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Colorectal adenoma

MedGen UID:
224904
•Concept ID:
C1302401
•
Neoplastic Process
Synonym: Colorectal adenomas
SNOMED CT: Adenoma of large intestine (399432003)
 
Monarch Initiative: MONDO:0005484

Definition

An adenoma that arises from the colon or rectum. The group of colorectal adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas, sessile serrated adenomas/polyps, and familial adenomatous polyposis. [from NCI]

Professional guidelines

PubMed

Type 2 diabetes impacts colorectal adenoma detection in screening colonoscopy.
Ottaviano LF, Li X, Murray M, Frye JT, Lung BE, Zhang YY, Yang J, Taub EM, Bucobo JC, Buscaglia JM, Li E, Miller JD
Sci Rep 2020 May 8;10(1):7793. doi: 10.1038/s41598-020-64344-2. PMID: 32385343Free PMC Article
Colorectal Adenomas-Genetics and Searching for New Molecular Screening Biomarkers.
Siskova A, Cervena K, Kral J, Hucl T, Vodicka P, Vymetalkova V
Int J Mol Sci 2020 May 5;21(9) doi: 10.3390/ijms21093260. PMID: 32380676Free PMC Article
Helicobacter pylori: clinical management.
Malfertheiner P, Selgrad M, Bornschein J
Curr Opin Gastroenterol 2012 Nov;28(6):608-14. doi: 10.1097/MOG.0b013e32835918a7. PMID: 23010682

Recent clinical studies

Therapy

Cyclooxygenase Inhibitors and Cancer: The Missing Pieces.
Patrono C
J Pharmacol Exp Ther 2023 Aug;386(2):181-189. Epub 2023 Jun 6 doi: 10.1124/jpet.122.001631. PMID: 37280092
Total, red and processed meat consumption and human health: an umbrella review of observational studies.
Grosso G, La Vignera S, Condorelli RA, Godos J, Marventano S, Tieri M, Ghelfi F, Titta L, Lafranconi A, Gambera A, Alonzo E, Sciacca S, Buscemi S, Ray S, Del Rio D, Galvano F
Int J Food Sci Nutr 2022 Sep;73(6):726-737. Epub 2022 Mar 15 doi: 10.1080/09637486.2022.2050996. PMID: 35291893
Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study.
Chen YX, Gao QY, Zou TH, Wang BM, Liu SD, Sheng JQ, Ren JL, Zou XP, Liu ZJ, Song YY, Xiao B, Sun XM, Dou XT, Cao HL, Yang XN, Li N, Kang Q, Zhu W, Xu HZ, Chen HM, Cao XC, Fang JY
Lancet Gastroenterol Hepatol 2020 Mar;5(3):267-275. Epub 2020 Jan 8 doi: 10.1016/S2468-1253(19)30409-1. PMID: 31926918
Gut microbiome development along the colorectal adenoma-carcinoma sequence.
Feng Q, Liang S, Jia H, Stadlmayr A, Tang L, Lan Z, Zhang D, Xia H, Xu X, Jie Z, Su L, Li X, Li X, Li J, Xiao L, Huber-Schönauer U, Niederseer D, Xu X, Al-Aama JY, Yang H, Wang J, Kristiansen K, Arumugam M, Tilg H, Datz C, Wang J
Nat Commun 2015 Mar 11;6:6528. doi: 10.1038/ncomms7528. PMID: 25758642
Nutritional supplements and cancer: potential benefits and proven harms.
Harvie M
Am Soc Clin Oncol Educ Book 2014:e478-86. doi: 10.14694/EdBook_AM.2014.34.e478. PMID: 24857143

Prognosis

Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma.
Chen F, Dai X, Zhou CC, Li KX, Zhang YJ, Lou XY, Zhu YM, Sun YL, Peng BX, Cui W
Gut 2022 Jul;71(7):1315-1325. Epub 2021 Aug 30 doi: 10.1136/gutjnl-2020-323476. PMID: 34462336Free PMC Article
CX3CR1 Acts as a Protective Biomarker in the Tumor Microenvironment of Colorectal Cancer.
Yue Y, Zhang Q, Sun Z
Front Immunol 2021;12:758040. Epub 2022 Jan 24 doi: 10.3389/fimmu.2021.758040. PMID: 35140706Free PMC Article
Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome.
Wang X, Jia Y, Wen L, Mu W, Wu X, Liu T, Liu X, Fang J, Luan Y, Chen P, Gao J, Nguyen KA, Cui J, Zeng G, Lan P, Chen Q, Cheng B, Wang Z
Cancer Res 2021 May 15;81(10):2745-2759. Epub 2021 Mar 18 doi: 10.1158/0008-5472.CAN-20-3827. PMID: 34003774
Obesity and Colorectal Cancer.
Jochem C, Leitzmann M
Recent Results Cancer Res 2016;208:17-41. doi: 10.1007/978-3-319-42542-9_2. PMID: 27909900
Obesity and colorectal cancer.
Bardou M, Barkun AN, Martel M
Gut 2013 Jun;62(6):933-47. Epub 2013 Mar 12 doi: 10.1136/gutjnl-2013-304701. PMID: 23481261

