2014 Aug 28;371(9):799-807. doi: 10.1056/NEJMoa1315870. PMID: 25162886
Expression of RUNX3 and β-catenin in the carcinogenesis of sporadic colorectal tubular adenoma.
Wang L, Li D, Liu Y, Wang Y, Cui J, Cui A, Wu W
Tumour Biol 2014 Jun;35(6):6039-46. Epub 2014 Mar 14 doi: 10.1007/s13277-014-1800-9. PMID: 24622886
Elevated osteopontin expression and proliferative/apoptotic ratio in the colorectal adenoma-dysplasia-carcinoma sequence.
Valcz G, Sipos F, Krenács T, Molnár J, Patai AV, Leiszter K, Tóth K, Solymosi N, Galamb O, Molnár B, Tulassay Z
Pathol Oncol Res 2010 Dec;16(4):541-5. Epub 2010 Mar 27 doi: 10.1007/s12253-010-9260-z. PMID: 20349162

Recent systematic reviews

Real-Time Computer-Aided Detection of Colorectal Neoplasia During Colonoscopy : A Systematic Review and Meta-analysis.
Hassan C, Spadaccini M, Mori Y, Foroutan F, Facciorusso A, Gkolfakis P, Tziatzios G, Triantafyllou K, Antonelli G, Khalaf K, Rizkala T, Vandvik PO, Fugazza A, Rondonotti E, Glissen-Brown JR, Kamba S, Maida M, Correale L, Bhandari P, Jover R, Sharma P, Rex DK, Repici A
Ann Intern Med 2023 Sep;176(9):1209-1220. Epub 2023 Aug 29 doi: 10.7326/M22-3678. PMID: 37639719
Systematic review with meta-analysis: the incidence of advanced neoplasia after polypectomy in patients with and without low-risk adenomas.
Hassan C, Gimeno-García A, Kalager M, Spada C, Zullo A, Costamagna G, Senore C, Rex DK, Quintero E
Aliment Pharmacol Ther 2014 May;39(9):905-12. Epub 2014 Mar 4 doi: 10.1111/apt.12682. PMID: 24593121

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