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Disorder of ovary

MedGen UID:
45256
•Concept ID:
C0029928
•
Disease or Syndrome
Synonyms: Disease, Ovarian; Diseases, Ovarian; Ovarian Disease; Ovarian Diseases
SNOMED CT: Ovarian disorder (5552004); Disorder of ovary (5552004)

Definition

A non-neoplastic or neoplastic disorder that affects the ovary. Representative examples of non-neoplastic disorders include endometriosis and polycystic ovarian disease. Representative examples of neoplastic disorders include ovarian surface epithelial-stromal tumors, germ cell tumors, and sex cord-stromal tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of ovary

Professional guidelines

PubMed

Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome.
Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE; International PCOS Network
Eur J Endocrinol 2023 Aug 2;189(2):G43-G64. doi: 10.1093/ejendo/lvad096. PMID: 37580861
Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.
Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE
J Clin Endocrinol Metab 2023 Sep 18;108(10):2447-2469. doi: 10.1210/clinem/dgad463. PMID: 37580314Free PMC Article
Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment.
Escobar-Morreale HF
Nat Rev Endocrinol 2018 May;14(5):270-284. Epub 2018 Mar 23 doi: 10.1038/nrendo.2018.24. PMID: 29569621

Recent clinical studies

Etiology

The Effect of Hormonal Treatment on Ovarian Endometriomas: A Systematic Review and Meta-Analysis.
Thiel PS, Donders F, Kobylianskii A, Maheux-Lacroix S, Matelski J, Walsh C, Murji A
J Minim Invasive Gynecol 2024 Apr;31(4):273-279. Epub 2024 Jan 6 doi: 10.1016/j.jmig.2024.01.002. PMID: 38190884
High risk and low prevalence diseases: Ovarian torsion.
Bridwell RE, Koyfman A, Long B
Am J Emerg Med 2022 Jun;56:145-150. Epub 2022 Mar 31 doi: 10.1016/j.ajem.2022.03.046. PMID: 35397355
Towards complication-free assisted reproduction technology.
Santos-Ribeiro S, Mackens S, Racca A, Blockeel C
Best Pract Res Clin Endocrinol Metab 2019 Feb;33(1):9-19. Epub 2018 Nov 3 doi: 10.1016/j.beem.2018.10.006. PMID: 30473208
Ovarian torsion.
Cass DL
Semin Pediatr Surg 2005 May;14(2):86-92. doi: 10.1053/j.sempedsurg.2005.01.003. PMID: 15846564
Terms, definitions and measurements to describe the sonographic features of adnexal tumors: a consensus opinion from the International Ovarian Tumor Analysis (IOTA) Group.
Timmerman D, Valentin L, Bourne TH, Collins WP, Verrelst H, Vergote I; International Ovarian Tumor Analysis (IOTA) Group
Ultrasound Obstet Gynecol 2000 Oct;16(5):500-5. doi: 10.1046/j.1469-0705.2000.00287.x. PMID: 11169340

Diagnosis

A comprehensive review of the new FIGO classification of ovulatory disorders.
Balen AH, Tamblyn J, Skorupskaite K, Munro MG
Hum Reprod Update 2024 May 2;30(3):355-382. doi: 10.1093/humupd/dmae003. PMID: 38412452
High risk and low prevalence diseases: Ovarian torsion.
Bridwell RE, Koyfman A, Long B
Am J Emerg Med 2022 Jun;56:145-150. Epub 2022 Mar 31 doi: 10.1016/j.ajem.2022.03.046. PMID: 35397355
Managing poor ovarian response in the patient with diminished ovarian reserve.
Cedars MI
Fertil Steril 2022 Apr;117(4):655-656. doi: 10.1016/j.fertnstert.2022.02.026. PMID: 35367010
Reproductive ovarian testing and the alphabet soup of diagnoses: DOR, POI, POF, POR, and FOR.
Pastore LM, Christianson MS, Stelling J, Kearns WG, Segars JH
J Assist Reprod Genet 2018 Jan;35(1):17-23. Epub 2017 Oct 2 doi: 10.1007/s10815-017-1058-4. PMID: 28971280Free PMC Article
Ovarian torsion.
Cass DL
Semin Pediatr Surg 2005 May;14(2):86-92. doi: 10.1053/j.sempedsurg.2005.01.003. PMID: 15846564

Therapy

Primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC) for FIGO stage III epithelial ovarian cancer: OVHIPEC-2, a phase III randomized clinical trial.
Koole S, van Stein R, Sikorska K, Barton D, Perrin L, Brennan D, Zivanovic O, Mosgaard BJ, Fagotti A, Colombo PE, Sonke G, Driel WJV; OVHIPEC-2 Steering Committee and the Dutch OVHIPEC group
Int J Gynecol Cancer 2020 Jun;30(6):888-892. Epub 2020 Mar 23 doi: 10.1136/ijgc-2020-001231. PMID: 32205449Free PMC Article
Towards complication-free assisted reproduction technology.
Santos-Ribeiro S, Mackens S, Racca A, Blockeel C
Best Pract Res Clin Endocrinol Metab 2019 Feb;33(1):9-19. Epub 2018 Nov 3 doi: 10.1016/j.beem.2018.10.006. PMID: 30473208
Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial.
Xu Y, Nisenblat V, Lu C, Li R, Qiao J, Zhen X, Wang S
Reprod Biol Endocrinol 2018 Mar 27;16(1):29. doi: 10.1186/s12958-018-0343-0. PMID: 29587861Free PMC Article
Imaging modalities for the non-invasive diagnosis of endometriosis.
Nisenblat V, Bossuyt PM, Farquhar C, Johnson N, Hull ML
Cochrane Database Syst Rev 2016 Feb 26;2(2):CD009591. doi: 10.1002/14651858.CD009591.pub2. PMID: 26919512Free PMC Article
Endometriosis after menopause.
Inceboz U
Womens Health (Lond) 2015 Aug;11(5):711-5. Epub 2015 Sep 7 doi: 10.2217/whe.15.59. PMID: 26343168