Clinical prediction guides

Total, red and processed meat consumption and human health: an umbrella review of observational studies.
Grosso G, La Vignera S, Condorelli RA, Godos J, Marventano S, Tieri M, Ghelfi F, Titta L, Lafranconi A, Gambera A, Alonzo E, Sciacca S, Buscemi S, Ray S, Del Rio D, Galvano F
Int J Food Sci Nutr 2022 Sep;73(6):726-737. Epub 2022 Mar 15 doi: 10.1080/09637486.2022.2050996. PMID: 35291893
Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma.
Chen F, Dai X, Zhou CC, Li KX, Zhang YJ, Lou XY, Zhu YM, Sun YL, Peng BX, Cui W
Gut 2022 Jul;71(7):1315-1325. Epub 2021 Aug 30 doi: 10.1136/gutjnl-2020-323476. PMID: 34462336Free PMC Article
CX3CR1 Acts as a Protective Biomarker in the Tumor Microenvironment of Colorectal Cancer.
Yue Y, Zhang Q, Sun Z
Front Immunol 2021;12:758040. Epub 2022 Jan 24 doi: 10.3389/fimmu.2021.758040. PMID: 35140706Free PMC Article
Nutritional prevention of colorectal cancer.
Hull MA
Proc Nutr Soc 2021 Feb;80(1):59-64. Epub 2020 Feb 5 doi: 10.1017/S0029665120000051. PMID: 32019626
Adult weight gain and colorectal adenomas-a systematic review and meta-analysis.
Schlesinger S, Aleksandrova K, Abar L, Vieria AR, Vingeliene S, Polemiti E, Stevens CAT, Greenwood DC, Chan DSM, Aune D, Norat T
Ann Oncol 2017 Jun 1;28(6):1217-1229. doi: 10.1093/annonc/mdx080. PMID: 28327995

Recent systematic reviews

Systematic review and meta-analysis: Associations between metabolic syndrome and colorectal neoplasia outcomes.
Lu L, Koo S, McPherson S, Hull MA, Rees CJ, Sharp L
Colorectal Dis 2022 Jun;24(6):681-694. Epub 2022 Mar 24 doi: 10.1111/codi.16092. PMID: 35156283
Metabolic syndrome and colorectal adenoma risk: A systematic review and meta‑analysis.
Wu H, Zhang J, Zhou B
Clin Res Hepatol Gastroenterol 2021 Sep;45(5):101749. Epub 2021 Jun 29 doi: 10.1016/j.clinre.2021.101749. PMID: 34214702
Metformin and colorectal cancer: a systematic review, meta-analysis and meta-regression.
Ng CW, Jiang AA, Toh EMS, Ng CH, Ong ZH, Peng S, Tham HY, Sundar R, Chong CS, Khoo CM
Int J Colorectal Dis 2020 Aug;35(8):1501-1512. Epub 2020 Jun 26 doi: 10.1007/s00384-020-03676-x. PMID: 32592092
Metformin use and the risk of colorectal adenoma: A systematic review and meta-analysis.
Jung YS, Park CH, Eun CS, Park DI, Han DS
J Gastroenterol Hepatol 2017 May;32(5):957-965. doi: 10.1111/jgh.13639. PMID: 28449338
Adult weight gain and colorectal adenomas-a systematic review and meta-analysis.
Schlesinger S, Aleksandrova K, Abar L, Vieria AR, Vingeliene S, Polemiti E, Stevens CAT, Greenwood DC, Chan DSM, Aune D, Norat T
Ann Oncol 2017 Jun 1;28(6):1217-1229. doi: 10.1093/annonc/mdx080. PMID: 28327995

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