Ovarian Leiomyoma

MedGen UID:: 1792083
•Concept ID:: C5555642
•: Neoplastic Process

Definition

A benign smooth muscle neoplasm arising from the ovary. It is usually characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. Variants with increased cellularity, increased mitotic activity, myxoid changes, or epithelioid morphology have also been reported. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVOvarian Leiomyoma

Benign neoplasm
- Benign connective and soft tissue neoplasm
  - Benign soft tissue neoplasm
    - Benign muscle neoplasm
      - Benign smooth muscle neoplasm
        Leiomyoma
        Ovarian Leiomyoma

Professional guidelines

PubMed

Smooth muscle tumors of the ovary: a clinicopathologic study of 54 cases emphasizing prognostic criteria, histologic variants, and differential diagnosis.

Lerwill MF, Sung R, Oliva E, Prat J, Young RH
Am J Surg Pathol 2004 Nov;28(11):1436-51. doi: 10.1097/01.pas.0000141393.99300.d0. PMID: 15489647

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Recent clinical studies

Etiology

A large ovarian leiomyoma discovered incidentally in a 76-year-old woman: case report.

Ichigo S, Takagi H, Matsunami K, Murase T, Ikeda T, Imai A
Eur J Gynaecol Oncol 2015;36(2):203-5. PMID: 26050361

Treatment of bilateral multiple primary ovarian leiomyomas during pregnancy by way of conservative surgery: a case report.

Daniel Y, Lessing JB, Bar-Am A, Kupferminc MJ, Jossiphov J, Peyser MR
Eur J Obstet Gynecol Reprod Biol 1997 Aug;74(2):125-6. doi: 10.1016/s0301-2115(97)00087-0. PMID: 9306103

Ovarian leiomyoma. Case report.

San Marco L, Londero F, Stefanutti V, Costa L, Rocco M
Clin Exp Obstet Gynecol 1991;18(2):145-8. PMID: 1914210

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Diagnosis

Primary ovarian leiomyoma: a rare ovarian tumour.

Pervan M, Gembicki M, Princk H, Rody A, Hanker L, Hemptenmacher F, Banys-Paluchowski M
Arch Gynecol Obstet 2023 Oct;308(4):1379-1380. Epub 2022 Dec 21 doi: 10.1007/s00404-022-06842-4. PMID: 36539622 Free PMC Article

Cystic Ovarian Leiomyoma in a Patient with Progressive Abdominal Pain.

Alshwairikh K, AlOtaibi W, Alshammari S, Alshammari T, Hakami R, Alswayyed M, Bin Traiki T
Am J Case Rep 2021 Jun 30;22:e930299. doi: 10.12659/AJCR.930299. PMID: 34191791 Free PMC Article

Bilateral ovarian edema with unilateral ovarian leiomyoma and double inferior vena cava: a case report.

Shrestha S, Homagain S, Kandel S, Jha P, Gurung G
J Med Case Rep 2020 Jul 12;14(1):97. doi: 10.1186/s13256-020-02418-5. PMID: 32653030 Free PMC Article

Robotic resection of a large ovarian leiomyoma.

Mangano A, Valle V, Bustos R, Gruessner S, Masrur M, Aguiluz G, Bianco F, Giulianotti PC
Minerva Chir 2020 Apr;75(2):121-124. doi: 10.23736/S0026-4733.20.08253-X. PMID: 32267137

Ovarian leiomyoma with myxoid stroma.

Moulla A, Magdy N, El-Bahrawy M
Pathologica 2017 Dec;109(4):389-391. PMID: 29449730

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Prognosis