Prognosis

Psychological factors increase the risk of ovarian cancer.
Geng S, Zhang X, Zhu X, Wang Y, Wang Y, Sun Y
J Obstet Gynaecol 2023 Dec;43(1):2187573. doi: 10.1080/01443615.2023.2187573. PMID: 36920175
Managing poor ovarian response in the patient with diminished ovarian reserve.
Cedars MI
Fertil Steril 2022 Apr;117(4):655-656. doi: 10.1016/j.fertnstert.2022.02.026. PMID: 35367010
Ovarian cancer today and tomorrow: A global assessment by world region and Human Development Index using GLOBOCAN 2020.
Cabasag CJ, Fagan PJ, Ferlay J, Vignat J, Laversanne M, Liu L, van der Aa MA, Bray F, Soerjomataram I
Int J Cancer 2022 Nov 1;151(9):1535-1541. Epub 2022 Mar 30 doi: 10.1002/ijc.34002. PMID: 35322413
Towards complication-free assisted reproduction technology.
Santos-Ribeiro S, Mackens S, Racca A, Blockeel C
Best Pract Res Clin Endocrinol Metab 2019 Feb;33(1):9-19. Epub 2018 Nov 3 doi: 10.1016/j.beem.2018.10.006. PMID: 30473208
Ultrasound Imaging for Ovarian and Deep Infiltrating Endometriosis.
Exacoustos C, Zupi E, Piccione E
Semin Reprod Med 2017 Jan;35(1):5-24. Epub 2017 Jan 11 doi: 10.1055/s-0036-1597127. PMID: 28076877

Clinical prediction guides

Pathophysiology and Clinical Implications of Ovarian Endometriomas.
Nezhat FR, Cathcart AM, Nezhat CH, Nezhat CR
Obstet Gynecol 2024 Jun 1;143(6):759-766. Epub 2024 Apr 16 doi: 10.1097/AOG.0000000000005587. PMID: 38626453Free PMC Article
Acupuncture and moxibustion for diminished ovarian reserve: A scoping review.
Xie Y, Shi W, Tan Y, Yao M, Qing M, Luo X, Zhang W
Complement Ther Med 2023 Oct;77:102973. Epub 2023 Aug 18 doi: 10.1016/j.ctim.2023.102973. PMID: 37598724
Adnexal Lesion Imaging: Past, Present, and Future.
Sadowski EA, Rockall A, Thomassin-Naggara I, Barroilhet LM, Wallace SK, Jha P, Gupta A, Shinagare AB, Guo Y, Reinhold C
Radiology 2023 Jun;307(5):e223281. Epub 2023 May 9 doi: 10.1148/radiol.223281. PMID: 37158725
Ovarian inguinal hernia.
Prodromidou A, Machairas N, Garoufalia Z, Kostakis ID, Kyriakidis AV, Spartalis E, Sotiropoulos GC
Ann R Coll Surg Engl 2020 Feb;102(2):75-83. Epub 2019 Nov 7 doi: 10.1308/rcsann.2019.0137. PMID: 31696731Free PMC Article
Criteria, prevalence, and phenotypes of polycystic ovary syndrome.
Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R
Fertil Steril 2016 Jul;106(1):6-15. Epub 2016 May 24 doi: 10.1016/j.fertnstert.2016.05.003. PMID: 27233760

Recent systematic reviews

Polycystic ovaries and herbal remedies: A systematic review.
Manouchehri A, Abbaszadeh S, Ahmadi M, Nejad FK, Bahmani M, Dastyar N
JBRA Assist Reprod 2023 Mar 30;27(1):85-91. doi: 10.5935/1518-0557.20220024. PMID: 35916457Free PMC Article
Life Modifications and PCOS: Old Story But New Tales.
Gu Y, Zhou G, Zhou F, Wu Q, Ma C, Zhang Y, Ding J, Hua K
Front Endocrinol (Lausanne) 2022;13:808898. Epub 2022 Apr 13 doi: 10.3389/fendo.2022.808898. PMID: 35498415Free PMC Article
Clinical Practice Guidelines on the Diagnosis and Management of Polycystic Ovary Syndrome: A Systematic Review and Quality Assessment Study.
Al Wattar BH, Fisher M, Bevington L, Talaulikar V, Davies M, Conway G, Yasmin E
J Clin Endocrinol Metab 2021 Jul 13;106(8):2436-2446. doi: 10.1210/clinem/dgab232. PMID: 33839790Free PMC Article
Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: a guideline.
Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org; Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2016 Dec;106(7):1634-1647. Epub 2016 Sep 24 doi: 10.1016/j.fertnstert.2016.08.048. PMID: 27678032
The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis.
Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO
Hum Reprod 2016 Dec;31(12):2841-2855. Epub 2016 Sep 22 doi: 10.1093/humrep/dew218. PMID: 27664216

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